Pathways genetic anticancer drugs or radiation. Medical search. Frequent questions

All of these alterations signal through the PI3-kinase/AKT/mTOR pathway, which is critical for tumour escape from radiation induced cell death. (ecancer.org)
Specifically, MAC exhibited a potent action in inhibiting the PI3K/Akt/mTOR pathway, whose aberrant activation was found in many types of cancer. (biomedcentral.com)
The Part 1 post was concerned principally with interventions that address the mTOR pathway, a growth pathway also of great interest from the viewpoint of longevity. (anti-agingfirewalls.com)

In conclusion, the current investigation regarding anticancer effects of piperine against breast cancer revealed remarkable suppression of cancer cells. (ijpsonline.com)

BC comprises of variant subtypes and those subtypes arise from basal progenitor or luminal progenitor cells undergoing different genetic mutations[ 2 ]. (ijpsonline.com)
The latest anti-cancer targeted therapies and immunotherapies are directed at the genetic DNA mutations that underlie the development and progression of brain cancer. (businesswire.com)
The fast implementation of these targeted therapies into routine clinical practice has been constrained by a lack of comprehensive genetic screening for these DNA mutations at diagnosis. (businesswire.com)
Oncologica's Next generation sequencing platform captures 764 of the leading anti-cancer targeted medicine drug combinations and immunotherapies via analysis of actionable genomic mutations across 505 genes. (businesswire.com)
Most patients had 3 or more actionable mutations affecting key cancer regulatory networks including mitogenic signalling pathways, DNA-damage repair pathways and cell cycle checkpoints. (businesswire.com)
However, cancer cells overcome these controls, in particular by acquiring genetic mutations leading to the activation of oncogenes (pten, myc) or loss of tumor suppressors (p53) [ 1 ]. (hindawi.com)
Conclusion: TS is a disease that affects mostly members of families with multiple genetic mutations and types of cancers. (benthamscience.com)
Genetic interaction can be defined as a deviation of the phenotypic quantitative effect of a double gene mutation from the effect predicted from single mutations using a simple (e.g., multiplicative or linear additive) statistical model. (researchgate.net)
We describe a computational methodology allowing to systematically and quantitatively characterize a Boolean mathematical model of a biological network in terms of genetic interactions between all loss of function and gain of function mutations with respect to all model phenotypes or outputs. (researchgate.net)
In genetic interactions, synergy occurs when the contribution of two mutations to the phenotype of a double mutant exceeds the expectations from the additive effects of the individual mutations [74]. (researchgate.net)
In addition, it can be used to predict genetic interactions [3] by comparing the sensitivity value of a double gene mutation from the value predicted from single mutations, and reveal the network intervention [4] by applying the state-flip mutation subject to a single gene. (researchgate.net)
In the second case study, we showed that edgetic mutations can predict drug-targets better than node-based mutations. (researchgate.net)
Mutations were found in over 70 percent of carcinomas, predominantly in the therapeutically targetable MAPK pathway (68 percent) and a few in the PI3K/AKT pathway (4 percent). (aacr.org)

Our molecular testing capabilities now cover cancer screening, tumour DNA sequencing, Covid -19 mutation profiling and allergen testing, with over 5 million genetic health tests performed during the last two years. (businesswire.com)
The most common reasons include genetic mutation, lifestyle and food, radiation, and hormonal variables. (ijpsr.com)
There are many factors and variables that contribute to the pathogenesis of cancers such as oxidative stress, DNA damage and mutation, ionizing radiations, carcinogenic chemicals, and so much more. (h2hubb.com)

It supports the treatment and prevention of numerous health conditions, targeting a diverse range of pathways with potent bioactivity. (dna-biopharm-sa.com)
This review summarizes the intracellular functions of Akt as a pivotal point of converging signaling pathways involved in cell growth, proliferation, apoptotis and neo‑angiogenesis, and focuses on the drug design strategies to develop potent anticancer agents targeting Akt. (spandidos-publications.com)
Pactamycin, although putatively touted as a potent antitumor agent, has never been used as an anticancer drug due to its high cytotoxicity. (biotiny.com)

