Pathways cell survival. Medical search. Frequent questions

This study investigated the effect of acylated synthetic ghrelin (AG) on the survival and proliferation of human chemosensitive ovarian cancer cells (A2780) and explored some mechanisms of action with a focus on the p53 apoptotic pathway and PI3K/Akt and NF- κ B survival pathways. (hindawi.com)
However, while AG treatment had no effect on control cell viability, it significantly increased cell viability and proliferation and inhibited cell death in Cis-treated cells. (hindawi.com)
Among them and over decades of research, it was shown that the PI3K/Akt/mTOR pathway is one of the most frequently hyperactive pathways in OC as well as other types of solid tumors and is associated with increased cell growth, proliferation, migration, protein synthesis, survival, and chemotherapy resistance [ 7 - 9 ]. (hindawi.com)
In the mating pheromone response pathway, G-protein-mediated growth arrest induced by cell contact has been confirmed, while GNG7 may be involved in this process to prevent growth arrest in multicellular organisms and control cell proliferation [ 19 ]. (biomedcentral.com)
According to this hypothesis, cells exposed to GNG7 will stop further proliferation and start the differentiation process mediated by G protein signals. (biomedcentral.com)
Since the activation of c-Src leads to the promotion of survival, angiogenesis, proliferation and invasion pathways, the aberrant growth of tumors in cancers is observed. (wikipedia.org)
These signaling pathways control many important cellular processes, such as cell growth and division (proliferation) and survival. (medlineplus.gov)
As a result, the proteins and the signaling pathways are constantly turned on (constitutively activated), which increases the proliferation and survival of cells and leads to the formation of tumors. (medlineplus.gov)
MAPK pathways refer to various cellular functions, including cell proliferation, differentiation and migration. (springer.com)
SCARA5 overexpression significantly inhibited cell proliferation and induced apoptosis of CAL-27 and SCC-9 cells. (degruyter.com)
In conclusion, SCARA5 inhibited the proliferation and EMT and induced the apoptosis of OSCC cells through the inhibition of STAT3 and PI3K/AKT signaling pathways, thereby exerting a tumor suppressor effect. (degruyter.com)
Menin mutations lead to increased Hedgehog signaling and cell proliferation. (medindia.net)
The GAS1 protein promotes Hedgehog signaling, and thus by inhibiting Gas1 expression, menin and PRMT5 effectively dial down the pathway's tendency towards cell proliferation. (medindia.net)
What's more, treating a mouse model of human MEN1 syndrome with a Hedgehog pathway inhibitor called Erivedge (FDA-approved in 2012 for metastatic or locally advanced basal cell carcinoma) reduced proliferation of tumor cells and blood insulin levels. (medindia.net)
Pathway analysis indicated that dust extract induced changes in gene expression influenced functions related to cellular growth and proliferation, cell death and survival, and cellular development. (cdc.gov)
Epidermal growth factor receptor (EGFR) inhibitors are part of an emerging class of anticancer medicines known as "targeted therapy," which target pathways more specific to neoplastic proliferation than traditional chemotherapeutic agents. (medscape.com)

The transforming growth factor beta (TGFB) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, cell migration, apoptosis, cellular homeostasis and other cellular functions. (wikipedia.org)
Like the BMPs, TGFβs are involved not only in embryogenesis and cell differentiation, but also in apoptosis and other functions. (wikipedia.org)
Molecular Cell paper provides evidence that FOXO3a triggers transcription of HIF1 target gene, which in turn inhibits HIF-1 induced apoptosis. (genengnews.com)
HIF-1 induced apoptosis in normal and breast cancer cells was inhibited due to FOXO3a stimulating the transcription of the HIF1 target gene, CITED2, according to Dr. Mak. (genengnews.com)
Akt pathways have effects on apoptosis, protein synthesis, metabolism and cell cycle. (springer.com)
Tumour cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. (researchgate.net)
The best studied is apoptosis, a form of programmed cell death used by all multicellular organisms to eliminate cells that are damaged, no longer needed or which might become a threat to the organism. (edu.au)
We use a combination of biochemical, cell biology, structural biology and medicinal chemistry approaches to understand the precise molecular mechanisms that control apoptosis. (edu.au)
Complementary projects in the lab focus on autophagy, a cell survival process that has significant cross-talk with apoptosis. (edu.au)
There is some evidence that Bcl-2 pro-survival proteins (which normally keep cells alive by inhibiting the cell death program of apoptosis) are expressed at unusually high levels in melanoma compared to normal melanocytes. (edu.au)
Communication between the cell survival pathway of autophagy and the cell death pathway of apoptosis is crucial for determining the best outcome for the cell, and ultimately its fate. (edu.au)
The first is to use an in vivo approach to analyse transgenic mice in which the autophagy regulator known as Beclin has been engineered to either disrupt or enhance its regulation by key components (i.e. proteins) of the apoptosis pathways. (edu.au)
These findings suggest that CHOP is a fundamental factor that links protein misfolding in the ER to oxidative stress and apoptosis in β cells under conditions of increased insulin demand. (jci.org)
Elimination of BCR/ABL-dependent intracellular signals triggers apoptosis, but it is unclear whether this activates additional cell survival and/or death pathways. (lu.se)

