AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Cell ProliferationCyclin-Dependent KinasesCells, CulturedCyclin-Dependent Kinase 2Cell CycleCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cell DivisionSignal TransductionApoptosisCell Line, TumorCell DifferentiationPhosphorylationCDC2-CDC28 KinasesCyclinsCyclin-Dependent Kinase Inhibitor p27Cyclin-Dependent Kinase 6Cell Cycle ProteinsCell LineRNA, MessengerBromodeoxyuridineCDC2 Protein KinaseLymphocyte ActivationCell SurvivalCell MovementCyclin D1G1 PhaseBlotting, WesternProtein-Serine-Threonine KinasesMice, Inbred C57BLCyclin EImmunohistochemistryProliferating Cell Nuclear AntigenTumor Cells, CulturedCyclin-Dependent Kinase Inhibitor p21Ki-67 AntigenReverse Transcriptase Polymerase Chain ReactionMice, KnockoutFlow CytometryRNA, Small InterferingGene Expression RegulationT-LymphocytesDown-RegulationS PhaseProto-Oncogene ProteinsStem CellsTransfectionGene Expression Regulation, NeoplasticFibroblastsMice, TransgenicMolecular Sequence DataMitosisTime FactorsCell Growth ProcessesEpithelial CellsEnzyme InhibitorsDose-Response Relationship, DrugCyclin-Dependent Kinase 9Transcription FactorsEnzyme ActivationCyclin DTumor Suppressor ProteinsGene ExpressionRNA InterferenceUp-RegulationMuscle, Smooth, VascularThymidineDNA-Binding ProteinsMice, Inbred BALB CMice, NudeCell CountMutationProto-Oncogene Proteins c-aktCell Transformation, NeoplasticNuclear ProteinsProtein BindingCyclin D3MitogensModels, BiologicalDNAHyperplasiaBase SequenceMyocytes, Smooth MuscleProto-Oncogene Proteins c-mycRecombinant ProteinsAmino Acid SequencePhenotypeRats, Sprague-DawleyCyclin D2Interleukin-2Antineoplastic AgentsGrowth InhibitorsTumor Suppressor Protein p53Extracellular Signal-Regulated MAP KinasesGene Expression Regulation, DevelopmentalCyclin-Dependent Kinase 8Cyclin-Dependent Kinase Inhibitor p16Transcription, GeneticGene Knockdown TechniquesDisease Models, Animal
ApoptosisCDK4MigrationInvasionProteinsDifferentiation and proliferationCellularGenesInhibitionMiRNAsMAPKPromotesKEGGMolecularMutationsEnrichmentProteinGenotypeTumor suppressorExtracellularRegulationMicroRNAsMalignantReceptorsModulateDifferentiallyMiRNASignificantlyLncRNAsMetabolicExpressionMechanismCellsDetectMutationDemonstrateHumanAnalysisActivation
Apoptosis9
  • As a consequence, any modulations of the target transcript expression, miRNAs can affect various signalling pathways and cellular process such as apoptosis, proliferation or differentiation. (ukessays.com)
  • Then, the relatively insensitive gastric cancer cell lines (MGC-803 and BGC-823) were treated with low concentrations of chidamide alone, bortezomib alone, or chidamide and bortezomib combination to detect the effects on cell proliferation, apoptosis, migration, and invasion. (dovepress.com)
  • Compared with low-dose chidamide or bortezomib alone, the low-dose drug combination significantly inhibited the proliferation, migration, and invasion of MGC-803 and BGC-823 cells and induced apoptosis of the cells. (dovepress.com)
  • Taken together, the current results demonstrate that MAPK1 promotes myeloid cell proliferation and differentiation simultaneously by cell cycle progression while suppresing apoptosis. (prinsesmaximacentrum.nl)
  • Transcriptome analysis after ectopic transfection of synthetic miR-29b into leukemia cells indicates that miR-29b target apoptosis, cell cycle, and proliferation pathways. (ashpublications.org)
  • Knockdown of CASP5 greatly inhibited GBM proliferation and resulted in G1 cell cycle arrest along with higher apoptosis ratios in vitro and in vivo, while overexpression led to the opposite phenomenon. (cancerindex.org)
  • Here, we determined the effect of Jiyuan oridonin A (JOA), an ent -kaurene diterpenoid compound, on the differentiation blockade in imatinib-sensitive, particularly, imatinib-resistant CML cells with BCR-ABL-T315I mutation by cell proliferation assay, apoptosis analysis, cell differentiation analysis, cell cycle analysis and colony formation assay. (jcancer.org)
  • All these are the central actors in cell cycle and apoptosis pathways taking part in the pathogenesis of Neuroblastoma. (mbpinc.net)
