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  • tumor
  • Here, we propose the PathScan significance test for the scenario where pathway mutations collectively contribute to tumor development. (nih.gov)
  • As an example calculation, we re-analyze KEGG-based lung adenocarcinoma pathway mutations from the Tumor Sequencing Project. (nih.gov)
  • cancer
  • Thus, this review will be focused on FAK and p53 signal transduction pathways in cancer. (nih.gov)
  • Finally, we show that RING1B is recruited to enhancer regions in other cancer types, suggesting that this RING1B-mediated mechanism of controlling oncogenic pathways occurs in multiple cancers. (nature.com)
  • We analyze four breast cancer prognosis studies and identify 97 pathways with significant predictive power for prognosis. (biomedcentral.com)
  • Identified pathways can provide further insights into breast cancer prognosis. (biomedcentral.com)
  • In cancer genomic studies, tremendous effort has been devoted to pathway based analysis. (biomedcentral.com)
  • whereas
  • Second, it can account for the joint effects of multiple genes in a pathway, whereas existing methods tend to focus on the marginal effects of genes. (biomedcentral.com)
  • significant
  • Our test recapitulates the most significant pathways and finds that others for which the original test battery was inconclusive are not actually significant. (nih.gov)