Pathways gene expression. Medical search. Frequent questions

The peroxisome proliferator- activated receptor gamma coactivator 1-alpha ( Ppargc1a ) gene was found to be involved in the networks generated using Ingenuity Pathway Studio (IPA) from the differentially expressed transcript cluster lists of week 2 versus 1, week 3 versus 2, week 6 versus 3, and week 8 versus 6. (molvis.org)
In this study, differentially expressed genes (DEGs) under drought and flooding conditions were investigated using Illumina RNA-Seq transcriptome profiling. (frontiersin.org)
A total of 104, 85, and 26 differentially expressed genes were identified based on PB vs. P, BP vs. AP, and P vs. AP comparisons, respectively. (sabanciuniv.edu)
Based on differentially expressed genes, possible mechanisms of SWCNT-associated apoptosis resistance and oncogenesis were identified, which included activation of pAkt/p53/Bcl-2 signaling axis, increased gene expression of Ras family for cell cycle control, Dsh-mediated Notch 1, and downregulation of apoptotic genes BAX and Noxa. (cdc.gov)
Objectives: The purpose of this study was to evaluate for differentially expressed genes and perturbed pathways associated with the gut-brain axis (GBA) across two independent samples of oncology patients who did and did not experience CIN. (nyu.edu)
Fisher's combined probability method was used to determine genes that were differentially expressed and pathways that were perturbed between the two nausea groups across both samples. (nyu.edu)
Across the two samples, 703 genes were differentially expressed, and 37 pathways were found to be perturbed between the two CIN groups. (nyu.edu)
Differentially expressed genes in the left atria of mitral regurgitation (MR) pigs have been linked to peroxisome proliferator-activated receptor (PPAR) signaling pathway in the KEGG pathway. (biomedcentral.com)
Gene expression profiling analysis through PCR assay identified 23 genes to be differentially expressed in the left atria of MR patients compared to normal controls. (biomedcentral.com)
Notably, only ACADM, FABP3, ECH1, ACAA2, EHHADH, CPT1A and PLTP of the PPAR pathway were significantly differentially expressed in the MR patients compared to patients with aortic valve disease and normal controls. (biomedcentral.com)
Differentially expressed genes of the PPAR pathway have been identified in the left atria of MR patients compared with patients with aortic valve disease and normal controls. (biomedcentral.com)
Interestingly, gene ontology and pathway enrichment analysis of the differentially expressed genes in that study showed that peroxisome proliferator-activated receptor (PPAR) signaling pathway was identified in the KEGG pathway. (biomedcentral.com)
In this study, we aim to explore the key element genes of the PPAR signaling pathway that were differentially expressed in the left atrial myocardium of MR patients vs. normal controls. (biomedcentral.com)
Functional analysis of differentially expressed genes revealed distinct expression profiles at 24h post fertilization for 0.1μM versus 80μM BPA and 0.1μM versus 15μM E2 exposure, identification of prothrombin activation as a top canonical pathway impacted by both 0.1μM BPA and 0.1μM E2 exposure, and suppressed expression of several genes involved in nervous system development and function following 0.1μM BPA exposure. (oregonstate.edu)
No differentially expressed genes (DEG) in either the PLC or THY were identified in UNINF, PLCO-VIA, and PLCO-MEC when compared to CTRL fetuses. (usda.gov)

The hexosamine biosynthetic pathway is a cellular 'sensor' of energy availability5-8 and mediates the effects of glucose on the expression of several gene products9-12. (elsevierpure.com)
Increased tissue concentrations of the end product of the hexosamine biosynthetic pathway, UDP-N-acetylglucosamine (UDP-GlcNAc), result in rapid and marked increases in leptin messenger RNA and protein levels (although these levels were much lower than those in fat). (elsevierpure.com)
However, AhbHLH and AhGL3 revealed nil-to-little relation with the expression of flavonoid biosynthetic pathway genes. (figshare.com)
This study would provide insight into the role of flavonoid biosynthetic pathway in drought response in peanut and would aid to develop drought-tolerant varieties of peanut. (figshare.com)