The identified genes were subjected to pathway analysis, and the expression of each represented pathway was summarized using principal component analysis. (nih.gov)
We found that several genes also confer high levels of sensitivity to mAMSA including strains with mutations in HPR5, a helicase involved in funneling DNA lesion into recombination-repair pathways, ASF1, a chromatin assembly factor that is required for gene silencing, and CTF4, a DNA polymerase alpha binding protein important for genome stability. (aacrjournals.org)
The downstream transformation of BA involved a meta -cleavage pathway, although its genetic organization and function was not revealed and the overall network of genes driving the full metabolic pathway of OPP is still not known. (nature.com)
A CCRCC prognostic model that involved 7 immune genes was further established to predict the survival probabilities of patients. (biomedcentral.com)
Currently, no cancer therapies specifically disrupt ALT pathways.1 Lee Zou, PhD, and his team at the Massachusetts General Hospital Cancer Center investigated the molecules and genes that drive the ALT pathway and how new treatments might disrupt this process. (massgeneral.org)
We imported "big data" from public data repositories and analyzed them with a focus on the genes in the RAS pathway. (cancer.gov)
The RAS Initiative, together with groups from the University of California, San Francisco, and the Broad Institute in Boston, have probed dozens of cancer cell lines for the effect of knocking down entire signaling nodes (such as all three RAS genes, all three RAF genes, etc. (cancer.gov)
Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
The KIT and PDGFRA genes provide instructions for making receptor proteins that are found in the cell membrane of certain cell types. (medlineplus.gov)
The expression of transthyretin, a protein shown to sequester Aβ and prevent amyloid fibril formation in vitro , and several genes in the insulin-signaling pathway, e.g., insulin-like growth factor-2, were increased selectively in the hippocampus of APP Sw mice. (jneurosci.org)
This study uncovered a new layer of regulation of pro-proliferative genes by menin via the Hedgehog signaling pathway," Hua says. (medindia.net)
We further demonstrated that suppression of autophagy using either pharmacological inhibitors or RNA interference of essential autophagy genes enhanced cell death induced by IM in cell lines and primary CML cells. (lu.se)
Gene expression profiling of the effects of organic dust in lung epithelial and THP-1 cells reveals inductive effects on inflammatory and immune response genes. (cdc.gov)
We found that A549 alveolar and Beas2B bronchial epithelial and THP-1 cells responded with unique changes in the gene expression profiles with regulation of genes encoding inflammatory cytokines, chemokines, and other inflammatory proteins being common to all the three cells. (cdc.gov)
Clinical correlation and immune analysis revealed that four hub genes were associated with tumor grade, immune cells, and antitumor drug sensitivity, and WTAP was significantly associated with microsatellite instability(MSI). (bvsalud.org)
Trial organizers announced that the first participant had been treated using immune cells with four base-edited genes, equipping the cells to better target and destroy tumors. (cdc.gov)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)

Two such proteins that mediate the TGFβ pathway include SARA (the SMAD anchor for receptor activation) and HGS (Hepatocyte growth factor-regulated tyrosine kinase substrate). (wikipedia.org)
The proteomic study has been carried out on two biological replicates of Panc1 and Panc1 CSCs whole-cell extracts: a total of 230 modulated proteins have been identified and classified by Ingenuity Pathway Analysis. (atlasofscience.org)
Our data indicated that, some key metabolic pathways, such as glycolysis, gluconeogenesis and penthose phosphate pathway (PPP), strongly represented the intracellular up-regulated Panc1 CSCs proteins. (atlasofscience.org)
A flavin-dependent monoxygenase (OppA1), one of the most up-regulated proteins in the OPP-growing cells, was isolated via heterologous expression and its catabolic activity was verified in vitro . (nature.com)
Click on one of the biological effects of VEGF-VEGF R2 signaling shown in the Explore Pathways box below to see the specific molecules involved in promoting each effect and the phosphorylation sites on VEGF R2 that are necessary for recruitment of key downstream adaptor proteins or kinases. (rndsystems.com)
Not only do these worms live longer, the researchers noted, their cells are relatively free from the toxic proteins that accumulate and clump together as an animal ages. (sciencedaily.com)
They also found that animals lacking VHL-1 were resistant to the toxic proteins known to cause Alzheimer's and Huntington's diseases, and that their cells accumulated less of an age-pigment called lipofuscin. (sciencedaily.com)
When a ligand attaches (binds), the KIT or PDGFRA receptor protein is turned on (activated), which leads to activation of a series of proteins in multiple signaling pathways. (medlineplus.gov)
The proteasome pathway is an enzyme complex existing in all cells, which degrades ubiquitinated proteins that control the cell cycle and cellular processes and maintains cellular homeostasis. (medscape.com)
This involves the study of mesothelioma cells and proteins. (mesothelioma.com)
Our aim is to develop new reagents, including drugs that could target and inhibit the actions of the key pro-survival protein proteins that keep cancers alive. (edu.au)
Our hypothesis is that Bcl-2 pro-survival proteins provide a survival advantage for melanomas and might contribute to resistance to standard chemotherapeutic drugs. (edu.au)
Our research aims to identify the key Bcl-2 pro-survival proteins that are responsible for melanoma survival. (edu.au)
The second aim is to determine whether resistance to current melanoma treatment arises due to elevated levels of Bcl-2 pro-survival proteins, and whether treatment with Bcl-2-targeting molecules will resensitise tumours to standard drugs, informing potential drug treatment combinations. (edu.au)

