• However, diagnosing bacteremia is challenging for clinicians, especially in children presenting with co-infections such as malaria and HIV. (listlabs.com)
  • Generally avoid synergistic combinations except for those pathogens for which such therapy is clearly indicated, such as enterococci, S viridans , HACEK isolates, and infections of intracardiac devices. (medscape.com)
  • P. oryzihabitans can also be a human pathogen, although infections are rare. (wikipedia.org)
  • Patients with GS present with a spectrum of sinopulmonary infections and pathogens similar to common variable immunodeficiency (CVID). (nih.gov)
  • The hematogenous is by far the most frequent route for systemic infections of various bacterial and fungal pathogens, in the most severe cases leading to blood stream infections ( 2 ). (frontiersin.org)
  • Thus, there is an incomplete understanding of diseases in which a conserved consortium of micro-organisms co-operates to induce pathogenesis, diseases involving pathogens that cause immune deficiency followed by secondary infections, and diseases that are influenced by a series of host and environmental factors. (nature.com)
  • K. pneumoniae causes suppurative infections, bacteremia and septicaemia. (scirp.org)
  • 2] In recent years, klebsiellae have become important pathogens in nosocomial infections. (medscape.com)
  • The most common sources are urinary tract infections and the transient bacteremia caused by genitourinary procedures. (wheelessonline.com)
  • Further ascent of pathogens is the cause of the majority of renal parenchymal infections. (logicalimages.com)
  • Most bacterial pathogens responsible for such infections are enclosed by polysaccharide capsules that protect them from phagocytosis and complement- mediated killing, ensuring their persistence on the respiratory mucosa and survival in the bloodstream and deep body tissues. (cdc.gov)
  • Now, with the increasing use of implanted medical equipment, they have become leading pathogens for nosocomial infections owing to their ability to form biofilms on foreign material [1,2]. (dermnetnz.org)
  • We believe that the properties of our lysins and amurin peptides will make them suitable for targeting antibiotic-resistant organisms, such as MRSA, Pseudomonas aeruginosa and Acinetobacter baumannii , which can cause serious infections such as bacteremia and pneumonia. (kfor.com)
  • Pseudomonas aeruginosa ( P. aeruginosa ), Acinetobacter species, Klebsiella species, Escherichia coli ( E. coli ) and Enterobacter cloacae are the most commonly implicated Gram-negative pathogens in HABP/VABP infections. (klfy.com)
  • The common theme of Bartonella infections in the reservoir host is the long-lasting intraerythrocytic bacteremia. (mgc.ac.cn)
  • Therefore, the aim of this study was to obtain data on the prevalence of feline vector-borne pathogens (FeVBPs) and haemoplasma infections in privately owned cats from different Italian regions using a comprehensive molecular methodology, and to assess the potential role of cats as reservoirs and potential sources of microorganisms that could be transmitted to humans. (biomedcentral.com)
  • It can cause peritonitis, endophthalmitis, sepsis and bacteremia. (wikipedia.org)
  • Illness is associated with bacteraemia ranges from self-limiting infection to life threatening sepsis that requires rapid and aggressive antimicrobial treatment, which is complicated by increasing worldwide antibiotic resistance (Reacher et al . (scialert.net)
  • In Papers I and II, we evaluated quantitative data from two commercial PCR tests for pathogen detection directly in blood, Magicplex Sepsis (I) and SeptiFast (II), from patients with suspected sepsis. (diva-portal.org)
  • We found that high quantification cycle (Cq) values, indicating low DNA loads, were associated with findings of pathogens with doubtful clinical relevance, whereas low Cq values, indicating high DNA loads, were correlated with sepsis and septic shock, as well as with positive blood culture results. (diva-portal.org)
  • Urinary Tract Infection (UTI) is one of the most common bacterial diseases worldwide that can present as asymptomatic or symptomatic characterized by a wide range of symptoms from mild irritative voiding to bacteremia, sepsis or even death. (banglajol.info)
