Pathways quiescent satellite cell. Medical search. Frequent questions

PKD is a family of serine-threonine kinases that regulate gene expression, protein secretion, cell proliferation, differentiation and inflammation. (bvsalud.org)
Functional assays showed that circIGF1R promoted myoblast differentiation of porcine skeletal muscle satellite cells (SMSCs), while it had no effect on cell proliferation. (bvsalud.org)
Furthermore, the rescue experiments showed that circIGF1R could counteract the inhibitory effect of miR-16 on cell myoblast differentiation. (bvsalud.org)
Myogenic regeneration occurs through a chain of events beginning with the output of satellite cells from quiescent state, formation of competent myoblasts and later fusion and differentiation into myofibres. (gla.ac.uk)
Yap expression increases during satellite cell activation and Yap remains highly expressed until after the differentiation versus self-renewal decision is made. (kcl.ac.uk)
Constitutive expression of Yap maintains Pax7 + and MyoD + satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. (kcl.ac.uk)
Constitutive expression of Yap maintains Pax7+ and MyoD+ satellite cells and satellite cell-derived myoblasts, promotes proliferation but prevents differentiation. (kcl.ac.uk)
Researchers at the Fujian Provincial Research Institution of Traditional Chinese Medicine conclude that acupuncture reduces muscle cell death while promoting the proliferation and differentiation of muscle satellite cells. (acupunctureofiowa.com)
The embryonic AMPs are at the origin of all adult fly muscles and, as we demonstrate here, they express repressors of myogenic differentiation and targets of the Notch pathway known to be involved in muscle cell stemness. (biologists.com)
Sonic 125256-00-0125B11 hedgehog (Shh) is a forty five-kDa potent signaling protein that regulates the proliferation, differentiation, and cellular patterning throughout a extensive selection of cell types [2,3]. (acthreceptor.com)
It was described that hedgehog proteins right act on osteogenic precursor cells and osteoblasts to stimulate osteogenic differentiation [7]. (acthreceptor.com)
Focal adhesion kinase (FAK) is a one hundred twenty five-kD non-receptor tyrosine kinase that plays a main position in mediating sign transduction by integrins, as effectively as by growth aspect receptors, in the regulation of cell adhesion, migration, proliferation, and differentiation in a range of mobile varieties [12,thirteen,fourteen]. (acthreceptor.com)
A novel FAK Tyr397 inhibitor suppresses osteoblast proliferation and differentiation, as well as osteoclast formation, via PTHrP-induced RANKL expression in murine bone stromal ST2 cells [twenty]. (acthreceptor.com)
The transcription factor CCAAT/enhancer binding protein beta (C/EBPβ) is expressed in Pax7 + satellite cells of healthy muscle and is downregulated during myoblast differentiation. (biomedcentral.com)
When overexpressed in the murine myoblast cell line C2C12 or in primary myoblasts, C/EBPβ reduced MyoD and other myogenic protein levels during differentiation, in addition to reducing myoblast fusion. (biomedcentral.com)

From pioneering research on the in vivo expression, structure and regulation of muscle genes, she and her lab went on to study the myogenic regulatory factors, showing that Myf5 is present before MyoD in the embryo and that in the absence of Myf5 and Mrf4, cells fail to form skeletal muscle and acquire other mesodermal cell fates. (wikipedia.org)
In the resected muscle and in the passively stretched antagonist muscle, there was a dramatic increase in the number of myofibers positive for neonatal MyHC and in the number of BrdU- and MyoD-positive satellite cells. (arvojournals.org)

These cells are located beneath the basal lamina of myofiber in a dormant state. (elifesciences.org)
For example, muscle stem cells (MuSCs), located beneath the basal lamina, exist in the quiescent state but can transition to an activated, proliferative state upon injury. (biomed.news)

