As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized in three stages and three discrete cell types. (analytica-world.com)
As the analyses showed, the entire biosynthetic pathway for the alkaloid vinblastine is organized into three stages and three discrete cell types. (hortidaily.com)
The researchers measured the concentrations of several intermediates in the metabolic pathway for vinblastine in single cells and were surprised by the results. (hortidaily.com)
Understanding the pathways involved in the biosynthesis of vinblastine enables chemical engineers to assemble vinblastine and many other related molecules used in a variety of drugs, says De Luca, who is Tier 1 Canada Research Chair in Plant Biochemistry and Biotechnology. (brocku.ca)
Members of the selection committee and the executive were very impressed with your outstanding contributions to the field of plant biochemistry, notably towards understanding the metabolic pathways involved in the biosynthesis of the anticancer drug vinblastine in the medicinal plant Catharanthus roseus ," CSPB President Daphne Goring wrote to De Luca earlier this year when informing him of his award. (brocku.ca)
5. Alam MM, Naeem M, Khan MMA and Uddin M. Vincristine and vinblastine anticancer catharanthus alkaloids: pharmacological applications and strategies for yield improvement. (jmp.ir)
Professor O'Connor also pointed out that this new study builds on the work of numerous other research groups around the world who contributed to the elucidation of the vinblastine pathway over the years. (healthproblemsnews.com)
The anticancer agents vinblastine and vincristine are bisindole alkaloids derived from coupling vindoline and catharanthine, monoterpenoid indole alkaloids produced exclusively by the Madagascar periwinkle (Catharanthus roseus). (uea.ac.uk)
Industrial production of vinblastine and vincristine currently relies on isolation from C. roseus leaves, a process that affords these compounds in 0.0003-0.01% yields. (uea.ac.uk)
Biosynthesis13
The research team studied the biosynthesis of two alkaloids from the plant Catharanthus roseus that are used in human medicine as anti-cancer agents. (analytica-world.com)
By using single-cell analyses, the scientists were able to discover new genes important for biosynthesis and show that the intermediates of the metabolic pathway accumulate in specific cell types. (analytica-world.com)
Led by Chenxin Li of UGA's Center for Applied Genetic Technologies in the College of Agricultural and Environmental Sciences, the research team studied the biosynthesis of two alkaloids from the Madagascar periwinkle (Catharanthus roseus) that are used as anti-cancer agents in human medicine. (hortidaily.com)
Published in Nature Chemical Biology, this collaborative work demonstrates a scalable de novo manufacturing platform for bioactive monoterpenoid indole alkaloids (MIAs, plant metabolites that possess various medicinal properties) in yeast and provides a foundation for further pathway refactoring toward microbial biosynthesis of both native and new-to-nature MIAs. (univ-tours.fr)
In this highlight published in ChemBioChem, we discuss how tropane alkaloid biosynthesis evolved via the recruitment of two distinct and convergent pathways in Erythroxylaceae and Solanaceae. (univ-tours.fr)
Review of abiotic and biotic elicitors' roles in secondary metabolites biosynthesis of periwinkle (Catharanthus roseus (Linn. (jmp.ir)
Amiri S, Fotovat R, Panahi B, Tarinezhad A, Mohammadi S A. Review of abiotic and biotic elicitors' roles in secondary metabolites biosynthesis of periwinkle ( Catharanthus roseus (Linn. (jmp.ir)
Since the terpenoid indole alkaloids (TIAS) biosynthesis pathway is adjustable, modification of underlying substrate and enzymes concentration by biotic and abiotic elicitors are important approaches for overproduction of these metabolites. (jmp.ir)
9. Hedhili S, Courdavault V, Giglioli-Guivarc'h N, Gantet P. Regulation of the terpene moiety biosynthesis of Catharanthus roseus terpene indole alkaloids. (jmp.ir)
