Pathway purkinje cells. Medical search. Frequent questions

We find that in patDp/+ mice delay eyeblink conditioning-a form of cerebellum-dependent motor learning-is impaired, and observe deregulation of a putative cellular mechanism for motor learning, long-term depression (LTD) at parallel fibre-Purkinje cell synapses. (nature.com)
[ citation needed ] This naming can extend to include any number of structures in a pathway, such that the cerebellorubrothalamocortical pathway originates in the cerebellum , synapses in the red nucleus ("ruber" in Latin), on to the thalamus , and finally terminating in the cerebral cortex . (wikipedia.org)
In the cerebellum one of the two major pathways is that of the mossy fibers . (wikipedia.org)
The functional output of the cerebellum is through Purkinje cells. (uab.edu)
Population calcium responses of Purkinje cells in the oculomotor cerebellum driven by non-visual input. (stanford.edu)
The climbing fiber input to the cerebellum conveys instructive signals that can induce synaptic plasticity and learning by triggering complex spikes accompanied by large calcium transients in Purkinje cells. (stanford.edu)
The histopathological changes strongly indicate selected damage to particular cell groups and lobules of the cerebellum rather than diffuse injury. (eurekaselect.com)
A number of studies have shown injury and abnormal development of the vermis of the cerebellum, with a predominance of neuronal loss among Purkinje cells and granule cells. (eurekaselect.com)
Newer studies have shown that the cerebellum may have significant cognitive and higher cortical functions, either by way of its connections to prefrontal-limbic areas or more indirect pathways. (eurekaselect.com)
The micrograph of the three layers of cerebellum (Light microscopy, ×100) The Purkinje cells counted were those having nucleoli clearly visible (as indicated by arrows). (jcimjournal.com)
Benedetti, B., Benedetti, A., and Flucher, B.E. (2016) Loss of the calcium channel β 4 subunit impairs parallel fiber volley and purkinje cell firing in cerebellum of adult ataxic mice. (i-med.ac.at)
The combined neuronal activity of two seemingly opposite types of Purkinje cell in the brain's cerebellum has been found to be required to control the jerky eye movements known as saccades in monkeys. (natureasia.com)
We have previously established that the mutated protein Af4, which is a member of the AF4/LAF4/FMR2 (ALF) family of transcription cofactors frequently translocated in childhood leukaemia, undergoes slower proteasomal turnover through the ubiquitin pathway and abnormally accumulates in Purkinje cells of the cerebellum. (ox.ac.uk)
With the forthcoming identification of the gene targets that trigger Purkinje cell death in the robotic cerebellum, and the functional conservation among the ALF proteins, the robotic mouse promises to deliver important insights into the pathogenesis of human ataxia, but also of mental retardation to which FMR2 and LAF4 have been linked. (ox.ac.uk)
The parameters of the model were tuned to the Purkinje cell of cerebellum to reproduce the inhibiion of these cells by noisy current injections. (yale.edu)
The abnormal ataxin protein leads to the loss of neurons in the CNS, especially Purkinje fibers in the cerebellum. (brainandnervecenter.com)
The mutation leads to misfolded protein production and aggregation in the nucleus of neurons, especially Purkinje cells in the cerebellum. (brainandnervecenter.com)
Medulloblastoma is defined by the World Health Organization (WHO) as "an embryonal neuroepithelial tumor arising in the cerebellum or dorsal brainstem, presenting mainly in childhood and consisting of densely packed small round undifferentiated cells with mild to moderate nuclear pleomorphism and high mitotic count. (medscape.com)
85. An expandable embryonic stem cell-derived Purkinje neuron progenitor population that exhibits in vivo maturation in the adult mouse cerebellum. (neuro.nl)
Patchy loss of Purkinje cells in the superior vermis of the cerebellum and of neurons in corresponding portions of the inferior olivary nuclei is typical. (medscape.com)
The order of decreased NADHTR activity for tissues was hepatocytes, parietal cells, kidney tubules, dorsal root ganglion, cerebellum and axons. (cdc.gov)
The medulloblastoma has been defined by the World Health Organization (WHO) as a "malignant, invasive embryonal tumor of the cerebellum with preferential manifestation in children , predominantly neuronal differentiation, and inherent tendency to metastasize via CSF [cerebrospinal fluid] pathways. (medscape.com)