  • We present two cases of Rhodococcus equi bacteremia as a cause of sepsis in premature infants who had increasing respiratory distress with multiple episodes of apnea. (turkishjournalpediatrics.org)
  • Taken together, these results demonstrate the significance of biochemistry in both our understanding of host-pathogen biology, and development of assay methodology, as well as demonstrate a potential new approach for the rapid, sensitive and accurate diagnosis of bacteremia at the point of need. (listlabs.com)
  • Assessing host-pathogen interactions in vivo in patients is challenging due to ethical and logistic limitations. (frontiersin.org)
  • They are ideal for the study of complex physiological interactions, cell signaling, and host pathogen defense. (jove.com)
  • Host-pathogen interaction in invasive Salmonellosis. (medscape.com)
  • Since MVs of many bacterial species are implicated in host-pathogen interactions, biofilm formation, horizontal gene transfer, and virulence factor secretion in other species, we sought to identify, describe, and functionally characterize MVs from E. faecalis . (biorxiv.org)
  • Amurin peptides are a novel class of DLAs which exhibit broad-spectrum activity against a wide range of antibiotic-resistant Gram-negative pathogens. (kfor.com)
  • Klebsiella pneumoniae is an opportunistic pathogen of medical importance and the capsule and mucoid phenotype in this organism are considered as requisite virulence determinants. (scirp.org)
  • Klebsiella pneumoniae is a gram negative bacteria and an opportunistic pathogen. (scirp.org)
  • R. equi has been identified frequently as an opportunistic pathogen in immunocompromised patients. (turkishjournalpediatrics.org)
  • Ralstonia insidiosa is an opportunistic pathogen considered an emerging problem among clinically vulnerable populations such as those with chronic kidney disease. (who.int)
  • Khomeini Hospital was reviewed to identify patients who had nosocomial bacteraemia between 1 May 1999 and 31 May 2001 and identify the pathogen responsible and its resisitance to antibiotics. (who.int)
  • Sensitivity analyses were consistent regardless of aetiological pathogens, septic shock, source of infection, nosocomial acquisition, lactate levels or albumin levels. (altmetric.com)
  • We conducted a retrospective, observational study among patients colonized with MDR AB admitted to our ICU to assess risk factors associated with the development of MDR AB nosocomial bacteremia. (biomedcentral.com)
  • [ 6 ] Therefore, additional testing remains necessary to identify the pathogen and to optimize therapy in CAP. (medscape.com)
  • All positive blood cultures should be evaluated by rapid diagnostic technology such as Malditof can identify pathogens(bacterial or fungal) within hours of documenting a positive gram stain. (medscape.com)
  • Therefore, we previously established an ex vivo human whole-blood infection model that allowed us to define which immune cells interact with the human fungal pathogen Candida albicans ( 4 ), to identify cross-talk between different components of the host response ( 5 ), and to detect substantial differences between related fungal pathogens ( 6 ). (frontiersin.org)
  • However, with the advent of novel diagnostic technologies, viral respiratory pathogens are increasingly being identified as frequent etiologies of CAP. (medscape.com)
  • This trend has substantial public health consequences because the incidence of infectious diseases in general, and of those caused by respiratory pathogens in particular, has substantially increased among daycare center attendees. (cdc.gov)
  • Multivariate analysis indicated infection and respiratory failure at the time of ICU admission, maintenance of mechanical ventilation, maintenance of endotracheal tube instead of switching to a tracheostomy, recent central venous catheter insertion, bacteremia caused by other microorganism after colonization by MDR AB, and prior antimicrobial therapy, were significant risk factors for MDR AB bacteremia. (biomedcentral.com)
  • This study aimed to describe clinical characteristics and outcome in patients with Eubacterium bacteremia. (lu.se)
  • Episodes of Eubacterium bacteremia were identified through the clinical microbiology laboratory in Lund, Sweden. (lu.se)
