NeoplasmAdenomaCarcinomaCarcinomasDifferential diagnosisLesionsPapillary mucinous neoplasmsTumorEpithelialSignet-ringColorectalMucinLymph nodeSmall-intestinalFindingsObstructionGastricPatientsSquamousMetastasisPathologicMetastatic adenocarcinomaTumorsEpitheliumPeritonealPancreasBiopsyPathologyIntussusceptionColumnarImmunohistochemistryManifestationsRecurrenceAcuteGlandularLiverOvarianExamination revealedChronicPrecursorPalliativeSurgeryInfectionAscitesClinical featuresLungPrognosisDisease
Neoplasm6
- The high proportion of mitotic cells and resemblance to well-differentiated adenocarcinoma of the large intestine suggested that this neoplasm was adenocarcinoma rather than adenoma. (hindawi.com)
- The international consensus guidelines for intraductal papillary mucinous neoplasm of the pancreas (IPMN) presented clinical features as indications for surgery. (biomedcentral.com)
- Pseudomyxoma peritonei (PMP) is a rare, slow growing mucinous ascites, typically associated with primary appendiceal or ovarian neoplasm [1]. (amsj.org)
- The 5-year DFS per tumor origin was: 96% for perforated low grade appendiceal mucinous neoplasm (LAMN II) and 68.1% for colon origin. (unav.edu)
- To study the relationship between carcinoembryonic antigen (CEA) level, intraductal papillary mucinous neoplasm (IPMN) subtype, and the presence of invasive carcinoma. (gastrores.org)
- Intraductal papillary mucinous neoplasm (IPMN) is a substantial subclass of pancreatic pathology, representing 20-50% of cystic pancreatic neoplasms [ 1 - 3 ]. (gastrores.org)
Adenoma4
- Pseudomyxoma Peritonei ( PMP ) is a more common name given to the "jelly belly" syndrome caused by mucinous adenoma and mucinous adenocarcinoma. (cancerindex.org)
- Adenoid cystic carcinoma, adenocarcinoma and expleomorphic adenoma were observed as primary malignant tumors. (selcukmedj.org)
- Exocrine cells in benign tumors (accounting for 10% of pancreatic tumors), including the origin of the catheter in the duct epithelial adenoma, intraductal papilloma, serous cystadenoma, mucinous cystadenoma, and originated in the solid and acinar cells cystic tumor. (cancerlive.net)
- The lattercan be particularly alarming if one is not aware that this type of change can occur (4).The main differential diagnosis is with extremely well-differentiated endocervicaladenocarcinoma (adenoma malignum). (fliphtml5.com)
Carcinoma13
- In the 4th edition of WHO classification of tumors of female reproductive organs, primary villoglandular mucinous adenocarcinoma is defined as a primary invasive glandular epithelial tumor of intestinal type and the synonyms are cloacogenic carcinoma or cloacogenic adenocarcinoma [ 1 ]. (hindawi.com)
- Benign and malignant exocrine tumors of the points, mainly from pancreatic ductal cancer epithelium to adenocarcinoma the most common (accounting for more than 90% of pancreatic cancer), squamous cell carcinoma, mucinous carcinoma and acinar cells derived from acinar cells carcinoma, acinar cystadenocarcinoma are rare (accounting for about 10%), the above collectively referred to as pancreatic cancer. (cancerlive.net)
- 2 Diagnosis of small cell (neuroendocrine) or mucinous adenocarcinoma of cervical cancer (ie, mucinous NOS, intestinal type, signet ring cell type, invasive stratified mucin producing carcinoma and gastric type) based on 2020 WHO classification of cervical cancer. (who.int)
- We describe the case of a 67-year-old female patient who presented with an unclear swelling on the right supraclavicular neck, two years after resection of a mucinous carcinoma on the right mastoid. (asploro.com)
- However, as no other primary tumor could be detected at that time, a Primary Mucinous Carcinoma of the Skin (PMCS) was also debated. (asploro.com)
- Using a variety of other markers, we were unable to detect neither significant morphological nor immunohistochemical characteristics that distinguished the lesion from a mucinous carcinoma of mammary origin. (asploro.com)
- This report demonstrates the limitations of currently used histopathological and immunohistochemical differentiation in metastatic mucinous carcinoma. (asploro.com)
