Pathologic retinal neovascularization. Medical search. Frequent questions

This paper highlighted the complications of pathologic myopia. (reviewofoptometry.com)
Pathologic myopia (PM) represents a spectrum of degenerative ocular structural complications that arise secondary to high myopia. (reviewofoptometry.com)
This case report will discuss a female patient with pathologic myopia and outlines the various manifestations and management options. (reviewofoptometry.com)
Figure 2: Clarus color fundus photograph of the left eye demonstrating signs of high myopia and prior retinal detachment. (eyerounds.org)
There is no consensus definition of the term pathologic myopia. (eyerounds.org)
Many studies define high myopia (HM) as -5.00 to -8.00 diopters axial myopia or >26.0 mm to >26.5 mm axial length and pathologic myopia (PM) as HM in addition to lesions or degenerative fundus changes that result in decreased best corrected visual acuity. (eyerounds.org)
visual impairment due to diabetic macular oedema (DME), macular edema secondary to retinal vein occlusion (RVO), choroidal neovascularization (CNV) secondary to pathologic myopia (PM) and CNV secondary to ocular conditions other than AMD or PM, including but not limited to angioid streaks, post-inflammatory retinochoroidopathy, central serous choriorentinopathy or idiopathic chorioretinopathy [4, 5]. (gabionline.net)
Long-term results of photodynamic therapy for subfoveal choroidal neovascularization with pathologic myopia. (giacomoabbruzzese.it)
These results indicate associations between types of pathological myopia and presence or absence of posterior staphyloma analyzed by ultra-widefield retinal imaging. (elsevierpure.com)
High myopia is a combination of refractive error and axial length, and can lead to complications such as chorioretinal atrophy, posterior staphyloma, foveoschisis, lacquer cracks, choroidal neovascularization, retinal tears and detachments. (retinacolorado.com)
Join us for an overview of novel technologies in myopia prevention and the retinal approaches in treating pathologic myopia. (retinacolorado.com)
The European Commission has granted Novartis a fourth approval for its eye drug Lucentis, this time to treat patients with visual impairment due to choroidal neovascularisation secondary to pathologic myopia. (pharmatimes.com)
Pathologic myopia is a major cause of vision loss worldwide, affecting 1%-3% of the general population, and CNV is the most common vision-threatening complication of high myopia. (pharmatimes.com)
Purpose: To investigate the development and progression patterns of macular neovascularization (MNV)-related atrophies in eyes with pathologic myopia (PM). Methods: Twenty-seven eyes of 26 patients. (octclub.org)
IMI 2021 taskforces leaders Professors Kyoko Ohno-Matsui, Jost B. Jonas, Padmaja Sankaridurg, Nicola Logan and Ian Morgan discussed the areas of pathologic myopia, prevention of myopia and its progression, impact of myopia, accommodation and binocular vision in myopia development and progression, and environmental risk factors in myopia. (myopiainstitute.org)
For CNV secondary to pathologic myopia (PM), many patients may only need one or two injections during the first year (see section 5.1). (medicines.org.uk)
a An additional cohort of patients with pathologic myopia and no evidence of mCNV were enrolled as a negative control group. (medscape.org)
Retinal detachment occurs more commonly in men than in women, in eyes with degenerative myopia, in aging and in aphakia. (lookformedical.com)
Causes of included multifocal choroiditis and panuveitis (N = 12), angioid streaks (N = 11), pathologic myopia (N = 10), and idiopathic or other causes (N = 6). (medscape.com)

