TumorsTumorNeoplasmsSquamousHepatocellular CarcinomaLarge cell neuroendocrine carcinomasMetastasisRenalPoorlyPathologyMetastaticDifferentiationUrothelial carcinomaMalignantNeoplasmDuctal carcEpithelialGastroenteropancreatic neuroendocrineClinico-pathologicDiagnosisAdenocarcinomaLung carcinomasPrognosisImmunohistochemicalThyroidPapillary carcinomaCancerClinicalFindingsSCLCChromograninMetastasesHistopathologyCorrelationPulmonaryNeoplasiaExaminationTumourHeterogeneous
Tumors26
- Endometrioid tumors are a class of tumor characterized by a resemblance to endometrium/ endometrial carcinoma, and over a third of cases have focal squamous differentiation. (wikipedia.org)
- Background/aim: Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a relatively uncommon and aggressive subset of pulmonary neuroendocrine tumors, which include typical and atypical carcinoid, and small-cell lung cancer. (tubitak.gov.tr)
- LCNECs show features of high-grade neuroendocrine tumors and patients with LCNEC have a very poor prognosis. (tubitak.gov.tr)
- The World Health Organization (2019) classified papillary neoplasms (i.e. benign or cancerous tumors) of the breast into 5 types: intraductal papilloma, papillary ductal carcinoma in situ (PDCIS), encapsulated papillary carcinoma (EPC), solid-papillary carcinoma (SPC), and invasive papillary carcinoma (IPC). (wikipedia.org)
- PDCIS tumors may occur alongside of (non-papillary) ductal carcinoma in situ or EPC tumors. (wikipedia.org)
- The purpose of our review is to explore global epidemiologic trends of gastroenteropancreatic (GEP) neuroendocrine tumors (NETs). (nih.gov)
- Neuroendocrine tumors are those which arise from the neural cells and hormone-producing cells of the tissue [1] . (epainassist.com)
- PNET's or pancreatic neuroendocrine tumors usually consists of all the tumors related to hormone-producing cells of the pancreas including alpha, beta, gamma, and f cells separately as each individual tumor. (epainassist.com)
- The most common of the pancreatic neuroendocrine tumors is beta cell tumor known as insulinoma. (epainassist.com)
- Due to the maximum incidence of insulinoma in the neuroendocrine tumors, these are generally referred to as islet cell tumors. (epainassist.com)
- Pancreatic neuroendocrine tumors are of idiopathic origin most of the times. (epainassist.com)
- Modifiable factors responsible for the pancreatic neuroendocrine tumors are smoking , obesity , diabetes mellitus , drinking alcohol , etc. [2] . (epainassist.com)
- Because this group consists of many types of tumors which vary in their prognosis, it is very difficult to tell that whether they would there be curable or not before the exact diagnosis of the type of pancreatic neuroendocrine tumor is made. (epainassist.com)
- If the pancreatic neuroendocrine tumors are detected in early stages of its development or the syndromic association is found in early age then the prophylactic treatment and early resection of the tumors can be done to make them curable. (epainassist.com)
- The prognosis of the pancreatic neuroendocrine tumors also depends upon the site of the tumor in the pancreas. (epainassist.com)
- Colonic neuroendocrine neoplasms (NENs) are relatively rare tumors with an incidence rate of 0.11-0.21/100,000. (biomedcentral.com)
- Neuroendocrine neoplasms (NENs) are rare tumors originating from neuroendocrine cells and include a series of heterogeneous tumors. (biomedcentral.com)
- According to the degree of differentiation, NENs have been divided into well differentiated NENs and poorly differentiated NENs in the 2010 World Health Organization classification of tumors of the digestive system, with the former being termed a neuroendocrine tumor (NET), and the latter, a neuroendocrine carcinoma (NEC) [ 1 ]. (biomedcentral.com)
- A Phase 1, Open-label, Dose-escalation Study of SNX 5422 and Everolimus in Subjects With Neuroendocrine Tumors. (stanford.edu)
- Aytac E, Ozdemir Y, Ozuner G: Long term outcomes of neuroendocrine carcinomas (high-grade neuroendocrine tumors) of the colon, rectum, and anal canal. (edu.pl)
- Carcinoid tumors are neuroendocrine neoplasms derived from the enterochromaffin cells. (biomedcentral.com)
- This cellular compartmentalization of PTEN was investigated in lung neuroendocrine tumors (lung NET). (biomedcentral.com)