- A 67-year-old female presented with a suspicious swelling on the right supraclavicular region two years after resection of a mucinous carcinoma on the surface of the skin overlying the right mastoid. (asploro.com)
- The mastoid skin lesion was originally diagnosed by two separate institutes to be most likely a metastatic mucinous carcinoma. (asploro.com)
- However, there was no correlation between CEA level and cystic mucinous secretions or mucinous epithelial cytoplasm CEA staining, mucin glycoprotein expression, size of lesion, grade of dysplasia or presence of invasive carcinoma. (gastrores.org)
- IPMN is thought to represent a precursor lesion to pancreatic adenocarcinoma due to its association with invasive carcinoma [ 5 ]. (gastrores.org)
- In addition to CEA being used to stratify mucinous vs. non-mucinous lesions, several studies have attempted to correlate pancreatic cyst fluid CEA level and the presence of invasive carcinoma, with discordant results [ 17 , 18 ]. (gastrores.org)
- Pathologic differential diagnosis of metastatic carcinoma in the liver. (nih.gov)
Carcinomas3
- The literature repeatedly describes difficulties in diagnosing PMCS, especially when attempting to differentiate the metastases from mucinous carcinomas of other origins. (asploro.com)
- Mucinous skin carcinomas are mostly seen in the head and neck region and isolated specimens from this area should raise suspicion for a PMCS. (asploro.com)
- Patients with low-grade appendiceal mucinous carcinomas (LAMNs) treated with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have a favorable prognosis. (rare-cancer.org)
Differential diagnosis8
- Pneumoconioses: pathological findings and differential diagnosis, in particular silicosis and asbestosis. (unibo.it)
- Granulomatous lung diseases: sarcoidosis and tuberculosis (and their differential diagnosis). (unibo.it)
- The differential diagnosis of rectal discharge is extensive, but the general etiological themes are infection and inflammation. (wikipedia.org)
- The differential diagnosis of an ovarian mass is complex as approximately 7% of ovarian masses encountered clinically are metastatic lesions, the most common sites of origin being the gastrointestinal tract and breast. (biomedcentral.com)
- The clinical implications of this are that PMP is not commonly considered a differential diagnosis in patients with these symptoms, which may then delay the diagnosis being made. (amsj.org)
- Binary Logistic regression analysis demonstrated that cystic and necrosis changes, 'Rosette' changes and 'incision sign' and texture Contrast could be considered as the specific texture variables for the differential diagnosis of glioblastoma and primary CNS lymphoma. (cams.cn)
- Health professionals must dedicate all their efforts to its realization as long as they have the necessary elements and means, both theoretical and practical, for the correct use of the clinical method, which is an essential element of differential diagnosis. (bvsalud.org)
- emphasis is placed on the necessary steps to carry out a true differential diagnosis that makes it possible to decant the etiological possibilities of the patient's clinical manifestations. (bvsalud.org)
Lesions13
- Mucous discharges can be thought of in three broad categories: Normal physiologically produced mucus Inappropriately expressed physiologically produced mucus (e.g. in the presence of sphincter defects, or lesions preventing normal sphincter closure, allowing seepage or soiling) Mucus produced in pathological quantities (e.g. from a lesion, or generalized coloproctitis or as a result of bacterial overgrowth) A mucous rectal discharge may be blood-streaked. (wikipedia.org)
- This procedure is also the primary method for obtaining a tissue diagnosis of suspected lesions. (medscape.com)
- Adenocarcinoma of the stomach is subclassified according to histologic description as follows: tubular, papillary, mucinous, or signet-ring cells, and undifferentiated lesions. (medscape.com)