Our data reveal a significant overlap between Notch-dependent genes in the fallopian epithelium and the defined 'stem cell signature' of the mouse intestine, suggesting the existence of a conserved pathway that regulates tissue renewal and directly controls cell fate specification and differentiation in the organoid by inhibiting cilliogenesis. (nature.com)
It specifically negatively regulates the PI3K-AKT signaling pathway to induce cell cycle arrest. (medscape.com)
Wnt/β-catenin pathway regulates MGMT gene expression in cancer and inhibition of Wnt signalling prevents chemoresistance. (lu.se)

Background: The causes of obesity are multifactorial and may include dysregulation of certain genes, such as peroxisome proliferator activated receptor gamma (PPAR gamma). (sages.org)
When activated, the PPAR gamma pathway promotes lipid metabolism. (sages.org)
Specifically, the PPAR gamma pathway from obese patients showed an increased number of genes that were dysregulated including TNF alpha. (sages.org)
RNA-sequence analysis revealed that curcumin intake affected hepatic lipid metabolism via the peroxisome proliferator-activated receptor (PPAR) pathway, especially PPARα activation, resulting in increased Apoa2 mRNA expression. (elifesciences.org)
Taken together, these results demonstrate that curcumin is a PPARα activator and may affect expression levels of proteins involved in amyloid deposition to influence amyloidosis and metabolism in a complex manner. (elifesciences.org)
Among the discovered deregulated processes, we focused on specific ones: complement and coagulation cascades, PPAR signaling, cardiac muscle contraction, and dilated cardiomyopathy pathways. (biomedcentral.com)
Moreover, we identified that PARIS actively modulates expression of PPARγ target genes by physically binding to the promoter regions. (nature.com)
Together, our work revealed how PARIS drives adverse effects on modulation of PPAR-γ associated gene clusters in DA neurons. (nature.com)
However, specific genes of the PPAR signaling pathway in the left atria of MR patients have never been explored. (biomedcentral.com)
We used PCR assay (84 genes) for PPAR pathway and quantitative RT-PCR to study specific genes of the PPAR pathway in the left atria. (biomedcentral.com)
The results from this study may identify specific genes of the PPAR signaling pathway that might be responsible for the atrial structural remodeling associated with atrial enlargement and progression of heart failure in patients with MR. (biomedcentral.com)

Microarray analysis reveals that inhibition of Notch signalling causes downregulation of stem cell-associated genes in parallel with decreased proliferation and increased numbers of ciliated cells and that organoids also respond to oestradiol and progesterone treatment in a physiological manner. (nature.com)
Higher water retention and flavonoid accumulation have been observed in BARI2011 but downregulation has been observed in the expression of genes and transcription factors (TFs) which indicated the maintenance of normal homeostasis. (figshare.com)
Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
A similar decline in apoptotic susceptibility associated with downregulation of Apaf-1 expression as a function of developmental age was also found in cultured primary rat cortical neurons. (jneurosci.org)
Gene expression in the thymus revealed strong downregulation of critical immune pathways associated with high viral load. (usda.gov)

Diagnostic subsets of coexpressed genes reflected signaling activity, cross talk, and overlap of multiple mitogen-activated protein kinase (MAPK) pathways. (nih.gov)
Furthermore, PD-98059 and U0126, two MAPK inhibitors, blocked PLC-γ1-induced expression of MDR1. (uky.edu)
These effects were blocked by inhibitors of the PLC-MAPK pathway. (uky.edu)
In summary, our results indicate for the first time that activation of PLC by a variety of cellular stimuli can regulate the expression of MDR1 and that the transcriptional modulation of MDR1 expression by PLC is mediated by the Raf-MAPK pathway. (uky.edu)
Our findings suggest that failed X inactivation, aberrant imprinting, decreased ERK/MAPK signaling and possibly elevated Wnt signaling, and reduced expression of genes for placental development collectively may contribute to abnormal placenta formation and failed fetal development in parthenogenetic embryos. (prinsesmaximacentrum.nl)
These results suggested that the cAMP-dependent pathway, which is independent of MAPK pathways, plays a negative role in γ-globin gene expression in K562 cells. (elsevierpure.com)

