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  • Targets
  • By using a genome-wide CRISPR-Cas9 knockout screen, we demonstrate that S. aureus -derived dAdo targets the purine salvage pathway to provoke caspase-3-dependent cell death in human macrophages, thereby antagonizing host immune responses and promoting the establishment of invasive disease. (pnas.org)
  • vivo
  • Genome-wide transcriptional analyses on human umbilical vein endothelial cells exposed to reversed flow conditions mimicking those occurring in vivo yielded 10-fold more significantly regulated transcripts, as well as enhanced activation of upstream regulators (nuclear factor κB [NFκB], vascular endothelial growth factor, fibroblast growth factor-2, and transforming growth factor-β) and arteriogenic canonical pathways (protein kinase A, phosphodiesterase, and mitogen-activated protein kinase). (ahajournals.org)
  • Tissue Factor
  • Abstract -Intravenous infusion of recombinant tissue factor pathway inhibitor (rTFPI) for 24 hours decreases neointimal thickening and luminal stenosis 1 month after balloon-induced injury to the carotid arteries in minipigs. (ahajournals.org)
  • Recently, we have reported a marked reduction in neointimal thickening and stenosis 1 month after balloon-induced injury to the carotid artery in minipigs given a 24-hour, but not a 3-hour, constant intravenous infusion of recombinant tissue factor pathway inhibitor (rTFPI), the full-length, recombinant mimic of the physiological inhibitor of the complex of tissue factor and factor VIIa. (ahajournals.org)
  • The main role of the tissue factor pathway is to generate a "thrombin burst", a process by which thrombin, the most important constituent of the coagulation cascade in terms of its feedback activation roles, is released very rapidly. (wikipedia.org)
  • cellular
  • It acts through cellular surface receptors which effect intracellular signalling pathways to increase coronary artery blood flow, slow heart rate, block atrioventricular node conduction, suppress cardiac automaticity, and decrease β-adrenergic effects on contractility. (wikipedia.org)
  • Center
  • Drawing on the information gained from two decades of research on cation transport in SS RBC, including the unique discovery made at this Center that dipyridamole inhibits the SI cation leak, we now propose a study of combined therapy using two transport inhibitors aimed at reducing SS RBC dehydration. (clinicaltrials.gov)