Inclusion BodiesUbiquitinAmyotrophic Lateral SclerosisDNA-Binding ProteinsUbiquitinated ProteinsUbiquitinationProteasome Endopeptidase ComplexUbiquitinsTorsades de PointesUbiquitin-Protein LigasesEndosomal Sorting Complexes Required for TransportPolyubiquitinCysteine EndopeptidasesProteasome InhibitorsMultienzyme ComplexesInclusion Bodies, ViralLeupeptinsProtein TransportProtein BindingProteolysisCell LineMyositis, Inclusion BodyUbiquitin-Conjugating EnzymesCells, CulturedPhosphoric Diester HydrolasesUbiquitin ThiolesteraseProtein Processing, Post-TranslationalMolecular Sequence DataAutophagySignal TransductionMutationAmino Acid SequenceLysosomesEndosomesModels, BiologicalHeLa CellsProtein Structure, TertiaryIntranuclear Inclusion BodiesLysineLigasesNeurodegenerative DiseasesNeuronsEndocytosisHEK293 CellsImmunoprecipitationBlotting, WesternUbiquitin-Protein Ligase ComplexesSaccharomyces cerevisiae ProteinsCarrier ProteinsMultivesicular BodiesBrainProteinsPathological Conditions, Signs and SymptomsTime FactorsPhosphorylationNuclear ProteinsEndoplasmic ReticulumImmunoblottingGene Expression RegulationAdaptor Proteins, Signal TransducingNerve Tissue Proteins