Of course, the same has also been shown for sub-sets of 'membrane-clock' ion currents, illustrating the redundancy of mechanisms involved in maintaining such basic functionality as the heartbeat, a theme that is common for vital physiological systems. (ox.ac.uk)
Commence in a critical examination of the physiological and pathophysiological mechanisms affecting individuals. (ucf.edu)
Building on these unique abilities, I will also investigate physiological and pathophysiological modulations of presynaptic plasticity. (europa.eu)
Evidence supporting the multiple mechanisms by which job stress contributes to cardiovascular diseases (and other chronic health conditions) comes from a vast body of international scientific literature that includes epidemiologic studies, patho-physiological studies of animals and humans, and behavioral studies. (cdc.gov)
This breakthrough has significantly advanced our knowledge of various physiological and pathophysiological processes in the brain. (lu.se)
Molecular mechanisms6
Multidrug resistance in cancer: understanding molecular mechanisms, immunoprevention and therapeutic approaches. (nature.com)
As such, ongoing research has attempted to determine the precise molecular mechanisms of the disorder. (frontiersin.org)
However, the exact molecular mechanisms of diabetes still need to be explored. (frontiersin.org)
The molecular mechanisms of cardiac remodeling during IHD are complex [ 2 - 4 ]. (hindawi.com)
The ambitious goal of this project is to reveal the molecular mechanisms of presynaptic plasticity in the vertebrate brain. (europa.eu)
His research focuses on pathophysiological and molecular mechanisms in human sensory neuropathies and chronic pain syndromes. (imperial.ac.uk)
Dysfunction3
Research has shown that overuse degeneration and aging also share some pathophysiological mechanisms including mitochondrial dysfunction, increased apoptosis, abnormal modulation of autophagy, decline in satellite cells, increased generation of reactive oxygen species, and modification of signalling and stress response pathways. (frontiersin.org)
2021). Mutation-specific pathophysiological mechanisms define different neurodevelopmental disorders associated with SATB1 dysfunction. (mpi.nl)
Notably, the mechanisms that link synaptic dysfunction with the manifestations of CAs can be explained by disruption of the "internal models. (springer.com)
Elucidate the mechanisms1
However, further research is required in this direction to elucidate the mechanisms by which orexins play a role in different testicular functions and effect of orexins on semen quality. (researchgate.net)
Processes1
Consequently, different adjunctive therapies aimed at modulating malaria pathophysiological processes are currently being tested. (fiocruz.br)
Cortical1
Cortical mechanisms of sensory and affective integration, however, remain poorly defined. (iasp-pain.org)
Immunological1
Considering gaseous administration as a promising adjunctive treatment against severe malaria cases, we review here the pathophysiological mechanisms and the immunological aspects of such therapies. (fiocruz.br)
Reports suggest that orexins may be the key brain components to mediate the mechanism of obesity resistance. (researchgate.net)
Neurophysiological mechanisms of deep brain stimulation across spatiotemporal resolutions. (medscape.com)
Brain plasticity: From pathophysiological mechanisms to therapeutic applications. (bvsalud.org)
Obesity1
Pathophysiological mechanisms linking obesity and esophageal adenocarcinoma. (bmj.com)
Cardiac2
Mechano-sensitivity of cardiac pacemaker function: pathophysiological relevance, experimental implications, and conceptual integration with other mechanisms of rhythmicity. (ox.ac.uk)
As the combined contributions of the various underlying oscillatory mechanisms are integrated at the pacemaker cell level into a single output--a train of pacemaker action potentials--we will not adhere to a metaphor that implies separate time-keeping units ('clocks'), and rather focus on cardiac pacemaking as the result of interactions of a set of coupled oscillators, whose individual contributions vary depending on the pathophysiological context. (ox.ac.uk)
Chronic4
For this reason, you need to understand the pathophysiological mechanisms of chronic asthma and acute asthma exacerbation. (savvyessaywriters.org)
The post Describe the pathophysiological mechanisms of chronic asthma and acute asthma exacerbation appeared first on Academic Research Bureau. (savvyessaywriters.org)
chronic changes in CO 2 allow the renal compensatory mechanism more time to adjust bicarbonate and pH accordingly. (medscape.com)