- Lung neuroendocrine tumors (NET) comprise the four histotypes typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). (biomedcentral.com)
- Neuroendocrine Tumors Presenting with Liver Metastasis, is it Necessary to Find the Primary Site for a Better Outcome? (cyprusjmedsci.com)
- Neuroendocrine tumors (NET) presenting with multiple liver metastasis are a heterogeneous group of tumors and their prognosis differs greatly from each other according to their differentiation, grade, and possibly to their primary site of origin. (cyprusjmedsci.com)
- Neuroendocrine tumors (NETs) constitute less than 5% of all cancers of unknown primary sites. (cyprusjmedsci.com)
Tumor17
- The TNM (tumor-node-metastasis) staging system from the American Joint Committee for Cancer Staging and End Results Reporting is used for all lung carcinomas except small-cell lung cancer. (medscape.com)
- What Causes Pancreatic Neuroendocrine Tumor & Is It Curable? (epainassist.com)
- What Causes Pancreatic Neuroendocrine Tumor? (epainassist.com)
- Is Pancreatic Neuroendocrine Tumor Curable? (epainassist.com)
- Merkel cell carcinoma (MCC) is a rare malignant cutaneous tumor of the elderly that is characterized by an aggressive course with regional nodal involvement, distant metastases and a high rate of recurrence. (ispub.com)
- Merkel cell carcinoma (MCC) is a rare cutaneous neuroendocrine tumor thought to be derived from a specialized epithelial cell, the Merkel cell. (ispub.com)
- Sixty-three cases were reclassified, mostly as well-differentiated neuroendocrine tumor (NET) or acinar cell carcinoma, and eliminated. (johnshopkins.edu)
- It is a high-grade and poorly differentiated neuroendocrine tumor, usually diagnosed in advanced stages, with a poor prognosis and few therapeutic options in that setting. (mdpi.com)
- Archived neuroendocrine tumor sample or biopsy sample (will also be used for genetic testing). (stanford.edu)
- 90 days after first line), locally advanced metastatic neuroendocrine tumor of gastro-entero, pancreatic, pulmonary (other than Small Cell Lung) or thymic origin, or advanced renal cell carcinoma for which everolimus is indicated. (stanford.edu)
- Neuroendocrine carcinoma of the colorectum is a kind of malignant tumor composed of neuroendocrine cells, with a unique hormone synthesis and secretory function. (edu.pl)
- The final pathologic diagnosis was well-differentiated carcinoid tumor of a malignant nature. (springer.com)
- A C7 corpectomy, en bloc resection of the tumor, and anterior C6-T1 fusion were performed to decompress the spinal cord and nerves and provide stability. (biomedcentral.com)
- Patients with SCA, specially with this pseudo solid-appearance, such as the present case, may have imaging findings that closely resemble those of patients with pancreatic neuroendocrine neoplasms (pNENs), metastatic renal cell carcinoma, solid pseudopapillary tumor or acinar cell carcinomas (1,4). (spg.pt)
- Herein, we present a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma (collision tumor) in the ampulla of Vater, which has seldom been reported in the literature. (koreamed.org)
- Histological examination revealed a combined lung tumor appearance with a predominant component (80%) consisting of a small cell neuroendocrine carcinoma associated with a solid adenocarcinomatous component, with massive infiltration of the lung, rupture of the visceral pleura, and extension to parietal fat tissue but with free surgical margin at this level and without sarcomatoid component. (hindawi.com)
- They are also at an increased risk of developing a type of kidney cancer called clear cell renal cell carcinoma and a type of pancreatic cancer called a pancreatic neuroendocrine tumor. (medlineplus.gov)
Neoplasms2
- Epidemiology, Incidence, and Prevalence of Neuroendocrine Neoplasms: Are There Global Differences? (nih.gov)
- Neuroendocrine Neoplasms top experts. (keyopinionleaders.com)
Squamous6
- Histologically, NSCLC is divided into adenocarcinoma, squamous cell carcinoma (SCC) (see the image below), and large cell carcinoma. (medscape.com)
- A cavitating right lower lobe squamous cell carcinoma. (medscape.com)