[ 2 , 3 ] Conventional techniques of gene investigation in cancer rely on the identification of single genetic alterations associated with disease. (medscape.com)
Arcaro A and Guerreiro AS: The phosphoinositide 3-kinase pathway in human cancer: Genetic alterations and therapeutic implications. (spandidos-publications.com)
The research of Tumour Suppressor Genes and Proto-Oncogenes Genetic Alterations in Solid Tumors has substantially improved our understanding of cancer biology. (cancersummit.org)

To prevent aberrant cell proliferation, these pathways are tightly regulated. (hindawi.com)

Moreover, a majority of chemotherapeutic drugs are highly hydrophobic and need to be diluted in organic solvents, which cause high toxicity, in order to reach effective therapeutic dose. (oaepublish.com)
Also, many effective chemotherapeutic drugs are hydrophobic and need to be diluted in an organic solvent (DMSO, Cremophor EL, ethanol etc .) that causes toxicity when injected. (oaepublish.com)
Schrodinger, online tools such as ProTOX, swissAdmet and Spartan 10.1 were used to examine the samples' Mmgbsa, Admet characteristics, drug-likeness, toxicity prediction and DFT. (ijpsr.com)
The most susceptible to radiation toxicity are the hematopoietic system, which is composed of the composition of the blood and blood-forming organs. (biotiny.com)
2. Prior chemotherapy, immunotherapy (tumour vaccine, cytokine or growth factor given to control the cancer) or other anti-cancer therapy within less than 2 weeks before study drug administration, or any persistent unresolved toxicity from such previous therapy that, according to the judgement of the investigator, may pose a risk for the subject if taking part in the study. (who.int)
More commonly, multidrug regimens incorporating drugs with different mechanisms of action and different toxicities are used to increase efficacy, reduce dose-related toxicity, and decrease the probability of drug resistance. (msdmanuals.com)

1 Drug Delivery and Targeting Group, Molecular Biology and Biochemistry Research Centre for Nanomedicine (CIBBIM-Nanomedicine), Vall d'Hebron Institut de Recerca, Universitat Autònoma de Barcelona , Barcelona 08035, Spain . (oaepublish.com)
In this review we deal in the molecular mechanisms, the epigenetic effects and modulation of the oxidative stress pathway of ketogenic diets, that underlie its possible role, in the treatment of infantile gliomas, as a complementary approach to conventional cancer therapy. (frontiersin.org)
Transporters on the plasma membrane of tumor cells are promising molecular "Trojan horses" to deliver drugs and imaging agents into cancer cells. (aspetjournals.org)
As the understanding of how key molecular pathways work in cancers has increased, so have more-sophisticated therapies been introduced, often used conjunction with the traditional slash, burn and poison approaches. (anti-agingfirewalls.com)
This blog entry is concerned with another "smart" approach: simultaneously targeting multiple molecular pathways in cancer cells to defeat their protective responses. (anti-agingfirewalls.com)
Based on scientific research, molecular hydrogen appears to have promising anticancer effects. (h2hubb.com)
Molecular hydrogen appears to stimulate cellular death pathways in cancerous cells. (h2hubb.com)
Targeted cancer therapies are used to inhibit the growth, progression, and metastasis of the tumor by interfering with specific molecular targets and are currently the focus of anticancer drug development. (spandidos-publications.com)
Mitsiades CS, Mitsiades N and Koutsilieris M: The Akt pathway: Molecular targets for anti-cancer drug development. (spandidos-publications.com)
Although older chemotherapeutic drugs are often toxic to normal cells, advances in genetics and cellular and molecular biology have led to development of more selective drugs. (msdmanuals.com)

Therefore, knowing the genetic variations (polymorphisms) will be effective in predicting the response to treatment, and accordingly, we can determine which patients will benefit from chemo- or radiotherapy (Ansell et al. (researchsquare.com)
Individual Genetic Variation Might Predict Acute Skin Reactions in Women Undergoing Adjuvant Breast Cancer Radiotherapy. (cancerindex.org)
3. Prior definitive radiation therapy within less than 4 weeks and prior palliative radiotherapy within less than 2 weeks before study drug administration. (who.int)