In this review we discuss the current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression. (nih.gov)
Transforming growth factor-beta (TGF-beta) plays a critical role in the regulation of extracellular matrix gene expression. (nih.gov)
To derive a systems view for the regulation of the metabolism when cells adapt to environmental changes, whole genome gene expression profiles can be analysed. (sciweavers.org)
Furthermore, Notch is responsible for the regulation of known stem cell factor genes. (nature.com)
Integrin-dependent adhesion plays a dual role in Egr-1 regulation, either being sufficient 'per se' to induce Egr-1, or required for EGF-dependent expression of Egr-1, which occurs only in adherent cells and not in cells in suspension. (unito.it)
Click on Explore Pathways below to highlight different stages of Notch regulation. (rndsystems.com)
cAMP and cGMP may have differential roles in the regulation of γ-globin gene expression in erythroid cells. (elsevierpure.com)
These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)

In general, mRNA levels of ECM and collagen genes have been found to be downregulated in both the adult mouse sclera [ 6 ] and cornea [ 7 ] when compared with samples from an earlier developmental stage. (molvis.org)
We used global gene expression analysis to identify candidate genes and signaling pathways that mediate BPA's developmental toxicity in zebrafish. (oregonstate.edu)

Resistance to antimicrobial drugs in bacteria can result from mutations in housekeeping structural or regulatory genes. (cdc.gov)
Emergence can result from mutations in housekeeping structural or regulatory genes or from acquiring foreign genetic information. (cdc.gov)
In recent years, our understanding of genetic predisposition to PD has advanced vastly, including causative mutations in the genes encoding α-synuclein, LRRK2, parkin, PINK1, and DJ-1 just to name a few 5 . (nature.com)
[ 3 ] Loss of function mutations in this gene are implicated in pediatric retinoblastoma. (medscape.com)
Mutations in the CTNNB1 gene can cause a type of aggressive but noncancerous (benign) growth called a desmoid tumor. (medlineplus.gov)
CTNNB1 gene mutations are found in about 85 percent of all noninherited (sporadic) desmoid tumors. (medlineplus.gov)
The CTNNB1 gene mutations that cause desmoid tumors are somatic, which means they are acquired during a person's lifetime and are present only in tumor cells. (medlineplus.gov)
The CTNNB1 gene mutations that cause desmoid tumors usually occur in a region of the gene called exon 3. (medlineplus.gov)
Somatic mutations in the CTNNB1 gene are found in almost all pilomatricomas, a type of benign skin tumor associated with hair follicles. (medlineplus.gov)
The CTNNB1 gene mutations found in pilomatricomas are described as gain-of-function mutations. (medlineplus.gov)
Like pilomatricomas, pilomatrix carcinomas have somatic mutations in the CTNNB1 gene. (medlineplus.gov)
Mutations in the CTNNB1 gene have been found in Wilms tumor, a rare form of kidney cancer that occurs almost exclusively in children. (medlineplus.gov)
CTNNB1 gene mutations in Wilms tumor result in an overly active protein. (medlineplus.gov)
[ 4 ] . Study of familial and sporadic cases of familial benign pemphigus in the Chinese population has revealed a number of mutations scattered throughout the ATP2C1 gene. (medscape.com)

A major challenge in gene expression analysis is to accurately infer relevant biological insights, such as variation in cell-type proportion or pathway activity, from global gene expression studies. (mssm.edu)
To understand the molecular mechanisms underlying the failure of parthenogenesis at early stages of development, we performed global gene expression profiling and functional analysis of parthenogenetic blastocysts in comparison with those of blastocysts from normally fertilized embryos. (prinsesmaximacentrum.nl)
Global gene expression analysis reveals pathway differences between teratogenic and non-teratogenic exposure concentrations of bisphenol A and 17β-estradiol in embryonic zebrafish. (oregonstate.edu)

