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  • Metabolic Pathways
  • The main research objectives of the project, as stated in Annex I of the application, is to decipher the cross-talk between the chylomicron and HDL metabolic pathways with adipose and hepatic tissues in the development of diet-induced obesity, type II diabetes and NAFLD. (europa.eu)
  • During the first reporting period, we focused our studies on the chylomicron metabolic pathways. (europa.eu)
  • aorta
  • The aim of this study was to examine tissue Ang II-forming activities and to identify the responsible enzyme in several organs (lung, heart, and aorta) in various species (human, hamster, rat, rabbit, dog, pig, and marmoset). (ahajournals.org)
  • Aorta exhibited a relatively high total Ang II-forming activity, with a predominance of chymaselike activity in all of the species except rabbit and pig, in which ACE was dominant. (ahajournals.org)
  • Abstract
  • Abstract -Angiotensin (Ang) II plays an important role in cardiovascular homeostasis, not only in the systemic circulation but also at the tissue level, and is involved in the remodeling of the heart and vasculature under pathological conditions. (ahajournals.org)
  • enzymes
  • Several other enzymes have also been reported to produce Ang II either from angiotensinogen or Ang I. 9 The biological demonstration of an alternative pathway for Ang II formation to ACE was reported by Cornish et al 10 in the hamster cheek pouch and by Trachte and Lefer 11 in the cat cardiac papillary muscle. (ahajournals.org)
  • 17 In these biological studies, however, the enzymes that are responsible for non-ACE-dependent Ang II formation were not identified. (ahajournals.org)
  • 2018
  • 210. D Mehn, IM Rio-Echevarria, D Gilliland, M Kaiser, K Vilsmeier, P Schuck, W. Wohlleben (2018) Identification of nanomaterials: A validation report of two laboratories using analytical ultracentrifugation with fixed and ramped speed options. (analyticalultracentrifugation.com)
  • Estrogen
  • The smallest construct that maintained E 2 responsiveness, the −256/+397 construct, does not contain a typical estrogen-responsive element. (ahajournals.org)
  • elucidate
  • 1 2 ACE inhibitors have also helped to elucidate the existence of alternative Ang II-forming pathways, since Ang II is formed despite chronic treatment with ACE inhibitor. (ahajournals.org)
  • Significance
  • Thus, the pathophysiological significance of alternative Ang II-forming pathways remained unclear, until Urata et al 18 19 found in humans that most of the cardiac Ang II formation in vitro was due to chymase, which was the most potent and specific Ang II-forming serine proteinase ever described. (ahajournals.org)
  • inhibitor
  • ACE inhibitor-insensitive Ang II formation has also been observed in the arteries of dogs, monkeys, and humans 12 13 and in rat hindlimb, 14 ischemic dog heart, 15 16 and hamster heart. (ahajournals.org)
  • angiotensin
  • The responsible enzyme for pulmonary Ang II formation was angiotensin I-converting enzyme (ACE) in all of the species except the human lung, in which a chymaselike enzyme was dominant. (ahajournals.org)
  • development
  • The report of recognizable cognitive changes in nuns half a century before the development of frank Alzheimer disease ( 2 ) could conceivably be used as a pretext to justify genetic screening for jobs that require intellectual capacity. (acpjc.org)
  • formation
  • To study the pathophysiological roles of ACE-independent Ang II formation, one should choose species and/or organs that have Ang II-forming pathways similar to those in humans. (ahajournals.org)
  • The first biochemical description of an alternative pathway for Ang II formation to ACE was reported by Boucher et al 4 for tonin in the rat salivary gland, followed by Arakawa et al for trypsin 3 5 and kallikrein, 6 Tonnesen et al 7 for cathepsin G, and Wintroub et al 8 for human and rat skin chymotryptic enzyme. (ahajournals.org)
  • common
  • The Alzheimer disease phenotype may represent a final common pathway of degenerative changes that are probably caused by many factors. (acpjc.org)
  • studies
  • In support of these findings, epidemiological studies have reported reduced cancer risk ( 9 ) and associated mortality ( 10 ) in type 2 diabetic patients treated with metformin compared with other antidiabetes drugs. (diabetesjournals.org)
  • activation
  • However, when the same set of transfections was performed by the calcium phosphate precipitation method, the E 2 effect on the apo A-I content in the culture medium and on transcription activation was nearly abolished. (ahajournals.org)
  • species
  • In the heart, the highest total Ang II-forming activity was observed in humans, and a chymaselike enzyme was dominant in all of the species except rabbit and pig. (ahajournals.org)
  • content
  • A time-course experiment indicated that there was no E 2 -dependent (10 μmol/L) increase in apo A-I medium content at 1 hour and 2 hours and that apo A-I was 165% of controls at 6 hours and 440% at 24 hours. (ahajournals.org)