• The surface topography of red blood cells (RBCs) was investigated under near-physiological conditions using atomic force microscopy (AFM). (degruyter.com)
  • In this thesis we aimed to see whether examining these cells with OCT could reflect physiological and pathological changes in the eye and brain.In cases of optic neuritis (Paper I), the OCT examination showed early thickening of the peripapillary (pRNFL) followed by thinning which takes 6-9 months to reduce to below normal thickness without the ability to distinguish between the real from pseudo thinning. (avhandlingar.se)
  • Changes in phosphorylation levels of Ser-98 and Ser-179 in Ldb3 were further confirmed in NRVMs and other pathological/physiological hypertrophy models, including transverse aortic constriction and swimming models, using site-specific phospho-antibodies. (molcells.org)
  • What is the role of bioelectricity under physiological and pathological conditions? (gla.ac.uk)
  • On corneal epithelium, increased expression of the alpha 2 subunit of VLA-2 was detected and ICAM-1 was induced on the basal epithelial cells. (nih.gov)
  • Many cells do not enter G0 and continue to divide throughout an organism's life, e.g., epithelial cells. (wikipedia.org)
  • More specifically, the deletion of the ferroptosis-regulating enzyme Gpx4 in a pre-clinical model results in high ferroptosis rates in kidney tubular epithelial cells causing acute renal failure. (sciencedaily.com)
  • the etiology and pathological mechanism of the disease are still unclear. (biomedcentral.com)
  • A pathological cardiac hypertrophy model, junctate-1 transgenic mice and control mice, were analyzed using label-free quantitative phosphoproteomics to identify differentially phosphorylated proteins and sites. (molcells.org)
  • The Max Planck researchers then used genetically modified mice in which RhoGEF12 could be switched off in cardiac muscle cells in their hypertrophy model. (mpg.de)
  • Sixteen histological tumor subtypes exist and the most common are papillary, chromophobe and clear cell renal cell carcinoma (ccRCC) representing 85% of all RCC. (frontiersin.org)
  • Pathological subtypes are associated with worse CSS and overall survival (OS) [ 68 ] (LE: 3). (uroweb.org)
  • Different phenotypes and subtypes of endothelial progenitor cells (EPCs), such as early and late EPCs, have been described according to their functionality. (intechopen.com)
  • The authors used artificial neural croarrays is to study changes in gene ex- .nature organ the tumor arose from, how big it networks (ANNs) to identify gene-ex- pression that accompany changes in is, and what it looks like after it has pression signatures associated with spe- cell physiology, such as during develop- been imbedded in wax and colored cific subtypes of tumors. (lu.se)
  • Pneumoconioses: pathological findings and differential diagnosis, in particular silicosis and asbestosis. (unibo.it)
  • Zhou JL, Liu JL, Zhang J and Zhang M: Thirty-nine cases of intracranial hemangiopericytoma and anaplastic hemangiopericytoma: A retrospective review of MRI features and pathological findings. (spandidos-publications.com)
  • Teratomas (from Greek teras, meaning "monster," and - oma, a suffix denoting a tumor or neoplasm) and other germ cell tumors are relatively common solid neoplasms in children. (medscape.com)
  • Intrathecal injection of MSC-NPs correlated with reduced immune cell infiltration, reduced area of demyelination, and increased number of endogenous nestin-positive progenitor cells in EAE mice. (listlabs.com)
  • Human endothelial progenitor cells (hEPCs) are adult stem cells, located in the bone marrow and peripheral blood. (intechopen.com)
  • The pathological diagnosis was extranodal natural killer (NK)/T-cell lymphoma (ENKL), nasal type, associated with Epstein-Barr virus (EBV). (hindawi.com)
  • The pathological diagnosis was ENKL. (hindawi.com)
  • The surgical samples underwent pathological analysis, and a diagnosis of extranodal NK/T cell lymphoma nasal type was confirmed. (frontiersin.org)
  • Early diagnosis of primary intestinal NK/T cell lymphoma is frequently difficult. (frontiersin.org)
  • Overall, myelination-related processes were recurrently perturbed in multiple cell types, suggesting that myelination has a key role in Alzheimer's disease pathophysiology. (nature.com)
