• Pathology of Human Coronary and Carotid Artery Atherosclerosis and Vascular Calcification in Diabetes Mellitus. (nih.gov)
  • AHA classification of coronary and carotid atherosclerotic plaques by grating-based phase-contrast computed tomography. (nih.gov)
  • They assessed the extent and severity of atherosclerosis in the aorta, coronary, carotid, and cerebral arteries, demonstrating that the cerebral arteries were free from atherosclerosis up to the fourth decade, almost 20 to 30 years later than extracranial arteries like coronary and carotid artery [ 5 - 7 ]. (j-stroke.org)
  • We sought to determine differences with cardiovascular magnetic resonance (CMR) in the morphology and composition of the carotid arteries between individuals with angiographically-defined obstructive coronary artery disease (CAD, ≥ 50% stenosis, cases) and those with angiographically normal coronaries (no lumen irregularities, controls). (biomedcentral.com)
  • 50.8% CAD cases) were imaged with a multi-sequence, carotid CMR protocol at 1.5T. For each segment of the carotid, lumen area, wall area, total vessel area (lumen area + wall area), mean wall thickness and the presence or absence of calcification and lipid-rich necrotic core were recorded bilaterally. (biomedcentral.com)
  • Carotid calcification was related to CAD status in both males and females. (biomedcentral.com)
  • We have used immunohistochemical analysis to investigate the expression of CD105-positive vessels in both large (carotid) and medium calibre (coronary and middle cerebral artery, MCAs) diseased vessels in an attempt to identify any correlation with plaque growth, stage and complication/type. (biomedcentral.com)
  • Here we show, that carotid arteries expressed intimal neovascularization associated with CD105-positive endothelial cells, concomitant with increased inflammation in early stage lesions, preatheroma (I-III) whilst they were not present in coronary plaques of the same grade. (biomedcentral.com)
  • Cardiac and coronary angiography were introduced into practice in the 1940s to 1960s by radiologists and cardiologists working competitively and collaboratively. (acr.org)
  • Therapeutic cardiac interventions, particularly coronary artery interventions, became possible because of the pioneering work of Charles Dotter (angioplasty) and Melvin Judkins (angiography), with Andreas Gruentzig subsequently performing the first coronary balloon angioplasty in the late 1970s. (acr.org)
  • Intracoronary imaging techniques can assess coronary plaques beyond luminal assessment (i.e. coronary angiography) and can visualise atheromatous plaques in vivo . (ecrjournal.com)
  • Recent advances in computer vision and machine learning technology have enabled the automated analysis of coronary angiography. (jmir.org)
  • The aim of this paper is to validate the performance of artificial intelligence-based quantitative coronary angiography (AI-QCA) in comparison with that of intravascular ultrasound (IVUS). (jmir.org)
  • Coronary angiography and echocardiography results revealed mobile lesions and plaques in aortic valve. (imjsu.org)
  • Progressive lysosomal lipid accumulation leads to the characteristic liver pathology and dysfunction (including hepatomegaly, liver fibrosis and/or cirrhosis, and elevated serum transaminases), dyslipidemia (elevated serum LDL-cholesterol and triglycerides, with normal to low HDL-cholesterol concentrations), premature atherosclerosis, splenomegaly and, eventually, end-stage liver failure. (orpha.net)
  • We examined the association of inflammation and progression of coronary artery calcification (CAC)-a marker of subclinical atherosclerosis-in adults with and without type 1 diabetes. (silverchair.com)
  • Not only started later in life, ICAS was much slighter in the amount and extent than aorta and coronary artery atherosclerosis for all decades [ 5 , 8 ]. (j-stroke.org)
  • The relationship between serum Lp (a) and coronary artery calcification (CAC), a measure of subclinical coronary artery atherosclerosis, has not been extensively explored. (elsevierpure.com)
  • In women, Lp(a) alone may be an independent risk factor for coronary atherosclerosis, while in men, Lp (a) may confer higher risk conditional on the presence and level of other risk factors. (elsevierpure.com)
  • The role of Lp (a) in the prediction and pathogenesis of subclinical coronary atherosclerosis needs to be further elucidated. (elsevierpure.com)
  • [6] Coronary artery disease, stroke, and peripheral artery disease involve atherosclerosis . (wikipedia.org)
  • Gated coronary CT was introduced in the 1980s and demonstrated a wide range of pathology, including intracardiac thrombus, ventricular aneurysms and cardiac scars. (acr.org)