Clear cell renal cell carcinoma (CCRCC) is a common tumor of the urological system for which surgery is the preferred treatment, but there is a lack of therapeutic options after surgery. (biomedcentral.com)
Typically, clear cell renal cell carcinoma (CCRCC) is the most important tissue subtype of renal cancer, accounting for 80% of all cases [ 4 ]. (biomedcentral.com)
The mammalian target of rapamycin (mTOR) is a key regulator of tumor progression in a variety of cancers and has been shown to be dysregulated in renal cell carcinoma (RCC). (unc.edu)
The mTORC1 complex consists of mTOR, Raptor, and GβL, while the mTORC2 complex consists of mTOR, Rictor, and GβL. Currently there are two FDA approved rapamycin derivatives (rapalogs) for the treatment of advanced renal cell carcinoma (RCC). (unc.edu)

In this study, we sought to confirm the activity of acetaminophen in OVCA cell lines and to investigate the molecular basis of response. (nih.gov)
Furthermore, we identified 4 molecular signaling pathways associated with acetaminophen response that may also affect overall survival in women with OVCA, including the JNK pathway, which has been previously implicated in the mechanism of action of acetaminophen and is predictive of decreased survival in women with OVCA. (nih.gov)
Thanks to the continuous research to understand the molecular aspects of OC in an attempt to better understand and consequently treat the disease Currently, the extensive genomic analysis has identified some common hyperactive intracellular signaling pathways responsible for the development and progression of OC in patients [ 5 , 6 ]. (hindawi.com)
Molecular classification of glioma stem cells Comprehensive genetic analysis of glioblastomas by The Cancer Genome Atlas (TCGA) has proposed a new classification based on genetic abnormalities. (atlasofscience.org)
The research will appear in the December 28 issue of Molecular Cell . (genengnews.com)
In this review, we studied on the effects and molecular mechanisms of Rhizoma coptidis on NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways. (springer.com)
In this review, we discuss the recent advances in our understanding of the molecular and cellular mechanisms that underlie Ehrlichia host cellular reprogramming strategies that enable intracellular survival. (frontiersin.org)
Cellular fate is controlled by multiple molecular pathways. (edu.au)
Her research has helped delineate molecular pathways that regulate cancer cell survival, motility, metastasis, and drug responsiveness. (genomeweb.com)
Researchers still did not exactly understand how menin mutations lead to MEN1 syndrome, and more importantly, what molecular pathways might be dysregulated by menin mutations and thus can be targeted to improve therapy against this type of cancer. (medindia.net)
Correspondence with low molecular weight chemicals that results in the priming of chemical-specific, Prof. Dr. Stefan F. Martin, Allergy Research skin-homing CD8+ Tc1/Tc17 and CD4+ Th1/Th17 cells. (cdc.gov)
DAMPs, damage-associated tissues and the molecular target structures and pathways. (cdc.gov)
Analyzing samples from 805 children with newly diagnosed ALL from three consecutive clinical trials, we determined the ex vivo sensitivity of primary leukemia cells to 18 therapeutic agents across 23 molecular subtypes defined by leukemia genomics. (cdc.gov)

Assistant Professor of Mathematics and Statistics Julia Chifman and her collaborators built a predictive mathematical model that connects four key cytosolic cellular signaling pathways in breast epithelial cells: the oncogenic pathway, the oxidative stress response pathway, the iron utilization pathway, and the iron homeostasis pathway. (american.edu)
Evidence presented in this review implicated that Rhizoma coptidis exerted beneficial effects on various diseases by regulation of NF-κB/MAPK/PI3K-Akt/AMPK/ERS and oxidative stress pathways, which support the clinical application of Rhizoma coptidis and offer references for future researches. (springer.com)
Oxidative stress pathways are caused by the imbalance of oxidation and antioxidation in body. (springer.com)
Oxidative stress pathways regulate redox balance by Nrf2 and other ways. (springer.com)
In this review, we sorted out the relationship of Rhizoma coptidis among components, diseases and NF-κB/MAPK/PI3K/Akt/AMPK/ERS/oxidative stress pathways, systematically studying on how Rhizoma coptidis exerts beneficial effects to various diseases, which supported the clinical application of Rhizoma coptidis and provided references for the future researches. (springer.com)

In some cases, cisplatin+AG-treated cells were pre-incubated either with [D-Lys3]-GHRP-6, a ghrelin receptor antagonist, or with LY294002, a PI3K inhibitor. (hindawi.com)
In both control and Cis-treated cells, AG treatment significantly increased PI3K/Akt/mTOR signaling and enhanced the nuclear accumulation of NF- κ B. Concomitantly, in both control and Cis-treated cells, AG significantly lowered the protein levels of p53, p-p53 (Ser16), PUMA, cytochrome C, and cleaved caspase-3. (hindawi.com)
In conclusion, the findings of this study show that AG promotes cell survival of the OC cells and renders them resistat to Cis therapy, an effect that is mediated by the activation of PI3K/Akt/mTOR and activation of NF- κ B, and requires GHS-R1a. (hindawi.com)
Allosteric mTOR inhibition (i.e. rapalogs) results in the release of negative feedback inhibition on the PI3K/AKT survival-signaling pathway as well as upregulates the metabolically protective process known as autophagy. (unc.edu)
Therefore, SCARA5 was related to STAT3 and PI3K/AKT signaling pathways in OSCC. (degruyter.com)

