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  • Somatic
  • Our approach provides a powerful precision oncology tool for identifying the driving signalling networks for malignancies not primarily driven by somatic mutations, such as paediatric cancers. (biomedcentral.com)
  • progression
  • Men have a much higher incidence of hepatocellular carcinoma (HCC), the predominant form of liver cancer , than women, suggesting that estrogens play a protective role in liver cancer development and progression. (hindawi.com)
  • Its classic physiological function is to regulate bone metabolism and serum calcium concentrations, but current knowledge now shows abundant extra skeletal actions by VitD, including modulation of cancer onset, progression, and mortality. (clinicsinsurgery.com)
  • differentiation
  • By applying global omics approaches to the signalling networks regulating neuroblastoma differentiation and stemness, we have determined the pathways involved in the MYCN-mediated retinoid resistance, with TGF-β signalling being a key regulator. (biomedcentral.com)
  • molecular
  • Department of Physiology, Department of Medicine, Department of Biochemistry and Molecular Biology, Division of Endocrinology and Metabolism, Division of Medical Oncology, and James Graham Brown cancer Center. (louisville.edu)
  • Our major/main research interest is to understand the molecular mechanism of causation and prevention of hormone related cancers. (louisville.edu)
  • novel
  • We report novel findings in the wnt pathway during rat liver regeneration after 70% partial hepatectomy using Western blot analyses, immunoprecipitation studies, and immunofluorescence. (pubmedcentralcanada.ca)
  • tissues
  • Prostate tissue microarray slides containing 129 cases (18 normal prostate tissues, 40 early stage cancers, and 71 late stage cancers) were assessed for midkine expression by immunohistochemical staining. (biomedcentral.com)
  • Diseases
  • Endogenous protective mechanisms have been mainly investigated in diverse pathological states such as vascular diseases, trauma, and cancer. (frontiersin.org)
  • induce
  • However, conflicting studies show that varying serum concentrations of VitD and its analogs can greatly affect the potency of its anti-cancer role, where too little exerts no influence and too much may even induce cancer. (clinicsinsurgery.com)
  • human
  • Although the JUN locus is not mutated in human cancer, it was recently shown to be a target of 1p32 amplifications in undifferentiated and aggressive human sarcomas 11 , 12 . (pubmedcentralcanada.ca)
  • regulation
  • Depletion of G3BP2, chemical inhibition of protein methyl transferase activity, and expression of methylation-deficient G3BP2 attenuated Wnt3a-induced LRP6 phosphorylation, revealing previously unknown modes of regulation of the Wnt pathway. (biologists.org)
  • incidence
  • Prostate cancer is a slowly developing disease of aging men and dogs and has an extremely low incidence of spontaneous occurrence in laboratory animals. (aacrjournals.org)
  • liver
  • Depending on the type of estrogens and animal models, the reported effects are controversial, although the majority of the literature supports estrogens' protective roles in liver cancer. (hindawi.com)
  • Some studies have reported promotional effects of synthetic estrogens ethinylestradiol in oral contraceptive [ 11 - 13 ] and diethylstilbestrol [ 14 ] on liver cancer growth. (hindawi.com)
  • suggests
  • Our recent data suggests ZNF217 binds to and represses the Apaf-1 (apoptotic protease-activating factor-1) promoter, which would otherwise trigger cell death pathways. (seekdotnet.com)
  • drugs
  • Statins are a class of drugs that inhibit the rate-limiting steps in the cholesterol biosynthesis pathway. (spandidos-publications.com)
  • Statins, also known as 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors, are a class of drugs that inhibit the rate-limiting steps in the cholesterol biosynthesis pathway ( 1 , 2 ). (spandidos-publications.com)
  • If that is the case, drugs that can regulate the removal of fatty acyl groups from oncoproteins may eventually form new cancer treatment options. (elifesciences.org)
  • Preclinical
  • The analysis will tie together all current evidence to compare the similarities and differences of how VitD affects major types of endocrine-related cancers, in the hopes of presenting a concise visual for future preclinical studies in this now vast field of research. (clinicsinsurgery.com)