Extended follow-up of treated and untreated retinopathy in incontinentia pigmenti: analysis of peripheral vascular changes and incidence of retinal detachment. (jamanetwork.com)
foliage from the treatment of inflamation related diseases.Target Pathologic intraocular neovascularization is a key component of many canine ophthalmic ailments for example uveitis, retinal detachment, intraocular neoplasms, as well as cornael perforation. (topoisomerasepathway.com)
Procedure This research examined 36 enucleated doggy sight with all the proper diagnosis of PIFM then one in the right after: lens-induced uveitis, retinal detachment, iridociliary adenoma, cornael perforation, extreme hyphema, as well as vitreal gliovascular filters (doggy ocular gliovascular affliction, COGS). (topoisomerasepathway.com)
Acquired retinoschisis with giant outer layer break and retinal detachment. (giacomoabbruzzese.it)
Pneumatic retinopexy for retinal detachment associated with choroidal coloboma. (giacomoabbruzzese.it)
Retinal detachment and retinal breaks are more observed in cases without posterior staphyloma (p = 0.017). (elsevierpure.com)
The rate of periocular disorders such as retinal detachment was significantly higher without posterior staphyloma. (elsevierpure.com)
One study used OCT to examine 84 eyes with ME secondary to uveitis, which provided the added benefit of re-vealing or confirming the presence of epiretinal membranes and serous retinal detachment in 41 and 20 percent of their cases, respectively. (reviewofophthalmology.com)
Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the premature retina that causes visual loss and blindness by the consequent effects of scarring and traction, creating macular displacement, macular distortion and retinal detachment. (insightnews.com.au)
Stage 1 resembles a line, Stage 2 a ridge, Stage 3 extraretinal neovascularisation, Stage 4 partial retinal detachment (4a macula attached, 4b macula detached) and Stage 5 total retinal detachment. (insightnews.com.au)
Her exam was notable for vitritis, bilateral serous retinal detachment, and choroidal infiltrates. (retinaroundup.com)
A CHOROID neovascularization characterized by serosanguineous retinal pigment epithelial detachment and leakage of serous exudate sometimes associated with aneurysmal polypoidal lesions. (bvsalud.org)

To evaluate the 12-month efficacy and safety of intravitreal conbercept for myopic choroidal neovascularization (CNV). (biomedcentral.com)
Thirty-four eyes of 34 pathologic myopic patients with CNV were treated with intravitreal conbercept (IVC) 0.5 mg with a follow up of 12 months. (biomedcentral.com)
proposed a classification system for myopic maculopathy based on fundus appearance in addition to "plus lesions," which included lacquer cracks, choroidal neovascularization, or Fuchs spots. (eyerounds.org)
In conclusion, the prevalence rates of myopic choroidal neovascularization, retinal choroidal atrophy, and optic neuropathy were significantly higher with posterior staphyloma. (elsevierpure.com)
The differential diagnosis was thought to include acute idiopathic maculopathy, acute macular neuroretinopathy, or myopic neovascularization. (retinaroundup.com)
D Dioptres, AL Axial length, FA Fluorescein angiography, OCTA Optical coherence tomography angiography, SD-OCT Spectral domain optical coherence tomography, mCNV Myopic choroidal neovascularisation. (medscape.org)

Retinal diseases, which are often characterized by leakage of fluid, hemorrhage and fibrous scarring in the eye, include wet age-related macular degeneration (wAMD), diabetic macular edema (DME), retinal vein occlusion (RVO) and choroidal neovascularization (CNV) not secondary to AMD. (biomedcentral.com)
diabetic macular oedemav and for visual impairment caused by macular oedema secondary to central or branch retinal vein occlusion. (pharmatimes.com)

These findings provide evidence that the new vessels arising in the choroid in these patients usually grow within the subsensory retinal space and not in the subpigment epithelial space, as occurs in patients with age-related macular degeneration. (nih.gov)
In presumed ocular histoplasmosis, the new vessels are partly engulfed by a monolayer of proliferating retinal pigment epithelium. (nih.gov)
Computer assisted evaluation of retinal vessels tortuosity in Fabry disease. (giacomoabbruzzese.it)
KDR immunoreactivity was only weakly associated with developing retinal vessels and was not observed in angioblasts throughout normal postnatal development. (johnshopkins.edu)
Immunoreactivity was very strong in reforming retinal vessels and intravitreal neovascularization in oxygen-treated animals. (johnshopkins.edu)
KDR/Flk-1 was only weakly associated with normal developing primary retinal vessels but was strongly expressed by proliferating endothelial cells in reforming retinal vessels and intravitreal neovascularization after hyperoxic insult. (johnshopkins.edu)
Evidence shows that when the retinal pigment epithelial (RPE) cells begin to wither from lack of nutrition (a condition called "ischemia"), the VEGF goes into action to create new vessels. (preventblindness.org)
Diabetic retinopathy is a complication of type 2 diabetes resulting from long-term accumulated damage to retinal blood vessels and one of the life-threatening complications and is the most common cause of acquired blindness in adults and it affects 93 million people worldwide. (clinmedjournals.org)

Specific ablation of PDGFRbeta-overexpressing pericytes with antibody-drug conjugate potently inhibits pathologic ocular neovascularization in mouse models. (stanford.edu)