  • Although the various stages of interphase are not usually morphologically distinguishable, each phase of the cell cycle has a distinct set of specialized biochemical processes that prepare the cell for initiation of the cell division. (wikipedia.org)
  • M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm divides forming two daughter cells. (wikipedia.org)
  • Magnetic resonance imaging of pathological processes in rodent models of amyotrophic lateral sclerosis. (ox.ac.uk)
  • Targeted MRI contrast agents, through tagging of various cell types and even individual molecules, will deliver an era of in vivo molecular neuroimaging, with greater specificity for the most relevant pathological processes. (ox.ac.uk)
  • The receptor interacts with proteins called endothelins to regulate several critical biological processes, including the development and function of blood vessels, the production of certain hormones, and the stimulation of cell growth and division (proliferation). (medlineplus.gov)
  • These cells can be differentiated into mature endothelial cells, which are involved in processes of angiogenesis and vessel regeneration. (intechopen.com)
  • They play pivotal roles in regulation of various biological and pathological processes, including various cancers. (lu.se)
  • Across six major brain cell types, we identified transcriptionally distinct subpopulations, including those associated with pathology and characterized by regulators of myelination, inflammation, and neuron survival. (nature.com)
  • In this immunohistochemical light-microscopic study we analyzed the expression pattern of adhesion molecules in normal and pathological human corneas (cases of corneal inflammation and degenerative disorders). (nih.gov)
  • The four parameters of toxicity included genotoxicity, inflammation, pathological changes, and the presence of CNT/F in areas of the body outside the lung, termed extrapulmonary translocation. (cdc.gov)
  • Manuscripts detailing the results of the studies on inflammation, pathological changes, and extrapulmonary translocation, are being drafted. (cdc.gov)
  • The strongest disease-associated changes appeared early in pathological progression and were highly cell-type specific, whereas genes upregulated at late stages were common across cell types and primarily involved in the global stress response. (nature.com)
  • In this review, we summarized the progression of the neuroimmune response in PD based on recent studies and focused on the use of mesenchymal stem cell (MSC) therapy and challenges as a strategy of disease-modifying therapy with multiple targets. (biomedcentral.com)
  • The strong correlation between pathological stage and OPN across multiple tumor types suggests a role for OPN in tumor progression. (aacrjournals.org)
  • These ANN ment, cell-cycle progression, drug treat- with different dyes. (lu.se)
  • Non-proliferative (non-dividing) cells in multicellular eukaryotes generally enter the quiescent G0 state from G1 and may remain quiescent for long periods of time, possibly indefinitely (as is often the case for neurons). (wikipedia.org)
  • It was previously believed that the main pathogenic mechanism of PD was the loss of dopaminergic neurons and most researchers considered that the therapeutic effect of MSCs on PD was attributable to their cell replacement ability [ 21 , 22 ]. (biomedcentral.com)
  • Can pathological oligomeric proteins make good biomarkers? (ox.ac.uk)
  • Endothelin 3 (produced from the EDN3 gene) is one of the proteins that interacts with endothelin receptor type B. During early development before birth (embryonic development), endothelin 3 and endothelin receptor type B together play an important role in neural crest cells. (medlineplus.gov)
  • Introduction: Over 95% of the oral cancers are squamous cell carcinoma (OSCC). (iomcworld.com)
  • The aim of this study was to evaluate the patients with squamous cell carcinoma (SCC) of the lip in terms of age, sex, tumor localization, tumor size, histopathological subtype, lymph node metastasis, and recurrence rates. (medicaljournal-ias.org)
  • Clinical and pathological features of squamous cell carcinoma of the lip. (medicaljournal-ias.org)