  • Histological studies shed new light on the initiation and characteristics of calcification of coronary artery aneurysms in Kawasaki disease. (qxmd.com)
  • Calcification of coronary artery aneurysms (CAAs) is common in the remote phase of Kawasaki disease (KD), but the detailed features of its development remain unclear. (qxmd.com)
  • The study materials consisted of 24 coronary artery branches with aneurysms that were obtained from 14 Japanese patients who died during the period from 40 days to 3 years after the onset of KD. (qxmd.com)
  • Results Coronary arterial lesions occurred in 40.6% of cases at their acute febrile stages, and persisted beyond 1 month in 196 (18.3%, M/F=138/58) patients: 125 (11.6%) had small aneurysms, 44 (4.1%) had medium aneurysms, and 27 (2.5%) had giant aneurysms. (bmj.com)
  • At follow-up (1-46 years), coronary aneurysms persisted in all with giant aneurysms, in 55% of those with medium aneurysms (18% with stenosis), and in 9% of those with small aneurysms. (bmj.com)
  • Among the patients with KD with coronary aneurysms, 10-year ischaemia event-free and aneurysm persistence probability was 87.5% and 20.6%, respectively. (bmj.com)
  • Although IVIG use improves the initial severity of coronary lesions, it does not further modify the long-term fate of coronary aneurysms. (bmj.com)
  • Several speakers at SCCT mentioned the use of CTA to examine the type of atherosclerotic plaques inside the coronary vessels to determine the patient's risk for a heart attack. (itnonline.com)
  • Calcification of soft tissue and blood vessels is typically a problem associated with aging but it is seen early in life for young patients with chronic kidney disease on dialysis treatments and greatly increases risk of early death due to heart disease. (effectiveselfcare.info)
  • Intravascular ultrasound (IVUS) offers detailed 3D tomographic views of coronary plaques and reference vessels. (jmir.org)
  • Acquired stenosis of the aortic valve, which affects adults, is most often caused by calcification of the leaflets themselves and is considered an age-related or degenerative process. (medscape.com)
  • Hardening of the aortic valve, usually by degenerative calcification, with a jet velocity of less than 5 mm/second is considered aortic sclerosis and is asymptomatic. (medscape.com)
  • Findings of echocardiography demonstrated calcification around the aortic valve and a mobile lesion, which was thought to be a thrombus. (imjsu.org)
  • Unfortunately, the early macroscopic examination only described the prevalence and severity of ICAS by characterizing the surface involvement of fatty streak, plaque, ulcerated lesion, and calcification changes, failing to provide the detailed features of individual intracranial atherosclerotic lesions. (j-stroke.org)
  • Morphological characteristics of the atheromatous plaque have been associated with the development of plaque rupture and the pathogenesis of acute coronary syndromes (ACS). (ecrjournal.com)
  • Consequently, OCT is a valuable research tool for examining the role of morphological characteristics of atheromatous plaques in the progression of coronary artery disease and plaque destabilisation, which leads to the clinical manifestation of ACS. (ecrjournal.com)
  • 1-3 Plaque rupture, the most frequent mechanism of coronary thrombosis, involves disruption of a thin fibrous cap that overlies a large necrotic core, causing the thrombogenic contents of the necrotic core to come into contact with the bloodstream and trigger thrombus formation. (ecrjournal.com)
  • Hot topics included quantification of low-attenuation coronary plaque as the next big cardiac risk assessment, coronary artery shear stress as a marker for heart attacks, CT for the assessment of non-STEMI patients, the role of CT in COVID-19, CT's role in structural heart assessments, as well as new CT technologies. (itnonline.com)
  • 2 , 5 " ( 17 ) *Medial calcification causes stiffening of the vessel wall but does not include plaque deposits that obstruct the interior of the blood vessel. (effectiveselfcare.info)
  • 80%, Right Coronary Artey (RCA): 70% plaque was detected. (imjsu.org)
  • Acute coronary syndromes (ACS) comprise a major cause of morbidity and mortality. (ecrjournal.com)
  • Overview of Acute Coronary Syndromes (ACS) Acute coronary syndromes result from acute obstruction of a coronary artery. (msdmanuals.com)
  • The earliest pathologic descriptions of atherosclerotic lesions focused on morphologies of fatty streaks to fibroatheromas (FAs) and advanced plaques complicated by hemorrhage, calcification, ulceration, and thrombosis. (medscape.com)
  • Generalized arterial calcification of infancy (GACI) is an extremely rare genetic disorder. (wikipedia.org)
