• Alterations in six metabolic pathways were found on D 17 and D 45, including variations in the level of alpha-linolenic acid metabolism, glycerophospholipid metabolism, pentose and glucuronate interconversions, glycerolipid metabolism, folate biosynthesis, and tyrosine metabolism. (nature.com)
  • Certain maternal metabolism pathways change due to the nutrient transport during early pregnancy. (nature.com)
  • However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. (rcsb.org)
  • Applying this technique to AD we demonstrate differences in proteins involved in glucose metabolism and neuroinflammation that collectively have potential clinical diagnostic utility. (lu.se)
  • Such dependant enzymes include those of the citric acid cycle, the mitochondrial electron transport chain, and several other pathways in the metabolism of carbohydrates, fats, and proteins. (medscape.com)
  • The fatty acid synthetic pathway is the principal route for the production of membrane phospholipid acyl chains in bacterial and plants. (wikipedia.org)
  • Malony-CoA:ACP Transacylase (FabD) is one such individual soluble protein and catalyzes the following reaction: malonyl-CoA + acyl carrier protein ⇌ CoA + malonyl-[acyl-carrier-protein] The transfer of malonate to acyl-carrier-protein (ACP) converts the acyl groups into thioester forms which are characteristic of acyl intermediates in fatty acid synthesis and which are strictly required for the condensation reactions catalyzed by β-ketoacyl-ACP synthetase. (wikipedia.org)
  • Among all known metabolic pathways in living systems, fatty acid biosynthesis yields the most energy dense products. (wikipedia.org)
  • have devised a procedure to reconstitute E.Coli Fatty Acid Synthase using purified protein components (including FabD) and reported a detailed kinetic analysis of this in-vitro reconstituted system. (wikipedia.org)
  • Fatty acid synthase pathways are divided into two distinct molecular forms: Type I and Type II. (wikipedia.org)
  • The bacterial type II fatty acid synthesis (FASII) pathway is an attractive target for the development of inhibitors and is particularly favourable due to the differences from mammalian type I fatty acid synthesis. (rcsb.org)
  • Inhibitors designed to target FabG proteins and thus prevent fatty acid synthesis may provide a platform for use against multidrug-resistant pathogens including A. baumannii. (rcsb.org)
  • Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
  • Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
  • An enzyme that catalyzes the oxidation of acyl-[acyl-carrier protein] to trans-2,3-dehydroacyl-[acyl-carrier protein] in the fatty acid biosynthesis pathway. (umassmed.edu)
  • Through a series of bioactivity assays, we found the transfer to the acyl carrier protein (ACP) in a fatty acyl-AMP ligase (FAAL)-dependent manner determined the specificity of lipids selected in the biosynthetic process. (duke.edu)
  • In enzymology, a [acyl-carrier-protein] S-malonyltransferase (EC 2.3.1.39) is an enzyme that catalyzes the chemical reaction malonyl-CoA + acyl carrier protein ⇌ CoA + malonyl-[acyl-carrier-protein] Thus, the two substrates of this enzyme are malonyl-CoA and acyl carrier protein, whereas its two products are CoA and malonyl-acyl-carrier-protein. (wikipedia.org)
  • The systematic name of this enzyme class is malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase. (wikipedia.org)
  • FabD (Acyl-Carrier-Protein S-Malonyltransferase) is a reasonable target given that a high resolution crystal structure is available. (wikipedia.org)
  • Discrete enzymes in this pathway include two reductase enzymes: 3-oxoacyl-acyl carrier protein (ACP) reductase (FabG) and enoyl-ACP reductase (FabI). (rcsb.org)
  • 3R)-hydroxymyristol acyl carrier protein. (wikigenes.org)
  • Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
  • Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (umassmed.edu)
  • This graph shows the total number of publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in this website by year, and whether "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" was a major or minor topic of these publications. (umassmed.edu)
  • Below are the most recent publications written about "Enoyl-(Acyl-Carrier Protein) Reductase (NADPH, B-Specific)" by people in Profiles. (umassmed.edu)
  • For detailed information about pimeloyl-[acyl-carrier protein] synthase, go to the full flat file . (brenda-enzymes.de)