There he first learned about Golgi's method, a cell staining method which uses potassium dichromate and silver nitrate to (randomly) stain a few neurons a dark black color, while leaving the surrounding cells transparent. (wikipedia.org)
In situ hybridization and immunohistochemical studies have shown that Purkinje cells (PCs), the output neurons of the cerebellar cortex, are the neuron type with the highest levels of GABA B receptors (Bowery et al. (springer.com)
Measuring the firing rate of high-resistance neurons with cell-attached recording. (sppin.fr)
In neuroanatomy , a neural pathway is the connection formed by axons that project from neurons to make synapses onto neurons in another location, to enable neurotransmission (the sending of a signal from one region of the nervous system to another). (wikipedia.org)
In general, neurons receive information either at their dendrites or cell bodies . (wikipedia.org)
5-HT2A-Rs are indicated on apical dendrites of cortical pyramidal neurons and cerebellar Purkinje cells. (bioinbrief.com)
The dorsal spinal ganglia show shrinkage and eventual disappearance of neurons associated with proliferation of capsular cells. (medscape.com)
Large neurons of the dorsal root ganglia, especially lumbosacral, and nerve cells in the Clarke column are reduced in number. (medscape.com)
The output neurons (ONs) of the BG are cells in globus pallidus pars interna (GPi) and in substantia nigra pars reticulata (SNr). (scholarpedia.org)
MBAA was without a significant effect on NADHTR activity within any of the tissues with the exception of the Purkinje neurons. (cdc.gov)

The other main pathway is from the climbing fibers and these project to Purkinje cells and also send collaterals directly to the deep nuclei. (wikipedia.org)

Electrical synapses are important where __________ activity among a group of cells are a major function. (flashcardmachine.com)
Single-cell recordings provided the first strong evidence for mammalian electrical synapses in the __________ nucleus of cranial nerve __________, the __________ nucleus, and the __________ __________ nucleus. (flashcardmachine.com)
synapses use neurotransmitter to carry information from cell to cell. (flashcardmachine.com)
Learning depends on training information generated from corrective movements and uses a temporally asymmetric form of plasticity for the parallel fiber synapses on Purkinje cells. (mit.edu)
However, the climbing fibre input continuously exerts an activity-dependent repression on parallel fibre synapses, thus confining them to the distal Purkinje cell dendritic domain. (123dok.org)

A missense variant (c.689G>T p.Gly230Val) in ELOVL5 causes Spinocerebellar Ataxia subtype 38 (SCA38), a neurodegenerative disorder characterized by autosomal dominant inheritance, cerebellar Purkinje cell demise and adult-onset ataxia. (bvsalud.org)
MicrocircuitDB: Inverse stochastic resonance of cerebellar Purkinje cell (Buchin et al. (yale.edu)
Inverse stochastic resonance of cerebellar Purkinje cell (Buchin et al. (yale.edu)

The __________ is the point where the neuron meets a target cell. (flashcardmachine.com)
Like a neuron, a given myocardial cell has a negative membrane potential when at rest. (wikipedia.org)

Mossy fibers project directly to the deep nuclei , but also give rise to the following pathway: mossy fibers → granule cells → parallel fibers → Purkinje cells → deep nuclei. (wikipedia.org)
GL: granule cell layer. (jcimjournal.com)

However, as the aetiology of the majority of these conditions is still unknown, a reverse approach based on large-scale random chemical mutagenesis is now being used in an attempt to identify new genes and associated signalling pathways that control neuronal cell death and survival. (ox.ac.uk)
I am currently working on understanding intracellular transport in long tubular cells such as neuronal axons and fungal hyphae. (ucsd.edu)

Descending motor pathways of the pyramidal tracts travel from the cerebral cortex to the brainstem or lower spinal cord . (wikipedia.org)

Scientists have identified a proteomic pathway, involving the proteins Homer-3 and mTORC1, that is involved in the degeneration of Purkinje cells, a pathogenesis central to Huntington's disease. (huntingtonsdiseasenews.com)
Loss of Wtap results in cerebellar ataxia and degeneration of Purkinje cells. (nih.gov)

Hundreds of his drawings illustrating the arborizations ("tree growing") of brain cells are still in use, since the mid-20th century, for educational and training purposes. (wikipedia.org)
However, there are some notable exceptions like Purkinje cells' dendritic arborizations that appear to be free from dendritic spines (see the below). (paydaysolobest.com)

