• Radiologically, multiple destructive lytic lesions of the skeleton, as well as severe demineralization, characterize multiple myeloma. (medscape.com)
  • Primary bone lesions are more commonly identified in patients under the age of 40, and can be subdivided into benign and malignant lesions. (crimsonpublishers.com)
  • The presence of multiple osteolytic bone lesions is a defining trademark of the disease. (crimsonpublishers.com)
  • Common manifestations include lytic lesions in bones that cause. (msdmanuals.com)
  • Unlike in metastatic disease, a radionuclide bone scan may not reliably show lesions and skeletal surveys should be done. (msdmanuals.com)
  • Skeletal surveys typically show sharply circumscribed lytic lesions (punched-out lesions) or diffuse demineralization. (msdmanuals.com)
  • Much less common are soft tissue lesions adjoining the pagetic bone that clinically and radiologically simulate sarcoma but histologically represent exaggerated periosteal bone formation as a manifestation of the basic pathologic process. (lookfordiagnosis.com)
  • Osteomalacia is a disease characterized by the softening of the bones caused by impaired bone metabolism primarily due to inadequate levels of available phosphate, calcium, and vitamin D, or because of resorption of calcium. (wikipedia.org)
  • On conventional skeletal survey, 10% had minimal subperiosteal bone resorption limited to the phalanges. (rsna.org)
  • By absorptometric analysis and fine-detail radiography, a majority were found to have demineralization and excessive bone resorption. (rsna.org)
  • Low doses of IGF-I constituted a real replacement therapy that normalized IGF-I serum levels improving the expression of most of these proteins closely involved in bone-forming, and reducing bone resorption by mechanisms related to osteoprotegerin, RANKL and PTH receptor. (biomedcentral.com)
  • Signs and symptoms can include diffuse body pains, muscle weakness, and fragility of the bones. (wikipedia.org)
  • Symptoms: Diffuse joint and bone pain (especially of spine, pelvis, and legs) Muscle weakness Difficulty walking, often with a waddling gait Hypocalcemia (positive Chvostek sign) Compressed vertebrae and diminished stature Pelvic flattening Weak, soft bones Easy fracturing Bending of bones Osteomalacia in adults starts insidiously as aches and pains in the lumbar (lower back) region and thighs before spreading to the arms and ribs. (wikipedia.org)
  • Tumor development and progression is usually multicentric and often involves the bone marrow so diffusely that bone marrow aspiration is diagnostic. (msdmanuals.com)
  • In addition to low systemic levels of circulating mineral ions (for example, caused by vitamin D deficiency or renal phosphate wasting) that result in decreased bone and tooth mineralization, accumulation of mineralization-inhibiting proteins and peptides (such as osteopontin and ASARM peptides), and small inhibitory molecules (such as pyrophosphate), can occur in the extracellular matrix of bones and teeth, contributing locally to cause matrix hypomineralization (osteomalacia/odontomalacia). (wikipedia.org)
  • Radiation dental caries is a term used for rapid tooth demineralization and severe cavities that occur with head and neck radiation, particularly when the parotid, submandibular, submental, or submaxillary salivary glands are in the radiation field. (1stdentist.com)
  • The impairment of bone metabolism causes inadequate bone mineralization. (wikipedia.org)
  • Osteosarcoma, Ewing sarcoma and chondrosarcoma represent 70% of primary bone tumor diagnoses, and malignant primary bone tumors represent around 3,300 new cases annually in the United States [5,6]. (crimsonpublishers.com)
  • Clinical features, incidence, and survivorship of malignant primary bone tumors [5-7]. (crimsonpublishers.com)
  • Primary malignant bone tumors are much less common than metastatic bone tumors, particularly in adults. (msdmanuals.com)
  • Overview of Bone and Joint Tumors Bone tumors may be benign or malignant. (msdmanuals.com)
  • Even if multiple myeloma is considered a hematologic tumor, the identified skeletal abnormality must be differentiated from other bone tumors. (msdmanuals.com)
  • Clinical definitions of the various myeloma subtypes have been updated, as have the imaging definitions of what constitutes bone marrow disease and individual bony involvement. (medscape.com)
  • [ 8 ] Patients suspected of having multiple myeloma based on bone marrow aspirate results or hypergammaglobulinemia should undergo a radiographic skeletal survey. (medscape.com)
  • [ 9 ] MRI is the gold-standard imaging modality for detection of bone marrow involvement and the preferred imaging technique to rule out spinal cord compression in patients with multiple myeloma, whereas PET/CT provides valuable prognostic data and aids in assessment of response to therapy. (medscape.com)
  • range, 44-83 years) with multiple myeloma proven by bone marrow biopsy. (medscape.com)
  • Standard 99m Tc bone scintigraphy should play no role in the routine staging of myeloma, and sequential dual-energy radiographic absorptiometry (DXA) scans are not recommended, according to the authors. (medscape.com)
  • Technically considered a plasma cell dyscrasia, multiple myeloma is the most common primary malignancy of bone [7,8]. (crimsonpublishers.com)
  • As many as 30% of myeloma patients may present with a pathologic fracture, and up to two-thirds with bone pain alone as the initial symptom of disease [7]. (crimsonpublishers.com)
  • Multiple Myeloma Multiple myeloma is a cancer of plasma cells that produce monoclonal immunoglobulin and invade and destroy adjacent bone tissue. (msdmanuals.com)
  • Osteosarcoma is the most common malignant primary bone tumor (if one considers myeloma a marrow cell tumor and not a primary bone tumor) and is highly malignant. (msdmanuals.com)
  • the alveolar bone (Roza, 2004). (researchgate.net)
  • Alveolar bone response to light-force tipping and bodily movement in maxillary incisor advancement: A prospective randomized clinical trial. (vcu.edu)
