Veratrum AlkaloidsSignal TransductionTOR Serine-Threonine KinasesCell Line, TumorHedgehog ProteinsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktPhosphatidylinositol 3-KinasesXenograft Model Antitumor AssaysCell ProliferationProto-Oncogene Proteins B-rafReceptors, NotchSirolimusMAP Kinase Signaling SystemPyrrolesSulfonamidesMice, NudeAntineoplastic AgentsApoptosisMorpholinesIndolesEnzyme InhibitorsPyridinesPhosphorylationDrug Resistance, NeoplasmNeoplasmsDrug SynergismCell SurvivalCells, CulturedBlotting, WesternDisease Models, AnimalProtein-Serine-Threonine KinasesMutationGene Expression Regulation, Neoplastic