  • Artemisinin - This study demonstrated that artemisinin -tagged transferrins (ART-Tf) conjugate kills the prostate carcinoma cell line DU 145 by the mitochondrial pathway of apoptosis. (compassionateacupuncture.com)
CDK45
  • The Cyclin D-CDK4/CDK6 complex phosphorylates RB and promotes cell entry into the S phase by releasing the E2F family of transcription factors (inducing CyclinE expression). (wikipedia.org)
  • p15 INK4b and p16 INK4a are closely related proteins and both act on the Rb-pathway through the inhibition of the proliferation-promoting cyclin-dependent kinases CDK4 and CDK6. (biomedcentral.com)
  • Introduction The commitment to cell proliferation is set up when extracellular signals converge on the cell cycle and induce the expression of D-type cyclins, their association with CDK4 and/or CDK6, as well as the activation from the holoenzyme complex [1C3]. (healthandwellnesssource.org)
  • Launch The dedication to cell proliferation is set up when extracellular indicators converge on the cell routine and stimulate the appearance of D-type cyclins, their association with CDK4 and/or CDK6, as well as the activation from the holoenzyme complicated [1C3]. (healthandwellnesssource.org)
  • Unchecked proliferation of Rb-positive tumor cells is often connected with mutations that dysregulate this pathway: like the overexpression of D-type cyclins, the overexpression or mutation of CDK4, or mutations in the Printer ink4 category of CDK inhibitors [3, 5, 6]. (healthandwellnesssource.org)
Migration16
  • AKAP12 knockdown in benign meningioma cells SF4433 increases proliferation, cell cycle, migration, invasion, and confers an anaplastic profile. (nature.com)
  • Our results suggest that the combination of chidamide and bortezomib can significantly reduce the proliferation, invasion, and migration of MGC-803 and BGC-823 cells, providing a framework for the clinical evaluation of combined therapies for gastric cancers. (dovepress.com)
  • VSMCs were transfected with the miR-128-5p mimic and inhibitor, and the migration, phenotypic modulation, and proliferation of VSMCs were investigated. (hindawi.com)
  • AA and the extracellular regulated protein kinase 1/2 (ERK1/2) blocker U0126 markedly inhibited migration, elevated smooth muscle 22 α (SM22 α ) expression, repressed VSMC proliferation, elevated miR-466f-3p and miR-425-3p expression, and suppressed miR-27a-5p and miR-128-5p expression in ox-LDL-induced VSMCs. (hindawi.com)
  • The miR-128-5p mimic promoted the migration and proliferation of VSMCs and suppressed p21, p27, and SM22ɑ expression. (hindawi.com)
  • The inhibitor increased p21, p27, and SM22ɑ expression and repressed the migration, phenotypic transformation, and proliferation of VSMCs. (hindawi.com)
  • Our research showed that the migration, phenotypic transformation, and proliferation of ox-LDL-induced VSMCs were repressed by AA through inhibiting miR-128-5p by targeting the p21 gene, which may provide an effective option for the treatment of atherosclerosis. (hindawi.com)
  • It has been shown that inflammation caused by oxidized low-density lipoprotein (ox-LDL) contributes to the occurrence and development of AS [ 1 ], which can promote vascular smooth muscle cell (VSMC) migration, proliferation, and transformation from a contractile to a synthetic phenotype [ 2 - 6 ]. (hindawi.com)
  • The migration, phenotypic transformation, and proliferation of VSMCs lead to vascular wall remodeling, which is mediated by activation of extracellular regulated protein kinases 1/2 (ERK1/2) signalling [ 9 ]. (hindawi.com)
  • Several studies have shown that miRNAs play multiple roles in the phenotypic transformation, migration, and proliferation of VSMCs by inhibiting ERK1/2 activation [ 11 , 12 ], partly by regulating the tissue inhibitor of metalloproteinases (TIMPs)-MMPs and p21-cyclins interactions [ 13 - 18 ]. (hindawi.com)
  • Cell proliferation, migration, and invasion assays were performed to evaluate the effects of miR-320d on GCA cells after transfection in vitro. (biomedcentral.com)
  • DC-SIGNR knockdown inhibited the proliferation, migration and invasion of gastric cancer cells in vitro and suppressed the liver metastasis in vivo. (biomedcentral.com)