  • This study aimed to describe clinical characteristics and outcome in patients with Eubacterium bacteremia.MethodsEpisodes of Eubacterium bacteremia were identified through the clinical microbiology laboratory in Lund, Sweden. (lu.se)
  • Historical clues and physical examination findings may suggest a causative pathogen, but the clinical signs and symptoms of CAP are not sufficiently specific to reliably differentiate the exact etiologic agent. (medscape.com)
  • The goal of universal precautions training is to minimize the risk of clinical cross-contamination of dangerous, hard-to-treat pathogens. (cna.com)
  • In conclusion, our results indicate that the pathogen DNA load in blood plays an important role in the clinical picture in BSI. (diva-portal.org)
  • No primary focus of infection was found in the majority of patients, most probably because L. monocytogenes bacteraemia has few clinical characteristics except for fever, which may subside intermittently. (marlerclark.com)
  • Increase in resistance of urinary pathogens to conventional antimicrobial agents is gaining the attention of many microbiologists worldwide in respect to treatment of urinary tract infection. (banglajol.info)
  • The objective of this study was to update the distribution of current urinary pathogens and to find out their antimicrobial susceptibility pattern. (banglajol.info)
  • None of the drug found was 100% effective against urinary pathogens. (banglajol.info)
  • Antimicrobial drug resistance is increasing among urinary pathogens. (banglajol.info)
  • This study updated the current occurrence of urinary pathogens and their antibiotic sensitivity pattern. (banglajol.info)
  • We recommend periodical determination of antimicrobial sensitivity pattern of urinary pathogens in a particular hospital or area. (banglajol.info)
  • The most common bacterial pathogen overall is S pneumoniae , although, in some settings, including in the United States, its incidence is decreasing, possibly owing to vaccination. (medscape.com)
  • Bartonella henselae is a fastidious, Gram-negative bacterial pathogen of cats and humans. (microbiologyresearch.org)
  • Thus study indicated that the bacterial blood pathogens are becoming resistant to commonly used antibiotics, which may be due to indiscriminate use of these antibiotics. (scialert.net)
  • [3] Vertebral osteomyelitis with alternate pathogens may present in endemic regions and immunocompromised patients. (nih.gov)
  • What it used to encompass was a lot of our older adults who did reside in a nursing home, a long-term care facility, rehab facilities, because again, they are at a higher risk of having more dangerous, more endemic pathogens that could have higher rates of resistance and maybe not be as well treated with our current antibiotics that we have. (reachmd.com)
  • In contrast, some bacterial pathogens (including Listeria monocytogenes and Shigella flexneri ) have mechanisms to escape from the phagosome and proliferate in the cytosol ( 13 ). (frontiersin.org)
  • In aerobic culture Staphylococcus aureus 71 (64.54%) was the most common cause of bacteraemia followed by Listeria monocytogenes 17 (15.45%), Diplococcus sp. (scialert.net)
  • In this manuscript, we also demonstrate the application of these methods for the detection of LPS in serum from pediatric patients with invasive Salmonella Typhimurium bacteremia (n=7) and those with Staphylococcal bacteremia (n=7) with 100% correlation with confirmatory culture. (listlabs.com)
  • Although the majority of microbes succumb to the microbicidal environment within the phagolysosome, some pathogens (including Mycobacterium tuberculosis and Salmonella Typhimurium ) can survive and replicate within this harsh environment ( 11 , 12 ). (frontiersin.org)
  • Usually results from bacteremia with virulent pathogens such as Staphylococcus aureus , Salmonella , or possibly Candida . (logicalimages.com)
  • We describe a case of systemic illness and bacteremia in a 5-month-old exclusively breastfed term infant associated with acute nontyphoidal Salmonella mastitis in his mother. (cfp.ca)
  • In the urban site, the overall crude incidence of Salmonella enterica serovar Typhi ( S . Typhi) bacteremia was 247 cases per 100,000 person-years of observation (pyo) with highest rates in children 5-9 years old (596 per 100,000 pyo) and 2-4 years old (521 per 100,000 pyo). (cdc.gov)