  • The bone fracture probabilities were obtained from a cohort study of 3614 women from USA with PMO treated with RIS-GR (1807) or ALN (1807) (Thomasius, 2022). (bvsalud.org)
  • The pharmacological cost and the cost of fractures were obtained from Spanish sources ( 2022). (bvsalud.org)
  • Aminobisphosphonates (N-BPs) that include pamidronate, zoledronate, or alendronate, are the first-line treatment of bone-related diseases including osteoporosis and bone malignancies. (bvsalud.org)
  • The case of a patient with Paget's disease of the pelvis ( acetabulum ) who had an intraoperative posterior wall fracture during the insertion of a noncemented acetabular component into an under-reamed acetabular bed of sclerotic Pagetoid bone is reported. (lookfordiagnosis.com)
  • In this condition MRI plays a fundamental role because it is the only imaging technique which can diagnose it and accurately assess its extent and any cortical bone and/or cartilage involvement. (cnr.it)
  • Spine infections are rare infections that can involve the intervertebral disc space (discitis), the vertebral bones, the spinal canal or adjacent soft tissues. (wheelessonline.com)
  • Vertebral osteomyelitis refers to an infection of the vertebral bones in the spine. (wheelessonline.com)
  • incidence is highest in adolescents and very young adults (coinciding with adolescent growth spurt) and secondary peak occurs in older adults (≥ age 60), especially in those with risk factors such as Paget disease, bone infarcts, and areas of bone previously exposed to high-dose radiation therapy for another cancer many years earlier. (msdmanuals.com)
  • RESULTS: Computed tomographic scans disclosed osseous changes of the temporal and frontal bones, with areas of high density consistent with Paget disease . (lookfordiagnosis.com)
  • MRI can provide information that is complementary to a skeletal survey and was recommended for use in patients with normal radiographic images and in all patients with an apparently solitary plasmacytoma of bone. (medscape.com)
  • Clinical manifestations, radiographic findings, and bone mineral measurements of 65 patients with primary hyperparathyroidism are reviewed. (rsna.org)
  • Stored samples from a prior clinical trial aimed at analyzing the effect of alendronate on bone mineral density, provided further evidence of alendronate-mediated latency reversal and activation of immune effector cells. (bvsalud.org)
  • Hemorrhage or bleeding of the oral cavity can occur when clotting factors are affected and during bone marrow suppression. (1stdentist.com)
  • We investigated the diagnostic potentials of 3 MR sequences in identifying and assessing the extent of bone contusion. (cnr.it)
  • patients with sclerotic bone, like those with osteoporotic bone, may also be at risk for periprosthetic acetabular fractures when an under-reaming technique is used. (lookfordiagnosis.com)
  • Most of the time, the only alleged symptom is chronic fatigue, while bone aches are not spontaneous but only revealed by pressure or shocks. (wikipedia.org)
  • Osteoradionecrosis (soft tissue and bone necrosis) can be spontaneous or secondary to trauma, extractions, or dental prostheses. (1stdentist.com)
  • Resin-modified glass ionomer showed less demineralisation at restoration margins when compared to non-fluoridated resin with the ability to form inhibition zones in dentin adjacent to restoration margins. (edu.au)
  • In a patient with a fractured, dislocated femur, treatment begins with reduction and immobilization of the affected leg. (rnpedia.com)
  • About half of chemotherapy patients experience oral complications, particularly those being treated for leukemia and those who receive bone marrow transplants. (1stdentist.com)
  • The utilities of patients with and without fracture (quality-adjusted life years [QALYs]) were obtained from the medical literature. (bvsalud.org)
  • Results: Compared with ALN, treatment with RIS-GR can avoid 79 fractures (between 75 and 82) every 1000 patients treated, and 0.0119 QALYs would be gained (between 0.0098 and 0.0140) per patient. (bvsalud.org)
  • The pain is symmetrical, non-radiating and accompanied by sensitivity in the involved bones. (wikipedia.org)
  • The Musculoskeletal Tumor Society (MSTS) staging system: Used by orthopedic oncology surgeons based on histologic grade (eg, Stage I-low-grade histology and Stage II-high-grade histology, whether the tumor is contained entirely within the bone (A) or has broken outside of the cortex into surrounding soft tissue (B), and metastases Stage III). (msdmanuals.com)
  • Extramedullary hematopoiesis usually occurs in hematological diseases but may also be found as an uncommon complication of Paget's disease , probably due to bone effraction mechanism. (lookfordiagnosis.com)
  • The appearance of a sarcoma of bone is a well-recognized complication of Paget's disease . (lookfordiagnosis.com)
  • Periprosthetic fracture of the acetabulum during total hip arthroplasty in a patient with Paget's disease . (lookfordiagnosis.com)
  • In the present work, a model of partial IGF-I deficiency was used in order to provide insight into the mechanisms of the beneficial actions of IGF-I replacement therapy in bone. (biomedcentral.com)
  • Pathologic fractures due to weight bearing may develop. (wikipedia.org)
  • Risk of a fat embolism is greatest in the first 48 hours after the fracture of a long bone. (rnpedia.com)
  • INTRODUCTION: Pharmacological strategies might influence bone healing in terms of time to union or quality of mature bone. (bvsalud.org)
  • We show that alginate-GO hydrogels exhibit improved mechanical performance in shear, compression, and tension, including a two-fold increase in shear modulus, a three-fold decrease in inelastic deformation, and a nine-fold increase in fracture energy relative to alginate-only hydrogels. (regenerativemedicine.net)
  • This expert opinion discussed the current level I evidence on the experimental pharmacological agents used to favor bone fracture healing. (bvsalud.org)