All known oncogenic pathogens can promote cell survival and transformation because of their common abilities to cause chronic insults, genetic and epigenetic alterations, deregulated metabolic pathways, and immune escape. (biomedcentral.com)

Global transcript analysis reflects biological responses associated with the activation and perturbation of signal transduction pathways. (nih.gov)
The cGAS-STING pathway is a component of the innate immune system that functions to detect the presence of cytosolic DNA and, in response, trigger expression of inflammatory genes that can lead to senescence or to the activation of defense mechanisms. (wikipedia.org)
The presence of DNA in the cytosol is indicative of cellular damage or infection and leads to activation of genes associated with the immune response. (wikipedia.org)
cGAMP then binds directly to stimulator of interferon genes (STING) which triggers phosphorylation/activation of the transcription factor IRF3 via TBK1. (wikipedia.org)
Because several of these factors regulate cellular function through the activation of phospholipase C (PLC), we postulated that PLC-mediated signaling could be central to regulating the expression of MDR1. (uky.edu)
The results of Northern blot analysis showed that activation of PLC by heat shock and growth factors increased expression of endogenous MDR1 mRNA in human renal carcinoma cells. (uky.edu)
Gene expression also linked reduced expression of Xist to activation of X chromosome. (prinsesmaximacentrum.nl)
Here we provide evidence for rapid activation of ob gene expression in skeletal muscle by glucosamine. (elsevierpure.com)
These data demonstrate that integrin/EGFR cross-talk is required for expression of Egr-1 through a novel regulatory cascade involving the activation of the PI3K/Akt/Forkhead pathway. (unito.it)
Activation of the cAMP-dependent pathway by forskolin inhibited hemin-induced expression of γ-globin mRNA and decreased transcriptional activity of the γ-globin gene promoter. (elsevierpure.com)
Injury-induced cytochrome c -specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. (jneurosci.org)
Eldadah and Faden, 2000 ), we hypothesized that suppression of apoptotic capability during maturation of mammalian brain results from repression of genes involved in the caspase-3 activation pathway, and that injury-induced neuronal apoptosis in the mature brain results from reactivation of these genes. (jneurosci.org)
They cause the beta-catenin protein to be turned on all the time (constitutively active), which leads to the abnormal activation of certain genes. (medlineplus.gov)

IRF3 can then go to the nucleus to trigger transcription of inflammatory genes. (wikipedia.org)
Upon recognition of a PAMP, PRRs generate signal cascades leading to transcription of genes associated with the immune response. (wikipedia.org)
IRF3 is able to enter the nucleus to promote transcription of inflammatory genes, such as IFN-β. (wikipedia.org)
These genes comprise 289 Transcription Factors (TFs) representing Basic Helix-loop Helix (bHLH), Ethylene Response Factors (ERFs), myeloblastosis (MYB), No apical meristem (NAC), and WRKY amino acid motif (WRKY) type major families known to be involved in the mechanism of stress tolerance. (frontiersin.org)
And the LEF / TCF family transcription factor, along with other proteins, binds to DNA and inhibits gene expression. (researchsquare.com)
The early gene early growth response (Egr-1), a broadly expressed member of the zing-finger family of transcription factors, is induced in many cell types by a variety of growth and differentiation stimuli, including epidermal growth factor (EGF). (unito.it)
Scherm B, Palomba M, Serra D, Marcello A, Migheli Q. Detection of transcripts of the aflatoxin genes aflD, aflO, and aflP by reverse transcription-polymerase chain reaction allows differentiation of aflatoxin-producing and non-producing isolates of Aspergillus flavus and Aspergillus parasiticus. (ac.ir)
The PPARs are ligand activated transcription factors that regulate genes important in cell differentiation, various metabolic processes, especially lipid and glucose homeostasis, insulin sensitivity, control of inflammatory processes and vascular integrity [ 6 ]. (biomedcentral.com)
p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)