In parallel with these events, quiescent muscle precursor cells (satellite cells), are activated. (cdc.gov)
Furthermore, Gln serves as a precursor for the synthesis of arginine, which is indispensable for the optimal growth of neonatal piglets 14 and plays important roles in essential metabolic pathways 15 . (nature.com)
CD34 is expressed on early precursor cells of myeloid and B-cell lineages, and CD15 is expressed on immature monocytic lineage cells and highly expressed on granulocytic lineage cells.31 As diseased muscle contains many myeloid cells such as neutrophils, monocytes, and macrophages, a more specific marker for mesenchymal cells with adipogenic potential is AAF-CMK required for detailed characterization of these cells in human diseased muscle. (phytid.org)
Postnatal growth and repair of skeletal muscle relies upon a population of quiescent muscle precursor cells, called satellite cells that can be activated to proliferate and differentiate into new myofibers, as well as self-renew to replenish the satellite cell population. (biomedcentral.com)

This property is primarily attributable to satellite cells which comprise a small population of quiescent mono-nucleated cells which first appear during late fetal life, and which reside between the basal lamina and the surface (sarcolemma) of mature skeletal muscle cells. (missouri.edu)

Mitotically quiescent in mature muscle, they can be activated to proliferate and generate myoblasts to supply further myonuclei to hypertrophying or regenerating muscle fibres, or self-renew to maintain the resident stem cell pool. (kcl.ac.uk)
The activated satellite cells proliferate, migrate and fuse with other cells to form new multinucleated myotubest and eventually replace the disrupted myofibers. (cdc.gov)
Morgan and Partridge note that skeletal muscle satellite cells "are normally quiescent in adult muscle, but act as a reserve population of cells, able to proliferate in response to injury and give rise to regenerated muscle and to more satellite cells. (acupunctureofiowa.com)
For bone formation to happen, osteoblast cells need to proliferate and migrate from the bone marrow compartment to bone surfaces, the place they adhere, differentiate, and deposit the bone matrix concurrently with bone and bony callus resorption by osteoclasts [1]. (acthreceptor.com)
Our laboratory has been working for several years with an in vitro model of human muscle regeneration, where activated muscle stem cells proliferate as myoblasts and differentiate into myotubes, but also reform a quiescent stem cell population, called reserve cells. (fsrmm.ch)

Cell Stem Cell , 23 (4), 530-543.e9. (umn.edu)
The premise behind this manuscript is important and timely for muscle biologists and for stem cell biologists. (sciety.org)
The identification of heterogenous distribution of factors across the myofiber is an important contribution for dissecting how muscle stem cell diversity in a tissue is achieved. (sciety.org)
The quiescent muscle stem cell (QSC) pool is heterogeneous and generally characterized by the presence and levels of intrinsic myogenic transcription factors. (sciety.org)
Therefore, these results establish the efficacy of diprotin A in stimulating muscle cell engraftment, and highlight the pre-clinical utility of a xenotransplantation model in assessing the relative efficacy of muscle stem cell populations. (biomedcentral.com)
We used a clinically acceptable regimen of hematopoietic stem cell transplantation to establish mixed donor/host blood cell chimerism and immune tolerance in a canine model of Duchenne muscular dystrophy ( cxmd ) [ 9 ]. (biomedcentral.com)