  • We set out to compare incidence of Salmonella enterica serovar Typhi ( S . Typhi) bacteremia in a densely populated urban slum and a rural community in Kenya, hypothesizing higher rates in the urban area, given crowding and suboptimal access to safe water, sanitation and hygiene and the high rates within urban settings in Asia with similar characteristics. (cdc.gov)
  • From the upper airways, pathogens may invade adjacent structures, such as the lungs, middle ear, or nasal sinuses, and may penetrate into the bloodstream, causing invasive diseases. (cdc.gov)
  • Because of the improved culture methods and sensitive nucleic acid amplification assays developed in recent years, Kingella kingae , a gram-negative coccobacillus of the Neisseriaceae family, is increasingly recognized as an invasive pathogen of early childhood. (cdc.gov)
  • Patients in the ICU, colonized with MDR AB, should be considered for minimizing invasive procedures and early removal of the invasive devices to prevent development of MDR AB bacteremia. (biomedcentral.com)
  • Blood isolates of Eubacterium were collected and antibiotic susceptibility testing was performed with agar dilution.ResultsSeventeen patients with Eubacterium bacteremia were identified of whom six had monomicrobial bacteremia. (lu.se)
  • The incidence was 1.7 cases of Eubacterium bacteremia per million inhabitants and year. (lu.se)
  • Results: The incidence of bacteremia with the 4 SLB genera was 30 episodes/1 000 000 population per year, of which Aerococcus contributed with 18. (lu.se)
  • The incidence of MDR AB bacteremia, which develops as a result of colonization, is increasing through widespread dissemination of the pathogen, and further colonization. (biomedcentral.com)
  • Bacteremia is a leading cause of death in sub-Saharan Africa where childhood mortality rates are the highest in the world. (listlabs.com)
  • Bacteraemia is an important and frequent condition with increasing mortality (Madsen et al . (scialert.net)
  • Importantly, the mortality of bacteremia is directly correlated to the first adequate anti-infectious therapy. (biomedcentral.com)
  • In a retrospective observational study conducted in Denmark between 1997 and 2012, the researchers found a statistically significant association between inadequate empiric therapy of L. monocytogenes bacteremia/meningitis and a higher 30-day mortality. (marlerclark.com)
  • Dissemination of pathogens from a primary site of colonization or infection can occur via different routes, including lymphatic vessels and the blood stream ( 1 ). (frontiersin.org)
  • Indwelling catheters facilitate ascent, and spermicides promote vaginal colonization with pathogens. (logicalimages.com)
  • However, there is limited data on risk factors associated with the development of MDR AB bacteremia from colonization in ICUs. (biomedcentral.com)
  • aggressive control measures to prevent the transmission and colonization of this pathogen are currently limited. (biomedcentral.com)
  • There is an urgent need for a rapid method for detecting bacteremia in pediatric patients with co-morbidities to inform treatment. (listlabs.com)
  • Seventeen patients with Eubacterium bacteremia were identified of whom six had monomicrobial bacteremia. (lu.se)
  • P. aeruginosa is a germ found in the environment it is an opportunistic human pathogen most commonly infecting immunocompromised patients, such as those with cancer ,diabetes, cystic fibrosis, severe burns, AIDS, or people who are very young or elderly. (wikipedia.org)
  • The aim of the study was to analyze this in a cohort of patients with SLB-bacteremia, focusing on Abiotrophia, Aerococcus, Gemella, and Granulicatella. (lu.se)
  • The most common viral pathogens recovered from hospitalized patients admitted with CAP include human rhinovirus and influenza . (medscape.com)
  • 5,14 That prevalence of this infection increases with age is possibly due to a number of factors: the increasing age of the population, increasing number of patients on renal replacement therapy, increasing number of patients with immunosuppressive medications and increasing rates of bacteremia due to intravascular devices and other forms of instrumentation. (wheelessonline.com)