Genetic manipulations allowed analysis of changes in gene expression underlying pheromone signaling, cell cycle control, and polarized morphogenesis. (nih.gov)
It was suggested that Tgfβ1 could possibly act as a signaling molecule in controlling collagen gene expression and modulate ECM during ocular growth. (molvis.org)
Other signaling mechanisms, such as the MAP/SAP kinase or Ras pathways, although potentially important for transmission of some of the TGF-beta signals, will not be described. (nih.gov)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells, so they can be involved in many cancers, including gliomas. (researchsquare.com)
The results show that the combination of TMZ and KC7F2 can be a promising anti-cancer agent for the treatment of glioblastoma through the Wnt / β-catenin signaling pathway. (researchsquare.com)
The Wnt signaling pathway creates a complex network of proteins that have different effects on cells. (researchsquare.com)
Understanding the mTOR signaling pathway via mathematical modeling. (crossref.org)
Our findings shed light on potential molecular mechanisms and signaling pathways involved in SWCNT oncogenic potential. (cdc.gov)
Geneset enrichment of these findings has identified pathways significant in metabolism, immune signaling, other psychiatric disorders, neurological signaling, and cellular structure. (cdc.gov)
The beta-catenin protein is also involved in cell signaling as an essential part of the Wnt signaling pathway. (medlineplus.gov)
The Wnt signaling pathway promotes the growth and division (proliferation) of cells and helps determine the specialized functions a cell will have (differentiation). (medlineplus.gov)
Pathways involved in PI3K-Akt signaling may play a role in the altered focal adhesion and extracellular matrix (ECM)‒receptor interactions noted in Hailey-Hailey disease. (medscape.com)
Aim: To detect the expression of molecules associated with Notch signaling pathway in stem cells from human exfoliated deciduous teeth (SHED) cultured in specific differentiation medium, namely, keratinocyte growth medium (KGM). (bvsalud.org)
RNA was reverse-transcribed to obtain the cDNA and then proceeded with PCR using specific primers for the Notch signaling pathway molecules (Notch1, Jagged-1, Jagged-2 and, Hes1) as well as stem cell marker (Nanog). (bvsalud.org)

We present pathway-level information extractor (PLIER) (https://github.com/wgmao/PLIER and http://gobie.csb.pitt.edu/PLIER), a broadly applicable solution for this problem that outperforms available cell proportion inference algorithms and can automatically identify specific pathways that regulate gene expression. (mssm.edu)

However, cell wall synthesis related genes were up-regulated under drought stress and down-regulated under flooding stress. (frontiersin.org)

The Real-time PCR results in treated cells showed an increase in the expression of genes in the mitochondrial apoptotic pathway as well as genes effective in regulating the cell cycle. (ac.ir)

GO and KEGG pathway enrichment analysis revealed that DEGs were significantly enriched in the "ubiquitin-dependent ERAD" and the "chaperone cofactor-dependent protein refolding" in BP vs. P and P vs. P, respectively. (sabanciuniv.edu)

Gene expression of eye diseases should be studied as early as postnatal weeks 1-2 to ensure that any changes in gene expression pattern during disease development are detected. (molvis.org)
This study aims to explore its mechanism by defining changes in gene expression between neoplastic and normal tissue samples before and after treatment. (karger.com)
Therefore, we investigated the combined effect of Temozolomide (TMZ) and KC7F2 on cell survival and changes in gene expression in the Wnt signal pathway. (researchsquare.com)

6 ], the transforming growth factor beta 1 ( Tgfβ1 ) gene and several collagen genes were significantly downregulated in 8-week-old B6 mice scleras when compared with 3-week-old B6 mice scleras. (molvis.org)
The expression of photosynthesis and chlorophyll synthesis related genes were significantly reduced under both types of stresses, which limit the metabolic processes and thus help prolong survival under extreme conditions. (frontiersin.org)
0.05 indicates that leprosy significantly influenced the levels of cytokine expression. (ajtmh.org)
We identified 66 genes significantly associated with total highest lifetime CAPS score (FDR-corrected p (cdc.gov)
In particular, we identified 82 genes significantly associated with lifetime anxious arousal symptoms. (cdc.gov)
Several genes significantly associated with multiple PTSD symptom dimensions and total lifetime CAPS score (SERPINA1, RPS6KA1, and STAT3) have been previously associated with PTSD. (cdc.gov)