They discovered a population of Pax3/Pax7-positive progenitors that are essential for foetal muscle development and showed that Pax-positive satellite cells associated with adult fibres constitute stem cells for muscle regeneration. (wikipedia.org)
Traditionally, growth factors are used to stimulate muscle regeneration but this involves serious off-target effects, including alterations in cell homeostasis and cancer. (gla.ac.uk)
Skeletal muscle is a complex tissue containing tissue resident muscle stem cells (satellite cells) (MuSCs) important for postnatal muscle growth and regeneration. (umn.edu)
Skeletal muscle regeneration is regulated by coordinated activation of multiple signaling pathways. (elifesciences.org)
Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
Satellite cells (SCs), which are precursors of skeletal muscles, such as the TA muscle, play a key role in muscle homeostasis and regeneration. (biomedcentral.com)
SCs are normally in a quiescent state in adult muscles, and start proliferating during muscle regeneration in response to denervation. (biomedcentral.com)
Furthermore, the implantation of Shhtransduced cells increased the bone regeneration in a rabbit product of calvaria problems [8]. (acthreceptor.com)
Using genetic tools to conditionally abrogate C/EBPβ expression in Pax7 + cells, we examined the role of C/EBPβ in self-renewal of satellite cells during muscle regeneration. (biomedcentral.com)
After a single muscle injury, C/EBPβ-deficient satellite cells fail to self-renew resulting in a reduction of satellite cells available for future rounds of regeneration. (biomedcentral.com)
These findings demonstrate that C/EBPβ is a novel regulator of satellite cell self-renewal during muscle regeneration acting at least in part through Notch2. (biomedcentral.com)
Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
Mechanisms regulating cardiomyocyte cell cycle arrest are of great interest partly because reversing this process could provide a way to stimulate cardiac regeneration after injury [ 17 ]. (springer.com)
1 2 Residing outside the sarcolemma but within the basal lamina of individual myofibers is a population of cells that are responsible for muscle repair and regeneration, the satellite cells. (arvojournals.org)
6 These manipulations result in satellite cell activation and proliferation, which in turn are responsible for muscle repair and regeneration. (arvojournals.org)
Aging lowers the replicative potential of most cells and the capacity for tissue regeneration ( 1 , 2 ). (diabetesjournals.org)
The regeneration process of skeletal muscle is induced after a lesion or an overloaded exercise and relies on the presence of muscle stem cells, called satellite cells. (fsrmm.ch)

Thus, these markers in combination with basal lamina staining were useful for the identification of human satellite cells. (phytid.org)
Basal and limbal stem cells contribute to mitosis. (medscape.com)

The mTORC1 signaling cascade receives inputs from various upstream cues related to the metabolic and nutritional status of the cell and translates these into cell growth [ 4 , 6 ]. (springer.com)

They identified genes, including Pitx2/3, that affect the behaviour of these cells and showed that Myf5 mRNA, present in quiescent satellite cells is sequestered until these cells are activated after injury. (wikipedia.org)
The expression of p16/INK4A mRNA did not change in heterochronic parabiosis, suggesting the involvement of other pathways. (diabetesjournals.org)
Quantifying the exact expression levels of the mRNA isoforms encoding these myogenic transcription factors is therefore key to understanding how MuSCs switch between cell states. (biomed.news)
We demonstrate that mdPCR can give exact molecule counts per cell for mRNA isoforms encoding the myogenic transcription factor Pax3. (biomed.news)

She has studied both the formation of skeletal muscle and of the heart, using the tools of mouse molecular genetics to characterise cell behaviour and to identify the genes that govern cell fate choices. (wikipedia.org)
Quantitative analysis of the biological function of MuSCs and the molecular pathways responsible for a potential juxtavascular niche for MuSCs is currently lacking. (umn.edu)
Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
It may also provide new insights into the molecular pathways that go awry in common forms of conditions such as obesity and diabetes, which represent major public health concerns [ 8 , 9 ]. (springer.com)
Collisions between giant molecular clouds (GMCs) are one of the pathways for massive star formation due to the high densities created. (klessen.org)

Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
Consistent with the cellular phenotype, microarrays show that Yap increases expression of genes associated with Yap inhibition, the cell cycle, ribosome biogenesis and that it represses several genes associated with angiotensin signalling. (kcl.ac.uk)
Therefore, we complemented our investigations into the cellular development of the skeletal muscle of neonatal piglets with in vitro studies using a primary porcine myogenic cell culture model with Gln supplementation. (nature.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
In some cases, the decline in proliferation reaches an irreversible state called cellular senescence, which is characterized by a total lack of cell divisions and altered cellular morphology, gene expression profile, and chromatin organization ( 3 ). (diabetesjournals.org)
Primary cilia are sensory organelles that coordinate multiple cellular signaling pathways, including Hedgehog (HH), Wingless/Int (WNT) and Transforming Growth Factor-β (TGF-β) signaling. (springer.com)
This delay is required for preparatory cellular changes prior to rapid cell movement. (medscape.com)