- Diagnostic imaging such as computed tomography (CT) and magnetic resonance imaging (MRI) may miss small lesions and often are unable to differentiate between small bowel adenocarcinoma and severe Crohn's disease [ 2 ]. (gastrores.org)
- In an attempt to identify pancreatic cystic lesions with an increased risk of associated invasive adenocarcinoma, carcinoembryonic antigen (CEA) level has emerged over the last few decades as a tool to assess pancreatic cystic fluid pre-operatively. (gastrores.org)
- During the diagnostic workup for pancreatic cysts, CEA is often utilized to distinguish those pancreatic cystic lesions that are likely to be mucinous [ 13 - 16 ]. (gastrores.org)
- Goblet cell hyperplasia is the precursor lesion of adenomas and dysplasia in the classical colorectal cancer pathway, of sessile serrated adenomas and serrated dysplasia in the serrated colorectal cancer pathway, and of flat and elevated dysplasia and dysplasia-associated lesions or masses in IIBD-associated intestinal cancers. (biomedcentral.com)
- many of these benign yet floridly proliferative lesions have been mistaken for invasive adenocarcinoma. (fliphtml5.com)
- 2Introduction The distinction between benign proliferative glandular lesions of the endocervixand well-differentiated invasive cervical adenocarcinoma continues to be problematic, ashighlighted by the number of reports in the literature considering this diagnostic issue.Interestingly, the relatively recent recognition of a number of potential mimics ofinvasive adenocarcinoma of the endocervix underscores the likelihood that in the pastmany of these benign yet floridly proliferative lesions have been mistaken for invasiveadenocarcinoma. (fliphtml5.com)
- For instance, in one institutional review five cases diagnosed asinvasive adenocarcinoma over a 14-year period were reclassified as benign mimics (1).Although a variety of immunoperoxidase stains have been tried, ultimately therecognition of benign pseudoneoplastic glandular lesions of the cervix rests upon theirdistinctive histologic features. (fliphtml5.com)
- Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
- The pattern of swelling, inflammation, ulcers, and fissures is similar to that of the lesions occurring in the intestinal tract. (medscape.com)
- No extra-intestinal lesions were found. (scielo.org)
Papillary mucinous neoplasms1
- Since recently, it has become possible to identify the preliminary stages of pancreatic cancer, which are referred to as intraductal papillary mucinous neoplasms (IPMN). (drschindl.at)
Tumor5
- Primary villoglandular mucinous adenocarcinoma of the vulva is rare tumor. (hindawi.com)
- The tumor had a large proportion of mitotic cells and its resemblance to adenocarcinoma of the large intestine was striking. (hindawi.com)
- Clinical and pathological variables including preoperative CA125, CEA and LDH levels, intraoperative evaluation, size of ovarian metastases of pathologic gross specimen, pathology reports, primary tumor site, surgical procedures, and subsequent therapy at the department of medical oncology for the primary cancer were collected. (biomedcentral.com)
- It is a big challenge to repair a large abdominal wall defect after tumor resection, and en bloc resection with vascularized tissue reconstruction might be an alternative to achieve an improved survival for abdominal wall tumors. (biomedcentral.com)
- Endocrine tumors, including insulinoma, gastrinoma (Zhuoyi syndrome), intestinal peptide tumors (Verner-Morrison syndrome), glucagon tumors, pancreatic somatostatin cell tumor, non-functional islet cell tumors (pancreatic polypeptide tumor). (cancerlive.net)
Epithelial1
- Moreover, siRNA-mediated knockdown of KLF5 blocked the expression of CDX2, MUC2 and villin, but transfection of a KLF5 expression vector into esophageal epithelial cells promoted their transdifferentiation into columnar-like cells, as demonstrated by increased expression of the intestinal markers CDX2, MUC2 and villin. (jcancer.org)
Signet-ring1
- Less common tumours of the appendix include signet-ring cell adenocarcinoma and paraganglioma . (cancerindex.org)