  • The signaling pathway enhances access to the promoters of genes encoding inflammatory mediators, thus increasing their expression. (medindia.net)
  • We already knew that the response to pathogenic bacteria in the gut involves remodeling of the DNA-protein package known as chromatin, enabling access for the expression of genes involved in inflammation," corresponding author Toshiaki Ohteki says. (medindia.net)
  • Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
  • A genome-wide association study identified variants in the ferredoxin fd ), apicoplast ribosomal protein S10 ( arps10 ), multidrug resistance protein 2 ( mdr2 ), and chloroquine resistance transporter ( crt ) genes as additional factors contributing to ART resistance, in which a missense fd mutation fd -D193Y) was the most frequent variant among resistant parasites [ 8 ]. (biorxiv.org)
  • Introduction: Proteins encoded by Fanconi anemia (FA) and/or breast cancer (BrCa) susceptibility genes cooperate in a common DNA damage repair signaling pathway. (lu.se)
  • Interestingly, RNA-seq revealed that G. haimaensis hosts responded to B. pettiboneaei parasitism through significant upregulation of protein and lipid anabolism related genes, and that this parasitism may enhance host mussel nutrient anabolism but inhibit the host's ability to absorb nutrients, thus potentially helping the parasite obtain nutrients from the host. (frontiersin.org)
  • Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • The difference in active site organization and predominance of type II FAS systems in bacteria make the enzymes of this pathway attractive targets for antibacterials. (wikipedia.org)
  • The mode of action of enzymes and macromolecular complexes as protein machines will be investigated. (manchester.ac.uk)
  • The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW. (expasy.org)
  • These coenzymes play a necessary role in most of the major energy-producing biochemical processes in the body, acting as electron carriers for enzymes in oxidation-reduction reactions. (medscape.com)
  • Modulations in lipid A and phospholipid biosynthesis pathways influence outer membrane protein assembly in Escherichia coli K-12. (wikigenes.org)
  • Mutations in the CDP-choline pathway for phospholipid biosynthesis bypass the requirement for an essential phospholipid transfer protein. (tamu.edu)
  • The coat on the budding vesicle comprises two layers, an inner layer of adaptor proteins (gray ovals) and an outer layer that forms a polyhedral cage. (biologists.com)
  • Secretory proteins exit the endoplasmic reticulum (ER) in coat protein complex II (COPII)-coated vesicles and then progress through the Golgi complex before delivery to their final destination. (biologists.com)
  • The accumulation of damaged, polyubiquitinated proteins rapidly induces lethal endoplasmic reticulum stress [ 1 ]. (biorxiv.org)
  • The N- glycosylation is an essential protein modification taking place in the membranes of the endoplasmic reticulum (ER) in eukaryotes and the plasma membranes in archaea. (biomedcentral.com)
  • In eukaryotes, the synthesis of the oligosaccharide core is mediated by a lipid carrier called dolichol-phosphate (Dol-P) which is located in the membranes of the endoplasmic reticulum (ER, Fig. 1a ). (biomedcentral.com)
  • This gene product belongs to the SCAMP family of proteins, which are secretory carrier membrane proteins. (nih.gov)
  • Homo sapiens secretory carrier membrane protein 2 (SCAMP2), transcript variant 2, mRNA. (origene.com)
  • In this Commentary, I review evidence in favor of the idea that partitioning of TMDs into bilayer domains that are endowed with distinct physico-chemical properties plays a pivotal role in the transport of membrane proteins within the early secretory pathway. (biologists.com)
  • The combination of such self-organizational phenomena with canonical intermolecular interactions is most likely to control the release of membrane proteins from the ER into the secretory pathway. (biologists.com)
  • set the stage for the still ongoing debate on the role of bulk flow versus receptor-mediated transport of cargo molecules through the secretory pathway of eukaryotic cells. (biologists.com)
  • SEC14p is the yeast phosphatidylinositol (PI)/phosphatidylcholine (PC) transfer protein, and it effects an essential stimulation of yeast Golgi secretory function. (tamu.edu)
  • This reaction is part of the lysine biosynthesis pathway in these organisms. (expasy.org)