However, due to the leaf-specific localization of vindoline biosynthesis, and the lack of production of this precursor in cell suspension and hairy root cultures of C. roseus, further elucidation of this pathway demands the development of reverse genetics approaches to assay gene function in planta. (uea.ac.uk)
Biochemistry is a component of his Methyl jasmonate, Complementary DNA, Open reading frame, Catharanthus roseus and Biosynthesis studies. (research.com)
His Biosynthesis study incorporates themes from Jasmonic acid, Regulation of gene expression, Catharanthus roseus and Oxidative phosphorylation. (research.com)
A pathway for stilbene biosynthesis was constructed in Escherichia coli with 4-coumaroyl CoA ligase 1 4CL1) from Arabidopsis thaliana and stilbene synthase (STS) cloned from Arachis hypogaea . (biomedcentral.com)
Indole2
The bHLH transcription factor BIS1 controls the iridoid branch of the monoterpenoid indole alkaloid pathway in Catharanthus roseus. (mpg.de)
Transient studies of nutrient uptake, growth, and indole alkaloid accumulation in heterotrophic cultures of hairy roots of Catharanthus roseus. (ac.ir)
Alkaloid2
Liscombe, DK & O'Connor, SE 2011, ' A virus-induced gene silencing approach to understanding alkaloid metabolism in Catharanthus roseus ', Phytochemistry , vol. 72, no. 16, pp. 1969-1977. (uea.ac.uk)
Vincristine (also named leurocristine) is a natural alkaloid isolated from the leaves of the Catharanthus roseus (commonly known as the Madagascar periwinkle). (smpdb.ca)
Madagascar3
And at the start of that road is a beautiful flower called Catharanthus roseus, commonly known as the Madagascar periwinkle, which set the course for decades of exploration. (brocku.ca)
Several medicinal plants are also added to this release, such as Madagascar periwinkle ( Catharanthus roseus ), red sage ( Salvia miltiorrhiza ) and flax ( Linum usitatissimum ). (plantcyc.org)
A potent inhibitor of cell division and used against lymphomas and testicular, breast, bladder and lung cancers, it is found in the leaves of Madagascar periwinkle ( Catharanthus roseus ). (healthproblemsnews.com)
Biosynthetic pathways3
The biosynthetic pathways of RIN and IRN are largely unknown. (biomedcentral.com)
The research team is confident that the organization of biosynthetic pathways for medicinally relevant alkaloids in Catharanthus roseus is not an isolated phenomenon. (hortidaily.com)
The genome mining of secondary metabolites produced by A. fumigatus , A. nidulans , A. niger , and A. terreus revealed unique biosynthetic gene clusters and biosynthetic pathways 9 . (nature.com)
Periwinkle1
6. Amiri S, Fotovat R, Tarinejad A, Panahi B, Mohammadi S.. In vitro regeneration of periwinkle (Catharanthus roseus L.) and fidelity analysis of regenerated plants with ISSR Markers. (jmp.ir)
Metabolic pathways2
In a new study published in Nature Chemical Biology, an international team of researchers from the University of Georgia, USA, and the Max Planck Institute for Chemical Ecology in Jena, Germany, presents a promising strategy for elucidating metabolic pathways for plant compounds of medicinal importance. (analytica-world.com)
An international team of researchers from the University of Georgia and the Max Planck Institute (MPI) for Chemical Ecology in Germany have discovered a promising strategy to decode the metabolic pathways for plant compounds important in medical treatments, according to a new study published in Nature Chemical Biology. (hortidaily.com)
Compounds1
Having assembled the genetic pathway and the formidable chemical structures, the team are now in a position to use the information to create more compounds much more quickly using synthetic biology techniques. (healthproblemsnews.com)
Genes7
Most DEGs were involved in plant hormone signal transduction, plant-pathogen interaction and phenylalanine metabolism, and the genes significantly up-regulated in PI 114490 at 6 DPI were associated with defense response pathways. (frontiersin.org)
In addition, analysis of genes expressed simultaneously in a particular cell type has helped us identify new players in this metabolic pathway, said Robin Buell, the Georgia Research Alliance (GRA) Eminent Scholar Chair in Crop Genomics at UGA. (hortidaily.com)