Colorectal3
- In conclusion, this case suggests an important role of 18 F-FDG PET/CT in early diagnosis and decision-making regarding therapy for recurrent disease in cases where a firm diagnosis of recurrent colorectal cancer is difficult to make. (biomedcentral.com)
- In a study of peritoneal cancer (PC) diagnosis, investigators found that the administration of carbonated water for dual-time point imaging may improve the accuracy of FDG PET/CT scanning for PC in patients previously diagnosed with colorectal cancer (CRC). (medscape.com)
- MAP's invasion of intestinal goblet cells may result in the initial pathologic lesion of IIBD and sporadic colorectal cancer. (biomedcentral.com)
Mucin2
- Mucinous cystadenocarcinoma account for about a fifth of appendix tumours, these produces mucin (a jelly-like substance). (cancerindex.org)
- Mucinous" strictly speaking refers to something having a mucin-like attribute, but it often is used interchangeably with the word "mucous" (as mucus usually contains a high percentage of mucin). (wikipedia.org)
Lymph node1
Small-intestinal4
- Small-intestinal adenocarcinomas are common initial manifestations of Lynch syndrome. (oncotarget.com)
- To define the incidence and characteristics of Lynch syndrome-related small-intestinal adenocarcinomas, meticulous familial and clinical histories were obtained from 195 patients with small-intestinal adenocarcinoma, and MMR protein immunohistochemistry, microsatellite instability, MLH1 methylation, and germline mutational analyses were performed. (oncotarget.com)
- Small-intestinal adenocarcinomas were the first clinical manifestation in 37% (3/8) of Lynch syndrome patients, and second malignancies developed within 5 years in 63% (5/8). (oncotarget.com)
- A meticulous patient history taking, MMR protein immunolabeling, and germline MMR gene mutational analysis are important for the diagnosis of Lynch syndrome-related small-intestinal adenocarcinomas. (oncotarget.com)
Findings5
- Depending on the symptoms and previous findings, the appropriate examinations have to be chosen to be able to make a correct diagnosis and start suitable treatment as soon as possible. (drschindl.at)
- Together with the strong link between GERD and esophageal adenocarcinoma, these findings suggest that bile salts play a role in the pathophysiology of BE and EAC. (jcancer.org)
- Oral findings as described above warrant a full systemic evaluation for intestinal Crohn disease, including referral for colonoscopy and biopsy with histopathologic correlation. (medscape.com)
- This is mainly based on the findings of imaging studies, surgical management is the cornerstone of treatment of this pathology and its success will be determined by timely diagnosis as well as by the expertise of the treating surgeon. (bvsalud.org)
- Findings We estimated that breast cancer diagnosis in Rwanda costs 138.29 United States dollars (US$) per patient when conducting biomarker analysis by immunohistochemistry. (bvsalud.org)
Obstruction3
- Intestinal obstruction. (cancer.gov)
- Intestinal intussusception in adult patients is a rare entity, which corresponds to about 5% of all causes of intestinal obstruction, its diagnosis is not easy given the lack of specific symptoms of patients who present it. (bvsalud.org)
- The major problems associated with PJS are acute complications due to (i) polyp-related intestinal obstruction, (ii) intussusception, and (iii) the risk of cancer in the long-term. (scielo.org)
Gastric4
- Adenocarcinoma of the stomach constitutes 90-95% of all gastric malignancies. (medscape.com)
- The Lauren system classifies gastric cancer pathology as either type I (intestinal) or type II (diffuse). (medscape.com)
- Diagnosis relies on serum gastrin in gastric juice analysis and determination of treatment including the control of gastric acid secretion and removal of the high gastrinoma in two ways. (cancerlive.net)
- Four main histologic subtypes of IPMN have been described: gastric, intestinal, pancreaticobiliary and oncocytic. (gastrores.org)
