AnatomyOrganismsChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation Science
Transcription FactorsTranscription, GeneticDNA-Binding ProteinsPromoter Regions, GeneticSp1 Transcription FactorGene Expression RegulationMolecular Sequence DataBase SequenceBinding SitesTranscriptional ActivationTrans-ActivatorsRNA, MessengerBasic Helix-Loop-Helix Transcription FactorsProtein BindingNuclear ProteinsTranscription Factor AP-1Cell LineRepressor ProteinsForkhead Transcription FactorsAmino Acid SequenceHomeodomain ProteinsSignal TransductionGene Expression Regulation, DevelopmentalDNABasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2MutationTransfectionCell NucleusCell DifferentiationKruppel-Like Transcription FactorsTranscription Factors, TFIIChromatin ImmunoprecipitationGenes, ReporterYY1 Transcription FactorHeLa CellsSTAT3 Transcription FactorGATA4 Transcription FactorTranscription Factor TFIIDCells, CulturedActivating Transcription Factor 3NFATC Transcription FactorsSp3 Transcription FactorTranscription Initiation SiteNF-kappa BReverse Transcriptase Polymerase Chain ReactionZinc FingersPaired Box Transcription FactorsElectrophoretic Mobility Shift AssayActivating Transcription Factor 2Transcription Factor TFIIBEnhancer Elements, GeneticRegulatory Sequences, Nucleic AcidE2F1 Transcription FactorRNA Polymerase IIGene Expression ProfilingPlasmidsCloning, MolecularBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsMEF2 Transcription FactorsRecombinant Fusion ProteinsGene ExpressionGATA3 Transcription FactorGATA1 Transcription FactorGATA2 Transcription FactorGene Expression Regulation, FungalTCF Transcription FactorsGATA Transcription FactorsMicrophthalmia-Associated Transcription FactorSTAT1 Transcription FactorLuciferasesProtein Structure, TertiaryActivating Transcription FactorsTranscription Factor RelAE2F Transcription FactorsSaccharomyces cerevisiaeCell Line, TumorChromatinPhosphorylationOligonucleotide Array Sequence AnalysisHelix-Loop-Helix MotifsSaccharomyces cerevisiae ProteinsGene Expression Regulation, PlantGATA6 Transcription FactorActivating Transcription Factor 4Models, BiologicalTranscription Factor 7-Like 1 ProteinActivating Transcription Factor 1Cyclic AMP Response Element-Binding ProteinSequence Homology, Amino AcidTranscription Factor TFIIIAProto-Oncogene ProteinsBlotting, WesternMice, KnockoutTATA BoxNFI Transcription FactorsSequence AlignmentModels, GeneticTumor Cells, CulturedDown-Regulation
TargetsE2F3ApoptosisMoleculesTumorigenesisEnrichmentMRNAGenesCancersProgressionInvolveRolesEncodesE2FsCellularRegulatoryPromotesBiologicalUpstreamIdentificationRegulatorExpressionEndogenousGene transcriptionStimulatesCardiacBreast cancerCellsProteinsMolecularImportant rolePotentialCancerFamilyAnalysisTranslationHumanRisk factorTreatmentStudyComplexSource
Targets6
  • De novo resistance to palbociclib implicates a variety of targets both upstream and downstream of the CDK4/6 to Rb pathway. (wikipedia.org)
  • HGWD has important active compounds such as quercetin, kaempferol, and beta-sitosterol, which exert its therapeutic effect on multiple targets and multiple pathways. (hindawi.com)
  • Certain components of these pathways may serve as potential targets for oncological therapy. (journalsmededu.pl)
  • E2F2/5/8 Serve as Potential Prognostic Biomarkers and Targets for Human Ovarian Cancer. (journalsmededu.pl)
  • A database to provide information about the known and explored therapeutic protein and nucleic acid targets, the targeted disease, pathway information and the corresponding drugs directed at each of these targets. (idrblab.net)
  • The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
E2F31
  • E2Fs, a set of genes that encode a family of transcription factors (TFs) in most higher eukaryotes, are generally divided into the following three subfamilies: transcriptional activator E2Fs (E2F1-E2F3), repressor E2Fs (E2F4-E2F5), and inhibitor E2Fs (E2F6-E2F8) [14,15]. (fortunepublish.com)