Outcomes included best corrected visual acuity (BCVA), central retinal thickness (CRT), CNV size, the total number of treatments, and adverse events. (biomedcentral.com)
5 The study found a moderate correlation be-tween retinal thickness and decreasing visual ac-uity, although the degree of correlation has varied across studies with other investigators reported weak, 6 mo-de-rate, 7 and strong 8,9,10 cor-relations using varying statistical methods in di-verse pa-tient pop-ulations, including pa-tients with diabetic retinopathy, uveitis and CME. (reviewofophthalmology.com)
The aim of this study was to evaluate the macular thickness (MT), ganglion cell complex (GCC), and circum-papillary retinal nerve fiber layer (RNFL) thickness in primary open-angle glaucoma (POAG) and normal tension glaucoma (NTG) with spectral domain optical coherence tomography (SD-OCT). (octclub.org)
Firat PG, Doganay S, Demirel EE, Colak C. Comparison of ganglion cell and retinal nerve fiber layer thickness in primary open-angle glaucoma and normal tension glaucoma with spectral-domain OCT. Graefes Arch Clin Exp Ophthalmol. (octclub.org)
Nancy Holekamp, M.D., discussed key anatomic endpoints in the MARINA trials, in particular, the total lesion area over time (no growth of the lesion area was noted in the treated patients), the mean area of leakage (the amount of decrease was statistically significant) and the mean foveal retinal thickness (treated eyes showed a significant thinning of the retina). (preventblindness.org)
Aim To evaluate the efficacy of a standardised combination therapy for clinically significant diabetic macular oedema using bevacizumab injections followed by navigated laser photocoagulation to stabilise retinal thickness. (bmj.com)

The study suggests that blocking KDR may be beneficial for treating pathologic angiogenesis in adult tissue. (johnshopkins.edu)
retinal vasculature and gene profile of retinal angiogenesis were assessed. (usp.br)
Cite this: Anti-angiogenesis in Eyes With Choroidal Neovascularization - Medscape - Aug 14, 2008. (medscape.com)

6 7 By contrast, vascular endothelial growth factor (VEGF) appears to stimulate retinal vasodilatation and neovascularization. (arvojournals.org)
Singerman LJ, Masonson H, Patel M, Adamis AP, Buggage R, Cunningham E. Pegaptanib sodium for neovascular age-related macular degeneration: third-year safety results of the VEGF Inhibition Study in Ocular Neovascularisation (VISION) trial. (medscape.com)
This may be due to its role as a permissive factor for vascular endothelial growth factor (VEGF) function in normal and pathologic vascular development. (usp.br)
Inevitable hyperoxia (to sustain life and reduce the incidence of cerebral palsy) downregulates VEGF, arresting vascularisation and, combined with loss of the benefits of the normal maternal-fetal interaction, retinal vaso-obliteration results. (insightnews.com.au)
At 32 weeks, the retina becomes metabolically active and again becomes hypoxic, upregulating VEGF, leading to pathologic vascularisation. (insightnews.com.au)
both modalities indirectly reducing VEGF and pathologic vascularisation and subsequent cicatrisation leading to Stages 4 and 5 ROP. (insightnews.com.au)
Since the US Food and Drug Administration approval of ranibizumab in 2006, antivascular endothelial growth factor (VEGF) therapy for choroidal neovascularization (CNV) for age-related macular degeneration (AMD) has become standard therapy. (medscape.com)

Macula: In the right eye, there was patchy chorioretinal atrophy with a small retinal hemorrhage in the superotemporal macula near a lacquer crack. (eyerounds.org)
The CNVM has resolved and there is some mild outer retinal atrophy in the area (arrow). (eyerounds.org)
Intraretinal fluid and outer retinal atrophy due to AMD. (reviewofoptometry.com)
The angioid streaks appear as crack-like breaks in Bruch's membrane and retinal pigment epithelium (RPE) atrophy. (reviewofoptometry.com)

Following preterm birth, the post- natal environment doesn't match the in-utero environment that supported retinal vascular development. (insightnews.com.au)

We demonstrated histological evidence of persistent ectopic synapses, prolonged cellular apoptosis, and gliosis in the OIR retina that corresponded with long-term in vivo evidence of capillary attrition, inner retinal thinning, and dysfunction despite full peripheral revascularization. (molvis.org)
Macular edema represents the pathologic accumulation of extracellular fluid within the retina, primarily in the outer plexiform and inner nuclear layers, as a nonspecific re-sponse to a breakdown in the blood-retinal barriers. (reviewofophthalmology.com)
In the normal eye, fluorescein is prevented from passing into the retina by the blood-retinal barriers. (reviewofophthalmology.com)
Neovascularization is then blocked, preventing bleeding into the retina. (preventblindness.org)