  • While, DC-SIGNR overexpression promoted cell proliferation, migration and invasion. (biomedcentral.com)
  • BCR-ABL oncogene encodes a BCR-ABL tyrosine kinase (TK), which triggers different downstream targets including c-Myc, STAT5 and CrkL, which participated in the control of cell differentiation, proliferation, migration and other cellular behaviors [ 3 - 5 ]. (jcancer.org)
  • The DEmRNAs were mainly enriched in tumorigenesis‑associated GO terms (angiogenesis, positive regulation of cell proliferation, positive regulation of fibroblast apoptotic processes and regulation of neutrophil migration) and pathways (Hippo signaling pathway, cancer pathways, and Wnt signaling pathway). (spandidos-publications.com)
  • Plasmid driven short hairpin RNA approach was employed to validate the role of HSP70-2 in cellular proliferation, senescence, migration, invasion and tumor growth. (biomedcentral.com)
Invasion3
  • EIF5B promotes HCC proliferation and invasion by increasing ASAP1 expression [ 5 ]. (techscience.com)
  • Modulating miR-320d function by transfection of miR-320 mimics or inhibitor led to inhibition or promotion of GCA cell proliferation and invasion, thus regulating tumor progression in GCA-tumor bearing mice. (biomedcentral.com)
  • For example, lncRNA nuclear paraspeckle assembly transcript 1 (NEAT1) is highly expressed in GBM tissues and perturbed expression of NEAT1 suppresses cell proliferation and invasion ( 10 ). (spandidos-publications.com)
Proteins2
  • HCC involves the actions and interactions of numerous genes, 1 , 2 and increasingly powerful bioinformatics tools and datasets, such as the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas (TCGA), have facilitated explorations of how specific proteins and pathways contribute to the disease. (xiahepublishing.com)
  • Thus specific inhibition of individual proteins or signalling pathways holds a great potential for subversion of this genetic plasticity of cancers. (biomedcentral.com)
Differentiation and proliferation2
  • Studies in recent years have demonstrated that long non-coding RNAs (lncRNAs) have multiple biological functions in cell growth, differentiation and proliferation. (oncotarget.com)
  • Although lncRNAs cannot encode any functional protein, they are involved in diverse biological processes, playing essential roles in maintaining cell growth, differentiation and proliferation [ 13 - 15 ]. (oncotarget.com)
Cellular3
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • A series of cellular pathophysiological mechanisms involved in AS (e.g., differentiation, proliferation, and signalling pathways) are under the control of miRNAs. (hindawi.com)
  • The Abu-Remaileh Lab is interested in identifying novel pathways that enable cellular and organismal adaptation to metabolic stress and changes in environmental conditions. (stanford.edu)
Genes6
  • Therefore, the aim of the present study was to investigate the gene expression patterns following siRNA‑mediated suppression of RUNX1‑RUNX1T1 and MAPK1 in Kasumi‑1 and SKNO‑1 cells and to determine the differentially expressed genes in enriched biological pathways. (prinsesmaximacentrum.nl)
  • BeadChip microarray and gene ontology analysis revealed that RUNX1‑RUNX1T1 and MAPK1 suppression reduced the proliferation rate of the t(8;21) cells with deregulated expression of several classical positive regulator genes that are otherwise known to enhance cell proliferation. (prinsesmaximacentrum.nl)
  • Potential molecular pathways through which PPP2CA may be involved in HCC were determined using miRWalk 2.0 as well as analysis of Gene Ontology categories, Kyoto Encyclopedia of Genes and Genomes pathways, and protein-protein interaction networks. (xiahepublishing.com)
  • Future studies should examine whether PPP2CA contributes to HCC through the candidate microRNAs, pathways and hub genes identified in this study. (xiahepublishing.com)
  • Further, the mechanism of ICA-induced cell proliferation of neural stem cells was investigated by analyzing the gene and protein expression of cell cycle related genes cyclin D1 and p21. (biomedcentral.com)
  • On the other hand, the miRNAs examined in this study can also be used to target other genes and pathways. (mbpinc.net)
