• By using blockers of PKA and CaMKII and a Caveolin-3-knockout mouse model, we conclude that the β2AR-LTCC regulation requires the presence of caveolin-3 and the activation of the CaMKII pathway. (imperial.ac.uk)
  • Collectively, we demonstrated that hyperglycemia was involved in mediating secondary injury after DAI by disrupting BBB integrity by inducing inflammation through the PPARγ/caveolin-1/TLR4 pathway. (researchsquare.com)
  • Körschgen H, Baeken M, Schmitt D, Nagel H, Behl C . Co-chaperone BAG3 enters autophagic pathway via its interaction with microtubule associated protein 1 light chain 3 beta. (unimedizin-mainz.de)
  • Since the discovery of autophagy-related ( Atg ) genes in the 1990s, there has been a proliferation of studies on the physiological and pathological roles of autophagy in a variety of autophagy knockout models. (nature.com)
  • For physiological or pathological understanding of bone disease caused by abnormal behavior of osteoclasts (OCs), functional studies of molecules that regulate the generation and action of OCs are required. (molcells.org)
  • Mitochondrial state 3 respirations and ATP synthesis were measured, and mitochondrial morphology was evaluated by electron microscopy. (omicsdi.org)
  • If initial targeted genetic testing (either single gene or a panel of LGMDs) is negative, a muslce biopsy showld be obtained to look at the immunohistochemical staining patterns using antibodies directed at known disease associated proteins (e.g. dystrophin, sarcoglycans, merosin, α-dystroglycan, dysferlin, cveloin-3, etc) and to look for distinguishing features (e.g. rimmed vacuoles, myofibrillar myopathy). (medscape.com)
  • Resveratrol (3,5,4′-trihydroxy-trans-stilbene, RSV), a kind of dietary polyphenol abundantly existed in red wine and Chinese herb rhizoma polygonum cuspidatum , might play an important role in 'French paradox' (Kopp 1998 ). (springer.com)
  • Inflammatory Breast Cancer (IBC) is a rare, although highly aggressive and lethal 3 type of cancer. (bvsalud.org)
  • Indeed, several human diseases are characterized by attenuated repair responses and imbalances in the inflammatory response with increased number of infiltrating macrophages [ 3 - 5 ]. (hindawi.com)
  • Subsequently, the PPARγ agonist RSG increased caveolin-1 expression and decreased TLR4 expression and inflammatory factor levels. (researchsquare.com)
  • In contrast, caveolin-1 siRNA abrogated the protective effects of RSG in the in vitro BBB model of hyperglycemia by increasing TLR4 and Myd88 expression and the levels of inflammatory factors, including TNF-α, IL-1β, and IL-6. (researchsquare.com)
  • 2010 ). Results from cav-1 (caveolin-1, the key structural protein of caveolae)-deficient mice indicated that cav-1 in endothelium is essential in the translocation of LDL-derived cholesterol into the vessel wall and in the development of atherosclerosis, and this result was further confirmed in apoE-/- mice (Fernandez-Hernando et al. (springer.com)
  • We separated lipid rafts, and analyzed Bcl10 protein and caveolin. (geneticsmr.com)
  • On the origin of BAG(3) and its consequences for an expansion of BAG3's role in protein homeostasis. (unimedizin-mainz.de)
  • During pathological hypertrophy, peroxisome proliferator-activated receptor coactivator 1? (omicsdi.org)
  • Pathological cardiac hypertrophy was induced using 4 wk of transverse aortic constriction (TAC) in mice overexpressing the human PGC-1? (omicsdi.org)
  • Abstract Caveolin-1, the first member of caveolin family reported, is recognized as the structural component of caveola, a plasma membrane invagination or vesicles that are a subcompartment distinct from clathrin-coated pits. (techscience.com)
  • Highest ranked abstract, Pathological Society of GB 195th Scientific Meeting 2009 and 202nd meeting 2012. (nottingham.ac.uk)