Her main contribution to cardiogenesis is the identification of the second heart field (SHF) as a major source of cardiac progenitor cells that form specific regions of the heart. (wikipedia.org)
Embryonic myogenic progenitor cells express CXCR4, G-protein coupled cell surface receptor, and migrate towards regions of SDF-1 expression during limb muscle development, suggesting that CXCR4/SDF-1 plays a role in muscle cell homing. (biomedcentral.com)

The use of mesenchymal stem cells (MSCs) as a regenerative therapy holds the promise of regrowing injured vasculature, helping DM patients live healthier and longer lives. (thno.org)

The role of the Hippo pathway effector YAP1 in soft tissue sarcomas is poorly defined. (elsevierpure.com)
They have proinflammatory functions: they produce effector molecules (reactive oxygen and nitrogen intermediates) and inflammatory cytokines (IL-1 β , TNF α , and IL-6) and participate as inducer and effector cells in polarized Th1 responses. (hindawi.com)
Furthermore, GSOs protected cells against GLU-induced apoptosis by reducing the expression of the mitochondrial apoptosis-associated Bcl-2 family effector proteins and protected cells from GLU-induced oxidative damage by increasing the nuclear translocation of Nrf2 and HO-1 expression. (sdbonline.org)
Reduced SMO-dependent expression of Gli1 was demonstrated in both Tsc1 −/− and Tsc2 −/− cells, and we found that Tsc1 is required for TGF-β induced phosphorylation of SMAD2/3 and subsequent expression of the HH signaling effector and transcription factor GLI2. (springer.com)

Myogenic transcription is tightly regulated by various intracellular signaling pathways, which include members of the protein kinase D (PKD) family. (bvsalud.org)
CCRl and CCR5, were colocalized, through immunostaining analysis, with mac-3, a marker of activated macrophages and myogenin, a transcription factor involved in satellite cell activation. (cdc.gov)
TEA domain-1 (TEAD1) transcription factor participates in both slow oxidative fiber type gene expression and plays a role in satellite cell biology. (missouri.edu)

In mice, sustained YAP1 hyperactivity in activated, but not quiescent, satellite cells induces ERMS with high penetrance and short latency. (elsevierpure.com)

We show that MuSCs express abundant VEGFA, which recruits endothelial cells (ECs) in vitro, whereas blocking VEGFA using both a vascular endothelial growth factor (VEGF) inhibitor and MuSC-specific VEGFA gene deletion reduces the proximity of MuSCs to capillaries. (umn.edu)

abstract = "Satellite cells are the resident stem cells of skeletal muscle. (kcl.ac.uk)

Further, using in vitro model, C2C12, a myoblast cell line, we demonstrated that satellite cells express CCR2 and CCRS receptors and these chemokine pathways are involved in satellite cell migration activity. (cdc.gov)

Myofiber-specific ablation of IRE1α dampens Notch signaling and canonical NF-κB pathway in skeletal muscle of adult mice. (elifesciences.org)
Here we show that the muscle fiber maintains a continuum of quiescent states, through a gradient of Notch ligand, Dll4, produced by the fiber and captured by QSCs. (sciety.org)
Our data shows that a post-translational mechanism controls spatial heterogeneity of Notch ligands in a multinucleated niche cell to maintain a continuum of diverse states within the SC pool during tissue homeostasis. (sciety.org)

Cell culture experiments indicated that Gln could promote cell proliferation in a dose dependent manner, but expression of myogenesis regulatory genes was not altered. (nature.com)
A second area if interest is how initial satellite cell number is determined during skeletal muscle formation (myogenesis). (missouri.edu)