Patients7
- Therefore, Patients with mucinous adenocarcinoma should be followed carefully after surgery, and receive rapid diagnosis and treatment if recurrence is suspected. (biomedcentral.com)
- Mismatch repair deficiency occurs in 5% to 10% of patients with rectal adenocarcinomas. (cancer.gov)
- This case demonstrates management of a retained capsule in Crohn's patients and emphasizes the importance of considering small bowel adenocarcinoma in Crohn's patients with obstructive signs. (gastrores.org)
- however, in patients with Crohn's disease as compared to the general population, there is over a 60-fold increased risk of small bowel adenocarcinoma [ 1 ]. (gastrores.org)
- Seventy percent of small bowel adenocarcinoma in Crohn's patients is found incidentally on pathological examination of resected specimens [ 2 ]. (gastrores.org)
- Intraoral involvement in Crohn disease occurs in 8-29% of patients and may precede intestinal involvement. (medscape.com)
- Diagnosis is the cornerstone of individual medicine, therefore, mastering it and knowing it is essential for every doctor when inquiring into the health and pathological status of patients. (bvsalud.org)
Squamous1
- It is widely accepted that chronic GERD leads to inflammation and ulceration of the esophageal squamous mucosa and that persistent and recurrent inflammation and ulceration may lead to columnar metaplasia and, ultimately, intestinal metaplasia. (jcancer.org)
Metastasis1
- We report a case in which 18 F-fluorodeoxyglucose positron emission/computed tomography ( 18 F-FDG PET/CT) was very useful for early diagnosis and planning a theraupetic strategy for a case of mucinous adenocarcinoma metastasis at a laparoscopic port site. (biomedcentral.com)
Pathologic1
Metastatic adenocarcinoma1
- Two pathological reports from separate universities diagnosed the primary mastoid skin lesion as a metastatic adenocarcinoma. (asploro.com)
Tumors1
- Nasir A, Ahmed MK, Saller JJ, Henderson-Jackson EB, Malafa MP, Yeatman TJ, Coppola D. p21 Protein Outperforms Clinico-pathological Criteria in Predicting Liver Metastases in Pancreatic Endocrine Tumors. (moffitt.org)
Epithelium3
- Villoglandular mucinous adenocarcinoma arises in the surface epithelium of the vulva. (hindawi.com)
- 3Type A tunnel clusters Type A tunnel clusters are characterized by a lobulated proliferation of small,closely packed glands that are lined by columnar mucinous epithelium. (fliphtml5.com)
- The common admixture of type A and B tunnelclusters, in combination with the predominantly lobulated architecture, absence ofdesmoplasia and lack of deep, widely infiltrative glands helps distinguish it fromadenoma malignum.Type B tunnel clusters Type B tunnel clusters also have a lobular architecture, but are composed ofdilated glands lined by cuboidal or flattened epithelium and filled with inspissated,mucinous secretions. (fliphtml5.com)
Peritoneal1
- Mucinous material fills the peritoneal cavity, causing enlargement of the abdomen and has been described as "jelly belly", due to its appearance at laparotomy [2]. (amsj.org)
Pancreas2
- The reason why the pancreas is the most important organs of the body, because it is a both endocrine and exocrine gland function, its physiological function and pathological changes are closely linked with life. (cancerlive.net)
- Pathological changes of the pancreas may be either inflammation (pancreatitis) or a tumour (benign or malignant). (drschindl.at)
Biopsy3
- The specimen of the vulvar biopsy was diagnosed vulvar adenocarcinoma. (hindawi.com)
- An enhanced computed tomography scan and biopsy of the mass were performed to achieve the definite diagnosis of abdominal mucinous adenocarcinoma. (biomedcentral.com)
- Then it was diagnosed as abdominal low-grade mucinous adenocarcinoma(cT4N0M0 stage IIB, ypT4N0M0), proved by pathological puncture biopsy. (biomedcentral.com)
Pathology1
- Final pathology revealed metastatic poorly differentiated adenocarcinoma. (gastrores.org)
Intussusception1
- an intestinal intussusception at the level of the distal ileum. (bvsalud.org)