Kalra, A. Endophytes of opium poppy differentially modulate host plant productivity and genes for the biosynthetic pathway of benzylisoquinoline alkaloids. (thelondonbridged.com)
But the new study - lead author Dr Lorenzo Caputi - which appears today in the peer-review journal Science , uses modern genome sequencing techniques to identify the final missing genes in the pathway. (healthproblemsnews.com)
The utility of this approach in understanding gene function in C. roseus leaves is demonstrated by silencing known vindoline biosynthetic genes previously characterized in vitro. (uea.ac.uk)
catharanthus roseus genes regulated differentially by mollicute infections. (liverpool.ac.uk)
Metabolic engineers tinker with the series of reactions that the host organisms use to build new molecules, adding genes for new enzymes that reshape these natural synthetic pathways. (mit.edu)
Organism1
On the other hand, the complexity of plant synthetic pathways means that in many cases, it may be easier to modify the plant rather than try to reconstitute the entire plant pathway in a different organism such as bacteria. (mit.edu)
Apocynaceae2
Catharanthus roseus is a perennial species of flowering plant in the family Apocynaceae. (stuartxchange.org)
7. Chen Q, Lu X, Guo X, Guo Q and Li D. Metabolomics characterization of two apocynaceae plants, Catharanthus roseus and Vinca minor, using GC-MS and LC-MS methods in combination. (jmp.ir)
Enzymes1
4. Dugede Bernonville T, Clastre M, Besseau S, Oudin A, Burlat V, Glévarec G, Lanoue A, Papon N, El-Sayed M. and Verpoorte R. Growth, metabolic profiling and enzymes activities of Catharanthus roseus seedlings treated with plant growth regulators. (jmp.ir)
Natacha studied the signaling pathways involved in the plant response to insect herbivory. (unil.ch)
8. Sain M and Sharma V. Catharanthus roseus (An anti-cancerous drug yielding plant). (jmp.ir)
Leaf2
The second stage of the biosynthetic pathway is expressed only in cells of the epidermis, the layer of cells that cover the leaves, and the last known steps of the biosynthetic pathway are expressed exclusively in idioblasts, a rare cell type of the leaf," Chenxin Li summarizes the results. (analytica-world.com)
Read our new study with Pr Chao SUN's group, on single-cell RNA sequencing of Catharanthus roseus leaf published in Nature plants! (univ-tours.fr)
Enzyme1
the enzyme is involved in the 2-C-methyl-D-erythritol-4-phosphate/terpenoid metabolic pathway part of the iridoid pathway, overview. (brenda-enzymes.info)
Gene2
He revealed a crucial role for MYC2, MYC3, and MYC4 as master regulators of defense gene expression in the JA pathway. (unil.ch)
A VIGS method was developed herein to investigate gene function in C. roseus plants using the pTRV vector system. (uea.ac.uk)
Cultures1
Radioactive tracer studies in cell cultures of Catharanthus roseus established the steps of the BR metabolic pathway. (5htreceptor.com)
Luca1
De Luca says the molecular pathways can be transferred to simple organisms such as bacteria or yeast for fermentation processes or to tobacco or other plants that can be cultivated locally. (brocku.ca)
Understanding1
This updated version should ease evolutionary studies leading to a better understanding of MIA biosynthetic pathway evolution. (univ-tours.fr)
Regulator1
COG1 encodes a Dof-type transcription factor found previously to act as a negative regulator of the phytochrome signaling pathway. (cas.cz)
Species2
Catharanthus roseus (L.) G.Don is an accepted species. (stuartxchange.org)
In this release we introduce 54 new species-specific metabolic pathway databases, which brings the total number of species-specific databases to 76. (plantcyc.org)
Cell1
It induced apoptosis, suppressed cell migration and invasion, blocked cell cycle and phosphatidylinositol 3-kinase/ protein kinase B signaling pathway. (ijpsonline.com)
Flower1
Stylish, modern gardens are often a mix of stone pathways and flower beds. (allergicliving.com)
Leaves1
Friederike discovered that egg deposition on Arabidopsis leaves inhibits defenses against caterpillars through antagonism between SA and the JA pathways. (unil.ch)