The international journal of biochemistry & cell biology 35, no. 8 (2003): 1151-1156. (acupunctureofiowa.com)

Satellite cells help to repair and regenerate muscle fibers. (acupunctureofiowa.com)
Recently, two independent models, one from rodents and the other from insects, have demonstrated that nuclei are not lost from skeletal muscle fibers when they undergo either atrophy or programmed cell death. (frontiersin.org)
Diprotin A stimulation of CXCR4, however, significantly increased the number of canine dystrophin-positive muscle fibers and canine-derived satellite cells by enhancing donor cell proliferation. (biomedcentral.com)
Until recently, scientists thought this meant that nuclei - the cell control centers that build and maintain muscle fibers - are also lost to sloth. (robert-gorter.info)

Here, we identify the transcriptional co-factor Yap as a novel regulator of satellite cell fate decisions. (kcl.ac.uk)

The development of transgenic mouse models that express genes of interest in specific cell types has transformed our understanding of basic biology and disease. (nature.com)
Heart, bone and even placenta are built on these networks of cells," says Lawrence Schwartz, Professor of Biology at the University of Massachusetts. (robert-gorter.info)

ERKi treatment of cells drives the poly-ubiquitylation and proteasome-dependent turnover of ERK2 and pharmacological or genetic inhibition of Cullin-RING E3 ligases prevents this. (babraham.ac.uk)
This suggests that DNA replication following escape from G1 arrest in drug is more error prone and provides a potential explanation for the DNA damage observed under long-term RAF-MEK-ERK1/2 pathway inhibition. (babraham.ac.uk)

Furthermore, TSC1 was demonstrated to be required for the proper activation of the transforming growth factor-β (TGF-β)-SMAD2/3 pathway in HeLa cells [ 11 ]. (springer.com)

Conversely, during starvation mTORC1 is inhibited and autophagy is induced by AMP-activated protein kinase (AMPK), leading to generation of intracellular nutrients and energy during degradation of non-functional or non-essential organelles or protein aggregates [ 4 , 6 ], in turn contributing to cell survival. (springer.com)

Margaret Buckingham is a developmental biologist who is interested in how naïve multipotent cells acquire tissue specificity during embryogenesis. (wikipedia.org)
performed skeletal muscle tissue clearing and unbiased fluorescent image analysis to show that muscle stem cells (satellite cells) pattern the microvasculature to be in close proximity to them via VEGFA. (umn.edu)
Overall, Gln supplementation stimulated cell proliferation in muscle tissue and in vitro in myogenic cell culture, whereas muscle growth regulatory genes were barely altered. (nature.com)
Skeletal muscle, the most abundant tissue of the body, has remarkable regenerative capacity mainly due to its resident muscle stem cells, also known as satellite cells. (elifesciences.org)
Both miRNAs and siRNAs need to be delivered into the target tissue or cell in order to activate the desired therapeutic effect," Muthiah Manoharan, Ph.D., senior vp, drug discovery, Alnylam Pharmaceuticals, explained. (genengnews.com)
However, since there are many different non-muscle cell populations that reside within the tissue, these experiments cannot easily distinguish true myonuclei from those of neighboring mononuclear cells. (frontiersin.org)
This research often requires the tissue-specific expression of transgenes to better mirror human diseases, to visualize pathways being studied or to modulate the expression of a disease-related gene. (nature.com)
Limitations in the usage of AAV in murine models include cell types that are refractory to transduction and difficulties achieving tissue-specificity. (nature.com)
It's actually a special type of tissue in your body, where cells are fused together extra close - so close, that they behave a like a giant single cell. (robert-gorter.info)
The levels of catalase (CAT) and glutathione (GSH) were measured in PC12 cells and Drosophila brain tissue. (sdbonline.org)
GSOs also mitigated the deleterious effects of GLU on the mitochondrial membrane potential and Cyt C release, thus alleviating mitochondrial dysfunction, and increased GSH levels and CAT activity in both cells and Drosophila brain tissue. (sdbonline.org)
The compromised tissue repair program is attributable to the gradual depletion of stem cells and to altered regulatory signals. (biomed.news)
Adult stem cells play key roles in homeostasis and tissue repair. (biomed.news)
Numerous cytokines and growth factors that are up-regulated in corneal cells further contribute to tissue inflammation. (medscape.com)