The concomitant presence of these different pathologies can be explained either by their intertwined pathophysiological mechanisms, or by the side effects of the various medications taken in the context of these chronic diseases. (who.int)
Investigate1
In a recent article published in bioRxiv * server, researchers used a preclinical animal model to investigate early pathophysiological mechanisms potentially underlying post-acute sequelae of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (PASC), especially its neurological symptoms. (polymerelektronik.org)
Context1
Studies are discussed in a pathophysiological or developmental context. (iospress.com)
Might dopamine release deficits prior to neurodegeneration be a pathophysiological hallmark of Parkinson's disease? (medscape.com)
Specifically1
Among the main mechanisms of this multidrug resistance is the overexpression of ATP-binding cassette (ABC) transporters that mediate drug efflux, and, specifically, ABCB1, ABCG2 and ABCC1 are known to cause cancer chemoresistance. (nature.com)
Important4
Hence, characteristics of the olfactory epithelium and pyriform cortex/amygdala may be important in PASC and its early pathophysiological symptoms. (polymerelektronik.org)
A review of migraine and cluster headache emphasizes how their shared pathophysiological pathways may be important for identifying future treatments. (ajmc.com)
A review, published by The Journal of Headache and Pain, evaluated past and current literature involving the phenotype, pathophysiology, triggers, imaging findings, and treatment options of migraine and cluster headache and emphasized how their shared pathophysiological pathways may be important for identifying future treatments. (ajmc.com)
These observations raise an important question on possible shared pathophysiological mechanisms. (ajmc.com)
Reveal1
Understanding the role of sTREM2 in AD may reveal new pathological mechanisms and lead to the identification of therapeutic targets. (lu.se)
Dynamics1
In this review, we discuss possible roles of mechano-sensitive mechanisms for the entrainment of membrane current dynamics and calcium-handling. (ox.ac.uk)
Review3
The review also explained that most of the drugs used for cluster headache prophylaxis also showed efficacy in migraine prophylaxis-demonstrating the similarities of their basic pathophysiological mechanisms. (ajmc.com)
This mini-review summarizes the pathophysiological mechanisms and aims to establish the basis of "auto-antibody-induced cerebellar synaptopathies. (springer.com)
AU - Cutolo,M, AU - Cimmino,M A, AU - Perez-Ruiz,F, PY - 2017/10/14/entrez PY - 2017/10/14/pubmed PY - 2018/7/17/medline SP - 4186 EP - 4195 JF - European review for medical and pharmacological sciences JO - Eur Rev Med Pharmacol Sci VL - 21 IS - 18 N2 - OBJECTIVE: Hyperuricemia leading to urate crystal formation in tissues represents the pathophysiological mechanism of gout. (unboundmedicine.com)
Cancer2
High-resolution structures, biophysical and in silico studies have led to tremendous progress in understanding the mechanism of drug transport by these ABC transporters, and several promising therapies, including irradiation-based immune and thermal therapies, and nanomedicine have been used to overcome ABC transporter-mediated cancer chemoresistance. (nature.com)
We suggest that current information regarding the structure, mechanism and regulation of ABC transporters should be used in clinical trials to improve the efficiency of chemotherapeutics for patients with cancer. (nature.com)
Researchers1
By selectively activating or inhibiting specific neurons using optogenetics, researchers have been able to elucidate the underlying mechanisms and identify key players involved in epileptic activity. (lu.se)
Research1
The goal of their research is to translate discoveries of the pathophysiological mechanisms into new therapies for HAND. (hopkinsmedicine.org)
Major1
The two major mechanisms of stroke consist of ischemia and haemorrhage. (bartleby.com)
Release3
What are the mechanisms by which these release deficits occur? (medscape.com)
This can contribute to biofilm dispersal, and provides a mechanism for the release of extracellular DNA (eDNA) within biofilms. (southampton.ac.uk)
First, since chained inhibitory neurons shape the output signals through the mechanism of disinhibition/inhibition, impairments of GABA release and LTD distort the conversion process from the "internal model" to the output signals. (springer.com)
Exact1
Exact pathophysiological mechanisms of bipolar disorder have not been sufficiently clarified. (researchgate.net)
Effect1
Clarification of the mechanism of this effect will enable an understanding of how impaired 5-HT activity contributes to the subjective experience of depression. (ox.ac.uk)
Cell1
He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)