  • It is characterized by generalized calcification of the arterial internal elastic lamina, leading to rupture of the lamina and occlusive changes in the tunica intima with stenosis and decreased elasticity of the vessel wall. (wikipedia.org)
  • Generalized arterial calcification of infancy should always be considered in infants and children presenting with hypertension, cardiac failure, or sudden death. (wikipedia.org)
  • With intravenous immunoglobulin therapy, the risk of coronary arterial lesions for patients with Kawasaki disease has been reduced from 20-25% to 5-10% during the acute stage. (bmj.com)
  • 1 Despite receiving intravenous immunoglobulin (IVIG) therapy, coronary arterial lesions (CALs) occurred in 5-20% of patients with KD during the acute stage. (bmj.com)
  • See also Aortic Stenosis , Pediatric Valvar Aortic Stenosis , Pediatric Rheumatic Heart Disease , and Pathology of Rheumatic Heart Disease . (medscape.com)
  • At present, the most common cause of valve replacement in the United States is aortic stenosis secondary to calcification. (medscape.com)
  • Reports exist of calcification and stenosis of the aortic annulus leading to coronary artery disease, and the risk of myocardial infarction is higher than normal in older patients with ochronosis. (medscape.com)
  • AI-QCA showed a moderate to strong correlation compared with IVUS in analyzing coronary lesions with significant stenosis. (jmir.org)
  • Dietary vitamin K is thought to decrease risk of cardiovascular disease by reducing coronary calcification, but inconsistent results are reported. (nih.gov)
  • Background: Elevated lipoprotein(a) [Lp(a)] and coronary artery calcium (CAC) score are individually associated with increased atherosclerotic cardiovascular disease (ASCVD) risk but have not been studied in combination. (umn.edu)
  • Beyond low-density lipoprotein cholesterol: respective contributions of non-high-density lipoprotein cholesterol levels, triglycerides, and the total cholesterol/high-density lipoprotein cholesterol ratio to coronary heart disease risk in apparently healthy men and women. (jamanetwork.com)
  • Then we measured the area of each calcification and examined for correlations between the calcified area, and (1) the disease duration, and (2) the aneurysm diameter. (qxmd.com)
  • The earliest observation of calcification was in an infant who died on the 49th disease day: it was a small, band-shaped calcified lesion in granulation tissue that had formed at the boundary between the thrombus and the blood vessel wall. (qxmd.com)
  • Total and severe exacerbation rates were compared between groups categorised by β-blocker use on longitudinal follow-up using negative binomial regression analyses, after adjustment for demographics, airflow obstruction, %emphysema on CT, respiratory medications, presence of coronary artery disease, congestive heart failure and coronary artery calcification, and after adjustment for propensity to prescribe β-blockers. (bmj.com)
  • Current understanding of intracranial atherosclerotic disease has been advanced by the high-resolution magnetic resonance imaging (HRMRI), a novel emerging imaging technique that can directly visualize the vessel wall pathology. (j-stroke.org)
  • Wang XR, Zhang JJ, Xu XX and Wu YG: Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: A systematic review and meta-analysis. (spandidos-publications.com)
  • Raggi P: Cardiovascular calcification in end stage renal disease. (spandidos-publications.com)
  • He said this is especially true of identifying coronary disease patients that can be treated conservatively. (itnonline.com)
  • [14] [15] Coronary artery disease and stroke account for 80% of CVD deaths in males and 75% of CVD deaths in females. (wikipedia.org)
  • [2] The average age of death from coronary artery disease in the developed world is around 80, while it is around 68 in the developing world. (wikipedia.org)
  • There is a correlation between coronary heart disease and gum inflammation. (dentalimplants-usa.com)
  • Ischemic injury due to coronary artery disease is the most common pathological cause of cardiac remodeling [ 6 ]. (biomedcentral.com)
  • Objective To explore acute and late coronary outcomes and their risk/modifiers in patients with Kawasaki disease (KD). (bmj.com)
  • Lesion reference to AHA types V and VI was discarded, because it failed to account for the 3 different morphologies (rupture, erosion, and calcified nodule) that give rise to acute coronary thrombosis. (medscape.com)
  • 2 Calcified nodules is a less common cause of coronary thrombosis, characterised by thrombus formation over nodular calcification protruding into the lumen through a disrupted thin fibrous cap. (ecrjournal.com)
  • Calcification showed two localizations: in the organized portion of the thrombus (seen in 12 CAAs) and deep in the thickened tunica of the intima (3 CAAs). (qxmd.com)