  • Oligomerisation of initiating proteins such as AIM2 (absent in melanoma-2) and NLRP3 (NOD-like receptor family, pyrin domain-containing-3) recruits procaspase-1 via the inflammasome adapter molecule ASC (apoptosis-associated speck-like protein containing a CARD). (nih.gov)
  • Baird, G. S., Zacharias, D. A. & Tsien, R. Y. Circular permutation and receptor insertion within green fluorescent proteins. (nature.com)
  • Another example of proteins in the cell membrane is receptor proteins. (bionity.com)
  • The CNS folate receptor protein alpha (FRA) transports 5MTHF directly into the CNS in a process that is dependent on mitochondrial function (ATP production). (autismfile.com)
  • Transport by partitioning is distinct from both bulk flow and receptor-mediated transport, because differently from bulk flow, cargo can be concentrated in transport carriers, yet the concentrating process does not depend on specific cargo receptors ( Fig. 1 and Box 1 ). (biologists.com)
  • Dennis et al suggest that vesicle-associated membrane protein (VAMP7) mediates fusion of BLOC-1-dependent transport carriers with melanosomes and that soluble attachment protein receptor (SNARE) recycling from melanosomes is a critical BLOC-3-dependent step. (medscape.com)
  • WF upregulated (1.4 to 1.7-fold) the mRNA transcripts for interferon-gamma (Ifng), inducible nitric oxide synthase (Nos2), matrix metalloproteinase 9 (Mmp9), dopamine D2 receptor (Drd2), and the solute carrier family 18 member A2 (Slc18a2 / Vmat2) in FCT after 1 d, suggestive of neuroinflammation and altered monoamine neurotransmitter signaling. (cdc.gov)
  • Thirteen FANCD2-monoubiquitinylation-positive FA cell lines excluded for genetic defects in the downstream pathway components and 300 familial BrCa patients negative for BRCA1/2 mutations were analyzed for genetic mutations. (lu.se)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
  • To solve this problem, the cell membrane contains proteins that are selective for unique, water soluble molecules. (wikibooks.org)
  • The TGF-β signaling pathway is also involved in bone and blood vessel development and the formation of the extracellular matrix, an intricate lattice of proteins and other molecules that forms in the spaces between cells and defines the structure and properties of connective tissues. (medlineplus.gov)
  • Electron transfer in proteins and nucleic acids occurs over large distances by a combination of short and long range tunneling mechanisms. (aps.org)
  • For membrane proteins, a third mechanism, based on the interaction of their transmembrane domain (TMD) with lipid microdomains, must also be considered. (biologists.com)
  • Key players of this heme uptake system were characterized including a secreted protein and two transmembrane proteins, all three specific to mycobacteria. (escholarship.org)
  • The hOAT3 cDNA consisted of 2179 base pairs that encoded a 543-amino-acid residue protein with 12 putative transmembrane domains. (aspetjournals.org)
  • Firstly, structural proteins are found attached to microfilaments in the cytoskeleton which ensures stability of the cell. (bionity.com)
  • Environmental sequences of ten novel plastid lineages and structural innovations in plastid proteins confirm that plastids in apicomplexans and their relatives are widespread and share a common, photosynthetic origin. (elifesciences.org)
  • Gaining a deeper understanding of structural components and biosynthetic pathways can lead to the creation of second-generation derivatives to improve bioactivity and pharmacological properties. (duke.edu)
  • Collectively, through each project we have gained a deeper understanding of the structural elements and biosynthetic pathways of lipid II-binding antimicrobials. (duke.edu)
  • In the case of DNA electron transport, a critical role is found for structural fluctuations and transport mediated by carrier injection to intervening bases, even at very short distances. (aps.org)
  • B)Structural model of PIN protein with a short HL. (chinbullbotany.com)
  • The PIN proteins are fine-tuned at multiple levels, including transcriptional regulation, post-transcriptional modification, intracellular recycling and vacuolar trafficking for degradation, in response to endogenous and exogenous signals. (chinbullbotany.com)
  • Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
  • This process depends on the general physico-chemical features of the cargo membrane protein and on the interactions of these features with the collective properties of the bilayer, instead of the one-to-one intermolecular interactions that exist between discrete signals and their receptors. (biologists.com)