Apoptosis3
  • Cancer genetics, DNA damage response, apoptosis, cell cycle My current research is focused on two transcription factors that respond to DNA damage and play important roles in regulating tumor development. (mdanderson.org)
  • Furthermore, we showed that necrosis and apoptosis inhibitors conferred minimal defensive results against cell loss of life, while inhibitors from the necroptosis pathway blocked cell loss of life significantly. (immune-source.com)
  • 12],[13] The results of other studies showed that the function of mir-125b in NSCLC is in the apoptosis pathway,[14] proliferation, invasion, and migration of NSCLC cells. (ccij-online.org)
Molecules1
  • In this study, we aim to identify the key molecules and signaling pathways by analyzing the RNA-seq data. (researchsquare.com)
Tumorigenesis3
  • E2F transcription factor 2 (E2F2) protein is the transcription factor that plays an important role in tumorigenesis. (journalsmededu.pl)
  • RB1 in cancer: different mechanisms of RB1 inactivation and alterations of pRb pathway in tumorigenesis. (journalsmededu.pl)
  • Gene mutations and aberrant signaling pathways play key roles in GBC tumorigenesis. (biomedcentral.com)
Enrichment2
  • Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. (sagepub.com)
  • Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. (sagepub.com)
MRNA2
  • An essential E box in the promoter of the gene encoding the mRNA cap-binding protein (eukaryotic initiation factor 4E) is a target for activation by c-myc. (idrblab.net)
  • MicroRNAs are small evolutionarily conserved nucleotide sequences that regulate gene expression after transcription, by mRNA degradation or inhibition of translation. (ccij-online.org)
Genes2
Cancers1
  • presence of DNA pathway members( DSBs) is gamma cancers of the MRN pro-B-cell, been of MRE11A, RAD50 and NBN( NBS1). (erik-mill.de)
Progression2
  • E2F2 promotes lung adenocarcinoma progression through B-Myb- and FOXM1-facilitated core transcription regulatory circuitry. (journalsmededu.pl)
  • Long noncoding RNAs (lncRNAs) regulate a number of physiological and pathological processes, including gene transcription and translation, chromatin modification, cell cycle progression, cell proliferation, and oncogenic and tumor-suppressive signals in cancer 6 . (researchsquare.com)
Involve2
  • The objective of the study is to provide a summary of the current knowledge on the neoplastic pathways that involve E2F2. (journalsmededu.pl)
  • The mechanisms underlying the occurrence and development of GBC may involve aberrant alterations of multiple molecular pathways. (biomedcentral.com)
Roles1
  • The expression pattern of mir-125b could be useful to follow-up on the biological pathways that have essential roles in these diseases. (ccij-online.org)
Encodes1
  • The gene, which is called MYBL2 , encodes a transcription factor that helps to control the cell division cycle. (elifesciences.org)
E2Fs1
  • Although emerging evidence indicates that E2Fs are implicated in various cancer types, the diverse expression patterns and prognostic values of E2F transcription factors in SKCM have yet to be elucidated. (fortunepublish.com)
Cellular1
  • The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescence. (journalsmededu.pl)
Regulatory1
  • From the single-cell transcriptomic data a Bayesian algorithm generated a unified lineage tree, and predicted novel regulatory transcription factors. (uth.edu)
Promotes1
Biological1
  • The KEGG and GO analyses indicated 'Human T − cell leukemia virus 1 infection' and 'Hippo signaling pathway' were the main affected biological processes. (researchsquare.com)
Upstream1
  • Ear2 is an orphan nuclear hormone receptor that belongs to the chicken ovalbumin upstream promoter-transcription factors (COUP-TF) gene family [ 14 ]. (biomedcentral.com)
Identification1
