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  • enzymes
  • The intermediate state, which is an off-pathway rather than on-pathway product, may mediate the formation of oligomers in vitro and play an important role in the recognition of partner enzymes in vivo. (nus.edu.sg)
  • The difference in active site organization and predominance of type II FAS systems in bacteria make the enzymes of this pathway attractive targets for antibacterials. (wikipedia.org)
  • The pathway and enzymes have been elucidated and reported in detail. (wikipedia.org)
  • metabolic
  • In October 2014, NHS Scotland advised use of lurasidone for schizophrenic adults who have not seen improvements with previous antipsychotics due to problems that arise from weight gain or changes in metabolic pathways when taking other medications. (wikipedia.org)
  • Sulfolobus
  • Here, the N-glycosylation pattern of cell-surface-exposed proteins of Sulfolobus solfataricus P2 were analyzed by lectin affinity purification, HPAEC-PAD, and multiple mass spectrometry-based techniques. (scoop.it)
  • Here we provide data suggesting that the transcriptional regulators belonging to the Lrs14-like protein family constitute a key regulatory factor during Sulfolobus biofilm development. (scoop.it)
  • Reactions
  • A cysteine specific NRPS module located on CurF follows after cyclopropyl ring formation, and due to the activity of a cyclizing condensation domain, forms a thiazole ring attached to the cylcopropyl moiety from previous reactions in the pathway. (wikipedia.org)
  • nucleotide
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • p>This subsection of the 'Function' section describes a region in the protein which binds nucleotide phosphates. (uniprot.org)
  • malonyl
  • An hydroxymethylglutaryl-CoA synthase cassette (mevalonate pathway) catlyzes the formation of hydroxymethylglutaryl acid by the addition of an malonyl-CoA unit to the terminal ketide of the aceto-acetyl-ACP moiety of ACP1,ACP2, or ACP3. (wikipedia.org)
  • The systematic name of this enzyme class is malonyl-CoA:[acyl-carrier-protein] S-malonyltransferase. (wikipedia.org)
  • decarboxylase
  • In this system, the H protein is a free lipoyl domain with additional helices, the L protein is a dihydrolipoamide dehydrogenase, the P protein is the decarboxylase, and the T protein transfers the methylamine from lipoate to tetrahydrofolate (THF) yielding methylene-THF and ammonia. (wikipedia.org)
  • Peptide
  • The ACPs are related in structure and mechanism to the peptidyl carrier proteins (PCP) from nonribosomal peptide synthases. (wikipedia.org)
  • These proteins contain a specific signal-peptide sequence, which is to be translated into the endoplasmic reticulum, but are, however, able to reach the cell surface unconventionally. (wikipedia.org)
  • NRPS
  • Analysis of the pathway demonstrated the presence of one NRPS/PKS hybrid module located on CurF, one HMG-CoA synthase cassette located on CurD, and seven monomodular PKS modules. (wikipedia.org)
  • sequence
  • SSO1273 protein is heavily glycosylated and all 20 theoretical N-X-S/T (where X is any amino acid except proline) consensus sequence sites were confirmed. (scoop.it)
  • View conserved domains detected in this protein sequence using CD-search. (nih.gov)
  • Yeast ADP/ATP carrier isoform 2: conformational dynamics and role of the RRRMMM signature sequence methionines. (nih.gov)
  • See the reference protein sequence for ADP/ATP carrier protein PET9 (NP_009523.1). (nih.gov)
  • Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed. (uniprot.org)
  • moiety
  • The protein is expressed in the inactive apo form and the 4'-phosphopantetheine moiety must be post-translationally attached to a conserved serine residue on the ACP by the action of holo-acyl carrier protein synthase (ACPS), a 4'-phosphopantetheinyl transferase. (wikipedia.org)
  • vesicular
  • These findings suggest that the SCAMPs may function at the same site during vesicular transport rather than in separate pathways. (wikipedia.org)
  • Non-vesicular mechanism use a carrier to get protein into extracellular space (for example phosphatidylinositol-4,5-bisphoshate). (wikipedia.org)
  • Vesicular mechanism can use lysosome-dependent pathway, microvesicle shedding or biogenesis of multivesicular bodies. (wikipedia.org)
  • binds
  • Mupirocin reversibly binds to the isoleucyl t-RNA synthetase in Staphylococcus aureus and Streptococcus, resulting in inhibition of protein synthesis. (wikipedia.org)
  • structures
  • To investigate the role of the minor states of an acyl carrier protein, NMR techniques were applied to determine the number of minor states and characterize their structures and kinetics. (nus.edu.sg)