It is also shown to enhance certain conventional cancer protocols -including synergy with chemotherapy and radiation- and prevent multi-drug resistance. (dna-biopharm-sa.com)
is known to exert anticancer effects, such as inducing cell cycle arrest, inhibiting metastasis, and overcoming immunotherapy resistance in breast cancer cells. (hindawi.com)
Potential of nanomedicines to overcome resistance, ameliorate solubility, improve pharmacological profile, and reduce adverse effects of chemotherapeutical drugs is thus highly regarded. (oaepublish.com)
Here, we provide a closer review of clinical prospects and mechanisms of action of nanomedicines to overcome drug resistance. (oaepublish.com)
Consequent drug resistance allows the tumour to grow and spread even with the treatment [ 3 ] . (oaepublish.com)
In addition, heterogeneity among patients and tumours make drug resistance a highly challenging event [ 5 ] . (oaepublish.com)
Closer understanding of the mechanisms involved in drug resistance is needed in order to achieve better outcomes in cancer treatment. (oaepublish.com)
Resistance to anticancer agents and apoptosis results in cancer relapse and is associated with cancer mortality. (oaepublish.com)
Several mechanisms participate in the drug and apoptosis resistance phenotype in CSCs in various cancers. (oaepublish.com)
These emerging strategies may help target CSC-associated drug resistance and metastasis in clinical settings. (oaepublish.com)
This article will review the CSCs drug and apoptosis resistance mechanisms and how to target CSCs. (oaepublish.com)
changes in the ability of apoptosis not only contribute to neoplasm enhancement but also lead to resistance to common cancer treatments such as radiation therapy or cytotoxic agents. (icbcongress.com)
one of the proposed mechanisms for resistance to cytotoxic and anti-neoplastic drugs is a change in the expression of the b-cell lymphoma-2 family, or bcl2. (icbcongress.com)
Resistance to cancer drugs is common. (msdmanuals.com)
For chemotherapy drugs, one of the best characterized resistance mechanisms is overexpression of MDR1 , a cell membrane transporter that causes efflux of certain drugs (eg, vinca alkaloids, taxanes, anthracyclines). (msdmanuals.com)
Attempts to alter MDR1 function and prevent drug resistance have been unsuccessful. (msdmanuals.com)

the main pathway for cellular death is called the mitochondrial pathway, which is activated by a wide range of signals including radiation, cytotoxic drugs, cellular stress, and growth factor receptors and involves the release of proteins such as cytochrome c from mitochondrial membrane space. (icbcongress.com)
the mitochondrial anticancer targets are called mitokan, which by selective accumulation in the mitochondria and damage to the mitochondrial membrane, leads to increased ros and apoptosis. (icbcongress.com)
some drugs are designed to disturb the respiratory tract and permeability of the mitochondrial membrane, which increases the levels of ros and regulates the expression of the gene in mitochondria. (icbcongress.com)

Anti-cancer: Extensive published research shows pure honokiol works on critical cell signaling and genetic pathways to halt cancer growth, promote apoptosis in cancer cells, and disable the metastatic process. (dna-biopharm-sa.com)

Finally, MAC was found to trigger apoptotic death pathway (based on expression levels of cleaved-caspase 3, Bax/Bcl-2 balance, p53 and p21). (biomedcentral.com)
Defects in apoptotic pathways can lead to cancer. (icbcongress.com)

the DSBR (double-strand break repair) pathway or the SDSA (synthesis-dependent strand annealing) pathway. (wikipedia.org)
DNA double-strand break repair pathway regulates PD-L1 expression in cancer cells. (ui.ac.id)

Recurrent tumors are highly aggressive, potentially cross-drug resistant, highly metastatic, and have a poor prognosis. (hindawi.com)
Despite its selective uptake by neuroendocrine tumors, mIBG accumulates in several normal tissues and leads to tissue-specific radiation toxicities. (aspetjournals.org)
Moreover, Wnt signaling cascades cross-talk with the FGF, Notch, Hedgehog (Hg), and TGFβ/BMP signaling pathways and regulate the expression of CSC markers, such as CD44, CD133 (PROM1), EPCAM, and LGR5 (GPR49) in these tumors [ 9 ] . (oaepublish.com)
Following the genetic ablation of IL22 in a mouse model of KRAS-mutant lung cancer, the number and size of tumors was significantly reduced compared to mice with functional IL22. (aacr.org)
An important development in cancer research over the past 2 decades has been the recognition that genetic changes drive the pathogenesis of tumors of both adulthood and childhood. (medscape.com)

Moreover, treatment with MAC was able to down-regulate MAPK pathway (results focused on JNK and p38 expression). (biomedcentral.com)
IL-21 activates both the Raf-ERK-MAPK and the Jak/STAT signaling pathways. (intechopen.com)