Moreover, utilising a network topology based on gene relationships may facilitate interpreting this vast amount of information, and extracting significant patterns within the networks. (sciweavers.org)
Expression patterns of Hedgehog signalling pathway members during mouse palate development. (bvsalud.org)
Gene Expr Patterns;6(2): 206-12, 2006 Jan. (bvsalud.org)
No differences were found in the expression patterns of Hh pathway members along the anterior-posterior axis of the developing palate . (bvsalud.org)
Therefore, 91 clinical MPM samples were digitally screened for gene expression patterns of HR members. (theihs.org)
By assessing targeted immune-related gene expression patterns and pathways in the placenta and fetal thymus we were able to elucidate molecular mechanisms involved in the resistance/tolerance and susceptibility of fetuses to PRRSV infection. (usda.gov)
By characterizing the transcriptome patterns and pathways for these symptoms, our goal is to shed light on the biological mechanisms underlying this comorbidity, which can help prevent the exacerbation of physical symptoms by intervening at the level of etiological pathway. (cdc.gov)

Conclusions: Microarrays are a powerful tool to identify biomarkers for obesity by analyzing differential gene expression profiles. (sages.org)

Interestingly, a cluster of dysregulated genes regarding cell metabolism and lipid formation were identified. (sages.org)
Results: Interpreting expression levels as pixels with grey value intensities and network topology as relationships between pixels, allows for an image-like representation of cellular metabolism. (sciweavers.org)
Transcript profiles involved in the starch and sugar metabolism pathways were also affected under both stress conditions. (frontiersin.org)

Also, Quantitative RT-PCR was used to evaluate the mRNA expression level of genes related to the Wnt signal pathway in treated cancer cells and control groups. (researchsquare.com)

Certain proteins in this pathway attach (bind) to beta-catenin, which triggers a multistep process that allows the protein to move into the cell nucleus. (medlineplus.gov)

This includes the analysis of genes in germline stem cell proliferation and differentiation. (ncl.ac.uk)
These genes increase the proliferation and differentiation of cells associated with the hair follicle matrix. (medlineplus.gov)

However, WSC induced cell cycle arrest and cellular senescence mediated by the p53-p21 pathway. (who.int)

The findings of this study provide new insights into the complex regulatory networks of the lactation process at three distinct stages, while suggesting several candidate genes that may be useful for future animal breeding programs. (sabanciuniv.edu)

Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. (nih.gov)
The cGAS - STING pathway acts to detect cytosolic DNA and induce an immune response. (wikipedia.org)
Methylation is one of the main physiological processes to induce silencing of gene expression. (karger.com)

This pathway plays a critical role in mediating immune defense against double-stranded DNA viruses. (wikipedia.org)
We found that the anti-viral immune response was initiated only after PRRSV reached detectable levels in the fetus when a core set of interferon inducible genes were strongly upregulated in both tissues. (usda.gov)
Also our study indicated that WSC induced an increase in the transcriptional expression of matrix metalloproteinases, MMP-2 and MMP-9 and an immune response regulator, Toll Like Receptor-4. (who.int)

In the present study, we evaluated the role of the intrinsic pathway in neuronal apoptosis at different stages of rat brain development and during maturation of primary cortical neurons in vivo as well as in response to brain injury. (jneurosci.org)
the effect of Fluorouracil on different stages of the cell cycle and the expression of genes involved in the internal pathway of apoptosis in the AsPC-1 cell line (human pancreatic cancer) were investigated. (ac.ir)

In order to identify the mechanisms involved in the lactation process, various mehods, including meta-analysis, weighted gene co-express network analysis (WGCNA), hub genes identification, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment at before peak (BP), peak (P), and after peak (AP) stages of the lactation processes have been employed. (sabanciuniv.edu)