Deeb KK, Trump DL, Johnson CSVitamin D signalling pathways in cancer: Potential for anticancer therapeutics. (researchgate.net)

In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. (wikipedia.org)
The oncogenic signaling pathway includes cellular species that regulate the growth, differentiation, and survival of cells. (american.edu)
We report here that SMN deficiency, induced in the astroglioma cell line U87MG after lentiviral transduction with a shSMN construct, was associated with an increase in the expression of the main components of Notch signaling pathway, namely its ligands, Jagged1 and Delta1, the Notch receptor and its active intracellular form (NICD). (mdpi.com)

Our laboratory focusses on how WNT5A expression is regulated in these cancers and deciphering the WNT5A signaling pathways governing cancer cell migration and invasion. (lu.se)
In particular, the interchangeable modes of migration tumour cells utilise during invasion and the factors involved. (lu.se)

We first asked what was the effect of allosteric versus catalytic mTOR inhibition in several conventional human RCC cell lines and novel patient derived xenograft cell lines on mTORC1 and mTORC2 signaling. (unc.edu)
We saw that only 1) catalytic mTOR inhibition decreased pAKTS473 expression, 2) that both allosteric and catalytic mTOR inhibition increase pERKT202/Y204 expression, and 3) combined MEK and mTOR inhibition induced cell death better than single pathway inhibition alone. (unc.edu)
Together these data support that there are differences in levels of activation of compensatory survival pathways in the context of allosteric and catalytic mTOR inhibition. (unc.edu)
Reversible proteasome inhibition disrupts pathways supporting cell growth, thus decreasing cancer cell survival. (medscape.com)
Some studies involving laboratory animals have shown promising results, such as tumor regression, inhibition of cancer cell growth, and improved survival rates. (medicalnewstoday.com)

these 2 events, in turn, can inhibit growth of neoplastic cells. (medscape.com)
AMPK pathways inhibit biosynthetic pathways with energy consumption, such as protein, fatty acid and glycogen synthesis. (springer.com)
Preclinical research indicates that the active metabolite of vitamin D, 1alpha,25(OH)2D3, also known as calcitriol, or vitamin D analogues might have potential as anticancer agents because their administration has antiproliferative effects, can activate apoptotic pathways and inhibit angiogenesis. (researchgate.net)
The second approach is to use either the new gene editing CRISPR/Cas9 technology or mass spectrometric/proteomics approaches (or both) to undertake screens to identify factors that can inhibit the cell death that occurs as a consequence of disarming the autophagy pathway through deletion of Beclin. (edu.au)
There are also combination therapies that affect multiple receptors such as lapatinib (approved for human epidermal growth factor receptor 2-positive [HER2+] breast cancer) and afatinib (approved for non-small cell lung cancer), which inhibit both the EGFR and HER2 receptors, and vandetanib (approved for advanced medullary thyroid cancer), which inhibits EGFR, vascular endothelial growth factor (VEGFR), and rearranged during transfection (RET) activities. (medscape.com)

Human A2780 ovarian cancer cells were cultured with or without AG treatment in the presence or absence of cisplatin. (hindawi.com)

The mitogen-activated protein kinase pathway evokes an intracellular signaling cascade in response to extracellular stimuli such as heat and stress. (tocris.com)

Depending on the cytokine profile, cell death or survival pathways are activated, and these opposing outcomes can lead to inflammation through different mechanisms. (edu.au)
Our existing knowledge of SARS-CoV-2 driven disease predominantly relies on correlative or in vitro studies, and it is yet unclear which pathways are causative of severe inflammation in vivo . (edu.au)
The fibers irritate mesothelial cells, causing inflammation. (mesothelioma.com)
Inflammation activates signaling pathways like the nuclear factor-kappa B (NF-kB) pathway. (mesothelioma.com)
NF-κB pathways are associated with immunity, inflammation and cell survival. (springer.com)
2012) . Sterile inflammation associat- The key mechanistic pathways and vation of inflammatory cel s (Balkwill, ed with inhalation of crystal ine silica mediators involved in inflamma- 2012 ). (who.int)

However, the microbial metabolic pathway of the fungicide and the genetic systems driving its degradation by strain P3 remain unknown. (nature.com)
Therefore, elucidation of the microbial metabolic pathway of OPP is a prerequisite for the downstream exploitation of strain P3 in any environmental application. (nature.com)
6 identified a gene cluster, hbpCAD , encoding the upper metabolic pathway of OPP which involves the transformation of OPP to 2-hydroxypenta-2,4-dienoateand benzoic acid (BA). (nature.com)
Scientists have identified that pancreatic cancer cells growth and spread are fueled by an unusual metabolic pathway that someday might be blocked with targeted drugs to control the deadly cancer. (medindia.net)
When a second nutrient and its metabolic pathway are introduced, the system must further decide whether and how to activate both pathways. (lu.se)

Novel DNA repair pathways required for cell survival following exposure to topoisomerase II targeting agents. (aacrjournals.org)