The intersection between the differentially expressed genes (DEGs) and the HNK-targets was determined using a Venn diagram, and the results were analyzed using a protein-protein interaction network, hub gene selection, gene ontology and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analyses, genetic alteration analysis, survival rate, and immune cell infiltration levels. (hindawi.com)
Hence, evidenced the blocking of phosphatidylinositol 3-kinase/protein kinase B signaling pathway. (ijpsonline.com)
It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
Further studies with pharmacological and genetic approaches revealed that TIGAR regulated the phosphorylation of ATM, a key protein in DDR, through Cdk5. (nature.com)
In addition to its role in glucose metabolism, this pathway also regulates the redirection of free amino acids to protein synthesis via the mTOR-signaling pathway. (hindawi.com)
For instance, CSC maintenance in glioblastoma, colon cancer, gastric cancer, and prostate cancer is regulated by CD133-mediated AKT, leucine-rich G-protein-coupled receptor 5 (LGR5)-mediated Wnt/β-catenin and speckle-type POZ protein (SPOP)-mediated Nanog pathways [ 4 - 8 ] . (oaepublish.com)
Arencibia JM, Pastor-Flores D, Bauer AF, Schulze JO and Biondi RM: AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases. (spandidos-publications.com)

Previous study revealed that the protective effect of TIGAR in cell survival is mediated through the increase in PPP (pentose phosphate pathway) flux. (nature.com)
The Cdk5-AMT signal pathway involved in regulation of DDR by TIGAR defines a new role of TIGAR in cancer cell survival and it suggests that TIGAR may be a therapeutic target for cancers. (nature.com)
The levels of pAkt and pGSK3β (cell survival pathways), mainly expressed in neurons, were markedly up-regulated. (h2hubb.com)
Song G, Ouyang G and Bao S: The activation of Akt/PKB signaling pathway and cell survival. (spandidos-publications.com)
These miRNAs can distinguish between lethal and non-lethal dose of radiation, and to accurately predict the overall survival. (biotiny.com)

Fundamentally, cancer is brought on by genetic alteration. (ijpsr.com)

Simultaneously, genetic analysis is done on the tumour tissue, whereby the response to the treatment is scored. (ecancer.org)

This study investigated the role of TIGAR in DNA damage response (DDR) induced by genotoxic drugs and hypoxia in tumor cells. (nature.com)
Ex vivo drug screening refers to the out-of-body assessment of drug efficacy in patient derived vital tumor cells. (biomedcentral.com)

It has been suggested that radiation sensitivity and chemosensitivity of cancer cells may play an important role in the local control of the tumor following these therapies. (researchsquare.com)
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. (ui.ac.id)

One of the latest trials can be viewed here: Graviola: A Novel Promising Natural-Derived Drug That Inhibits Tumorigenicity and Metastasis of Pancreatic Cancer Cells In Vitro and In Vivo Through Altering Cell Metabolism. (dna-biopharm-sa.com)

Both chemotherapy and radiation therapy have from the onset been focused on killing cancer cells, in one case by using highly toxic chemicals and in the other case by using focused radiation. (anti-agingfirewalls.com)

Akbari MR, Malekzadeh R, Nasrollahzadeh D, activates EGFR pathway signaling in the lung. (who.int)

However, a newly published study from the research team at Oncologica the world-leading genetic cancer testing laboratory based in Cambridge UK, explains how their genetic sequencing research into predictive glioblastoma biomarkers can empower patients and doctors with DNA blueprints to make better targeted therapy decisions. (businesswire.com)

Women tested at high risk for breast cancer using non-clinical genetic tests overlooking family history may decide to undergo unnecessary breast surgery. (medindia.net)
In recent years, thanks to the study of genetic variants, significant information associated with the prognosis and clinical course of glioma has been acquired. (frontiersin.org)
Clinical trials are ongoing for cancer therapy with benzimidazole drugs. (cures.news)
Because the experimental treatment regimens described in this and the previous blog entry draw on drugs already approved for cancer treatment or for other indications, clinical usage and experience seems to be increasing rapidly in the areas characterized. (anti-agingfirewalls.com)
Cold Spring Harbor, NY -- Cold Spring Harbor Laboratory Press announced the release of Genetic Counseling: Clinical Practice and Ethical Considerations, available on its website in Hardcover and Paperback formats. (cshlpress.com)
We explore the pipeline of Akt inhibitors and their preclinical and clinical examination status, presenting the potential clinical application of these agents as a monotherapy or in combination with ionizing radiation, other targeted therapies, or chemotherapy. (spandidos-publications.com)
They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. (ui.ac.id)

