AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Otx Transcription FactorsTranscription FactorsTranscription, GeneticPromoter Regions, GeneticDNA-Binding ProteinsSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceTrans-ActivatorsHomeodomain ProteinsTranscriptional ActivationBinding SitesBasic Helix-Loop-Helix Transcription FactorsRNA, MessengerGene Expression Regulation, DevelopmentalProtein BindingNuclear ProteinsTranscription Factor AP-1Repressor ProteinsCell LineForkhead Transcription FactorsAmino Acid SequenceSignal TransductionDNAMutationBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2Cell DifferentiationCell NucleusTransfectionKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorCells, CulturedTranscription Factor TFIIDActivating Transcription Factor 3Paired Box Transcription FactorsNFATC Transcription FactorsReverse Transcriptase Polymerase Chain ReactionTranscription Initiation SiteSp3 Transcription FactorEnhancer Elements, GeneticNF-kappa BElectrophoretic Mobility Shift AssayZinc FingersActivating Transcription Factor 2Transcription Factor TFIIBGene Expression ProfilingRegulatory Sequences, Nucleic AcidCloning, MolecularE2F1 Transcription FactorRNA Polymerase IIMicrophthalmia-Associated Transcription FactorRecombinant Fusion ProteinsBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsPlasmidsGene ExpressionGATA3 Transcription FactorGATA Transcription FactorsGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsLuciferasesProtein Structure, TertiarySTAT1 Transcription FactorActivating Transcription FactorsIn Situ HybridizationCell Line, TumorTranscription Factor RelAE2F Transcription FactorsPhosphorylationOligonucleotide Array Sequence AnalysisHelix-Loop-Helix MotifsChromatinSequence Homology, Amino AcidSaccharomyces cerevisiaeModels, BiologicalMice, KnockoutSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Transcription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinNerve Tissue ProteinsPhenotypeProto-Oncogene ProteinsBlotting, WesternMice, TransgenicTranscription Factor TFIIIADrosophila Proteins
GenesOTX2MolecularNOTCHNeuralReceptorProteinsExpressionMechanismSpecificPax2EmbryonicFibroblast growthSeries of transcription factorsSignaling moleculesRegulatoryGeneSequenceFunctionsCellImportant
Genes9
  • TAZ-AS202 regulates the expression of a set of genes belonging to cancer-associated pathways, including WNT and EPH-Ephrin signaling. (bvsalud.org)
  • The molecular mechanism underlying TAZ-AS202 function does not involve change of TAZ expression or activity, but increases the protein level of the transcription factor E2F1, which in turn regulates the expression of a large set of target genes, including the EPHB2 receptor. (bvsalud.org)
  • Identification of transcription and processing signals of ribosomal genes of D. melanogaster. (cnr.it)
  • We found by quantitative real time PCR that NOTCH1, NOTCH2, Dll-1, Jagged-1, and NOTCH pathway downstream genes hes1, hey1, hey2, heyL were considerably decreased in ND-hMSCs after shifting them from normal culture medium to OD medium, indicating that NOTCH signalling was gradually suppressed during MSC osteogenesis. (vub.be)
  • When the NOTCH signalling inhibitor DAPT was added to MM-hMSCs in OD medium, we found that hes1 expression was suppressed while, RUNX2 expression, a key transcription factor for osteoblastogenesis, as well as ALP activity, osteogenic genes expression and mineralization deposition were all increased. (vub.be)
  • gatae and otx genes provide input into the pregastrular regulatory system of foxa , and Foxa represses its own transcription,resulting in an oscillatory temporal expression profile. (biologists.com)
  • NK genes are a group of homeobox transcription factors that are involved in various molecular pathways across bilaterians. (biomedcentral.com)
  • An underlying principle is that Otx marks target genes for head specification to be regulated positively or negatively by partner TFs through specific types of CRMs. (xenbase.org)
  • At the transition point, where the hindbrain system of segmentation gives way to regional patterning by local gradients in the midbrain, the most anterior hindbrain segment, rhombomere 1 (r1), expresses neither Hox or Otx genes and displays aspects of both patterning systems. (biomedcentral.com)
OTX21
Molecular1
  • However, the molecular mechanisms by which Otx and other transcription factors (TFs) interact with the genome to direct head formation are largely unknown. (xenbase.org)
NOTCH2
  • This implicates that the NOTCH signaling pathway remains in MM-hMSCs over-activated even in the presence of osteogenesis inducing signals. (vub.be)
  • In conclusion our data indicate that MM-hMSCs exhibit in vitro lower osteogenic differentiation ability compared to ND-hMSCs, and that this impairement is associated with an inappropriate NOTCH pathway deactivation during the osteogenesis process. (vub.be)
Neural3
  • Here, we use mathematical modeling to demonstrate that geometry dictates the neural-epidermal cell fate choice in the 32-cell stage ascidian embryo by a two-step process involving first the modulation of ERK signaling and second, the expression of the neural marker gene, Otx. (bvsalud.org)