Glioblastoma multiforme (GBM) is the most prevalent primary malignant brain tumor and, remains one of the most lethal cancers, with a median survival of only 15 months upon diagnosis 1 . (nature.com)
The normal prostate and early-stage prostate cancers depend on androgens for growth and survival, and androgen ablation therapy causes them to regress. (researchgate.net)
We predict that understanding the pathways that lead to the development of androgen-independent prostate cancer will pave the way to effective therapies for these, at present, untreatable cancers. (researchgate.net)
Head and neck cancer most commonly is of the squamous cell carcinoma type (HNSCC) and includes cancers of the oral cavity, oropharynx, hypopharynx, larynx, sinonasal tract, and nasopharynx. (cdc.gov)

Patients in the report had a 5-year overall survival rate of 93.1%, although survival rates were lower in children who experienced symptoms, local recurrence, or metastasis or who did not undergo treatment with surgery or surgery plus radiotherapy. (medscape.com)
In contrast, WNT5A expression is associated with increased metastasis and reduced survival in melanoma patients. (lu.se)

Associations were observed between patient survival from OVCA and expression of the following pathways: Development/angiotensin signaling via β-arrestin (P=0.04), protein folding and maturation/angiotensin system maturation (P=0.02), signal transduction/c-Jun N-terminal kinase (JNK) pathway (P=0.03) and androstenedione and testosterone biosynthesis and metabolism (P=0.02). (nih.gov)

The phenomenon of field cancerization (the existence of histologically abnormal tissue beyond a neoplastic area that predisposes to tumour formation) was described in the 1950s on the basis of analyses of squamous cell carcinomas (SCCs). (researchgate.net)
Oral squamous cell carcinoma (OSCC) is a common tumor in the world. (degruyter.com)
Excretory stem cells give rise to squamous cell and mucoepidermoid carcinomas, while intercalated stem cells give rise to pleomorphic adenomas, oncocytomas, adenoid cystic carcinomas, adenocarcinomas, and acinic cell carcinomas. (medscape.com)
Squamous cell carcinomas arise from excretory duct cells, pleomorphic adenomas arise from the intercalated duct cells, oncocytomas arise from the striated duct cells, and acinic cell carcinomas arise from acinar cells. (medscape.com)
Zdenka is investigating the role of WNT5A signaling in Oral Squamous cell Carcinoma. (lu.se)
A growing body of research shows that human papillomavirus (HPV) is a common and increasing cause of oropharyngeal squamous cell carcinoma (OSCC). (cdc.gov)
We focus on the role of HPV in the increased incidence of oropharyngeal squamous cell carcinoma (OSCC), the head and neck cancer in which HPV is most commonly found ( 4 ). (cdc.gov)
[ 3 , 4 ] These antibodies are approved for the treatment of advanced EGFR-expressing colorectal cancer, and cetuximab is also approved for treatment of squamous cell carcinoma of the head and neck. (medscape.com)

A biochemical pathway that keeps cells alive when oxygen is low has now been showed to play a role in longevity and resistance against some diseases of old age. (sciencedaily.com)
He proposed that they work by targeting various biochemical pathways involved in cancer cell growth and survival. (medicalnewstoday.com)

Kaeberlein cautions, however, that "mutation of VHL-1 is associated with a variety of tumors, and any therapies targeted toward activation of HIF would most likely need to be specific for cells that are not rapidly dividing, such as brain cells or muscle cells. (sciencedaily.com)
The activation of the c-Src pathway has been observed in about 50% of tumors from colon, liver, lung, breast and the pancreas. (wikipedia.org)
People with a family history of GISTs (called familial GISTs) often have multiple tumors and additional signs or symptoms, including noncancerous overgrowth (hyperplasia) of other cells in the gastrointestinal tract and patches of dark skin on various areas of the body. (medlineplus.gov)
Individuals with MEN1 are at a substantially increased risk of developing neuroendocrine tumors, including cancer of the pancreatic islet cells that secrete insulin. (medindia.net)
Now, researchers at the Perelman School of Medicine at the University of Pennsylvania have found that pathway, which may lead to a new treatment for patients with MEN1 and sporadic endocrine tumors. (medindia.net)
This theory holds that tumors arise from 1 of 2 undifferentiated stem cells: the excretory duct reserve cell or the intercalated duct reserve cell. (medscape.com)

Scientists working in basic, translational, and clinical cancer metabolism research are invited to join the Academy in New York on April 17th to discuss the intersection between cell signaling and metabolism. (nyas.org)
It can influence cell division, metabolism and survival. (tocris.com)
Labeling of Trypanosoma brucei cell cultures with 50% uniformly 13C-labeled glucose demonstrated incorporation of glucose-derived carbon into 187 of 588 putatively identified metabolites in diverse pathways including carbohydrate, nucleotide, lipid, and amino acid metabolism. (acs.org)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)

Researchers at the University of Washington (UW) have found that nematode worms live longer if their genetic make-up permits their cells to turn on the hypoxic response under normal oxygen conditions. (sciencedaily.com)
To their surprise, however, genetic experiments mapped the hypoxic response to a previously unknown longevity pathway, different from dietary restriction. (sciencedaily.com)
However, we don't know if future studies might reveal that all of these different genetic pathways converge somewhere down the line into a common mechanism for delaying the effects of age. (sciencedaily.com)
These results suggest that the slow progression and lack of full-fledged Alzheimer's disease pathology in the hippocampal neurons of APP Sw mice result from the genetic reprogramming of neural cells to cope with increased levels of Aβ. (jneurosci.org)
In both genetic and diet-induced models of insulin resistance, CHOP deficiency improved β cell ultrastructure and promoted cell survival. (jci.org)
We make genetic and functional maps of cancer cell evolution in patients by analyzing multiple tumour samples from the same patient. (lu.se)
These treatments target specific genetic characteristics of the tumor cells. (msdmanuals.com)