Stimulation of postsynaptic GABA B receptors generally triggers inhibition of adenylate cyclase and activation of G protein-gated inwardly rectifying K + (GIRK/Kir3) channels, leading to cell hyperpolarisation (Kaupmann et al. (springer.com)
Together, these findings suggested that Homer3 in Purkinje cells might function as a reversible coupler regulated by CaMKII phosphorylation and that the phosphorylation is capable of regulating the postsynaptic molecular architecture in response to synaptic activity. (jneurosci.org)
These results suggest that the phosphorylation may regulate postsynaptic molecular architecture and Ca 2+ signaling of Purkinje cells in response to synaptic activity. (jneurosci.org)
In addition, glutamate released into the synaptic cleft is cleared via transporters found on the postsynaptic Purkinje cells. (uab.edu)

In addition to locally aggressive behavior with fourth ventricular obstruction and hydrocephalus, medulloblastomas can metastasize via cerebrospinal fluid (CSF) pathways. (medscape.com)
Dissemination of medulloblastoma within cerebrospinal fluid (CSF) pathways is a defining pathobiologic characteristic of this tumor, and about 30% of patients will have CSF metastasis at presentation. (medscape.com)

Sympathetic ganglia comprises the thousands of afferent and efferent nerve cell bodies that run along either side of the spinal cord, connecting major organ systems, such as the renal system, to the spinal cord and brain. (nih.gov)
By including realistic mossy fiber signals, as well as realistic conduction delays in afferent and efferent pathways, the model allowed the investigation of timing and predictive processes relevant to cerebellar involvement in the control of movement. (mit.edu)

Second, these antibodies impair the induction of synaptic plasticity, rebound potentiation, and LTD, on Purkinje cells, resulting in loss of restoration and compensation of the distorted "internal models. (springer.com)
The CaMello technique may be expanded to every GPCR coupling towards the Gq/11 pathway to greatly help unravel brand-new receptor-specific functions according to synaptic plasticity and GPCR localization. (bioinbrief.com)

We are a small research group in the field of cerebellar neurobiology with a special focus on the role of Protein Kinase Cgamma (PKCγ) for Purkinje cell dendritic development and the pathogenesis of spinocerebellar ataxias (SCAs). (fens.org)
In the moment the focus of our research is on identifying and characterizing molecules which are part of the PKCγ signaling pathway in Purkinje cells and which are involved in the regulation of Purkinje cell dendritic development and the pathogenesis of SCA. (fens.org)
Max Planck Institute of Biochemistry researchers have shown that the intracellular location of protein aggregates, long suspected to be involved in the pathogenesis of neurodegenerative diseases like Huntington's, is extremely important to the survival of nerve cells. (huntingtonsdiseasenews.com)

Each Purkinje cell receives excitatory input from thousands of parallel fibers and a single climbing fiber. (uab.edu)

Protein kinase C regulates human pluripotent stem cell self-renewal. (rndsystems.com)
Serine/threonine kinase 17b (STK17B) signalling regulates Purkinje cell dendritic development and is altered in multiple spinocerebellar ataxias. (fens.org)
PKCγ-Mediated Phosphorylation of CRMP2 Regulates Dendritic Outgrowth in Cerebellar Purkinje Cells. (fens.org)

A New Mouse Model Related to SCA14 Carrying a Pseudosubstrate Domain Mutation in PKCγ Shows Perturbed Purkinje Cell Maturation and Ataxic Motor Behavior. (fens.org)
Here, we review the characterisation of a novel model of autosomal dominant cerebellar ataxia which shows general growth retardation and develops adult-onset region-specific Purkinje cell loss as well as cataracts and defects in early T-cell maturation. (ox.ac.uk)

In Purkinje cells, Homer3 is distributed throughout the dendrites, axons, and soma, but the most remarkable accumulation of Homer3 was observed in dendritic spines. (jneurosci.org)

Influence of spatially segregated IP-producing pathways on spike generation and transmitter release in Purkinje cell axons. (sppin.fr)
[1] Shorter neural pathways are found within grey matter in the brain , whereas longer projections, made up of myelinated axons, constitute white matter . (wikipedia.org)
A neural pathway connects one part of the nervous system to another using bundles of axons called tracts. (wikipedia.org)
Therefore, most neural pathways are made up of axons . (wikipedia.org)
[ citation needed ] If the axons have myelin sheaths, then the pathway appears bright white because myelin is primarily lipid . (wikipedia.org)
[ citation needed ] If most or all of the axons lack myelin sheaths (i.e., are unmyelinated ), then the pathway will appear a darker beige color, which is generally called grey . (wikipedia.org)