In vivo , the identification of macrophage phenotype is complicated since macrophages are obviously exposed to a microenvironment that is more complex respect to cell culture conditions, and they display characteristics that do not conform to the in vitro defined phenotypic categories. (hindawi.com)
10 Even more compelling is a recent study that subjected individual quiescent satellite cells isolated from adult limb muscle to stretching in vitro, and showed that direct stretching of the satellite cells themselves results in activation and bromodeoxyuridine (BrdU) incorporation. (arvojournals.org)

Ex vivo cultures of myofiber explants demonstrate that ablation of IRE1α reduces the proliferative capacity of myofiber-associated satellite cells. (elifesciences.org)
LY294002 (PI3K inhibitor) and U0126 (MEK1/2 inhibitor) completely inhibited the stimulatory effect of PDGF-AA, but PD98059 (MEK1 inhibitor) had no effect (Figure 5g), suggesting that PDGFRexerts its proliferative effect through PI3K-Akt and MEK2-MAPK pathways. (phytid.org)

We demonstrate that this process occurs through the PI3K/Akt pathway, via zinc stimulation of transporter Zip7. (gla.ac.uk)
Activated TPKR could activate its downstream signaling elements, like Ras/Raf/MEK/ERK, PI3K/Akt/eIF4E, PI3K/Akt/eNOS and PLC-gamma/PKC pathways. (biomedcentral.com)

We hypothesize that early inflammatory mediators, such as chemokines, are released during the muscle disruption and degeneration and are involved in macrophage recruitment and satellite cell migration and activation. (cdc.gov)
Firstly, loss of dGLYAT suppressed scrib depletion- or Egr overexpression-induced JNK pathway activation and invasive cell migration. (sdbonline.org)
However, we showed that the activation is independent of the calcium signal while the migration of reserve cells depends on calcium response. (fsrmm.ch)

By directing AAV transduction through the regulated expression of its receptor, the approach provides precise control over which cells express the AAV-vectored transgene. (nature.com)

Moreover, we show that mature myofibres, obtained through stimulation with high concentrations of zinc, accumulate zinc and so we hypothesise their function as zinc reservoirs into the cell. (gla.ac.uk)
Serum stimulation triggered the re-entry into the cell cycle (activation) of a subset of reserve cells, that is associated with an elevation of the cytosolic calcium concentration. (fsrmm.ch)

Satellite cells are considered adult skeletal muscle stem cells that are responsible for the majority of post-birth skeletal muscle growth (maturation and hypertrophy) and adult skeletal muscle homeostasis. (missouri.edu)

A single, early local administration of high-dose bFGF prevented atrophic changes in the thyroarytenoid muscles by activating satellite cell proliferation and reforming neuromuscular junctions. (biomedcentral.com)
Skeletal muscles are the largest cells in the body and are one of the few syncytial ones. (frontiersin.org)
There is a general agreement that hypertrophy is accompanied by the addition of new nuclei from stem cells to help the muscles meet the enhanced synthetic demands of a larger cell. (frontiersin.org)
But by far our biggest cells - and biggest syncytia - are our muscles. (robert-gorter.info)
Both active and passive stretch of the rectus muscles produced by strabismus surgery dramatically upregulated the processes of satellite cell activation, integration of new myonuclei into existing myofibers, and concomitant upregulation of immature myosin heavy chain isoforms. (arvojournals.org)
Irradiation treatment, which eliminates satellite cells from these muscles, prevents the compensatory hypertrophy in these types of experiments. (arvojournals.org)