Overview of key metabolic pathways in pancreatic cancer stem cells. (atlasofscience.org)
Emerging insights have suggested the presence of a small subpopulation of cells, termed as cancer stem cells (CSCs), which are responsible for tumour initiation, formation and progression in several types of cancer, including pancreatic tumour. (atlasofscience.org)
The present study contributes to broadening the knowledge on pancreatic cancer stem cells and could be used as a starting point for the development of novel therapeutic strategies for the treatment of pancreatic cancer. (atlasofscience.org)
Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways. (atlasofscience.org)
Here, we tested whether ALKBH6 plays a significant role in preventing alkylating DNA damage and decreasing genomic instability in pancreatic cancer cells. (frontiersin.org)
In particular, the loss of ALKBH6 in human pancreatic cancer cells increases alkylating agent-induced DNA damage and significantly decreases cell survival. (frontiersin.org)
Furthermore, in silico analysis from The Cancer Genome Atlas (TCGA) database suggests that overexpression of ALKBH6 provides better survival outcomes in patients with pancreatic cancer. (frontiersin.org)
Overall, our data suggest that ALKBH6 is required to maintain the integrity of the genome and promote cell survival of pancreatic cancer cells. (frontiersin.org)
The extremely low 5-year overall survival of patients is, in part, due to pancreatic cancer cells having several mechanisms of resistance to different chemotherapeutic treatments, one of which is their capacity to efficiently repair alkylating agent-induced DNA damage. (frontiersin.org)
The progression from insulin resistance to type 2 diabetes is caused by the failure of pancreatic β cells to produce sufficient levels of insulin to meet the metabolic demand. (jci.org)
This resistance makes surgery the best option for pancreatic adenocarcinoma (PAAD) treatment, and for 10-20% of patients who undergo surgery, the 5-year survival rate is still only 15-25% [ 8 ]. (hindawi.com)
[ 3 , 4 ] Both gefitinib and erlotinib are approved for the treatment of non-small cell lung cancer, and erlotinib in combination with gemcitabine is approved for the treatment of advanced pancreatic cancer. (medscape.com)

A total of 16 OVCA cell lines underwent pretreatment (baseline) genome-wide expression measurements and were then treated with and analyzed for acetaminophen sensitivity. (nih.gov)
These results indicate the utility of genomic approaches using model organisms to identifying pathways for sensitivity to chemotherapeutic agents. (aacrjournals.org)
The sensitivity to these reagents will be assessed in cell culture systems as well as in mouse models. (edu.au)
Leukemia sensitivity to these two agents was highly associated with MRD although with distinct patterns and only in B cell ALL. (cdc.gov)

Synaptic NMDA receptors have anti-apoptotic activity, whereas stimulation of extrasynaptic NMDA receptors caused loss of mitochondrial membrane potential (an early marker for glutamate-induced neuronal damage) and cell death. (nih.gov)

Previously published research had shown that cancer cell lines using ALT commonly carry mutations in the ATRX gene, but researchers did not have a working model of its mechanisms. (massgeneral.org)
While there is no full understanding of their exact mechanisms of action, proponents hypothesize that antineoplastons restore normal cellular functions and balance, promoting the body's natural defense against cancer cells. (medicalnewstoday.com)

Patients suffering of PDAC have a 5-years survival of 7.7%, a finding that is consistent with early spread: moreover, standard chemo and radio-therapy, as well as treatments based on known oncogenes or growth factors, have not improved the median survival. (atlasofscience.org)
Despite the fact that most follicular lymphomas are advanced at the time of diagnosis, many patients may not require treatment for prolonged periods of time, and the median survival of patients with follicular lymphomas has historically been approximately 8-10 years. (medscape.com)
Trial patients had a median survival of about two years. (mesothelioma.com)
Adjuvant treatment with a modified FOLFIRINOX regimen has recently demonstrated an extended median overall survival of 4.53 years and a 3-year survival rate of 63.4% in patients after surgical operation [ 9 ]. (hindawi.com)

To enhance the benefit of TMZ and avoid therapeutic resistance, effective combination strategies were tested using a small molecule inhibitor blocking the Wnt/β-catenin pathway in addition to TMZ. (nature.com)
Cerulenin, a fatty acid synthase (FASN) natural inhibitor, and Atorvastatin, a competitive inhibitor of the mevalonate pathway, have been used to test the cytotoxic effects on PDAC CSCs. (atlasofscience.org)
HP-1, a potent EGFRL858R/T790M (epidermal growth factor receptor) mutant inhibitor, was developed by the group in an effort to treat acquired resistance in nonsmall cell lung cancer (NSCLC), but its cellular off-targets were not identified. (bvsalud.org)

We have shown here that IM induces autophagy in CML blast crisis cell lines, CML primary cells, and p210BCR/ABL-expressing myeloid precursor cells. (lu.se)

Using insights from our research, we will engineer novel therapies to modulate the pathways that govern human disease. (stanford.edu)