  • The present study aimed to determine the diagnostic applicability of 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (FDG-PET/CT) to evaluating the response and prognosis after trimodality therapy for esophageal squamous cell carcinoma (ESCC). (biomedcentral.com)
  • High cytoplasmic OPN staining was observed in 100% of gastric carcinomas, 85% of colorectal carcinomas, 82% of transitional cell carcinomas of the renal pelvis, 81% of pancreatic carcinomas, 72% of renal cell carcinomas, 71% of lung and endometrial carcinomas, 70% of esophageal carcinomas, 58% of squamous cell carcinomas of the head and neck, and 59% of ovarian carcinomas. (aacrjournals.org)
  • Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
  • Fig. 1: Cell-type-specific gene-expression changes in AD pathology. (nature.com)
  • Yet, ferroptosis also occurs in non-transformed tissues as demonstrated by this study, thus implicating this cell death pathway in the development of a wide range of pathological conditions. (sciencedaily.com)
  • We were able to use this signal chain for pharmacological intervention and consequently to protect cells and tissues. (sciencedaily.com)
  • Placental tissues from patients with EVD have demonstrated EBOV antigen throughout numerous different types of placental cells on pathological exams. (cdc.gov)
  • hEPCs have been used for cell-based therapies due to their capacity to contribute in the re-endothelialization of injured blood vessels and neovascularization in ischemic tissues. (intechopen.com)
  • But for the most part, normal tissues and 9 cell lines). (lu.se)
  • Do you want to alert Stem Cell Therapy Center to receive Catalogue? (mumbaionline.in)
  • Cell proliferation and invasion were assayed using the kidney cell lines HEK293 with wild-type p53 and a ccRCC cell line MZ1257RC mutated for p53. (frontiersin.org)
  • HEK293 cells demonstrated a restriction of ERV-K113 env expression and invasion with no changes in proliferation in the absence of Aza. (frontiersin.org)
  • PSMD3-ILF3 signaling cascade drives lung cancer cell proliferation and migration. (nih.gov)
  • Bone marrow examination showed the proliferation of hematopoietic cells were active, mainly granulocytes, and immature granulocytes increased. (frontiersin.org)
  • Shredded pieces of evidence suggest that flavonoids can enhance drug sensitivity and suppress proliferation, metastasis, and angiogenesis of cancer cells by modulating several oncogenic or oncosuppressor microRNAs (miRNAs, miRs). (lu.se)
  • The EDNRB gene provides instructions for making a protein called endothelin receptor type B. This protein is located on the surface of cells and functions as a signaling mechanism, transmitting information from outside the cell to inside the cell. (medlineplus.gov)
  • There have been some attempts to outline the differences between a pathological and a nonpathological lie, but more research is necessary to make appropriate distinctions. (medicalnewstoday.com)
  • 1998. Protection of human upper respiratory tract cell lines against sulphur mustard toxicity by hexamethylenetetramine (HMT). (cdc.gov)
  • Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing significant toxicity towards the normal cells. (lu.se)
  • A case study of one person showing signs of pathological lying found that their behavior patterns were similar to those that can occur with frontotemporal dementia . (medicalnewstoday.com)
  • Recently, mesenchymal stem cells (MSCs) have been suggested for use in the cell-based treatment of cartilage lesions. (researchgate.net)
  • These melanocytic cells are of neuroectodermal origin, and melanocytic tumors may arise from these cells. (medscape.com)
  • 0 blue-cell tumors (SRBCTs), which type, 41 (including 7 expressed often masquerade as each other. (lu.se)
  • These tumors are grouped together because they all appear to arise from postmeiotic germ cells. (medscape.com)
  • Normal migration of these germ cells may cause gonadal tumors, whereas abnormal migration produces extragonadal tumors. (medscape.com)
  • In 1965, Teilum first suggested the germ cell origin of gonadal tumors. (medscape.com)