In murine-to-murine transplantation experiments, CXCR4 expression marks a population of adult murine satellite cells with robust engraftment potential in mdx mice, and CXCR4-positive murine muscle-derived SP cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice. (biomedcentral.com)
In this study, we used a canine-to-murine xenotransplantation model to quantitatively compare canine muscle cell engraftment, and test the most effective cell population and modulating factor in a canine model of DMD using allogeneic transplantation experiments. (biomedcentral.com)
Yet, it remains unclear from murine transplantation experiments which cell population most effectively engrafts into diseased skeletal muscle. (biomedcentral.com)
SHH stimulates osteoclast formation with PTHrP in a co-lifestyle technique consisting of ST2 cells and murine CD11b+ bone marrow cells [ten]. (acthreceptor.com)

Myofiber-specific TEAD1 overexpression drives satellite cell hyperplasia and counters pathological effects of dystrophin deficiency. (missouri.edu)
Understanding the effects of strabismus surgery on muscle cell biological reactions and myofiber remodeling may suggest new approaches for improving surgical outcomes. (arvojournals.org)

Previous work has shown that slow-oxidative fibers are associated with more satellite cells per-unit length than are fast-glycolytic myofibers. (missouri.edu)
Our current studies are designed to identify potential signaling pathways connecting increased TEAD-1 expression in skeletal muscle to activation of genes encoding proteins typically restricted to slow-twitch fibers, as well as satellite cell numbers that exceed homeostatic numbers associated with slow-fibers. (missouri.edu)
3 When a muscle is injured, this specialized cell population becomes activated, divides, and either repairs damaged fibers or forms new myofibers. (arvojournals.org)
Vinculin, a plasma protein, links fibers to talin, which is a cell membrane protein. (medscape.com)
Contraction of actin fibers pulls the cell body forward. (medscape.com)

However, diprotin A, a positive modulator of CXCR4-SDF-1 binding, significantly enhanced engraftment and stimulated sustained proliferation of donor cells in vivo . (biomedcentral.com)
FAK deficiency in osteoblasts and osteocytes in vivo benefits in delayed bone healing and transforming and interrupts the response of bone marrow cells to anabolic mechanical stimuli in a tibial injuries product [seventeen,18]. (acthreceptor.com)
Here we generate a robust system for in vivo transgene delivery by combining the versatility of AAV-mediated transgene delivery with the specificity of cell-type-specific Cre-mediated recombination. (nature.com)

However, recent studies have suggested that BRAFi/MEKi and ERK1/2i resistance can arise through activation of a parallel signalling pathway leading to activation of ERK5, an unusual protein kinase that contains both a kinase domain and a transcriptional transactivation domain. (babraham.ac.uk)
In the presence of nutrients, mTORC1 is activated and promotes cell growth, including protein synthesis and energy storage. (springer.com)

In Drosophila , a population of muscle-committed stem-like cells called adult muscle precursors (AMPs) keeps an undifferentiated and quiescent state during embryonic life. (biologists.com)

In turn, this juxtavascular niche keeps the satellite cells in a more quiescent state, suggesting a beneficial cross-talk. (umn.edu)
Almost all PDGFRsingle-positive state, and so did CD56+ cells in our culture condition (Figures 2c and d). (phytid.org)

Skeletal muscle injuries are associated with local infiltration of large numbers of mononuclear cell, degeneration of the injured myofibers and removal of the cell debris by phagocytosis. (cdc.gov)

Within minutes after a small corneal epithelial injury, cells at the edge of the abrasion begin to migrate centripetally to cover the defect rapidly at a rate of 60-80 µm/h. (medscape.com)
Epithelial cells adjacent to the area of the defect flatten, lose their hemidesmosome attachments, and migrate on transient focal contact zones that are formed between cytoplasmic actin filaments and extracellular matrix proteins. (medscape.com)

The light must be absorbed by the endogenous chromophores of cells or tissues for actions. (biomedcentral.com)
We hypothesized that AAV transgene expression could be targeted to specific tissues or cell types by selectively overexpressing AAVR. (nature.com)