- RESULTS: Of the 32 cases, pathologic findings revealed squamous cell carcinoma (n = 27), mucoepidermoid carcinoma (n = 2), neuroendocrine carcinoma (n = 1), papillary thyroid carcinoma (n = 1), and adenocarcinoma (n = 1). (nyu.edu)
- The next most common kind of lung malignancy is definitely squamous cell carcinoma and minimal common type is definitely huge cell carcinoma 16-18. (colinsbraincancer.com)
- Evidence for Lymphangiogenesis and Its Prognostic Implications in Head and Neck Squamous Cell Carcinoma," Journal of Pathology, Vol. 206, No. 2, 2005, pp. 170-177. (scirp.org)
- Describe current testing guidelines with an optimized approach for histologic and cytologic samples of suspected HPV-related squamous cell carcinoma. (cme-video.com)
Hepatocellular Carcinoma1
- Objective@#To investigate the regulatory relationship of Protein Phosphatase 2 Regulatory Subunit B"Alpha ( PPP2R3A) and hexokinase 1 ( HK1) in glycolysis of hepatocellular carcinoma (HCC). (bvsalud.org)
Large cell neuroendocrine carcinomas2
- Most (61%) are large cell neuroendocrine carcinomas. (johnshopkins.edu)
- The multicentre cohort included 58 typical carcinoids (TC), 42 atypical carcinoids (AC), 32 large cell neuroendocrine carcinomas (LCNEC) and 60 small cell lung carcinomas (SCLC). (biomedcentral.com)
Metastasis5
- Cutaneous metastases of colonic neuroendocrine carcinomas (NECs) are very infrequent, while cases of scalp metastasis are even fewer. (biomedcentral.com)
- In front of an aggressive sellar and suprasellar lesion with a subacute clinical presentation, the main diagnoses are a pituitary carcinoma or aggressive adenoma, a pituitary metastasis of a carcinoma of unknown origin, or a solid craniopharyngioma. (medscape.com)
- Tumour Angiogenesis and Metastasis-Correlation in Invasive Breast Carcinoma," The New England Journal of Medicine, Vol. 324, No. 1, 1991, pp. 1-8. (scirp.org)
- He underwent an en bloc resection, and pathological findings concluded to a metastasis of a pulmonary combined small cell carcinoma and adenocarcinoma. (hindawi.com)
- In this present case, we report the observation of a patient who presented with an acute intestinal intussusception caused by a jejunal metastasis of pulmonary combined small cell carcinoma and adenocarcinoma and we present a review of the literature. (hindawi.com)
Renal5
- Ipsen remains on track to submit the regulatory dossier for cabozantinib as a treatment for first-line advanced renal cell carcinoma in Europe in the third quarter of 2017. (businesswire.com)
- The relationship between blood pressure and risk of renal cell carcinoma. (who.int)
- Epidemiology of Renal Cell Carcinoma: 2022 Update. (who.int)
- Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. (who.int)
- Biomarkers of the transsulfuration pathway and risk of renal cell carcinoma in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. (who.int)
Poorly9
- A total of 107 pancreatic resections originally diagnosed as poorly differentiated neuroendocrine carcinomas were reassessed using the classification and grading (mitotic rate/Ki67 index) criteria put forth by the World Health Organization in 2010 for the gastroenteropancreatic system. (johnshopkins.edu)
- The clinicopathologic features and survival of the remaining 44 poorly differentiated neuroendocrine carcinomas were further assessed. (johnshopkins.edu)
- Poorly differentiated neuroendocrine carcinoma of the pancreas is a highly aggressive neoplasm, with frequent metastases and poor survival. (johnshopkins.edu)
- Well-differentiated NET and acinar cell carcinoma are often misdiagnosed as poorly differentiated neuroendocrine carcinoma, emphasizing that diagnostic criteria need to be clearly followed to ensure accurate diagnosis. (johnshopkins.edu)
- La Rosa S, Marando A, Furlan D, Sahnane N, Capella C: Colorectal poorly differentiated neuroendocrine carcinomas and mixed adenoneuroendocrine carcinomas: Insights into the diagnostic immunophenotype, assessment of methylation profile, and search for prognostic markers. (edu.pl)
- Smith J, Reidy-Lagunes D: The management of extrapulmonary poorly differentiated (high-grade) neuroendocrine carcinomas. (edu.pl)
- Pathologically, sections on the ampulla of Vater showed conventional ductal adenocarcinoma extended and collided with poorly differentiated neuroendocrine carcinoma. (koreamed.org)