  • Highest ranked abstract, Pathological Society of GB & Ireland and Dutch Pathological Society, Amsterdam, 2004. (nottingham.ac.uk)
  • Endoplasmic reticulum stress (ERS) is a self-protective mechanism resulting from an imbalance in quality control of unfolded proteins when cells are stressed, which plays an active role in lung cancer development, but the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients remains unclear. (biomedcentral.com)
  • However, the relationship between ERS and the pathological characteristics and clinical prognosis of LUAD patients is still unknown and needs to be further explored. (biomedcentral.com)
  • The main reason that persistent hyperglycemia leads to a poor prognosis may be because of a series of pathological changes, and rupture of the BBB is an important pathogenic mechanisms [ 5 ] . (researchsquare.com)
  • We characterized a role for STRN in cardiomyocyte spontaneous contraction, and in the interaction between caveolin-3 and calmodulin in the heart. (ku.ac.ae)
  • Perturbations of macrophage function and/or activation may result in impaired regeneration and fibrosis deposition as described in several chronic pathological diseases. (hindawi.com)
  • Clinical significance of serum caveolin -1 levels in patients with melanoma. (immpact-international.org)
  • I am the General Secretary of the International Society of Breast Pathology, Breast Specialty Editor of Histopathology, a member of the National Coordinating Committee of Breast Pathology (BIG18), National Institute of Cancer Research (NICR) Breast Clinical Studies Group (CSG) and its Breast Translational Subgroup, Breast Cancer Screening Programme Research Advisory Committee, the Pathological Society of Great Britain and Ireland Management Committee, and the international Breast Pathology Group. (nottingham.ac.uk)
  • Therapeutic induction of Bcl2-associated athanogene 3-mediated autophagy in idiopathic pulmonary fibrosis. (unimedizin-mainz.de)
  • NOS catalyzes the reaction: 2 L-arginine + 3 NADPH + 3 H+ + 4 O2 ⇌ {\displaystyle \rightleftharpoons } 2 citrulline +2 nitric oxide + 4 H2O + 3 NADP+ NOS isoforms catalyze other leak and side reactions, such as superoxide production at the expense of NADPH. (wikipedia.org)
  • There is an overwhelming mass of evidence demonstrating the development of endothelial dysfunction in animal models of diabetes and in human blood vessels from diabetic patients, as evidenced by increased release of reactive oxygen species, decreased nitric oxide (NO) bioactivity, decreased release of prostacyclin (PGI 2 ), and enhanced endothelial production of vasoconstrictor thromboxane (Tx)A 2 /prostaglandin (PG)H 2 in early stages of diabetes ( 1 - 3 ). (diabetesjournals.org)
  • In parallel, high glucose, but not mannitol, significantly increased superoxide and 3-nitrotyrosine in PGI 2 synthase (PGIS). (diabetesjournals.org)
  • Hyperglycemia further reduced the expression of PPARγ and caveolin-1, which significantly decreased after DAI and OGD. (researchsquare.com)
  • Endothelial dysfunction is a hallmark of vascular injury in diabetes and is preceded by the development of overt cardiovascular diseases ( 1 - 3 ). (diabetesjournals.org)
  • Figure 3: Therapeutic targeting and exploitation of extracellular vesicles. (nature.com)
  • The aim of this study was to determine the expression of caveolin-1 in adult rat Leydig cells. (techscience.com)
  • Increased permeability and caveolin-1 (cav-1) expression were observed in monolayer ECs exposed to high glucose. (springer.com)
  • Male mice were intraperitoneally injected with a single dose of 1/3 LD50 of Parathion®, both PP and PC. (techscience.com)
  • As the most predominant subtype of NSCLC, lung adenocarcinoma (LUAD) accounts for approximately 50% of the total lung cancers [ 3 ]. (biomedcentral.com)
  • Best studied are mammals, where three distinct genes encode NOS isozymes: neuronal (nNOS or NOS-1), cytokine-inducible (iNOS or NOS-2) and endothelial (eNOS or NOS-3). (wikipedia.org)