Chemoresistance, or the insensitivity of cancer cells to drug therapy, is a major factor in the failure of chemotherapy against breast cancer. (hindawi.com)
In contrast, cancer cells shift their metabolism toward lactate production even in the presence of oxygen [ 4 ], partly through genetic modifications that stabilize the transcription factor Hypoxia Inducible Factor (HIF) involved in the adaptation of the cells to hypoxia, under nonhypoxic conditions as well as generating an adaptive response to the hypoxic microenvironment (Figure 1 ). (hindawi.com)
benzimidazole drugs are also found to prevent the radiation-induced transformation of cancer cells into radiation-resistant cells, and furthermore sensitize some drug-resistant cells. (cures.news)
Dr. Multani has extensive expertise in the field of Human and Mammalian Cytogenetics, and specializes in the evaluation of genetic instability and complex chromosomal rearrangements in cancer cells, telomere dysfunction, characterization of embryonic stem cells, and authentication of cell lines. (mdanderson.org)
The ideal drug would target only cancer cells and have no adverse effects on normal cells. (msdmanuals.com)
Cytotoxic drugs damage DNA and kill many normal cells as well as cancer cells. (msdmanuals.com)
In contrast, other drugs (eg, DNA cross-linkers, also known as alkylating agents) have a linear dose-response relationship, killing more cancer cells at higher doses. (msdmanuals.com)

Assessments used the Radiation Therapy Oncology Group scoring system for acute RT skin reaction (RTOG scale). (cancerindex.org)

Substantial data have provided convincing evidence establishing that human cancers emerge from cancer stem cells (CSCs), which display self-renewal and are resistant to anticancer drugs, radiation, and apoptosis, and express enhanced epithelial to mesenchymal progression. (oaepublish.com)
Single drugs may cure selected cancers (eg, choriocarcinoma, hairy cell leukemia). (msdmanuals.com)

Our findings are basis of proposing 2HF as therapeutic or preventative drug for lung cancer. (oncotarget.com)
[ 6 ] The biochemical pathways that this process follows may be therapeutic targets for FTC. (medscape.com)

New study of genetic brain cancer biomarkers empowers patients and doctors with DNA blueprints for better targeted therapy decisions. (businesswire.com)
Surgery to the extent that this is feasible in terms of safety, followed by involved-field radiation therapy and concomitant and maintenance chemotherapy with temozolomide, has set the standard of care since 2005. (frontiersin.org)
Hence, a major goal in cancer drug development and therapy is to increase tumor-specific drug uptake while reducing uptake into normal tissues to minimize toxicities. (aspetjournals.org)
At the same time researchers also analyzed the correlation between radiation therapy and miRNAs, they found that mice receiving radiation therapy before in contact with lethal doses of radiation, its RNA expression profiles reflect the protective effect of the drug, and can predict the serious injury suffered in a lesser extent. (biotiny.com)
This study investigated whether BRD4 inhibition can alter the immunomodulatory and antitumor effects of radiation therapy (RT). (preprints.org)
When used in combination with the chemotherapy drug 5-fluorouracil, or radiation therapy, spread was also halted. (snipear.org)
For chemotherapy, two-drug cytotoxic regimens that include a platinum agent are generally preferred for first-line therapy. (medscape.com)
Radiation therapy is often given with chemotherapy. (medscape.com)
External beam radiation therapy (EBRT) is used. (medscape.com)
Taking proanthocyanidin, a chemical found in grape seed extract, does not reduce breast tissue hardness, pain, or tenderness in people treated with radiation therapy for breast cancer. (medlineplus.gov)
The major modalities of therapy are Surgery (for local and local-regional disease) Radiation. (msdmanuals.com)

HNK controls various intracellular signaling pathways involved in cancer, including those related to nuclear factor kappa B (NF- B), signal transducers and activators of transcription 3 (STAT3), epidermal growth factor receptor (EGFR), and mammalian targets of rapamycin (mTOR) [ 12 ]. (hindawi.com)
The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
Curr Cancer Drug Targets. (spandidos-publications.com)