It has been shown that the calcium transients accompanying each complex spike can vary in amplitude, even within a given cell, therefore, we compared the calcium responses associated with the visual and non-visual inputs to floccular Purkinje cells. (stanford.edu)

2 . Steuber V, Schultheiss NW, Silver RA, De Schutter E, Jaeger D (2011) Determinants of synaptic integration and heterogeneity in rebound firing explored with data-driven models of deep cerebellar nucleus cells. (yale.edu)
CCS escorts copper only to SOD-1 and fails to deliver copper to proteins in the mitochondria, nucleus or secretory pathway. (nkmaxbio.com)
The cerebellar ataxia is explained by loss of the lateral and ventral spinocerebellar tracts and involvement of the Clarke column, dentate nucleus, superior vermis, and dentatorubral pathways. (medscape.com)

Not to be confused with Neurotransmitter pathways . (wikipedia.org)

Furthermore, both robust phosphorylation of Homer3 and its dissociation from metabotropic glutamate receptor 1α (mGluR1α) were triggered by depolarization in primary cultured Purkinje cells, and these events were inhibited by CaMKII inhibitor. (jneurosci.org)
In this study, we revealed that Homer3 was phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) in Purkinje cells, and the phosphorylation reduces the affinity for Homer target molecules, resulting in change of the solubility. (jneurosci.org)
Infection with SARS-CoV-2 virus leads to alterations in host cell phosphorylation signal, which systematically modulates the immune response. (bvsalud.org)
METHOD: Identification and analysis of SARS-CoV-2 virus infection phosphorylation sites enable insight into the mechanisms of viral infection and effects on host cells, providing important fundamental data for the study and development of potent drugs for the treatment of immune inflammatory diseases. (bvsalud.org)

Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. (rndsystems.com)

Cerebellar Purkinje cells are innervated by two different excitatory inputs. (123dok.org)

Metabotropic GABA B receptors mediate slow inhibitory effects presynaptically and postsynaptically through the modulation of different effector signalling pathways. (springer.com)
The epithelial cells that line the intestine have been found to sense tight attachment of bacteria, and to respond by producing proteins that shape the effector functions of the immune system's T H 17 cells. (natureasia.com)

Viewpoint: spinocerebellar ataxias as diseases of Purkinje cell dysfunction rather than Purkinje cell loss. (fens.org)
There are multiple causes of these disruptions, and lesions along different points in interconnected pathways can yield similar motor dysfunction. (touchneurology.com)

We found that Homer3, the predominant isoform in Purkinje cells, is phosphorylated by calcium/calmodulin-dependent protein kinase II (CaMKII) both in vitro and in vivo . (jneurosci.org)
Finally, we show that both natural variation and pre-induction conditions achieve changes in modality by tuning the expression and activity of a single signaling protein in the GAL pathway. (elifesciences.org)
11. Rapamycin, an mTOR inhibitor, upregulates autophagy, one of the pathways to remove aggregated misfolded protein. (brainandnervecenter.com)
Preexisting antivector immunity can severely compromise the ability of Salmonella enterica serovar Typhimurium live vaccines to induce protective CD8 T-cell frequencies after type III secretion system-mediated heterologous protein translocation in orally immunized mice. (cipsm.de)

His early work at these two universities focused on the pathology of inflammation, the microbiology of cholera, and the structure of epithelial cells and tissues. (wikipedia.org)
While many tissues express CCS, the chaperone is most abundant in the kidney, liver and Purkinje cells in the neuropil of the central nervous system. (nkmaxbio.com)
They are involved in multiple cellular processes in different tissues, where they regulate cell shape and position. (123dok.org)
Crown antibodies pass additional stringent quality requirements, including extended control sets, uniform results against multiple biologically relevant cell lines and tissues, and function in multiple applications. (abcepta.com)
Abcepta's portfolio of cell lines, tissues and lysates are drawn from a range of species and immortalized cell lines. (abcepta.com)

By recording and imaging Purkinje cells and Bergmann glia, we study how transporters can influence the strength of synaptic signals and regulate the signal transduction pathways underlying cerebellar long-lasting plasticity. (uab.edu)

Noncanonical Modulation of the eIF2 Pathway Controls an Increase in Local Translation during Neural Wiring. (rndsystems.com)