  • This change in shape leads to a metabolic pathway being formed in the cell which changes gene expression. (bionity.com)
  • When a second nutrient and its metabolic pathway are introduced, the system must further decide whether and how to activate both pathways. (lu.se)
  • Secondly, cell recognition proteins allow cells to recognise each other as from the same organism. (bionity.com)
  • osteopontin and cystatin C. In an independent multivariate orthogonal projection to latent structures discriminant analysis (OPLS-DA), these proteins were also identified as major contributors to the separation between AD and non-AD in both cohorts. (lu.se)
  • DAMPs, damage-associated tissues and the molecular target structures and pathways. (cdc.gov)
  • Poor coupling across nonbonded interfaces produces a strong bias in favor of covalent and hydrogen-bonded pathways between redox sites in proteins. (aps.org)
  • The coupling disparity between bonded and nonbonded interfaces accounts in large part for the finding that protein electron-transfer rates do not exhibit a uniform dependence on distance, but instead depend critically on the composition of the medium between redox sites. (aps.org)
  • We found that TRIM13 mRNA and protein expression was reduced in NSCLC tissues and cell lines in comparison to paired non-cancerous tissues and a human normal bronchial epithelial cell line, respectively. (cancerindex.org)
  • Here, a phylogenomic analysis was carried out to examine the validity of rival hypotheses suggesting alternative archaeal or bacterial origins to the eukaryotic N- glycosylation pathway. (biomedcentral.com)
  • The origin of the eukaryotic N- glycosylation pathway is not unique and less straightforward than previously thought: some basic components likely have proteoarchaeal origins, but the pathway was extensively developed before the eukaryotic diversification through multiple gene duplications, protein co-options, neofunctionalizations and even possible horizontal gene transfers from bacteria. (biomedcentral.com)
  • Following the success of comparative analyses to trace back particular machineries to LECA [ 25 - 32 ], the origin and evolution of the eukaryotic N- glycosylation pathway will be studied here. (biomedcentral.com)
  • More than half of all eukaryotic proteins are glycoproteins, and 90 % of those are N- glycosylated [ 33 ]. (biomedcentral.com)
  • Biochemical and functional assays in human, mouse and Caenorhabditis elegans models were carried out to characterize pathway components. (lu.se)
  • Common genetic variants were genotyped in 9,573 BRCA1/2 mutation carriers for associations with BrCa risk. (lu.se)
  • The antagonistic action of the CKI gene product on SEC14p function revealed a previously unsuspected influence of biosynthetic activities of the CDP-choline pathway for PC biosynthesis on yeast Golgi function and indicated that SEC14p controls the phospholipid content of yeast Golgi membranes in vivo. (tamu.edu)
  • ART and its derivatives are bio-transformed by the liver to the active metabolite, dihydroartemisinin (DHA) ( Figure 1 ), which can be activated by iron, resulting in endoperoxide radicals that damage proteins via the formation of covalent adducts. (biorxiv.org)
  • TRIM13 inhibited cell proliferation and induced cell apoptosis by regulating NF-κB pathway in non-small-cell lung carcinoma cells. (cancerindex.org)
  • TRIM13-induced NSCLC cell apoptosis was attenuated by a caspase-3 inhibitor Ac-DEVD-CHO, suggesting that TRIM13 induced cell apoptosis partially through a caspase-3-dependent pathway. (cancerindex.org)
  • In the absence of T. whipplei infection and were asymptomatic carriers. (cdc.gov)
  • Author affi litaion: Université de la Méditerranée, Marseille, France infections and 3 asymptomatic carriers of T. whipplei . (cdc.gov)
  • Of these 203, 73 were still asymptomatic carriers, 29 (14.5%) were symptomatic, 9 (4.5%) were FAP liver transplanted patients and 89 (44.5%) were non-carriers. (bvsalud.org)
  • Asymptomatic carriers and non-carriers had similar scores but it was impossible to dif- ferentiate the psychological impact between the medium and long-term. (bvsalud.org)
  • Tripartite Motif Containing 13 (TRIM13), a member of TRIM proteins, is deleted in multiple tumor types, especially in B-cell chronic lymphocytic leukemia and multiple myeloma. (cancerindex.org)
  • Not surprisingly, the major groups of differentially expressed proteins were involved in tumor migration, invasion, and progression. (genengnews.com)