Columnar1
- The region of columnar esophageal metaplasia is considered the "cancerization field" in which esophageal adenocarcinoma (EAC) develops [ 3 - 5 ]. (jcancer.org)
Immunohistochemistry1
- The diagnosis is guided by histology and immunohistochemistry. (biomedcentral.com)
Manifestations2
- Oral manifestations can prove crucial in diagnosis and usually parallel the intestinal disease course. (medscape.com)
- [ 8 ] However, oral manifestations at follow-up once disease is controlled may not be a marker for recurring intestinal disease. (medscape.com)
Recurrence2
- A 2-cm, firm, ill-defined, tender mass was palpable in the incision site, and was suspected to be a recurrence of the cecal mucinous adenocarcinoma. (biomedcentral.com)
- Risk factors for Rem-Panc recurrence were reported to be the presence of high-grade dysplasia in resected specimens, positive surgical margins, and a family history of pancreatic ductal adenocarcinoma (PDAC). (biomedcentral.com)
Acute1
- Research has demonstrated MAP's ability to invade intestinal goblet cells and cause acute and chronic goblet cell hyperplasia. (biomedcentral.com)
Glandular1
- Benign Mimics of Invasive Adenocarcinoma of the Cervix Tunnel Clusters Microglandular Hyperplasia Mesonephric Hyperplasia Endocervical Glandular Hyperplasias Arias-Stella ReactionTunnel Clusters Fluhmann first introduced the term "tunnel cluster" in his description of thehistology of the endocervix (2;3). (fliphtml5.com)
Liver2
- The optimal cut-off value for the diagnosis of liver cirrhosis (LC) was measured. (go.jp)
- Pathological processes of the LIVER. (lookformedical.com)
Ovarian1
- Conclusion: right-sided pelvic lesion consistent with ovarian mucinous cystadenomatous-type lesion. (amsj.org)
Examination revealed2
- The histological examination revealed a mucinous adenocarcinoma which invaded the cecal subserosa. (biomedcentral.com)
- The postmortem examination revealed ulcers involving the entire colon and intestinal perforation. (scielo.org)
Chronic2
- Mycobacterium avium subspecies paratuberculosis (MAP), the cause of a chronic intestinal disease in domestic and wild ruminants, is one suspected cause of IIBD. (biomedcentral.com)
- The potential role of aging or drug-causing immunosuppression and the evolution of chronic and latent intestinal infection to a severe and invasive form of amebiasis is discussed. (scielo.org)
Precursor1
- BE is known as a precursor of esophageal adenocarcinoma. (jcancer.org)
Palliative1
- While radiotherapy and chemotherapy for small bowel adenocarcinoma are primarily palliative measures, surgery can be curative [ 8 ]. (gastrores.org)
Surgery1
- A 57-year-old man, who underwent laparoscopic surgery for advanced mucinous adenocarcinoma of the cecum 6 years prior, developed a nodule in the surgical wound at the lower right abdomen. (biomedcentral.com)
Infection1
- Occasionally, intestinal parasitic infection can present with discharge, for example whipworm. (wikipedia.org)
Ascites1
- The presence of ascites and possible omental caking suggests adenocarcinoma. (amsj.org)
Clinical features1
- The pathological and clinical features were evaluated. (biomedcentral.com)
Lung1
- Grading of lung adenocarcinomas with simultaneous segmentation by artificial intelligence (GLASS-AI). (moffitt.org)
Prognosis1
- Prognosis of intestinal mucinous adenocarcinoma is reported to be poorer than that of non-mucinous adenocarcinoma. (biomedcentral.com)
Disease4
- With the exception of obstructive symptoms, these symptoms do not necessarily correlate with the stage of disease or signify a particular diagnosis. (cancer.gov)
- Small bowel adenocarcinoma is a recognized complication of Crohn's disease [ 2 ]. (gastrores.org)
- Adenocarcinoma often develops in the small bowel segments that are involved in Crohn's disease as well as within strictures [ 2 , 4 ]. (gastrores.org)
- MRI and clinical examination alone are not useful for definitive diagnosis and it is better to examine biomarkers and artificial intelligence for non-invasive and accurate diagnosis of this disease. (jogcr.com)