  • cellular
  • Cell surface proteins of hyperthermophilic Archaea actively participate in intercellular communication, cellular uptake, and energy conversion to sustain survival strategies in extreme habitats. (scoop.it)
  • mechanism
  • Two hydrogens of octanoate are replaced with sulfur groups via a radical SAM mechanism, by lipoyl synthase As a result, lipoic acid is synthesized attached to proteins and no free lipoic acid is produced. (wikipedia.org)
  • modification
  • As a result of these advances, recent efforts have not only succeeded in delineating the pathways involved in archaeal N-glycosylation, but also begun to reveal how such post-translational protein modification helps archaea to survive in some of the harshest environments on the planet. (scoop.it)
  • involves
  • This pathway involves condensation of a thiamine-activated acetyl group arising from the decarboxylation of pyruvate and glyceraldehyde-3-phosphate followed by a transposition step. (wikipedia.org)
  • Thus
  • Thus, the terpenoid building blocks, dimethylallyl diphosphate and isopentenyl diphosphate, synthesized by the non-mevalonate pathway utilizing pyruvate and glyceraldehyde-3-phosphate, condense to form the diterpenoid precursor geranylgeranyl diphosphate that cyclizes to intermediate 3 which is related to (or derived from) ent-kaurene. (wikipedia.org)
  • organisms
  • The ABC protein ABCE1, formerly named RNase L inhibitor RLI1, is one of the most conserved proteins in evolution and is expressed in all organisms except eubacteria. (scoop.it)
  • several
  • Remarkably, we show that several other proteins in the surface fraction of S. solfataricus are N-glycosylated by the same sulfated oligosaccharide and we identified 56 N-glycosylation sites in this subproteome. (scoop.it)
  • The mupirocin pathway also contains several tandem acyl carrier protein doublets or triplets. (wikipedia.org)
  • genes
  • To investigate whether common variants associated with DAE were involved in breast cancer susceptibility among BRCA1 and BRCA2 mutation carriers, a list of 175 genes was developed based of their involvement in cancer-related pathways. (springer.com)
  • Using data from a genome-wide map of SNPs associated with allelic expression, we assessed the association of ~320 SNPs located in the vicinity of these genes with breast and ovarian cancer risks in 15,252 BRCA1 and 8211 BRCA2 mutation carriers ascertained from 54 studies participating in the Consortium of Investigators of Modifiers of BRCA1/2 . (springer.com)
  • Click on genes, proteins and metabolites below to link to respective articles. (wikipedia.org)
  • modulates
  • Deposition of matricellular proteins modulates growth factor signaling and contributes to the spatial and temporal regulation of the reparative response. (jci.org)
  • regulate
  • Together with histone acetylases (HATs), HDACs regulate acetylation level of histones (H3, H2AK5, H4K5, H4K12, H2B, H4K8, and H4K16) as well as some other proteins (p65 and myocyte enhancer factor 2) [ 5 ]. (hindawi.com)
  • The structure, function and molecular biology of Ca2+ dependent regulatory proteins (particularly calmodulin) and the target proteins which they regulate is under study. (uky.edu)
  • bind
  • Prenylation is a common type of covalent post-translational modification at C-terminal CaaX motifs that allows proteins to localize to membranes or bind to one another. (wikipedia.org)
  • variants
  • At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4. (wikipedia.org)
  • this transcript contains an alternate open reading frame (ARF) that specifies a protein that is structurally unrelated to the products of the other variants. (wikipedia.org)
  • mutation
  • We identified a region on 11q22.3 that is significantly associated with breast cancer risk in BRCA1 mutation carriers (most significant SNP rs228595 p = 7 × 10 −6 ). (springer.com)
  • mutations
  • Carriers of germline mutations in CDKN2A have besides their high risks of melanoma also increased risks of pancreatic, lung, laryngeal and oropharyngeal cancers and tobacco smoking exacerbates carriers' susceptibility for such non-melanoma cancers. (wikipedia.org)
  • Methods
  • Using very sensitive methods, LECT2 protein can also be detected at low levels in the endothelial cells of hepatic arteries and veins including central veins. (wikipedia.org)
  • subunit
  • These are subunit vaccines, consisting of specific protein antigens (such as tetanus or diphtheria toxoid) or recombinant protein components (such as the hepatitis B surface antigen). (wikipedia.org)
  • function