Inhibition2
  • 1) For example, the down-regulation of miR15s and miR - 16 - 1 in chronic lymphocytic leukaemia, prostate cancer and pituitary tumours, leading to the inhibition of tumour growth and induce cell cycle arrest at the G 1 - phase by target cell cycle regulators ( cyclin D1, cyclin E1, cyclin D3 and CDK6). (ukessays.com)
  • Crataeva Nurvala - (Lupeol is the active compound in Crateva) - Collectively, these data suggest the multitarget efficacy of Lupeol on beta-catenin-signaling network thus resulting in the inhibition prostate cancer cell proliferation. (compassionateacupuncture.com)
MiRNAs1
  • Scientists further worked showed that despite of the differences between cell lines in the gene expression level, the miRNAs-gene network is very slightly influenced or disrupted in these pathways. (mbpinc.net)
MAPK1
Promotes2
  • The results demonstrate that DLEU1 and TRAF4 is highly expressed in GBM tissues and promotes proliferation of GBM cells. (spandidos-publications.com)
  • The present study showed that icariin promotes the growth and proliferation of neural stem cells from rat hippocampus in a dose-dependent manner. (biomedcentral.com)
KEGG1
  • Based on the ceRNA hypothesis ( 15 ), the lncRNA-miRNA-mRNA network was constructed and Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes (KEGG) pathway analysis of mRNAs in the network were performed. (spandidos-publications.com)
Molecular4
  • Although the molecular biology mechanisms for BRCA1 and BRCA2 are not understood very well, more and more evidence shows that there are abnormal BRBC1 pathway existing in BLBC. (wikipedia.org)
  • This abberation deregulates numerous molecular pathways including the ERK signalling pathway among others. (prinsesmaximacentrum.nl)
  • This study aimed to clarify whether PPP2CA, which encodes the alpha isoform of the catalytic subunit of PP2A, plays a role in hepatocellular carcinoma (HCC) and to identify the potential underlying molecular pathways. (xiahepublishing.com)
  • Some of these natural mushroom compounds have demonstrated specific activity against signaling pathways that are aberrantly activated in cancer cells and have been shown to negatively modulate specific molecular targets involved in cell proliferation, survival, and angiogenesis [ 10 ] [ 11 ] . (encyclopedia.pub)
Mutations1
  • Usurping these processes to deregulate functional pathways is likely simpler than generating mutations or chromosomal aberrations (unless DNA repair is deficient and genetic instability is present). (aacrjournals.org)
Enrichment1
  • In a recent study functional themes associated with Gleason grade include developmental processes, signal transduction, chemokine and embryonic stem cell pathways with specific enrichment of the androgen receptor, EGFR, TNF-alpha, and Notch signaling cascades. (compassionateacupuncture.com)
Protein2
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • This study evidently demonstrates the potentiating effect of ICA on neural stem cell growth and proliferation, which might be mediated through regulation of cell cycle gene and protein expression promoting cell cycle progression. (biomedcentral.com)
Genotype1
  • Broccoli - Consuming broccoli interacts with GSTM1 (glutathione S-transferase mu 1) genotype to result in complex changes to signalling pathways associated with inflammation and carcinogenesis in the prostate. (compassionateacupuncture.com)
Tumor suppressor1
  • The cyclin D-associated kinases are essential for the proliferation of Rb-positive cells because they initiate the phosphorylation-dependent cascade that inactivates this tumor suppressor [2, 4]. (healthandwellnesssource.org)
Extracellular1
Regulation3
MicroRNAs2
  • MicroRNAs control the levels of numerous cell cycle regulators that controls cell proliferation. (ukessays.com)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
Malignant1
  • Deletion of RB gene and overexpression of cyclin E play a significant role in the malignant proliferation of BLBC. (wikipedia.org)
Receptors1
  • Actually maybe it's confirmed LRRFIP1 antibody that mitogenic sign transduction pathways from three classes of receptors converge and firmly need the cyclin D-CDK activity to induce S stage (31). (bibf1120.com)