A possible pathway that contributes to the postnatal development of the sclera was investigated using Ingenuity Pathway Analysis software. (molvis.org)
A combination of de novo transcriptome assembly and DGE analysis was shown to be a powerful method for identifying genes encoding enzymes potentially involved in the biosynthesis of important secondary metabolites in a non-model plant. (biomedcentral.com)
Furthermore, this study supports the notion that in combination with a meta-analysis, the WGCNA represents an opportunity to achieve a higher resolution analysis that can better predict the most important functional genes that might provide a more robust bio-signature for phenotypic traits, thus providing more suitable biomarker candidates for future studies. (sabanciuniv.edu)
In this study, understanding of the biosynthesis of flavonoids in peanut under water deficit conditions was developed through expression analysis and correlational analysis and determining the accumulation pattern of phenols, flavonols, and anthocyanins. (figshare.com)
Correlation analysis between expression of flavonoid biosynthetic genes and TFs indicated the role of AhMYB111 and AhMYB7 as an inhibitor for AhF3H and AhFLS, respectively, and AhMYB7, AhTTG1, and AhCSU2 as a positive regulator for the expression of Ah4CL, AhCHS, and AhF3H, respectively. (figshare.com)
Correlational analysis between the expression of TFs related to the biosynthesis of flavonoids and the accumulation of phenolics, flavonols, and anthocyanins indicated coregulation of flavonoid synthesis by TFs under water deficit conditions in peanut. (figshare.com)
The left atrial myocardium of patients with severe aortic valve disease was also used as a reference for gene analysis. (biomedcentral.com)
Analysis of gene expression from these individuals can help in identifying biomarkers of PTSD. (cdc.gov)
Future studies should be clear about methods used to analyze PTSD status, as phenotypes based on PTSD symptom dimensions may yield different gene sets than combined CAPS score analysis. (cdc.gov)

abstract = "Resistance to multiple, unrelated cancer chemotherapeutic drugs can be mediated by P-glycoprotein the MDR1 gene product. (uky.edu)
abstract = "Leptin, the protein encoded by the obese (ob) gene, is synthesized and released in response to increased energy storage in adipose tissue1-4. (elsevierpure.com)

687 genes differentiated tumor samples before and after treatment, among which 310 genes did not show the same differential expression in the placebo group or normal samples. (karger.com)
Gene expression profiling in kidney cancer: combining differential expression and chromosomal and pathway analyses. (uchicago.edu)

We identified nine perturbed pathways that are involved in mechanisms associated with alterations in the GBA (i.e., mucosal inflammation, disruption of gut microbiome). (nyu.edu)
We also assessed the effect of WSC on the expression of genes involved in cell cycle arrest and inflammation. (who.int)

Acute myeloid leukemia FLT3 Gene profiling Histone deacetylases Methylation Integrated data obtained from. (karger.com)

This study uses microarray technology to evaluate differential gene expression profiles in obese patients undergoing bariatric surgery versus non-obese controls. (sages.org)
Gene expression analyses were performed in two independent samples using ribonucleic acid sequencing (Sample 1, n = 357) and microarray (Sample 2, n = 352) methodologies. (nyu.edu)

This review focuses primarily on the mechanisms underlying Smad modulation of gene expression and how they relate to wound healing. (nih.gov)
Here, we further examined the gene expression profile by using genome microarrays to profile molecular mechanisms of SWCNT oncogenesis. (cdc.gov)

Our method improves interstudy replicability and reveals biological insights when applied to trans-eQTL (expression quantitative trait loci) identification. (mssm.edu)

Transcriptional dysregulation is considered a key molecular mechanism responsible of HD pathogenesis but, although numerous studies investigated mRNA alterations in HD, so far none evaluated a whole gene expression profile in blood of R6/2 mouse model. (biomedcentral.com)
Expression of γ-globin mRNA was examined by primer extension, and transcriptional activity of the γ-globin gene promoter was determined by reporter gene assays. (elsevierpure.com)