A complete blood cell count (CBC) with differential should be obtained, including examination of the peripheral blood smear if the differential is abnormal. (medscape.com)

MW) chemicals interact with host cells and molecules and In our daily life, we are confronted with a plethora of natural influence biologic processes such as signal transduction. (cdc.gov)

We show that maximal growth is achieved when pathway activation is a more or less steeply graded function of the nutrient concentration. (lu.se)

OVCA acetaminophen response pathways were analyzed in 4 external clinico-genomic datasets from 820 women for associations with overall survival from OVCA. (nih.gov)

[ 2 ] Literature since the rituximab era has shown a further increase in overall survival. (medscape.com)
Overall survival was significantly higher in cluster 2 than in cluster 1. (bvsalud.org)

Here, we utilise our pre-clinical models to conduct a detailed gene-targeted investigation to understand and systematically dissect the pathways underlying SARS-CoV-2 pathogenesis. (edu.au)

We describe the characteristics and pathways of progression of patients with PM in a large multi-institutional consortium and compare them to patients with metastases from ccRCC at other sites. (unisr.it)
Differences in mRNA expression and patient survival of GNG7 in patients with CCRCC and healthy patients were analyzed using the TCGA database. (biomedcentral.com)
Therefore, improving the survival rate of CCRCC patients after surgical treatment has always been a problem for urologists. (biomedcentral.com)
We assessed the influence of referral pathway on ETC case-fatality rates with a retrospective cohort of 126 patients treated at the Mathaska ETC in Port Loko, Sierra Leone. (cdc.gov)
None of these studies examined the care pathway of EVD patients or the extent to which direct admission to an ETC versus transfer from an EIC influenced case-fatality rates measured in ETCs. (cdc.gov)
We hypothesized that patients transplanted with FluTreo would have a long-term survival advantage over other treatment alternatives. (confex.com)
This will be achieved through the use of Bcl-2 protein-selective reagents, which were engineered in the Fairlie laboratory, to profile melanoma cell lines, as well as samples from patients. (edu.au)
Based on the risk score and other independent prognostic indicators, a nomogram with a good ability to predict the survival of PAAD patients was developed. (hindawi.com)
With regard to chemotherapy, for approximately 80% of patients with locally advanced or metastatic illness, gemcitabine or 5-fluorouracil chemotherapy provides a survival time of months, and nab-paclitaxel combined with gemcitabine or FOLFIRINOX provides slight improvements [ 10 , 11 ]. (hindawi.com)
Les concentrations sériques de sCD40L circulant et d'interleukine 10 circulante ont été analysées à l'aide de la méthode immuno-enzymatique chez 30 patients positifs pour le VHC avec un CHC, chez 30 patients patients positifs pour le VHC avec une cirrhose du foie, et chez 30 volontaires d'âge correspondant en bonne santé avec des anticorps anti-VHC négatifs servant de groupe témoin. (who.int)
Similar to HNSCC, in general, survival rates for patients with OSCC are poor. (cdc.gov)
Patients with OSCC have an overall 5-year survival rate of ≈25% ( 6 , 9 ). (cdc.gov)

It is an alkylating agent, and its mechanism of action of active metabolites may involve cross-linking of DNA, which may interfere with growth of normal and neoplastic cells. (medscape.com)
in contrast, EGFR inhibitors (EGFRIs) target pathways more specific to survival of neoplastic cells, thus belonging to a new class of chemotherapeutic agents - so-called "targeted therapy. (medscape.com)

They are involved in a multitude of cellular functions including osteogenesis, cell differentiation, anterior/posterior axis specification, growth, and homeostasis. (wikipedia.org)

The knockdown of ATG9B expression in GBM cells suppressed TMZ-induced autophagy as well as TMZ-resistance. (nature.com)
IM, nilotinib, or dasatinib, with inhibitors of autophagy resulted in near complete elimination of phenotypically and functionally defined CML stem cells. (lu.se)

WNT5A act as both tumor promoter as well as tumor suppressor, depending on cell type. (lu.se)

levels to affect cell growth. (aacrjournals.org)
It plays a role in the regulation of embryonic development and cell growth. (wikipedia.org)
Most studies have looked at the receptor tyrosine kinases and examples of these are platelet derived growth factor receptor (PDGFR) pathway and epidermal growth factor receptor (EGFR). (wikipedia.org)
This proto-oncogene may play a role in the regulation of embryonic development and cell growth. (wikipedia.org)
Scientists report that an evolutionarily conserved transcription factor may have both positive and negative effects on tumor growth depending on whether or not the tumor cells have enough oxygen. (genengnews.com)
NF-kB or similar pathways increase the survival and growth of mesothelial cells. (mesothelioma.com)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)
Published September 5, 2007 transcription factors and replicating extra DNA, rather than going directly into growth of the cell. (lu.se)

Furthermore, catalytic mTOR inhibitors attenuate mTORC1 downstream signaling nodes more completely, but also diminishes mTORC2 mediated AKT survival signals induced by allosteric mTOR inhibitors. (unc.edu)
To determine if this was due to catalytic mTOR inhibitors' ability to attenuate mTORC2 signaling we assessed autophagic flux in cell lines stably expressing shRNAs targeting Raptor or Rictor, essential components for mTORC1 and mTORC2 signaling, respectively. (unc.edu)