  • Alpha-synuclein (α-Syn), the primary pathological marker of PD, can gather in the SN and trigger a neuroinflammatory response by activating microglia which can further activate the dopaminergic neuron's neuroimmune response mediated by reactive T cells through antigen presentation. (biomedcentral.com)
  • Consis- with COVID-19 in Wuhan, China: a retrospective cohort tently, reports about pathological changes in organs study. (cdc.gov)
  • A retrospective analysis of radiological and pathological features of five cases of intracranial hemangiopericytoma was conducted between 2006 and 2012 in the Second Xiangya Hospital of Central South University. (spandidos-publications.com)
  • Moreover, primary signet ring cell carcinomaof the appendix is an exceedingly rare entity. (wjgnet.com)
  • It is unclear whether pathological lying is a symptom of another condition or a condition itself. (medicalnewstoday.com)
  • Renal cell carcinoma (RCC) is one of the ten most common cancers for men and women with an approximate 75% overall 5-year survival. (frontiersin.org)
  • In an effort to develop cell therapy-based strategies for progressive MS, we investigated the pre-clinical efficacy of bone marrow mesenchymal stem cell-derived neural progenitors (MSC-NPs) as an autologous source of stem cells. (listlabs.com)
  • MSC-NPs consist of a subpopulation of bone marrow MSCs with neural progenitor and immunoregulatory properties, and a reduced capacity for mesodermal differentiation, suggesting that this cell population may be appropriate for clinical application in the CNS. (listlabs.com)
  • Bone marrow smear and biopsy showed active hyperplasia, immature lymphocytes accounting for 3%, and heterotypic large cells having a scattered distribution (Figure 4 ). (hindawi.com)
  • Flow cytometry analysis showed lymphocytes accounting for 6.8% and suggested phenotypic abnormal NK cells in the bone marrow. (hindawi.com)
  • We have identified a novel pathway that directs Lyn/Src family tyrosine kinase signals to the invadopodia to regulate sarcoma cell invasion via the molecule AFAP-1-like-1 (AFAP1L1), a new member of the AFAP (actin filament-associated protein) family. (nature.com)
  • The distribution of this molecule in normal and pathological synovia from patients with osteoarthritis (OA) and rheumatoid arthritis (RA) was investigated by indirect immunofluorescence utilizing specific monoclonal antibodies. (nih.gov)
  • The triggers for this pathological change can include, for example, high blood pressure, arteriosclerosis and cardiac valve defects. (mpg.de)
  • We recently discovered that cancer cells commonly depend on aberrant activation of two major genome maintenance pathways (Trans-Lesion Synthesis or TLS, and Homologous Recombination or HR) for DNA damage tolerance. (nih.gov)
  • At present, about 5% of the world's population are carriers of a potentially pathological haemoglobin gene (i.e. healthy people who have inherited only one mutant gene from one parent). (who.int)
  • Up until now, this form of cell death has only been thought to be a possible therapeutic approach to treat tumor cells. (sciencedaily.com)
  • It is usually possible to determine why someone has told a lie - such as to benefit themselves or avoid an embarrassing or stressful social situation - but pathological lying occurs for no clear reason and does not seem to benefit the individual. (medicalnewstoday.com)
  • Subsequent literature regarding this newly recognized (but of course not truly new) "mast cell activation syndrome" (MCAS) included case reports as well as formal studies (mostly relatively small scale), reviews, and various proposals for formal diagnostic criteria. (degruyter.com)
  • We present a case of primary intestinal NK/T cell lymphoma with diagnostic challenge, which eventually developed into multiple intestinal perforations. (frontiersin.org)
  • Adhesion molecules are cell surface receptors that are probably important in various cell-cell and cell-extracellular matrix interactions of the cornea. (nih.gov)
  • Although cardiac hypertrophy is initiated by various receptors at cell membranes sensing biomechanical signals and hormones, it is generally mediated by cellular signaling cascades. (molcells.org)