  • To address these issues, we retrospectively reviewed male BRCAm carriers with a diagnosis of tumor from our cancer genetics database (SYSUCC cohort, n = 52) and a public database (TCGA cohort, n = 294). (biomedcentral.com)
  • Inflammatory monocytes and macrophages in the colons of IBD mice showed increased expression of proteins that promote inflammatory responses compared with other cell populations. (medindia.net)
  • The present study provides in vivo evidence that a GSH mediated pathway underlies asthma-like eosinophilic inflammatory responses to respiratory tract isocyanate exposure. (cdc.gov)
  • Scientists aim to pinpoint particular functional pathways affected by these bacteria that may have an impact on skeletal health. (medindia.net)
  • Their multi‑functional cargo have been indicated to regulate a vast number of biological pathways in target cells. (spandidos-publications.com)
  • Exosomal markers include microRNAs like miR-21 and miR-141, plus various proteins that belong in functional groups such as tetraspanins (CD9, CD63 and CD81), heat shock proteins (Hsp70, Hsp73 and Hsp90) and membrane transporters (GTPases) ( 4 ). (spandidos-publications.com)
  • Here we reviewed the research progress of PIN protein in Arabidopsis thaliana and cereal crops from the aspects of protein structure, activity regulation and functional verification to provide new ideas and clues for exploring the auxin polar transport mediated by PIN protein family. (chinbullbotany.com)
  • By mechanisms that are not well understood, a lack (deficiency) of functional GLUT10 protein leads to overactivity (upregulation) of TGF-β signaling. (medlineplus.gov)
  • On the other hand, each enzymatic activity (Condensation reaction, Reduction Reaction, Dehydration reaction) is found as a discrete protein in type II systems. (wikipedia.org)
  • The mechanisms by which isocyanates cause asthma remain unclear, hampering disease prevention, diagnosis, and treatment.7 It is assumed the reactive nature of N=C=O groups underlies isocyanate asthma, with a hapten-based mechanism as the most obvious pathway to pathogenesis.8 However, the critical "self" reaction targets for isocyanate in vivo remain uncertain. (cdc.gov)
  • Recent studies of protein electron transfer indicate when and why electron tunneling kinetics is sensitive to the structure of the protein's tunneling pathways. (aps.org)
  • Electron transfer across protein-protein interfaces involves thin structured water layers that play a key role in tunneling mediation as well. (aps.org)
  • Tunneling analysis that takes the dynamical fluctuations of the macromolecules into explicit account provides a unified view that links structure and function in protein electron transfer. (aps.org)
  • Our investigations of electron tunneling through proteins and solvents are aimed at elucidating the factors that determine long-range D-A couplings. (aps.org)
  • The PIN protein contains a central hydrophilic loop (HL) and two separated hydrophobic regions, and the multiple phosphorylation sites on HL are the targets of protein kinases. (chinbullbotany.com)
  • Channel proteins often have hydrophilic pores that allow the diffusion of other ions. (bionity.com)
  • Conclusions: While the present study expands on the role of MRG15 in the control of genomic stability, weak associations cannot be ruled out for potential low-penetrance variants at MORF4L1 and BrCa risk among BRCA2 mutation carriers. (lu.se)
  • 6. Improves mineral and protein absorption by modulating pH levels and assisting beneficial bacteria growth. (king-cart.com)
  • To use this carrier-free antibody for conjugation experiment, we strongly recommend performing another round of desalting process. (origene.com)
  • 7. Enhances mineral dispersion using natural carrier agents (microporous silica). (king-cart.com)
  • These findings suggest that these protein family members may function at the same site during vesicular transport rather than in separate pathways. (nih.gov)
  • The transport may be active transport by carrier proteins with an energy source, or it may be facilitated diffusion or passive transport via channels. (wikibooks.org)
  • These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. (origene.com)
  • Finally, transport proteins play an important role in the maintenance of concentrations of ions and such like. (bionity.com)
  • These transport proteins come in two forms: carrier proteins and channel proteins. (bionity.com)
  • Channel proteins are involved in using the energy released from ATP being broken down to facilitate active transport and ion exchange. (bionity.com)