Our findings are the first evidence of inducible leptin expression in skeletal muscle and unveil an important biochemical link between increased availability of nutrients and leptin expression. (elsevierpure.com)

Mammalian parthenogenesis could not survive but aborted during mid-gestation, presumably because of lack of paternal gene expression. (prinsesmaximacentrum.nl)

Genes identified as involved in the main biologic processes during postnatal scleral development were further confirmed using qPCR. (molvis.org)

Driver events in pediatric malignancies can occur through loss of function in tumor suppressor genes or gain of function in proto-oncogenes. (medscape.com)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)

The gene ATP2C1 encodes the human secretory pathway Ca ++ -ATPase hSPCA1, which is dysfunctional and causes abnormal calcium release from the Golgi apparatus and endoplasmic reticulum. (medscape.com)

The changes in expression of genes involved in regulating the flux of cell wall precursors and starch/sugar content can serve as an adaptive mechanism for soybean survival under stress conditions. (frontiersin.org)
The CDKN2A/B locus contains genes encoding cell cycle inhibitors, including p16 Ink4a , which have not yet been implicated in the control of hepatic glucose homeostasis. (diabetesjournals.org)
Fluorouracil also caused cell cycle arrest in these cells by regulating the (p53, p21) genes. (ac.ir)

ANOVA revealed that the expression of flavonoid genes and TFs is highly dependent upon the genotype of peanut in a spatiotemporal manner. (figshare.com)

Using the Ingenuity program, potential pathways were identified and real-time quantitative RT-PCR (QPCR) was used to validate the array data. (sages.org)

Our unique blood analyses confirm previous tissue data from our lab and shed new light on the ensuing cascade of gene dysfunction associated with obesity. (sages.org)
Our more granular analyses of PTSD symptom dimensions identified additional genes that did not reach statistical significance in our analyses with total CAPS scores. (cdc.gov)

These dysfunctional genes engender a cascade of pathophysiology that contributes to the complications associated with the metabolic syndrome. (sages.org)
These data indicate that the glycolytic pathway is operative in distal axons and contributes to the rate of axon extension and growth cone dynamics in the presence of NGF and that, in the absence of NGF, the axonal glycolytic pathway is required for axon maintenance. (jneurosci.org)

Selected genes derived from these pathways were additionally investigated in other accessible tissues to validate these matrices as source of biomarkers, and in brain, to link central and peripheral disease manifestations. (biomedcentral.com)
In adult tissues, this pathway plays a role in the maintenance and renewal of stem cells, which are cells that help repair tissue damage and can give rise to other types of cells. (medlineplus.gov)

While recent work has emphasized the importance of mitochondrial oxidative phosphorylation, the role of the glycolytic pathway in axon morphogenesis and maintenance remains minimally understood. (jneurosci.org)

Anatomy15

Organisms20

Diseases6

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment32

Phenomena and Processes91

Disciplines and Occupations3

Technology, Industry, Agriculture4

Information Science7

Named Groups2

Health Care6

Differentially expressed15

Biosynthetic pathway4

Regulates3

PPAR11

Downregulation5

MAPK6

Regulation8

Developmental2

Mutations14

Global gene expression3

Metabolic pathways1

Activation13

Transcription9

Signaling14

Regulate1

Related genes were up-regulated1

Apoptotic1

Enrichment analysis1

Changes in gene expression3

Significantly6

Patterns7

Conclusions1

Metabolism3

Level of genes1

Proteins in this pathway1

Differentiation2

Cellular1

Candidate genes1

Induce3

Immune3

Apoptosis2

KEGG1

Analysis9

Abstract2

Differential expression2

Inflammation2

Profiling1

Microarray2

Mechanisms2

Reveals1

Transcriptional2

Findings1

Mammalian1

Processes1

Tumor3

Abnormal1

Cell3

ANOVA1

Quantitative1

Analyses2

Contributes2

Tissues2

Mitochondrial1