  • 34 Many now believe that the sluggish flow, scarcity of valves and convolution of the arterial or venous supply leads to vertebral osteomyelitis in patients with bacteremia. (wheelessonline.com)
  • In this study, samples from the 2013-2016 West African Ebola virus outbreak from patients in Guinea with Ebola virus disease (EVD) were analyzed to discover and classify what other pathogens were present. (asm.org)
  • IMPORTANCE Our results highlight the identification of an array of pathogens in the blood of patients with Ebola virus disease (EVD). (asm.org)
  • [2] Mycobacterium avium complex is a pathogen common to patients with HIV. (nih.gov)
  • Adult patients with monomicrobial 3GCRE bacteraemia receiving carbapenems within 24 h were included at two hospitals in Thailand. (altmetric.com)
  • Empirical carbapenems were prescribed in 427/1032 (41%) patients with 3GCRE bacteraemia, of whom 221 received ertapenem and 206 received class 2 carbapenems. (altmetric.com)
  • We sought to determine risk factors for MDR AB bacteremia in patients colonized with MDR AB in the ICU. (biomedcentral.com)
  • Of the 200 patients colonized with MDR AB, 108 developed MDR AB bacteremia, and 92 did not. (biomedcentral.com)
  • HAIs develop when bacteria, viruses, fungi or other pathogens invade the blood and/or tissues of patients while they are receiving treatment for other medical conditions. (cna.com)
  • This study presents three cases of Ralstonia bacteraemia among chronic kidney disease patients in a haemodialysis unit in Baguio City, the Philippines. (who.int)
  • Whole-blood models can help to elucidate host-pathogens interactions and have been used for several Candida species in human blood. (frontiersin.org)
  • However, our understanding of how pathogens interact with cellular and humoral host factors in blood is limited, mainly due to technical issues: While it is relatively easy to study the interaction of pathogens with isolated blood cells, or their survival in serum or plasma, such approaches lack the complexity of interactions between different types of immune cells and additional factors, e.g., complement, present in blood. (frontiersin.org)
  • Introduced to France in the 1970s, C . gigas suffers mass mortalities associated with complex interactions between the host, the environment and pathogens 5 . (nature.com)
  • 2 Stemming the tide of HAIs requires in-service education of front-line staff on sources of infection, common pathogens and their prevention through universal infection control precautions. (cna.com)
  • We aim to describe the prevalence of bacteremia among children presenting to the emergency department (ED) with fever and acute lower extremity pain and identify predictors of bacteremia. (aap.org)
  • The prevalence of bacteremia among children presenting to the ED with fever and acute lower extremity pain is high. (aap.org)
  • From aerobic culture 111 (27%) pathogens and from anaerobic culture 6 (13%) pathogens were identified. (scialert.net)
  • A total of 448 blood samples (405 aerobically and 43 aerobically) were cultured, out of them, 111 (27%) pathogens from aerobic and 6 (5%) pathogens from anaerobic culture were isolated and identified. (scialert.net)
  • Despite sparse scientific data, some studies indicate that individuals with periodontitis are at increased risk for cancer development, due to the increased inflammatory burden sustained by the presence of periodontal pathogens. (intechopen.com)
  • Periodontal pathogens can, thus, disseminate through the blood and can contribute to development of adverse systemic effects by direct (endothelial injury or dysfunction) indirect (through lipopolysaccharide (LPS) activated cytokine profiles) mechanisms [8]. (bvsalud.org)
  • Autophagy is an evolutionarily conserved process of intracellular degradation, recognized as an important defense mechanism against intracellular pathogens ( 15 ). (frontiersin.org)
  • Intracellular pathogens are also detected via nucleotide-binding oligomerization domain-like receptors (NLRs), a class of PRRs that reside in the cytosol ( 28 ). (frontiersin.org)
  • Facultative intracellular pathogen. (mgc.ac.cn)
  • Pathogen restriction is enhanced by the nutrient-limiting ability of the phagolysosome and the input of antimicrobial agents into the lumen, such as reactive oxygen/nitrogen species (ROS/RNS) ( 10 ). (frontiersin.org)
  • Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. (nature.com)
  • 20 cells/ µL ) but no identified viral pathogen had "probable" meningitis. (medscape.com)
  • For decades, methodological limitations have restricted the study of infectious diseases to simplified experimental pathosystems in which the influences of host and pathogen diversity and biotic and abiotic environments have been minimized. (nature.com)
  • Periodontitis is a highly prevalent, chronic multifactorial infectious disease, induced by the dysbiotic biofilm that triggers a persistent systemic inflammation and recurrent bacteremia. (intechopen.com)
  • And the reason why this is so significant that there is a specific time cutoff is that this shows us the risk of more dangerous pathogens such as pseudomonas, such as MRSA, that require more broader therapies to be used. (reachmd.com)
  • Background: Many genera and species of Streptococcus-like bacteria (SLB) can cause infective endocarditis (IE), but little is known about the epidemiology of and the risk factors for IE in SLB-bacteremia. (lu.se)
  • Infective endocarditis was most common in bacteremia with Abiotrophia (4 of 19) followed by Granulicatella (9 of 124), Gemella (6 of 87), and Aerococcus (13 of 338). (lu.se)
  • Vertebral osteomyelitis is most often a single pathogen infection. (nih.gov)
  • [2] Thus a diagnosis of vertebral osteomyelitis should be assumed (without the need for a disc space aspiration or another tissue sampling) in a patient with S. aureus bacteremia within the preceding 3 months and compatible spine magnetic resonance imaging (MRI) findings. (nih.gov)
  • E-plex technology enhances traditional culture and sensitivity results by detecting specific resistance factors of a given pathogen. (medscape.com)
  • E-plex complements traditional methods of culture and sensitivity because it only surveys select pathogens and genes. (medscape.com)
  • So it is very much important to have culture and sensitivity test of concern pathogens. (scialert.net)
  • Abbreviations: CDI/HOB = Hospital-onset, antibiotic-treated C. difficile infection (CDI) / Hospital-onset bacteremia/fungemia (HOB), HA-VTE= Healthcare-associated venous thromboembolism *Listing of EHR vendors does not imply endorsement by the vendors. (cdc.gov)
  • Specifically, we have exploited the interaction of amphiphilic pathogen biomarkers such as lipopolysaccharides (LPS) from Gram-negative bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria with host lipoprotein carriers in blood, in order to develop two tailored assays - lipoprotein capture and membrane insertion - for their direct detection. (listlabs.com)
  • The evidence that supports the oral route is best established for gram-positive pathogens such as enterococci, MRSA, and CoNS. (medscape.com)
  • We also evaluated whether published scoring systems generated for other Gram-positive bacteria known to cause IE (HANDOC for streptococci and NOVA and DENOVA for enterococci) could be used in SLB bacteremia to decide whether transesophageal echocardiography (TEE) could be omitted. (lu.se)
  • [2] Conversely, coagulase-negative staphylococci and Propionibacterium acnes are the most common pathogens in cases of exogenous osteomyelitis after spinal surgery, particularly with the use of spinal fixation devices. (nih.gov)
  • Bacterial pathogens are the most common cause of pyelonephritis. (medscape.com)
  • Chryseobacterium gleum , a NFGNB and pathogen predominantly documented in southeast Asia, has been implicated in both CLABSI and VAP and is resistant to broad-spectrum antibiotics commonly used to treat NFGNB. (hindawi.com)
  • Conclusions: Bacteremia with these SLB is relatively rare, and the decision whether TEE should be performed or not could be based on either HANDOC or DENOVA. (lu.se)
  • The company has a license agreement with The Rockefeller University to identify novel lysin therapeutic candidates targeting gram-negative pathogens. (ashkon.com)
  • In this manuscript, we have developed and clinically validated a novel method for the direct detection of amphiphilic pathogen biomarkers indicative of bacteremia, directly in aqueous blood, by mimicking innate immune recognition. (listlabs.com)
  • For other pathogens, true synergistic effect seldom is achieved, and possible side effects are more frequent. (medscape.com)