BC is both histopathologically as well as genetically heterogeneous, thus underlying mechanisms of developing BC still remains uncertain[ 3 ], which cause hurdles in BC diagnosis as well as treatment, owing to this conventional treatment for BC like surgery, radiation and chemotherapy does not hold good efficiency. (ijpsonline.com)
Individual genetic variations lead to different responses of patients to a single treatment regimen. (researchsquare.com)
The potency of each of these strategies is further enhanced by radiation treatment, leading to increased amounts of DNA damage with profound delay in DNA damage resolution. (nature.com)
An increasingly popular strategy is pharmaconutrition, which combines a tailored pharmacological treatment with a diet designed to synergize the effects of drugs. (frontiersin.org)
benzimidazole drugs are also being combined with other chemotherapeutics, such as paclitaxel, trametinib, gemcitabine and methoxyestradiol, to enhance the anti-cancer treatment efficacy. (cures.news)
Consistent with increased drug accumulation, combined treatment with 1-chloro-2, 4-dinitrobenzene, reduced the GI 50 of 2HF by an order of magnitude. (oncotarget.com)
Treatment with both H2 waters (HHW and NHW) increased the expression of p-AMPK, AIF and Caspase 3 (cell apoptosis pathways) in colon 26 cells. (h2hubb.com)
A recent study pointed out that this small RNA molecules not only attribute to diagnosis and treatment of cancer and other diseases in a prominent, but also to predict long-term damage caused by radiation exposure in living organisms within 24 hours, and its estimated speed is much faster than existing radiation absorbed dose method. (biotiny.com)
Damage required months or a few weeks to reflect after radiation exposure out, this will hinder timely medical treatment, and methods currently used to predict in vivo radiation dose to the patient are detecting the loss of white blood cells, damage DNA or chromosomal abnormalities which are often tedious and time-consuming. (biotiny.com)
In the future, these molecules may serve as diagnostic biomarkers to guide the early treatment of radiation accident victims. (biotiny.com)
The researchers note that since both PDT and 5FU are approved by the U.S. Food and Drug Administration for the treatment of actinic keratosis, clinicians can readily utilize this combinatorial regimen for their patients. (aacr.org)

Multidrug regimens typically are given as repetitive cycles of a fixed combination of drugs. (msdmanuals.com)

In each category, studies related to growth control genes, cell proliferation, apoptosis, DNA repair genes, antioxidant and drug detoxification genes, genes of drug metabolizing enzymes, tissue remodeling genes and genes of antibody-dependent cellular cytotoxicity were discussed separately. (researchsquare.com)
Samples of commonly utilized anticancer plants obtained from the chosen areas using physical and virtual oral seminars were studied for physiochemical composition and a possible antioxidant and cytotoxic potential to validate the basis for the use of the selected anticancer plants. (who.int)
The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)

Homologous recombination is a type of genetic recombination in which genetic information is exchanged between two similar or identical molecules of double-stranded or single-stranded nucleic acids (usually DNA as in cellular organisms but may be also RNA in viruses). (wikipedia.org)

Acute toxicities are rarely reported for these drugs. (cures.news)
7. Major surgery within 4 weeks before the first dose of the study drug or minor surgery within 1 week (subject must also have recovered from any surgery-related toxicities to less than CTCAE Grade 2). (who.int)
End-organ function should be assessed before giving drugs with organ-specific toxicities. (msdmanuals.com)

Nanotechnology-based drug delivery systems are able to incorporate drugs or gene products with active anti-cancer activity but poor solubility, low bioavailability, or inadequate toxicological profile. (oaepublish.com)
1991. Genetic activity of the human carcinogen sulphur mustard towards salmonella and the mouse bone marrow. (cdc.gov)
SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)

Glioblastoma, the most aggressive form of brain cancer is commonly treated with surgery, radiation, and chemotherapy. (businesswire.com)

Dose modification or exclusion of certain drugs may be necessary in patients with lung disease (eg, bleomycin), kidney failure (eg, methotrexate), liver dysfunction (eg, taxanes) or heart disease (daunorubicin, cyclophosphamide). (msdmanuals.com)

The study findings validate metal-enhanced photo-oxidation for future metal-based anticancer drugs. (medindia.net)