  • In the present study, the team was able to show that Liproxstatin-1 suppresses ferroptosis both in human kidney cells, Gpx4 deletion-induced acute renal failure and in a pre-clinical model of hepatic ischemia reperfusion injury. (sciencedaily.com)
  • We anticipate that our compilations related to miRNA-mediated regulation of cancer cells by flavonoids might catapult the clinical investigations and affirmation in the future. (lu.se)
  • Some haemoglobinopathy genes ( alpha-thal, beta-thal and HbS ) cause alpha-thalassaemia, beta-thalassaemia and sickle-cell anaemia, respectively, but others ( HbE and HbC ) cause severe clinical manifestations of the disease only when combined with one of the former genes. (who.int)
  • Stem cell therapy is a non-invasive procedure it is innovation in the medical field providing treatment for various diseases which are not treatable by conventional medicine. (mumbaionline.in)
  • Stem cell therapy in India provides best stem cell procedure at an affordable cost with best results and encourages patients to consult with us for their ailments. (mumbaionline.in)
  • Do you want to receive special deals and offers from Stem Cell Therapy Center? (mumbaionline.in)
  • Nerve repair, replacement, and regeneration have become possible with the development of stem cell technology and progress has been made in treating PD with stem cell transplantation. (biomedcentral.com)
  • This is a case report of a 77-year-old Spanish male patient with localized SCC of the colon, who presented a pathological complete response in the surgical specimen after neoadjuvant chemotherapy with cisplatin and etoposide. (mdpi.com)
  • This chapter provides an overview of the key role of hEPC in promoting angiogenesis and their potential use for cell therapy. (intechopen.com)
  • SCCs located on the lower lip were more aggressive than basal cell carcinomas, which were quite common in the head and neck regions. (medicaljournal-ias.org)
  • Together with mucus-secreting goblet cells within the stratified epithelium, melanocytic cells are found in the basal layer of the conjunctiva. (medscape.com)
  • I will present some of the work done on the detection of metabolites released by cells undergoing osteogenic differentiation and on the development of 3D architectures that can be used to host and monitor stem cells. (gla.ac.uk)
  • The best evidence suggests that most are due to abnormal differentiation of fetal germ cells that arise from the fetal yolk sac. (medscape.com)
  • Therefore a potential benefit pathologically to confirm the presence cells, which leads to abnormal differen- could be expected if we had a feasible or absence of gastritis and/or malignan- tiation of cells [3]. (who.int)
  • This reliance on 'pathologically-activated' DNA repair is a new molecular vulnerability of cancer cells and provides opportunities for highly selective targeted therapies. (nih.gov)
  • Some cells enter the G0 phase semi-permanently and are considered post-mitotic, e.g., some liver, kidney, and stomach cells. (wikipedia.org)
  • Extranodal natural killer (NK)/T-cell lymphoma (ENKL), nasal type, is the common nasal lymphoma in Asian and South America male adults [ 2 ]. (hindawi.com)
  • Extranodal NK/T cell lymphoma nasal type (ENKTL) is a subtype of non-Hodgkin lymphoma (NHL). (frontiersin.org)
  • Before a patient begins lung cancer treatment, an experienced lung cancer pathologist must review the pathological material. (cancer.gov)
  • However, even these patients are at risk of dying from lung cancer (both small and non-small cell types). (cancer.gov)
  • Non-neoplastic smoke-related lung disease: chronic obstructive pulmonary disease, small airways disease/respiratory bronchiolitis, Langerhans cell histiocytosis of the lung. (unibo.it)
  • The present study aimed to evaluate the radiological and pathological features of intracranial hemangiopericytoma, and improve the understanding of this tumor. (spandidos-publications.com)
  • Identification of AFAP1L1 as a prognostic marker for spindle cell sarcomas. (nature.com)
  • The objective here is to define signaling mechanisms by which cancer cells activate TLS and HR. Our central hypothesis is that pathological DNA repair activity sustains cancer cell growth and confers resistance to therapy. (nih.gov)