  • After all, many subject themselves to coronary and cardiac calcium scans in order to ascertain their risk of cardiovascular events and/or cardiac mortality. (greenmedinfo.com)
  • Lacking this "delivery system," the calcium may end up going to places you do not want (ectopic calcification), or go to places you do want (e.g. the bones), but in excessive amounts, stimulating unnaturally accelerated cell-division (osteoblasts), resulting in higher bone turnover rates later in life (this is explained in the article below). (greenmedinfo.com)
  • Alizarin Red S staining and calcium (Ca) content analysis were carried out to detect calcification in VSMCs. (spandidos-publications.com)
  • LEFT: Lobular calcifications: punctate, round or 'milk of calcium' RIGHT: Intraductal calcifications: pleomorph and form casts in a linear or branching distribution. (radiologyassistant.nl)
  • An accurate quantitative analysis of coronary artery stenotic lesions is essential to make optimal clinical decisions. (jmir.org)
  • We first examined the CAAs for the presence of thrombi and calcification. (qxmd.com)
  • Thrombi were also seen in 13 of 14 CAAs with calcification. (qxmd.com)
  • Histologically, CAA calcification starts early in the remote phase of KD, and it is closely related to organization of thrombi. (qxmd.com)
  • Additionally, long-term excessive sustained exercise may be associated with coronary artery calcification, diastolic dysfunction, and large-artery wall stiffening. (nih.gov)
  • Calcification in renal tissue or other organs of the body would cause dysfunction in different ways - disrupting the function of that organ type. (effectiveselfcare.info)
  • These calcifications are calcified cellular debris or secretions within the intraductal lumen. (radiologyassistant.nl)
  • Since atherothrombosis represents the most common cause of stroke, it is important to investigate whether coronary artery calcification, a commonly used measure of cardiac atherosclerotic burden, can be a similarly useful measure of atherosclerotic burden in the brain. (authorea.com)
  • Despite many speculations that this polymer deposition is associated with cardiac pathology, no reports of mortality directly related to the homozygous state for alkaptonuria exist. (medscape.com)
  • Cardiac and pericardial calcifications on chest radiographs. (radiopaedia.org)
  • Male patients and intravenous γ-immunoglobulin (IVIG) therapy were independent risk factors of initial coronary severity but were not associated with the late coronary outcomes, even in severity stratified subgroups. (bmj.com)
  • Conclusions The coronary severity 1 month after KD onset is most crucial to the late coronary outcomes. (bmj.com)
  • Probable causes of failure include the following: large anatomical variations, calcification, isthmuses, lateral canals 6 , intra and extra-root microbial factors 7 , and systemic complications. (bvsalud.org)
  • Calcification is an intrinsic part of the degenerative process. (medscape.com)
  • Because of calcifications that occur in these sites, however, the radiologic picture is more consistent with osteoarthritis. (medscape.com)
  • Diagnoses range from chronic sinusitis to intracranial calcifications, multiple myeloma, soft tissue masses, osteoarthritis of the TMJ, degenerative cervical spine, and narrowing of the airway. (dentalimplants-usa.com)
  • Coronary artery calcification evaluation by gated CT was also introduced in the late 1980s. (acr.org)
  • Lobular calcifications usually have a diffuse or scattered distribution, since most of the breast is involved in the process that forms the calcifications. (radiologyassistant.nl)
  • ENPP1 regulates extracellular inorganic pyrophosphate (PPi), a major inhibitor of extracellular matrix calcification. (wikipedia.org)
  • Furthermore, lithium chloride (Wnt activator) reversed the protective effect of STAT1 inhibition on VSMC calcification, while Dickkopf‑1 (Wnt inhibitor) exerted the opposite effect, suggesting that activation of the Wnt/β‑catenin signaling pathway was involved in STAT1‑mediated VSMC calcification. (spandidos-publications.com)
  • In addition, it may have a role in the identification of stroke patients who may benefit from closer cardiac monitoring as it can aid traditional scores in the detection of coronary pathology in stroke survivors. (authorea.com)
  • After inges- size, calcification and number of cysts, and acute pericarditis and mimic acute tion, larvae pass the intestine and reach integrity of the cyst, and effect of the coronary syndrome or acute aortic dis- the right side of the heart through the cysts, palpitations and presence of com- section. (who.int)
  • This retrospective study included patients who underwent IVUS-guided coronary intervention at a single tertiary center in Korea. (jmir.org)