However, both markers are expressed on many different cell types, including myeloid cells of hematopoietic lineage. (phytid.org)

Alternatively activated M2 macrophages comprise cells exposed to low concentrations of M-CSF in the presence of IL-4, IL-13, or IL-10. (hindawi.com)

We also identify known regulators of satellite cell function such as BMP4, CD34 and Myf6 (Mrf4) as genes whose expression is dependent on Yap activity. (kcl.ac.uk)
Previous studies have shown the involvement of cell-autonomous factors in this phenomenon, particularly the decline of polycomb genes and accumulation of p16/INK4A. (diabetesjournals.org)
Selumetinib causes long-term G1 arrest accompanied by reduced expression of DNA replication and repair genes, but cells stochastically re-enter the cell cycle during treatment despite continued repression of pERK1/2. (babraham.ac.uk)

Several studies reported the identification of satellite cells in human skeletal muscle. (phytid.org)

Down-regulation of MCP-l and MIP-l J3 responses by application of CCR5 deficient mice and MCP-l neutralizing antibody, resulted in minimal effects in inflammatory cell influx but a significant delay in muscle function recovery. (cdc.gov)
The second is a pinhead-sized region known as the periaqueductal grey or PAG, which contains a group of nerve cells that release dopamine and, in mice, respond to other mice. (phys.org)
Indeed, CXCR4-positive muscle-derived side population (SP) cells home more effectively to dystrophic muscle after intra-arterial delivery in mdx 5cv mice [ 10 ]. (biomedcentral.com)
Here, we demonstrate that a systemic factor found in the circulation of young mice is able to increase the proliferation rate of old pancreatic β-cells. (diabetesjournals.org)
Old mice parabiosed to young mice have increased β-cell replication compared with unjoined old mice or old mice parabiosed to old mice. (diabetesjournals.org)
conversely, young β-cells transplanted into old mice decrease their replication rate compared with young cells transplanted into young recipients. (diabetesjournals.org)
however, we have recently found that a residual replicative potential is retained even in β-cells of very old mice ( 8 ). (diabetesjournals.org)

We conclude that systemic factors contribute to the replicative decline of old pancreatic β-cells. (diabetesjournals.org)

However, the mechanisms of cell proliferation induced by LPLI are poorly understood. (biomedcentral.com)
In a quantification of acupuncture's effective mechanisms, the Fujian Provincial Research Institution of Traditional Chinese Medicine researchers identified an important signaling pathway activated by acupuncture that is responsible for producing its therapeutic benefits. (acupunctureofiowa.com)

The gradual decrease in the rate of cell division seen already in early postnatal life, before any evidence of senescence, is even less well-understood. (diabetesjournals.org)

Anatomy6

Organisms2

Diseases2

Chemicals and Drugs10

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes5

Disciplines and Occupations1

Technology, Industry, Agriculture1

Information Science2

Health Care1

Differentiation15

MYOD2

Located beneath the basal lamina2

Precursor4

Population of quiescent1

Proliferate5

Stem Cell6

Regeneration20

Basal2

Metabolic1

MRNA4

Molecular5

Cellular7

Progenitor cells2

Mesenchymal stem1

Effector4

Transcription3

Induces1

Endothelial cells1

Abstract1

Myoblast cell line1

Notch3

Myogenesis2

Biochemistry1

Muscle fibers4

Novel regulator of satellite cell1

Biology2

Inhibition2

HeLa1

Intracellular1

Tissue14

Vitro2

Proliferative2

PI3K2

Migration3

Transduction1

Stimulation2

Adult skeletal muscle1

Muscles6

Murine4

Myofiber2

Fibers5

Vivo3

Protein2

Embryonic1

State2

Myofibers1

Migrate2

Tissues2

Hematopoietic1

Comprise1

Genes3

Human skeletal muscle1

Mice7

Conclude1

Mechanisms2

Postnatal1