Pathological neovascularization plays a pivotal role in the onset and progression of tumors and neovascular eye diseases. (biomedcentral.com)
Tumor xenograft model and ocular pathological neovascularization model were constructed as well as Isolectin B4 (IsoB4) staining and immunofluorescence staining were used to assess the effects of AFAP1L1 on the progression of neoplasms and neovascular eye diseases in vivo. (biomedcentral.com)
Real-world data (RWD) has been a valuable addition to the scientific literature regarding treatment pathways, clinical outcomes and characteristics of patients with retinal diseases in recent years. (biomedcentral.com)
Using a systematic approach, we identified RWD sources for patients with retinal diseases and assessed them for completeness of data relating to different outcomes. (biomedcentral.com)
Genetic testing was notable for a heterozygous pathologic sequence variant of Crumbs homolog 1 (CRB1), which has been implicated in a wide range of inherited retinal diseases. (retinaroundup.com)
Excluded patients with other retinal or choroidal diseases, or dense cataracts. (medscape.org)

Retinopathy of prematurity (ROP) is a condition of aberrant retinal vascularization in premature infants in response to high levels of oxygen used for critical care that can potentially cause blindness. (molvis.org)
This study investigated long-term outcomes of hyperoxia on retinal morphology and function using a mouse model of oxygen-induced ischemic retinopathy (OIR). (molvis.org)
Retinopathy of prematurity (ROP) is a disorder of retinal vascular development primarily affecting premature infants exposed to high levels of supplemental oxygen. (molvis.org)
5 Although basic science may lead to clinical treatments to reduce or prevent retinopathy by blocking the pathologic effects of ischemia-induced growth factors and deranged autoregulation, the precise mechanisms responsible for various stages of disease progression remain unclear. (arvojournals.org)

outer and inner retinal dysfunction were demonstrated with fERG. (molvis.org)
Inner retinal thinning in the inferotemporal macula (arrowhead). (jamanetwork.com)
Inner retinal thinning in the superotemporal macula (arrowhead). (jamanetwork.com)
Flow loss in the superficial (C) and deep (D) plexus inferotemporal to the fovea, corresponding to an area of inner retinal thinning. (jamanetwork.com)

The patient had an extensive ocular history with regards to retinal changes related to PM. She underwent barrier laser retinopexy of retinal tears in both eyes approximately twelve years prior with re-treatment ten years later for additional laser barricade around the retinal tears in addition to inferior lattice degeneration in her left eye. (reviewofoptometry.com)

Wide-field retinal imaging in the management of noninfectious posterior uveitis. (jamanetwork.com)
ME is a frequent cause of vision loss in pa-tients with diabetes mellitus, retinal venous oc-clusion, uveitis, and following in--traocular surgery. (reviewofophthalmology.com)

Anti-KDR antibody delivered by slow-release pellets had no effect on normal vasculogenesis, but it inhibited the formation of intravitreal neovascularization and retinal vessel development in OIR. (johnshopkins.edu)
On further questioning, our patient reported being followed by a retinal specialist in the community for CNV in both eyes and had multiple intravitreal injections in both eyes to control the bleeding. (reviewofoptometry.com)

DR is characterized by signs of retinal ischemia (retinal microvascular abnormalities, microaneurysms, hemorrhages, cotton wool spots, and neovascularization) and/or signs of increased retinal vascular permeability and It particularly affects patients with type 2 diabetes (T2DM) whose vision may be threatened by diabetic macular edema (DMO) [ 10 ]. (clinmedjournals.org)

Excessive axial length elongation drives biomechanical stretching of the posterior globe often associated with retinal and choroidal changes that inevitably lead to severe and irreversible visual impairment. (reviewofoptometry.com)

Her OCT was notable for loss of outer retinal layers peripherally and normal retinal layers centrally. (retinaroundup.com)
Baseline OCT demonstrated a small area of ellipsoid zone preserved at the fovea and otherwise diffuse outer retinal loss. (retinaroundup.com)

Surgical excision of this membrane permits reapproximation of the retinal receptors and native pigment epithelium and may be associated with remarkable return of visual acuity. (nih.gov)
Immunofluorescence staining of whole-mount retinas and retinal pigment epithelium-choroid-scleral complexes, electroretinography, and OptoMotry test were used to evaluate the effect and safety of ADC targeting mPDGFRbeta in the mouse models of pathologic ocular neovascularization.Results: ADC targeting mPDGFRbeta is effectively internalized into mouse brain vascular pericytes and showed significant cytotoxicity compared with the control ADC. (stanford.edu)