These new genomic targeted drugs have greater specificity and reduce toxic effects for patients compared to conventional chemotherapy. (businesswire.com)
In this chapter, we will focus on IL-21's biological effects and signaling pathways as well as discuss the potential implications and applications of IL-21 in leukemia cells. (intechopen.com)
These pathways mediate some of the effects of IL-21. (intechopen.com)

I-SceI) to cut chromosomes for genetic engineering of mammalian cells, where nonhomologous recombination is more frequent than in yeast. (wikipedia.org)
Epirubicin, a DNA damaging anticancer agent and CoCl 2 , which was used to imitate hypoxia condition, was applied to induce DNA damage in TIGAR knockdown HepG2 cells. (nature.com)
Lipids, amino acids, and nucleotides necessary for the biosynthesis of the daughter cells are mostly provided by intermediate metabolites of these pathways. (hindawi.com)
Studying such mechanisms not only provides mechanistic insights into these cells that are unresponsive to drugs, but may lead to the development of targeted and effective therapeutics to eradicate CSCs. (oaepublish.com)

In contrast, regulation of breast cancer CSCs (BCSCs) occurs by CD44 standard splice isoform (CD44s)-activated platelet-derived growth factor receptor b (PDGFRb)/signal transducer and activator of transcription 3 (STAT3), forkhead box C1 (FOXC1)-activated sonic hedgehog (SHH), and sphingosine-1-phosphate (S1P)/S1PR3-activated NOTCH pathways [ 10 - 13 ] . (oaepublish.com)

Inflammatory Drugs and Risk of Breast Cancer: Evidence from a General Female Population and a Mammographic Screening Cohort in Sweden. (cancercentrum.se)

Homologous recombination is also used in horizontal gene transfer to exchange genetic material between different strains and species of bacteria and viruses. (wikipedia.org)
L. egeregia was regarded as the prototype of the anticancer species due to its profound flavonoid concentration (85.40 µg/mL) and cytotoxicity (9.46 µg/mL) compared to other extracts. (who.int)

there are two known methods for delivering medication to mitochondria: 1- direct binding of the target ligand to the drug, 2- attach the target ligand to the nanoparticle. (icbcongress.com)

The researchers gave mice exposed to low, high, and lethal dose of total body irradiation and exposure to radiation is detected within 24 hours of miRNA concentration in blood. (biotiny.com)
The most common thyroid tumor to develop after exposure to radiation is papillary thyroid cancer. (medscape.com)

This Part 2 post is concerned with anti-cancer drug and other interventions that simultaneously address multiple growth pathways. (anti-agingfirewalls.com)

High dose pharmaceutical drugs interact and inhibit Vitamin D conversion. (cancertutor.com)
Researchers from the Dana-Farber Cancer Institute presented this novel blood test, before labor tests showed that the method can reveal the fate of victims of radiation accidents, as well as the dose of radiation received by them within 24 hours, which will caused severe bone damage, or damage to other organs. (biotiny.com)

Pretreatment with 5FU increased the production of protoporphyrin IX (the active photosensitizer) and proapoptotic p53 expression and upregulated the enzymes in the heme synthesis pathway, compared with control lesions. (aacr.org)

Anatomy14

Organisms5

Diseases26

Chemicals and Drugs93

Analytical, Diagnostic and Therapeutic Techniques and Equipment55

Phenomena and Processes54

Disciplines and Occupations8

Anthropology, Education, Sociology and Social Phenomena3

Technology, Industry, Agriculture8

Information Science5

Health Care23

MTOR pathway3

Regarding anticancer effects1

Mutations13

Mutation3

Potent3

Alterations3

Aberrant1

Toxicity6

Molecular10

Radiotherapy3

Resistance16

Mitochondrial3

Apoptosis in cancer cells1

Apoptotic2

Double-strand break repair2

Tumors5

MAPK2

Protein7

Survival5

Alteration1

Tumour1

Tumor cells2

Sensitivity2

Metastasis1

Chemotherapy and radiation1

Activates1

Predictive1

Clinical7

Cancer cells7

Oncology1

Cancers2

Therapeutic2

Therapy11

Targets3

Treatment11

Regimens1

Antioxidant3

Molecules1

Toxicities3

Activity3

Commonly1

Lung1

Findings1

Effects3

Cells4

Regulation1

Breast cancer1

Species2

Nanoparticle1

Exposure to radiation2

Simultaneously1

Dose2

Enzymes1