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  • intracellular
  • We conclude that Tor1 is more effective than Tor2 at providing rapamycin-sensitive Tor signaling under conditions of amino acid limitation, and that an intact class C Vps complex is required to mediate intracellular amino acid homeostasis for efficient Tor signaling. (genetics.org)
  • Following axotomy, the activation of multiple intracellular signaling cascades causes the expression of a cocktail of regeneration-associated transcription factors which interact with each other to determine the fate of the injured neurons. (frontiersin.org)
  • They also respond to intracellular signals to dynamically change their adhesive function to control the organization and mobility of cells in tissues as well as their physiological properties. (seattlechildrens.org)
  • inhibit
  • However, these deletions also inhibit some of the early microglial activation - within 24 h and long before the appearance of cell death, suggesting that these transcription factors may also interfere with the synthesis of injury signals from lesioned but not dying neurons. (frontiersin.org)
  • canonical
  • By establishing a reliable in vivo NLS assay based on confocal microscopy, we found that many canonical monopartite and bipartite classical NLSs (cNLSs) mediated nuclear import poorly in P. sojae . (frontiersin.org)
  • NLSs
  • These results showed that functional P. sojae PY-NLSs include an additional cluster of basic residues for efficient nuclear import. (frontiersin.org)
  • genes
  • Comparative transcriptomics profiling revealed that a set of genes, related to the ribosome, ribosome biogenesis, proteasome, and nitrogen metabolism, were significantly up- or down-regulated under nitrogen sufficient conditions, which could be regulated by the TOR signaling pathway. (biomedcentral.com)
  • Low concentration of nitrogen was beneficial for PMA biosynthesis, which could upregulate the expression of key genes involved in the PMA biosynthesis pathway. (biomedcentral.com)
  • Prominent among these genes, is the latency-associated nuclear antigen (LANA). (frontiersin.org)
  • divergent
  • Evolutionary studies have shown that core components of the TOR signaling network are conserved among divergent species and likely evolved from an archaic pathway of the last eukaryotic common ancestor [ 12 ]. (mdpi.com)
  • Gat1
  • In addition, TOR effector pathways play an important role, and loss of the NCR (nitrogen catabolite repression) gene regulators Gat1 and Gln3 reduced chlamydospore formation. (frontiersin.org)
  • Gzf3 interfered with Gat1 by nuclear sequestration and by competition at its own promoter. (asm.org)
  • stimulation
  • In reporter gene assays, addition of a TGF-β receptor inhibitor at various times after stimulation of the pathway with TGF-β1 showed that the inhibitor was ineffective if added 4 hours after the ligand, suggesting that the pathway was no longer active. (sciencemag.org)
  • Thus
  • Thus, cAMP-signaling is a second major pathway to control chlamydospore production. (frontiersin.org)
  • Using in vitro transport assays we showed that the pUL84 nuclear import required importin α, importin β, and Ran, thus following the classical importin-mediated import pathway. (asm.org)
  • metabolic
  • Although the metabolic steps of LD biogenesis are well known, the signals that govern LD dynamics are not clear yet. (asm.org)
  • cell
  • In this study, the effects of different nitrogen concentration on cell growth and PMA biosynthesis were investigated via comparative transcriptomics and proteomics analyses, and a related signaling pathway was also evaluated. (biomedcentral.com)
  • Cell growth and PMA biosynthesis might be mediated by the TOR signaling pathway in response to nitrogen. (biomedcentral.com)
  • Importantly, Wg pathway components have been found to affect stem cell maintenance and tumor progression. (genetics.org)
  • results
  • The rapid arrival of signals from the injured axon results in a remarkable shift of the injured neuron from a transmitting to a growth promoting phenotype. (frontiersin.org)