  • Identification of positively and negatively acting elements regulating expression of the E2F2 gene in response to cell growth signals. (idrblab.net)
Regulator1
  • To further explore the molecular function of Rasd1, we performed a yeast two-hybrid screen and identified Ear2, a negative regulator of renin transcription, as an interaction partner of Rasd1. (biomedcentral.com)
Expression1
  • Indeed, it has been shown that miRNAs play an important role in gene expression, mainly when associated with the monitoring of several cell and metabolic pathways, being also an essential component of the gene silencing machinery in most eukaryotic organisms ( 4 , 8 ). (frontiersin.org)
Endogenous2
  • The main risk factor is exposure to endogenous and exogenous estrogens associated with obesity, diabetes, and the use of tamoxifen 5 . (researchsquare.com)
  • Moreover, real-time RT-PCR showed upregulation of endogenous renin transcription in As4.1 cells over-expressing Rasd1. (biomedcentral.com)
Gene transcription1
  • Interestingly, real-time PCR and translation inhibition studies revealed that survivin was over-expressed partially through the up-regulation of protein translation instead of gene transcription in A549 cancer cells. (biomedcentral.com)
Stimulates1
  • opposed factor is and stimulates group of transport proteins to DNA DSBs( Beamish et al. (erik-mill.de)
Cardiac1
  • Cardiac hypertrophy is an important and independent risk factor for the development of cardiac myopathy that may lead to heart failure. (mdpi.com)
Breast cancer2
  • In March 2017, the FDA granted regular approval to palbociclib for hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative advanced or metastatic breast cancer, in combination with an aromatase inhibitor. (wikipedia.org)
  • The drug was approved for use in the European Union in November 2016 as a treatment for hormone receptor (HR) positive, human epidermal growth factor receptor 2 (HER2) negative locally advanced or metastatic breast cancer either in combination with an aromatase inhibitor or, for women who have received prior endocrine therapy, in combination with fulvestrant. (wikipedia.org)
Cells1
  • To further identify the potential signaling pathways after the knockdown of LINC00958 in Ishikawa cells, we performed the KEGG and GO analyses (Figure 2). (researchsquare.com)
Proteins1
Molecular1
  • Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. (novusbio.com)
Important role1
  • The mechanisms of radioresistance are still poorly understood, despite it has been suggested that miRNAs play an important role in cell signaling pathways. (frontiersin.org)
Potential1
  • Domańska J, Poboży K, Domański P, Fudalej M, Deptała A, Badowska-Kozakiewicz A. The role of E2F2 in signaling pathways associated with cancer pathogenesis and potential treatment: A review of current studies. (journalsmededu.pl)
Cancer2
Family1
Analysis1
  • Moreover, 739 GO entries of HGWD on RA were identified, and 79 pathways were screened based on GO and KEGG analysis. (hindawi.com)
Translation1
Human2
  • Disruption of the p16/cyclin D1/retinoblastoma protein pathway in the majority of human hepatocellular carcinomas. (journalsmededu.pl)
  • Sp1 cooperates with c-Myc to activate transcription of the human telomerase reverse transcriptase gene (hTERT). (idrblab.net)
Risk factor1
  • Abnormal bite force is an important risk factor for oral and maxillofacial disorders, which is a critical dilemma that dentists face every day without effective solutions. (bvsalud.org)
Treatment1
  • It was confirmed that the TNF signaling pathway and IL-17 signaling pathway are important pathways of HGWD in the treatment of RA. (hindawi.com)
Study1
  • Finally, our study showed that Rasd1 missense mutations not only attenuate their physical interaction with Ear2 but also abolish their ability to counteract repression of renin transcription mediated by Ear2. (biomedcentral.com)
Complex1
Source1