Modulate1
  • Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease. (stanford.edu)
Differentially1
  • Differentially regulated pathways were characteristic of high-grade meningiomas. (nature.com)
MiRNA1
  • Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genomes pathway analysis of DEmRNAs in the DElncRNA‑miRNA‑DEmRNA network was performed. (spandidos-publications.com)
Significantly2
  • In the HCC cells, activation of the NF-kappa B signaling pathway and IkB phosphorylation was significantly reduced by EIF5B silencing. (techscience.com)
  • We found that JOA at lower concentration significantly inhibited the proliferation of CML cells expressing mutant BCR-ABL (T315I mutation included) and wild-type BCR-ABL, which was due to that JOA induced the cell differentiation and the cell cycle arrest at G0/G1 phase. (jcancer.org)
LncRNAs1
Metabolic2
  • The annotated metabolic pathways encompassed biosynthesis of secondary metabolites, carbohydrate metabolism, and lipid metabolism. (bvsalud.org)
  • We also study how these pathways go awry in human diseases such as cancer, neurodegeneration and metabolic syndrome, in order to engineer new therapeutic modalities. (stanford.edu)
Expression6
  • Developmentally regulated EZH2 levels are one of the factors that can determine the higher order chromatin structure and expression pattern of the INK4b-ARF-INK4a locus, coupling human progenitor cell differentiation to proliferation control. (biomedcentral.com)
  • INK4b-ARF-INK4a expression is controlled by various signal transduction pathways and patterns of expression vary depending on physiological circumstances. (biomedcentral.com)
  • RUNX1‑RUNX1T1 suppression supported myeloid differentiation by the differential expression of CEBPA, CEBPE, ID2, JMJD6, IKZF1, CBFB, KIT and CDK6, while MAPK1 depletion inhibited the differentiation of t(8;21) cells by elevated expression of ADA and downregulation of JUN. (prinsesmaximacentrum.nl)
  • Accumulation of cells in the G1 phase was largely the result of downregulated expression of TBRG4, CCNE2, FOXO4, CDK6, ING4, IL8, MAD2L1 and CCNG2 in the case of RUNX1‑RUNX1T1 depletion and increased expression of RASSF1, FBXO6, DADD45A and P53 in the case of MAPK1 depletion. (prinsesmaximacentrum.nl)
  • miR-128-5p directly targeted the 3′UTR-binding sequences of the p21 gene, negatively regulated p21 expression, and supported the proliferation of VSMCs. (hindawi.com)
  • Several observations have suggested a role of the NF-κB and IκB gene products in cell proliferation transformation and tumor development (47 53 NF-κB controls the expression of a number of growth-promoting cytokines. (bibf1120.com)
Mechanism1
  • The purpose of this study was to investigate the potentiating effect of ICA on the proliferation of rat hippocampal neural stem cells, and explore the possible mechanism involved. (biomedcentral.com)
Cells3
  • The effect of ICA on the growth and proliferation of the neural stem cells was evaluated by 5-ethynyl-2-deoxyuridine (EdU) labeling of proliferating cells, and photomicrographic images of the cultured neural stem cells. (biomedcentral.com)
  • In this regard, the growth and proliferation of the neural stem cells in vitro are critical as the number of cells available for transplantation is essential to achieve beneficial effect in replacing injury or loss of the neuronal cells. (biomedcentral.com)
  • Exploring the effect of pharmacological manipulation, such as usage of traditional medicine, on the growth and proliferation of neural stem cells is thus valuable towards the development of the stem cells therapies of the neurodegenerative disorders. (biomedcentral.com)
Detect1
  • Bromodeoxyuridine (BrdU) immunocytochemistry and flow cytometry were applied to detect the proliferation of VSMCs. (hindawi.com)
Mutation1
Demonstrate1
Human1
Analysis1
  • Our computational analysis provided a rationalization to the ability of naturally occurring WA to alter the chaperone signalling pathway. (biomedcentral.com)
Activation1
  • p14 ARF is structurally and functionally unrelated to p15 INK4b or p16 INK4a and works primarily through activation of the p53 pathway. (biomedcentral.com)