- Thyroid transcription factor 1 (TTF-1) is positive in poorly differentiated neuroendocrine carcinomas (NECs) and some well-differentiated NETs of lung origin but caudal-type homeobox-2 (CD-X2) is positive in well-differentiated NETs of intestinal origin. (cyprusjmedsci.com)
- This study presents a case of a man, aged 56 years, found to have a 26-mm exophytic lesion on the vertex scalp identified to contain a distinct population of basal cell carcinoma as well as another population of spindled cells representing a poorly differentiated sarcomatous component. (cancernetwork.com)
Pathology4
- BACKGROUND: In men undergoing upfront active surveillance, predictors of adverse pathology in radical prostatectomy specimens, including intraductal carcinoma of the prostate and cribriform patterns, remain unknown. (bvsalud.org)
- We defined adverse pathology on radical prostatectomy specimens as Gleason grade group ≥3, pT stage ≥3, pN positivity or the presence of intraductal carcinoma of the prostate or cribriform patterns. (bvsalud.org)
- Patients showing adverse pathology with intraductal carcinoma of the prostate or cribriform patterns had lower biochemical recurrence-free survival (log-rank P = 0.0166). (bvsalud.org)
- Prognostic Value of Lymphatic and Blood Vessel Invasion in Neuroendocrine Tumours of the Lung," The American Journal of Surgical Pathology, Vol. 29, 2005, pp. 324-328. (scirp.org)
Metastatic2
- Being aware of this unusual and rare presentation of metastatic prostate carcinoma might decrease diagnostic delay and allow earlier treatment. (hindawi.com)
- The diagnosis was stage IV metastatic prostate carcinoma (pM1a). (hindawi.com)
Differentiation2
- Immunohistochemical labeling for neuroendocrine and acinar differentiation markers was performed. (johnshopkins.edu)
- SCLC stem from cells with neuroendocrine differentiation that can be found at unique anatomic sites along the bronchial tree 19. (colinsbraincancer.com)
Urothelial carcinoma2
- The dual biomarker of ARID1A mutations and CXCL13 expression was associated with improved overall survival in patients with advanced urothelial carcinoma. (urologytimes.com)
- Anti-PD-1/PD-L1 agents were associated with similar efficacy across pure and variant histologies in patients with advanced urothelial carcinoma, with the exception of those with a neuroendocrine variant. (urologytimes.com)
Malignant3
- Papillary carcinomas of the breast (PCB), also termed malignant papillary carcinomas of the breast, are rare forms of the breast cancers. (wikipedia.org)
- Prostate carcinoma is the second most common malignant disease in men. (hindawi.com)
- By definition, pseudomesotheliomatous carcinoma refers to an epithelial neoplasm that secondarily involves the pleura and encases the lung, thereby simulating the radiologic and macroscopic appearance of malignant mesothelioma. (medscape.com)
Neoplasm3
- Extrapulmonary small-cell carcinoma (SCC) is a rare neoplasm that shares certain features with its pulmonary counterpart and occurs predominantly in the gastrointestinal tract (GIT). (mdpi.com)
- According to the WHO classification, SCNs are classified into microcystic SCA, macrocystic SCA, solid serous adenoma, von Hippel-Lindau-associated serous cyst neoplasm, and mixed serous-neuroendocrine neoplasm (2). (spg.pt)
- Microcystic serous cystadenoma mimicking pancreatic neuroendocrine neoplasm: report of a resected case with preoperative diagnostic difficulty and review of the literature. (spg.pt)
Ductal carc2
- It is the most common type of ductal carcinoma in situ diagnosed in men. (wikipedia.org)
- Pathologic findings from the National Surgical Adjuvant Breast Project (NSABP) Protocol B-17: Intraductal Carcinoma (Ductal Carcinoma in Situ)," Cancer, Vol. 75, No. 6, 1995, pp. 1310-1319. (scirp.org)
Epithelial1
- PCB are carcinomas derived from the epithelial cells of mammary gland ducts. (wikipedia.org)
Gastroenteropancreatic neuroendocrine1
- We have also reviewed the literature concerning gastroenteropancreatic neuroendocrine carcinomas (GEP-NECs) in this article. (biomedcentral.com)
Clinico-pathologic3
- A clinico-pathologic study of 12 cases. (edu.pl)
- Clinico-pathologic data including overall survival, proliferation rate and diagnostic markers (synaptophysin, chromogranin A, Mib-1, TTF-1) were recorded. (biomedcentral.com)