  • To ensure the proper replication of cellular components and division, there are control mechanisms known as cell cycle checkpoints after each of the key steps of the cycle that determine if the cell can progress to the next phase. (wikipedia.org)
  • However, older thalassaemics may have to contend with multiple conditions including early osteoporosis, cardiac disease, pulmonary hypertension and diabetes, some of which result from increased iron deposition in the endocrine glands and myocardial cells. (who.int)
  • The application of atomic force microscopy to the study of living vertebrate cells in culture. (degruyter.com)
  • This study is an introduction to maternal representations during pathological pregnancies of women with sickle cell disease. (bvsalud.org)
  • In this study, an integrated approach combining quantitative phosphoproteomics and cell-based functional screening using phosphorylation competition peptides was developed. (molcells.org)
  • We observed a clear increase in RhoGEF12 activation in the cardiac muscle cells of these mice, " said Nina Wettschureck, who carried out the study in collaboration with Mikito Takefuji. (mpg.de)
  • Bioelectricity and Bioelectronics to study and influence cell fate. (gla.ac.uk)
  • We show that AFAP1L1 can transform cells, promote migration and co-expression with active Lyn profoundly influences cell morphology and movement. (nature.com)
  • Significantly, in osteosarcoma cell lines, knockdown of AFAP1L1 inhibits phosphorylated MLC2 recruitment to filamentous-actin structures, disrupts invadopodia formation, cell attachment, migration and invasion. (nature.com)
  • These data define a novel pathway that directs Lyn/Src family tyrosine kinase signals to sarcoma cell invadopodia through specific recruitment of Vav2 and Nck2 to phosphorylated AFAP1L1, to control cell migration and invasion. (nature.com)
  • The retinal ganglion cell is situated in the inner retina and its axons, composing the retinal nerve fiber layer (RNFL), leave the eye to form the optic nerve. (avhandlingar.se)
  • The ganglion cell -inner plexiform layer (GCL-IPL) layer, however, showed a thickness reduction within a few weeks to 3 months without pseudo thinning. (avhandlingar.se)
  • Seasonal fluctuations of the pathological cycle phases Spraguea lophii (Doflein, 1898) Weissenberg, 1976 in the ganglion cells of Lophius budegassa Spinola, 1807. (ub.edu)
  • Associations between SUVmax and pathological response of primary tumor and prognosis were analyzed. (biomedcentral.com)
  • The eukaryotic cell cycle consists of four distinct phases: G1 phase, S phase (synthesis), G2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). (wikipedia.org)
  • Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. (nih.gov)
  • Laboratory tests showed leukocytosis (20.79 × 10 9 /L), moderate anemia (69 g/L), increased percent of neutrophils (91.6%), increased C-reactive protein (CRP) (80.90 mg/L), procalcitonin (PCT) (5.87 ng/ml) and erythrocyte sedimentation rate (ESR) (106.0 mm/h) level, and mild hypoalbuminemia (31.0 g/L). Stool routine revealed Leukocyte ++++/HP, pus cell ++++/HP, stool blood was positive. (frontiersin.org)
  • Transport to the nucleus may involve specific protein-to-protein interactions that occur in certain cell types only, possibly explaining the selective neuronal vulnerability present in patients with HD. (medscape.com)
  • Adhesion molecules in normal and pathological corneas. (nih.gov)
  • Tenascin was found in normal synovium just beneath the whole lining cell layer. (nih.gov)
  • They are involved in virtually every normal and pathological process in the CNS. (imperial.ac.uk)
  • The decreased expression of adhesion molecules in corneal degenerative disorders is probably a sign of reduced cell-cell and cell-extracellular matrix interactions. (nih.gov)
  • Haemoglobinopathies, mainly thalassaemias and sickle-cell anaemia, are inherited disorders. (who.int)
  • In the United States of America, 10% of the population is at risk of sickle-cell anaemia, and in north-western Europe between 2% and 9% belong to the ethnic minorities at risk of haemoglobin disorders. (who.int)
  • D: Microscopy showing mononuclear intermediate trophoblastic cells, increased mitotic activity, and destructive invasion of the left ovary, 2020. (wjgnet.com)