  • Secreted from neighboring tissues, signaling molecules of the Wnt, Fgf, and Bmp families cooperate to activate a distinct combination of transcription factors at the neural plate border. (biomedcentral.com)
  • The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells. (unibas.ch)
Receptor1
  • Biological functions and signaling pathways mediated by gp130, a signal-transducing receptor component shared by the IL-6 family of cytokines. (nii.ac.jp)
Proteins1
Expression5
  • The model describes signal transduction by the ERK pathway that is stimulated by FGF and attenuated by ephrin, and ERK-mediated control of Otx gene expression, which involves both an activator and a repressor of ETS-family transcription factors. (bvsalud.org)
  • Considering the measured area of cell surface contacts with FGF- or ephrin-expressing cells as inputs, the solutions of the model reproduce the experimental observations about ERK activation and Otx expression in the different cells under normal and perturbed conditions. (bvsalud.org)
  • Combined expression analysis of Otx, Emx, Dlx and Otp during development and definition of brain segmentary identities. (cnr.it)
  • In this study, we observed that MM-hMSCs, especially for those from MM patients with bone lesions, exhibited in the presence of osteogenic differentiation (OD) medium, significantly decreased alkaline phosphatase (ALP) activity, reduced expression of specific osteogenic markers (OPN, BMP2, OTX and BSP) and impaired matrix mineralization, compared to ND-hMSCs. (vub.be)
  • By contrast, the development of the midbrain and forebrain, which lie within the Otx expression domain, is regulated by signalling centres generating graded patterning cues. (biomedcentral.com)
Mechanism1
  • Identification of an Otx gene-dosage dependent mechanism required for patterning of developing brain and proper positioning of midbrain-hindbrain isthmic organizer. (cnr.it)
Specific2
  • Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. (zfin.org)
  • Sequence-specific transcription factor that binds gene promoters and activates their transcription. (affbiotech.com)
Pax21
  • Subsequently, a series of transcription factors including Pax2 , Pax5 , Pax8 , En1 , En2 are expressed at the Otx 2- Gbx 2 boundary that are required for maintenance of the MHB organizer and specification of the midbrain territory. (biomedcentral.com)
Embryonic2
  • We propose a novel model for ectoderm regionalization, in which neural ectoderm is the default fate in the absence of TGF beta signaling, and suggest that the stomodeal and neural subcircuits that we uncovered may represent ancient regulatory pathways controlling embryonic patterning. (echinobase.org)
  • Each of these embryonic zones is patterned by a combination of genetic pathways and the influences of local signaling centres. (biomedcentral.com)
Fibroblast growth2
  • The caudalmost group constitutes the epibranchial placodes , which are located just dorsal to the region where the first through third pharyngeal pouches abut the cervical ectoderm (see Fig. 6.6A ). Their specification depends on signals (fibroblast growth factor [FGF] and bone morphogenetic protein [BMP]) emanating from the pharyngeal pouch endoderm. (clinicalgate.com)
  • Here, we show that fibroblast growth factor 21 (FGF21), a lipid metabolism-related hormone, may play a role in this relationship. (tokushima-u.ac.jp)
Series of transcription factors1
  • As for the latter, it has been long known that a series of transcription factors (TFs) involves the development of mdDA neurons, specifying cell types and controlling developmental patterns. (nih.gov)
Signaling molecules1
Regulatory4
  • First, for many developmental regulatory systems there is no convincing evidence that it is specific morphogenetic pathways per se that are conserved, rather than cell-type specification and differentiation processes. (silverchair.com)
  • Second, goosecoid was identified as a central player in a regulatory sub-circuit controlling mouth formation, while tbx2/3 emerged as a critical factor for differentiation of the dorsal ectoderm . (echinobase.org)
  • In various transcription factors with a key regulatory role, the homeobox sequence encodes a "homeodomain" DNA-binding motif. (bvsalud.org)
  • In this Review, we outline the signaling and transcription factors that drive vertebrate photoreceptor development and discuss how these function together in gene regulatory networks to control photoreceptor cell fate specification. (biologists.com)
Gene1
Sequence1
  • During transcription, a DNA sequence is read by an RNA polymerase, which produces a complementary, anti-parallel RNA strand called a primary transcript. (homeodomains.com)
Functions1
Cell2
  • 7. Loss of B cell identity correlates with loss of B cell-specific transcription factors in Hodgkin/Reed-Sternberg cells of classical Hodgkin lymphoma. (nih.gov)
  • Disclosed herein are methods for the in vitro differentiation of a precursor cell into definitive endoderm, which may further be differentiated into a human colonic organoid (HCO), via modulation of signaling pathways. (justia.com)
Important1