  • Testis sections incubated with an antibody to caveolin-1 showed, by immunohistochemistry, a moderate number of Leydig cells with different degrees of immunoreaction and a strong reaction in endothelial cells and in the lamina propia of seminiferous tubules. (techscience.com)
  • The pathomechanism of ME/CFS is unresolved yet, but there is ample evidence for an autoimmune process involved ( 3 ). (frontiersin.org)
  • Metazoan miRNAs guide the miRISC to partially complementary sites in the 3' UTRs of target mRNAs to promote their translational repression or deadenylation and degradation. (biomedcentral.com)
  • The miRNA sequence being complementary to the 3′UTR of its target mRNA determines the regulatory effect of miRNA ( 6 ). (frontiersin.org)
  • Hyperglycemia related to diabetes is less important than stress-induced hyperglycemia in terms of mortality in acute trauma and TBI patients [ 3 ] . (researchsquare.com)
  • The synthesis of the peptides may provide sufficient material to enable further studies and to determine the structure-activity relationships or may provide discovery of new analogues with improved properties [ 1 , 2 , 3 , 4 , 5 , 6 , 7 ]. (intechopen.com)
  • Preclinical research on non-invasive biomarkers for the detection and monitoring of a number of pathological conditions (inflammation, cancer, neurodegeneration, etc. (immpact-international.org)
  • The development of L24M in to cHIV(NL4-3) (cHIV(NL4-3L24M)) interfered along with TPV's dimerization inhibition, whilst L24M improved HIV-1's inclination towards TPV together with the HIVNL4-3 genetic background. (methylation-inhibitors.com)
  • Any time selected with TPV, cHIV(NL4-3I54V/V82T) the majority of easily created TPV opposition and acquired E34D, that jeopardized TPV's dimerization inhibition together with the HIVNL4-3 genetic track record. (methylation-inhibitors.com)
  • Autoantibodies (AAB) against nuclear and membrane structures as well as neurotransmitter receptors including muscarinic cholinergic receptor M3/M4-antibodies (M3-mAChR/M4-mAChR) and beta-1 and -2-adrenergic receptor (beta1-AR/beta2-AR) have been described in patients with ME/CFS ( 3 , 6 - 8 ). (frontiersin.org)
  • Routine postoperative radiographs can Nutlin-3 concentration be a source of inconvenience and cost to patients, radiation exposure, and possibly, confounding information. (peptide-solubility.com)
  • Results: Mean overall duration of RUF treatment was 14.5 months (range: 3-18 months). (peptide-solubility.com)
  • The molecular mechanisms that control the pathological signaling of the diseased myocardium are not well understood. (ku.ac.ae)
  • To investigate apoptosis in hyperlipidemia induced atherosclerosis, genetically induced hyperlipidemia in Froxfield Heritable Hypercholesterolemic Rabbits (FFH, n=8) was compared with New Zealand White rabbits either fed with a cholesterol diet (H, n=8, 0,25% cholesterol, 3% coconut oil) or with a normal diet (control, n=5) for 12 weeks. (uni-frankfurt.de)
  • PAH can present at any age, but the ~ 3:1 female to male ratio in adult-onset disease is not observed in pediatric-onset disease, in which the disease incidence is similar for males and females. (biomedcentral.com)
  • Physiologically, the N-terminal domain of p126 binds the Src-homology 3 (SH3) domain of c-Abl, leading to activation of the MAPK/ERK2 kinase. (molcells.org)
  • An α-actinin-3 Knockout Mouse Suffers Increased Sarcomeric Damage from Eccentric Exercise. (edu.au)
  • The other autosomal recessive LGMDs usually cause CK elevations that are 3-80 times normal. (medscape.com)
  • Human noroviruses (HuNoVs) are a major cause of viral gastroenteritis, with an estimated 3 million cases per year in the United Kingdom. (worktribe.com)
  • In such cases, hyperglycemia results from defects in insulin secretion and/or insulin action ( 3 ). (frontiersin.org)