  • Subsequent studies have defined LECT2 as a hepatokine, i.e. a substance made and released into the circulation by liver hepatocyte cells that regulates the function of other cells: it is a hepatocyte-derived, hormone-like, signaling protein. (wikipedia.org)
  • A third domain of the protein is rich in O-linked oligosaccharides but appears to show little function. (wikipedia.org)
  • leukocyte
  • Leukocyte cell-derived chemotaxin-2 (LECT2) is a protein first described in 1996 as a chemotactic factor for neutrophils, i.e. it stimulated human neutrophils to move directionally in an in vitro assay system. (wikipedia.org)
  • evolutionary
  • These findings indicate that LECT is an evolutionary conserved protein, has one or more important functions, and may be involved in various diseases. (wikipedia.org)
  • functions
  • The attachment of a hydrophobic aliphatic chain as those present in farnesyl or geranylgeranyl groups allows small G-proteins to tether from membranes and carry out effector functions. (wikipedia.org)
  • Cell
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • The C-terminal domain of Beta2-adaptin is a protein domain is involved in cell trafficking by aiding import and export of substances in and out of the cell. (wikipedia.org)
  • The protein was detected in and purified from cultures of Phytohaemagglutinin-activated human T-cell leukemia SKW-3 cells. (wikipedia.org)
  • Alternatively, the DNA may be encapsulated in protein to facilitate cell entry. (wikipedia.org)
  • known
  • Biochemical and biotechnological development has allowed novel approaches to this issue, in the form of engineered O2 carriers, widely known as "blood substitutes. (wikipedia.org)
  • functional
  • Although grown worldwide for its protein and oil, high value added products such as plant functional nutraceuticals, including phospholipids, saponins, isoflavones, oligosaccharides and edible fibre, have gained importance in the last decade. (intechopen.com)
  • essential
  • These biochemicals can be joined together to make polymers such as DNA and proteins, essential macromolecules of life. (wikipedia.org)
  • Zinc plays an essential role in numerous biochemical pathways. (wikipedia.org)
  • Because the plasmid is the "vehicle" from which the immunogen is expressed, optimising vector design for maximal protein expression is essential. (wikipedia.org)
  • belongs
  • This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. (wikipedia.org)
  • Immunogen
  • Polycistronic vectors (ones located at multiple genome sites) are sometimes constructed to express more than one immunogen, or to express an immunogen and an immunostimulatory protein. (wikipedia.org)
  • found
  • Serum ferritin" presents a paradox, as the iron storage protein ferritin is not synthesised in serum yet is to be found there. (rsc.org)
  • The mupirocin cluster exhibits an atypical acyltransferase (AT) organization, in that there are only two AT domains, and both are found on the same protein, MmpC. (wikipedia.org)
  • domain
  • Both the cyclooxygenase and the peroxidase active sites are located in the catalytic domain, which accounts for approximately 80% of the protein. (wikipedia.org)
  • mainly
  • Soybean ( Glycine max (L.) Merrill) is a globally important commercial crop, grown mainly for its protein, oil and nutraceutical contents. (intechopen.com)
  • response
  • In conclusion, our data provided a hint that RGFP966 may be a potential therapeutic medication combating microglia activation and inflammatory response in central nervous system, which was probably related to its repressive impacts on TLR signaling pathways and STAT3/STAT5 pathways. (hindawi.com)
  • leads
  • Matveeva, E.A.;Price, D.A.;Whiteheart, S.W.;Vanaman, T.C.;Gerhardt, G.A.;Slevin, J.T. "Reduction of vesicle-associated membrane protein 2 expression leads to a kindling-resistant phenotype in a murine model of epilepsy. (uky.edu)
  • Conversely, activation of p16 through the ROS pathway, DNA damage, or senescence leads to the buildup of p16 in tissues and is implicated in aging of cells. (wikipedia.org)
  • domains
  • MyD88 (myeloid differentiation factor 88), There is such high homology in the cytoplasmic domains of the TLRs that, initially, it was suggested that similar signaling pathways exist for all TLRs (Re, F., Strominger, J. L., Immunobiology 2004, 209:191-198). (allindianpatents.com)
  • expression
  • Intron A may sometimes be included to improve mRNA stability and hence increase protein expression. (wikipedia.org)
  • One way of enhancing protein expression is by optimising the codon usage of pathogenic mRNAs for eukaryotic cells. (wikipedia.org)