  • The FRA has a high affinity for the FRA autoantibodies, which block the transport of folate metabolites across this carrier on the blood side. (autismfile.com)
  • The polar transport of auxin mainly depends on three transporters: AUX/LAX, PIN and ABCB protein families. (chinbullbotany.com)
  • In particular, the organic anion transport pathway has been shown to mediate the elimination of various drugs. (aspetjournals.org)
  • DctA and DcuB exert regulatory functions and link transport to metabolic control through interaction with regulatory proteins. (bvsalud.org)
  • Entry of the vitamin into cells is mainly facilitated by carrier-mediated transport through a specific riboflavin-binding protein on cell membranes. (medscape.com)
  • They function as carriers to the cell surface in post-golgi recycling pathways. (nih.gov)
  • Inflammasomes are protein complexes assembled upon recognition of infection or cell damage signals, and serve as platforms for clustering and activation of procaspase-1. (nih.gov)
  • Full length human recombinant protein of human SCAMP2(NP_005688) produced in HEK293T cell. (origene.com)
  • Proteins themselves play an important role in the membrane to ensure the cell can live as efficiently and effectively as possible. (bionity.com)
  • Thirdly, enzyme proteins are crucial in producing a variety of substances essential for cell function. (bionity.com)
  • It uses material from the Wikipedia article "Protein_Function_in_Cell_Membranes" . (bionity.com)
  • Analysis of immunophenotypically defined cell populations markedly increased specificity of liquid chromatography-tandem mass spectroscopy (LC-MS/MS). Over 375 differentially expressed proteins were analyzed by Ingenuity Pathway Analysis (Ingenuity Systems). (genengnews.com)
  • It shares mechanistic similarities based on the use of polyisoprenol lipid carriers with other glycosylation pathways involved in the synthesis of bacterial cell wall components (e.g. peptidoglycan and teichoic acids). (biomedcentral.com)
  • this type of protein moves the simple sugar glucose across cell membranes and helps maintain proper levels of glucose within cells. (medlineplus.gov)
  • This pathway is involved in cell growth and division (proliferation) and the process by which cells mature to carry out special functions (differentiation). (medlineplus.gov)
  • We show that maximal growth is achieved when pathway activation is a more or less steeply graded function of the nutrient concentration. (lu.se)
  • HPLC-QTOF/MS was used in combination with pattern recognition methods and pathway analysis methods to look for variation in the metabolic phenotype and to generate a better understanding of the metabolic mechanisms occurring in pregnant dairy cows. (nature.com)
  • The unusual physical attributes of protein particles lead to difficulties in obtaining accurate particle counts with traditional calibration standards and methods. (nist.gov)
  • Methods: Protein physical interactions were screened using the yeast two-hybrid system. (lu.se)
  • These findings suggest that the neurological underpinnings in PD, manganism, and WF-mediated PD-like manifestation encompasses much more than degeneration of the nigrostriatal dopaminergic pathway and involves brain areas associated with sensorimotor, fine motor, and cognitive tasks, such as the cortex, thalamus, and cerebellum. (cdc.gov)
  • 8. Opens and clears mineral delivery pathways using full-spectrum, free radical scavengers. (king-cart.com)
  • The discovery of a unique mycobacterial heme acquisition pathway opens new avenues of exploration into mycobacterial therapeutics. (escholarship.org)
  • The comparison of several polyisoprenol-based glycosylation pathways from the three domains of life shows that most of the implicated proteins belong to a limited number of superfamilies. (biomedcentral.com)
  • A team of Japanese scientists led by Tokyo Medical and Dental University (TMDU) used a chemically induced mouse model of IBD to show that a protein signaling pathway is crucial to the generation of macrophages that cause colonic inflammation. (medindia.net)
  • The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. (cancerindex.org)
  • 5MTHF is also transported into the CNS through the reduced folate carrier (RFC). (autismfile.com)
  • Exosomes are one of the most researched classes of extracellular vesicles because they are carriers of targeted protein and DNA/RNA loads. (spandidos-publications.com)