- Both nuclear and cytosolic PTEN immunoreactivity should be considered for correlation with clinico-pathologic parameters. (biomedcentral.com)
Diagnosis4
- The final diagnosis was carcinoma of unknown primary site. (imrpress.com)
- Objective: To investigate the clinicopathological features and differential diagnosis of NTRK3 gene rearrangement thyroid papillary carcinoma (PTC). (bvsalud.org)
- This immunophenotype excluded a carcinoma, a lymphoid, melanocytic, germ cell, or neuroglial proliferation, and the diagnosis of sellar and suprasellar epithelioid angiosarcoma was made. (medscape.com)
- Describe the WHO criteria for the diagnosis of lobular carcinoma in situ and the uses and limitations of e-cadherin immunohistochemistry in evaluating in-situ lesions of the breast. (cme-video.com)
Adenocarcinoma3
- The medical, radiologic, molecular and pathologic range is broadly divergent within lung adenocarcinoma, and lately a fresh classification continues to be revised 18. (colinsbraincancer.com)
- In conclusion, we hereby presented a case of coexisting neuroendocrine carcinoma and conventional adenocarcinoma in the ampulla of Vater. (koreamed.org)
- [ 3 , 4 ] The term "pseudomesotheliomatous carcinoma" was first applied by Harwood and colleagues in 1976 to 6 cases of peripheral lung adenocarcinoma that closely mimicked mesothelioma. (medscape.com)
Lung carcinomas1
- See Clinical Presentations of Lung Cancer: Slideshow , a Critical Images slideshow, to help efficiently distinguish lung carcinomas from other lung lesions, as well as how to stage and treat them. (medscape.com)
Prognosis2
Immunohistochemical1
- Immunohistochemical stains suggested high-grade neuroendocrine carcinoma. (imrpress.com)
Thyroid1
- Neuroendocrine cancer of the thyroid or thymus. (stanford.edu)
Papillary carcinoma2
- The World Health Organization regarded solid papillary carcinoma as having two subtypes: in situ and invasive SPC. (wikipedia.org)
- Information on the frequency and clinical features of PDCIS is limited since it and EPC were regarded as the same lesion termed intracystic papillary carcinoma until 2012. (wikipedia.org)
Cancer3
- There is an association with endometriosis and concurrent primary endometrial carcinoma (endometrial cancer). (wikipedia.org)
- However, there is limited research on the immune microenvironment of adeno-neuroendocrine prostate cancer (NEPC). (biomedcentral.com)
- Review relevant updates in prostate cancer grading and unfavorable pathologic features and their impact on reporting. (cme-video.com)
Clinical2
- data regarding their pathologic and clinical features are very limited. (johnshopkins.edu)
- The clinical data on 49 patients treated for neuroendocrine carcinoma of the colorectum from January 1995 to January 2013 were retrospectively analyzed and relevant scientific literature was investigated. (edu.pl)
Findings1
- Pathologic examination findings of the specimen were consistent with carcinoma. (imrpress.com)
SCLC1
- SCLC accounts for approximately 15% of bronchogenic carcinomas. (cancer.gov)
Chromogranin1
- MCC express both neuroendocrine (neuron-specific enolase, synaptophysin, chromogranin) and cytokeratin markers (cytokeratin 20, as a paranuclear dot, CAM 5.2) and is negative for S100 and the common leukocyte antigen ( 2 ). (ispub.com)
Metastases1
- Unusual prostate carcinoma metastases are usually encountered in the presence of known advanced disease but rarely as the first presentation. (hindawi.com)
Histopathology1
- Relative incidences of endometrial carcinomas by histopathology, being endometrioid in a majority of cases Light microscopy shows tubular glands, resembling endometrium. (wikipedia.org)
Correlation1
- The many faces of pancreatic serous cystadenoma: Radiologic and pathologic correlation. (spg.pt)
Pulmonary1
- range 48 to 77 years) who underwent pulmonary resection for large-cell neuroendocrine carcinoma between January 2004 and December 2014 were investigated retrospectively. (tubitak.gov.tr)
Neoplasia1
- Characterize the common elements of neuroendocrine neoplasia throughout the body. (cme-video.com)
Examination1
- Pathologic examination revealed a pT2 undifferentiated carcinoma with a sarcomatoid component involving all layers of the jejunum and expressing only cytokeratin 7. (hindawi.com)