The calcium indicator GCaMP6f was selectively expressed in Purkinje cells, and fiber photometry was used to record the calcium responses from a population of Purkinje cells in the flocculus of awake behaving mice. (stanford.edu)
In particular, I am investigating the significance of endoplasmic reticulum geometry in mediating calcium ion dynamics via the IP3-Ca pathway. (ucsd.edu)
8. Dantrolene inhibits the release of calcium from its stores and preserves the functioning of Purkinje cells. (brainandnervecenter.com)
9. Chlorzoxazone is the FDA-approved activator of calcium-activated potassium channels, and it normalizes the electrophysiology and action potential firing of Purkinje cells. (brainandnervecenter.com)

The conduction system consists of specialized heart muscle cells , situated within the myocardium . (wikipedia.org)
Embryologic evidence of generation of the cardiac conduction system illuminates the respective roles of this specialized set of cells. (wikipedia.org)

It was only Intrigued possible to observe the cell body, proximal portions and dendrites, and the axon. (paydaysolobest.com)
When electrical activity is blocked in vivo by tetrodotoxin leading to a high spine density in Purkinje cell proximal dendrites, stimulation of Eph receptor activation recapitulates the spine repressive effects of climbing fibres. (123dok.org)
These results suggest that Eph receptor signalling mediates the repression of spine proliferation induced by climbing fibre activity in Purkinje cell proximal dendrites. (123dok.org)

The previously mentioned tendency of medulloblastoma to spread via CSF pathways can lead to diffuse "sugar coating" of the subarachnoid space and to nodular growths along the spinal cord or even ventricular surfaces. (medscape.com)

The axon of a nerve cell is, in general, responsible for transmitting information over a relatively long distance. (wikipedia.org)
Figure 1 depicts the structure of the olfactory bulbs (nerve cells, pathways), while Figure 2 shows the cerebellar cortex in great morphological detail. (paydaysolobest.com)

We aim to study how the mechanisms of synaptic transmission and the regulation of vesicular fusion affect Purkinje cell integration and firing properties. (uab.edu)

This coordination is accomplished by specialized cardiac muscle cells that comprise the conducting system of the heart. (bodyviz.com)

Here, we present a quantitative and comprehensive study of the abundance levels of histone PTMs during the differentiation of mouse embryonic stem cells (ESCs) using mass spectrometry (MS). We observed dynamic changes of histone PTMs including increased H3K9 methylation levels in agreement with previously reported results. (biomedcentral.com)
Embryonic stem cells (ESCs) are self-renewing, pluripotent cells derived from the inner cell mass (ICM) of a blastocyst [ 1 , 2 ]. (biomedcentral.com)

are proteins and __________ are tubes in the cell membrane. (flashcardmachine.com)

On the microscopic level, the wave of depolarization propagates to adjacent cells via gap junctions located on the intercalated disc . (wikipedia.org)
The positively charged ions entering the cell cause the depolarization characteristic of an action potential. (wikipedia.org)

Histone acetylation has been implicated to be important for the pluripotent cell state, as some HDAC inhibitors have been shown to improve reprogramming efficiency of induced pluripotent stem cells (iPSCs) or maintain a pluripotent stem cell state. (biomedcentral.com)

In the developing brain, they act as migratory and cell adhesive cues while in the adult brain they regulate dendritic spine plasticity. (123dok.org)

[4] [5] Ascending sensory tracts in the dorsal column-medial lemniscus pathway (DCML) carry information from the periphery to the cortex of the brain. (wikipedia.org)

These peptides can be used for antigen specific T-cell stimulation in T-cell assays or T-cell expansion. (abcepta.com)
Stimulation above a threshold value induces the opening of voltage-gated ion channels and a flood of cations into the cell. (wikipedia.org)

In addition, depending on the cell-type and agonist 5-HT2A-Rs not merely stimulate the NOS3 Gq-PLC pathway, but various other pathways like the G12/13-PLA2 and Gi/o-Src pathway16C18 also. (bioinbrief.com)
The Purkinje fibers transmit the signals more rapidly to stimulate contraction of the ventricles. (wikipedia.org)
Although other irritants in the smoke may have contributed to the incident, there is supporting evidence that stable strontium can stimulate the release of histamine from mast cells in vitro (ATSDR 2001e). (cdc.gov)

Interestingly, Purkinje cells have the intrinsic ability to generate a high number of spines over their entire dendritic arborisations, which can be innervated by the parallel fibres. (123dok.org)