In contrast, calcium entry through extrasynaptic NMDA receptors, triggered by bath glutamate exposure or hypoxic/ischemic conditions, activated a general and dominant CREB shut-off pathway that blocked induction of BDNF expression. (nih.gov)
Exposure occurs through an exposure pathway between the contaminant in the physical environment and the exposed person. (cdc.gov)
An exposure pathway has five parts. (cdc.gov)
When all five parts are present, the exposure pathway is termed "a completed exposure pathway" [ATSDR 2005]. (cdc.gov)
Its presence in the body can lead to toxic effects, regardless of age, gender, or exposure pathway. (cdc.gov)
To better understand the effects of organic dust on lung inflammatory responses, we characterized the gene expression profiles of A549 alveolar and Beas2B bronchial epithelial and THP-1 monocytic cells influenced by exposure to poultry dust extract by DNA microarray analysis using Illumina Human HT-12 v4 Expression BeadChip. (cdc.gov)

In the schema of our project, our team sought two central goals: to increase the biological accuracy of the model through the addition of cellular species and intra-pathway connections to the oncogenic pathway, and to conduct new simulations using the updated oncogenic pathway. (american.edu)
Results from this work will significantly advance our understanding of how the interplay between cell death and cell survival is regulated, which is still poorly understood despite its considerable biological importance. (edu.au)

Second-line chemotherapy regimens vary, depending on whether hematopoietic stem cell transplantation (HSCT) is being considered. (medscape.com)
The choice of chemotherapy depends on several factors, including the patient's performance status, age, renal function, desire for inpatient or outpatient therapy, and likelihood of receiving future autologous stem cell transplantation. (medscape.com)
A study in Nature suggests epitope editing in donor stem cells prior to bone marrow transplants can stave off toxicity when targeting acute myeloid leukemia with immunotherapy. (genomeweb.com)
Kim also described the self-regenerating nature of a unique cell type Sanals in the system and these cells are now confirmed to be a type of stem cells. (who.int)
Two theories predominate: the bicellular stem cell theory and the multicellular theory. (medscape.com)
Recent evidence suggests that the bicellular stem cell theory is the more probable etiology of salivary gland neoplasms. (medscape.com)

however, the potential implication of the Notch pathway in SMA pathogenesis has not been studied yet. (mdpi.com)

Njainday's research focuses on WNT5A, and its role in tumour cell progression and plasticity. (lu.se)

We confirmed that acetaminophen was active against OVCA cells in vitro . (nih.gov)
elicits antiproliferative and proapoptotic activities in vitro in solid and hematologic tumor cells. (medscape.com)

Several alkylating agents are commonly used in chemotherapy but may induce DNA damage to cancer cells as well as normal cells. (frontiersin.org)
The following factors were studied in the whole cohort: age, type of disease (treatment-related or post myelodysplastic syndrome/MDS), previous intensive chemotherapy cycles, cytogenetic risk, overall (OS) and disease-free survival (DFS). (confex.com)
Chemotherapy is a form of systemic treatment that uses drugs to kill cancer cells or to stop them from growing. (msdmanuals.com)

This is the first report on organic dust induced changes in expression profiles in lung epithelial and THP-1 monocytic cells. (cdc.gov)

Clinically, grade 3B follicular lymphoma is treated like diffuse large B-cell lymphoma . (medscape.com)

A research team led by Xianxin Hua, MD, PhD, associate professor of Cancer Biology at the Abramson Family Cancer Research Institute, report in Cancer Research that menin suppresses signaling in the much-studied Hedgehog pathway in endocrine organs. (medindia.net)
The essential biochemistry, genetics, cell biology, and metabolic pathways underlying the survival and success of all living organisms. (queensu.ca)

Targeting of this pathway may benefit cancer treatment. (genengnews.com)
Antineoplaston therapy aims to provide a more targeted and personalized approach to cancer treatment by selectively targeting cancer cells and minimizing harm to healthy cells. (medicalnewstoday.com)

RPA functions as a DNA repair protein that promotes DNA recombination, and the ALT pathway is known to be a process that is dependent on recombination. (massgeneral.org)

Anatomy19

Organisms8

Diseases34

Chemicals and Drugs83

Analytical, Diagnostic and Therapeutic Techniques and Equipment51

Phenomena and Processes58

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science6

Health Care21

Proliferation16

Apoptosis14

Genes19

Proteins14

Renal cell carc4

Molecular13

Oxidative stress5

PI3K5

Signalling pathways in cancer1

Signaling Pathway3

Migration2

Inhibition5

Inhibit5

Ovarian cancer1

Mitogen-Activa1

Inflammation6

Metabolic pathway5

Repair pathways1

Cancers4

Metastasis2

Kinase1

Squamous8

Biochemical2

Tumors6

Metabolism4

Genetic7

Pancreatic12

Sensitivity4

Apoptotic1

Mechanisms2

Median4

Inhibitor3

Induces1

Therapies1

Differential1

Molecules1

Activation1

Genomic1

Overall survival2

Systematically1

Patients12

Neoplastic cells2

Differentiation1

Autophagy2

Tumor suppressor1

Growth8

MTOR2

Exposure6

Biological2

Stem6

Pathogenesis1

Tumour1

Vitro2

Chemotherapy3

Lung1

Diffuse large B-1

Biology2

Targeting2

Promotes1