Background: Crosstalk between pericytes and endothelial cells is critical for ocular neovascularization. (stanford.edu)
Targeted suppression of AFAP1L1 specifically in endothelial cells in vivo proves effective in inhibiting tumor formation and ocular pathological neovascularization. (biomedcentral.com)

There was a small amount of subretinal fluid underlying the retinal tears that did not extend beyond the newer laser scars, otherwise there was no new breaks or detachments with scleral indentation performed 360 in each eye. (reviewofoptometry.com)

The study provides a comprehensive list of RWD sources for patients with retinal disease, many of which will be useful for conducting real-world studies in the field of ophthalmology. (biomedcentral.com)

Our causal analysis identifies the temporary preschool program effect on intellectual performance as the gateway to longer-term script rapid fire battlefront 2 inhibit the development and promote the regression of pathologic retinal neovascularization in the Vldlr knockout mouse. (iransolarium.com)

Rogers AH, Martidis A, Greenberg PB, Puliafito CA. Optical coherence tomography findings following photodynamic therapy of choroidal neovascularization. (medscape.com)
Kiss CG, Simader C, Michels S, Schmidt-Erfurth U. Combination of verteporfin photodynamic therapy and ranibizumab: effects on retinal anatomy, choroidal perfusion and visual function in the protect study. (medscape.com)

A systematic literature review was carried out to identify RWD sources for patients with retinal disease. (biomedcentral.com)
Canadians with retinal vascular disorders now have a new treatment available with Byooviz, a biosimilar that provides these patients the option to be treated with an effective therapy, with the added benefit of cost savings to the healthcare system', said Eric Tse, General Manager at Biogen Canada. (gabionline.net)
A retrospective study was performed for the patients, who have more than 26 mm of the axial length and of whom fundus photography was taken with an ultra-widefield retinal imaging system. (elsevierpure.com)
Our blog offers our referring providers and patients' essential information and insights into the world of retinal health. (retinacolorado.com)
Excluded patients with co-existing retinal conditions, history of ocular inﬂammation in the study eye, signiﬁcant media opacities, or large haemorrhage. (medscape.org)
Excluded patients with co- existing retinal conditions, or previous ocular treatments in the study eye. (medscape.org)
Pathologic processes that affect patients after a surgical procedure. (lookformedical.com)

We tested whether an antibody-drug conjugate (ADC) - an engineered monoclonal antibody linked to a cytotoxic agent - could selectively ablate pericytes and suppress retinal and choroidal neovascularization.Methods: Immunoblotting, flow cytometry, cell viability test, and confocal microscopy were conducted to assess the internalization and cytotoxic effect of ADC targeting mPDGFRbeta in an in vitro setting. (stanford.edu)

Plus' disease relates to vascular activity and is recognised by venous congestion and arterial tortuosity in the posterior retinal vasculature. (insightnews.com.au)

In the mouse model of retinal vascular development, neonatal mice administrated with IL-37 displayed increased neovascularization. (johnshopkins.edu)

Subretinal fluid and hemorrhage due to choroidal neovascularization. (reviewofoptometry.com)

Freund KB, Zweifel SA, Engelbert M. Do we need a new classification for choroidal neovascularization in age-related macular degeneration? (medscape.com)
The previously reported posterior pole findings appreciated via dilated fundoscopy were as follows: treated retinal tear with old cryotherapy and new barrier laser scars (12:30) in the right eye, and treated retinal tears (11:00, 1:30) with pigmented lattice degeneration (5:00-6:00), all surrounded by barrier laser in the left eye. (reviewofoptometry.com)

Therefore, enhanced understanding of the long-term effects of oxidative stress on the developing retinal structure beyond retinal vascularization would be important in discovering more effective treatment alternatives to preserve long-term visual function. (molvis.org)

Anatomy3

Organisms2

Diseases11

Chemicals and Drugs7

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Phenomena and Processes1

Myopia19

Detachment12

Myopic6

Vein2

Vessels8

Inhibits pathologic1

Thickness6

Angiogenesis3

VEGF7

Atrophy4

Supported retinal vascular1

Retina4

Diseases6

Retinopathy4

Inner retinal4

Ocular history1

Uveitis2

Intravitreal2

Macular edema1

Visual impairment1

Outer2

Pigment epithelium2

Endothelial cells2

Detachments1

Ophthalmology1

Knockout1

Photodynamic therapy2

Patients7

Methods1

Vasculature1

Mice1

Subretinal1

Degeneration2

Oxidative stress1