Bimodal gene expression by genetically identical cells is a pervasive feature of signaling networks and has been suggested to allow organisms to hedge their 'bets' in uncertain conditions. (elifesciences.org)
In the galactose-utilization (GAL) pathway of Saccharomyces cerevisiae , gene induction is unimodal or bimodal depending on natural genetic variation and pre-induction conditions. (elifesciences.org)
DNA methylation and histone modifications play a central role in the epigenetic regulation of gene expression and cell differentiation. (cipsm.de)

Histologic subtypes of medulloblastoma include: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, and (3) large-cell/anaplastic medulloblastoma. (medscape.com)
[ 1 ] Several subtypes of medulloblastoma have been recognized including: (1) desmoplastic/nodular type, (2) medulloblastoma with extensive nodularity, (3) large-cell variant, and (4) anaplastic medulloblastoma. (medscape.com)

In the hippocampus there are neural pathways involved in its circuitry including the perforant pathway , that provides a connectional route from the entorhinal cortex [2] to all fields of the hippocampal formation , including the dentate gyrus , all CA fields (including CA1), [3] and the subiculum . (wikipedia.org)
[ citation needed ] Note that the "old" name was primarily descriptive, evoking the pyramids of antiquity, from the appearance of this neural pathway in the medulla oblongata . (wikipedia.org)
Neural specificity of acrylamide action upon enzymes associated with oxidative energy-producing pathways. (cdc.gov)

The research group "Developmental Neurobiology and Regeneration" at the Department of Biomedicine, University Basel is seeking a postdoctoral scientist with a background in neuroscience and molecular and cell biology. (fens.org)
5-HTRs coupling to the Gq/11 pathway such as 5-HT2A/C-Rs are abundantly indicated in the brain and are molecular focuses on for atypical antipsychotic medicines and most hallucinogens7. (bioinbrief.com)

the dendritic arbor, the cell body, and the axon. (nih.gov)

Stem Cell Reports, 2020 Oct 13. (nih.gov)

Here, we find that this variation in modality arises from regulation of two features of the pathway response: the fraction of cells that show induction and their level of expression. (elifesciences.org)
In this work, we confirm and expand the observation that the pattern of GAL pathway induction can be either unimodal or bimodal depending on genetic background and pre-induction conditions. (elifesciences.org)

No Purkinje cell loss was observed as a result of one month intraperitoneal injection of ethanol. (jcimjournal.com)
Loss of cells in the nuclei of cranial nerves VII, X, and XII results in facial weakness and speech and swallowing difficulties. (medscape.com)

Ephrin ligands and their receptors, the Eph receptor (Eph) tyrosine kinases, are cell surface molecules that mediate commu-nication between cells. (123dok.org)

In a functional syncytium, electrical impulses propagate freely between cells in every direction, so that the myocardium functions as a single contractile unit. (wikipedia.org)

WTAP Mediated the N6-methyladenosine Modification of PDK4 to Regulate the Malignant Behaviors of Colorectal Cancer Cells In Vitro and In Vivo. (nih.gov)
Pluripotent cells can be differentiated into many different cell types in vitro. (biomedcentral.com)

Anatomy18

Organisms9

Diseases7

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment9

Psychiatry and Psychology1

Phenomena and Processes13

Disciplines and Occupations2

Cerebellum22

Neurons10

Climbing fibers1

Synapses5

Cerebellar Purkinje cell3

Neuron2

Granule2

Neuronal2

Pyramidal1

Degeneration2

Arborizations2

Postsynaptic4

Cerebrospinal fluid2

Afferent and efferent2

Synaptic plasticity2

Pathogenesis3

Parallel fibers1

Regulates3

Maturation2

Dendritic spines1

Axons6

Floccular1

Nucleus3

Neurotransmitter1

Phosphorylation4

Inhibition1

Excitatory1

Effector2

Dysfunction2

Protein4

Tissues5

Signal transduction1

Modulation1

Calcium4

Conduction2

Dendrites3

Ventricular1

Nerve2

Vesicular1

Cardiac1

Embryonic2

Proteins1

Depolarization2

Pluripotent stem1

Plasticity1

Dorsal1

Stimulation2

Stimulate3

Intrinsic1

Gene3

Medulloblastoma2

Neural3

Molecular2

Axon1

20201

Induction2

Loss2

Molecules1

Functional1

Vitro2