Being a close non-pathogenic relative of the pathogenic dimorphic fungiCoccidioides immitis and Coccidioides posadasii, which cause Coccidioidomycosis, it is used in genomic research to help develop human vaccination, which might alleviate the Valley fever silent epidemic. (wikipedia.org)
In addition, comparison among Onygenales genomes revealed evolutionary changes in Coccidioides that may underlie its infectious phenotype, the identification of which may facilitate improved treatment and prevention of coccidioidomycosis. (nau.edu)
It is important to have its genome sequences because Coccidioides immitis, along with its relative Coccidioides posadasii, can cause a disease called Coccidioidomycosis (Valley Fever), and it is a rare cause of meningitis, mostly in immunocompromised persons, and the disease can be fatal. (kenyon.edu)
Fungi that live in soil or other parts of the natural environment cause diseases such as coccidioidomycosis (Valley fever) and histoplasmosis . (cdc.gov)
Coccidioidomycosis is caused by Coccidioides immitis, a soil fungus native to the San Joaquin Valley of California, and by C posadasii , which is endemic to certain arid-to-semiarid areas of the southwestern United States, northern portions of Mexico, and scattered areas in Central America and South America. (medscape.com)
Coccidioidomycosis typically is transmitted by inhalation of airborne spores of C immitis or C posadasii (see Etiology). (medscape.com)
Coccidioidomycosis, also known as Valley fever, is a disease of growing public health concern and is caused by 2 closely related fungal species, Coccidioides immitis and C. posadasii . (cdc.gov)
Climate suitability projections predict expansion of the suitable environment for coccidioidomycosis and increasing incidence in areas that already sustain Coccidioides growth ( 11 ). (cdc.gov)
Species7
Overall, the results suggest that Coccidioides species are not soil saprophytes, but that they have evolved to remain associated with their dead animal hosts in soil, and that Coccidioides metabolism genes, membrane-related proteins, and putatively antigenic compounds have evolved in response to interaction with an animal host. (nau.edu)
Coccidioides immitis strains contain either a MAT1-1 or a MAT1-2 idiomorph, which is 8.1 or 9 kb in length, respectively, the longest reported for any ascomycete species. (kenyon.edu)
An analysis of 436 Coccidioides isolates from patients and the environment indicates that in both Coccidioides immitis and C. posadasii, there is a 1:1 distribution of MAT loci, as would be expected for sexually reproducing species. (kenyon.edu)
Climate factors are predicted to further extend the range of environments suitable for the growth and dispersal of Coccidioides species. (cdc.gov)
2006. Eukaryotic microbes, species recognition and the geographic limits of species: examples from the kingdom Fungi. (berkeley.edu)
Infection resulting from inhalation or ingestion of spores of the fungus of the genus HISTOPLASMA, species H. capsulatum. (lookformedical.com)
Candida albicans is an opportunistic pathogenic yeast It is one of the few species of the genus Candida that causes the human infection candidiasis, which results from an overgrowth of the fungus. (ensembl.org)
Organisms3
Chorioretinitis is the inflammation Inflammation Inflammation is a complex set of responses to infection and injury involving leukocytes as the principal cellular mediators in the body's defense against pathogenic organisms. (lecturio.com)
Fungi are eukaryotic organisms that exist as yeast, molds, or both forms. (msdmanuals.com)
Opportunistic fungal infections Fungi are eukaryotic organisms that exist as yeast, molds, or both forms. (msdmanuals.com)
Soil4
are dimorphic, forming mycelia in soil and arthroconidia capable of infecting humans and certain other mammals, and spherules in mammalian tissue ( 1 ). (cdc.gov)
Infection is generally caused by inhalation of pathogenic arthroconidia from disturbed soil or dust, such as through occupational or recreational activities or weather events that raise dust ( 2 - 7 ). (cdc.gov)
Subsequently, Coccidioides DNA and viable propagules were isolated from soil at a location of suspected exposure for 1 of these cases ( 12 , 13 ). (cdc.gov)
Whole-genome sequencing (WGS) analysis of the recovered isolates demonstrated near identical genetic identity between soil and clinical isolates, further confirming endemic presence of infectious C. immitis in Washington ( 13 ). (cdc.gov)
The parasitic cell surface glycoprotein encoded by the SOWgp gene appears to function as an adhesion and contributes to the virulence of C. immitis. (kenyon.edu)
My research is focused on studies of virulence factors of Coccidioides spp. (rtrn.net)
and a more diverged pathogenic fungus, Histoplasma capsulatum, were sequenced and compared with those of 13 more distantly related Ascomycetes. (nau.edu)
Asymptomatic1
Most patients infected with Coccidioides are asymptomatic or have self-limited symptoms and require only supportive care. (medscape.com)
Genus4
Uncinocarpus is a genus of fungi within the Onygenaceae family. (wikipedia.org)
Infection in humans and animals caused by fungi in the class Zygomycetes. (lookformedical.com)
The latter is a tropical infection of subcutaneous tissue or paranasal sinuses caused by fungi in the order Entomophthorales. (lookformedical.com)
An infection caused by an organism which becomes pathogenic under certain conditions, e.g., during immunosuppression. (lookformedical.com)
Saprophytic1
Coccidioides immitis is a dimorphic fungus exist in two distinct forms, saprophytic and parasitic. (kenyon.edu)
Strains1
Genetic differences among these strains suggest multiple environmental reservoirs of C. immitis in the state. (cdc.gov)
SOWgp1
2005. Concerted evolution of the repeats of an immunomodulating cell surface protein, SOWgp, of the human pathogenic fungiCoccidioides immitis and C. posadasii. (berkeley.edu)
Isolates1
Isolates from locally acquired cases clustered within the previously established Washington clade of C. immitis . (cdc.gov)
Mycoses1
Primary fungal infections may have a characteristic geographic distribution, which is especially true for the endemic mycoses caused by certain dimorphic fungi. (msdmanuals.com)
Gene1
2006. Phase-specific gene expression underlying morphological adaptations of the dimorphic human pathogenic fungus, Coccidioides posadasii. (berkeley.edu)
Molds1
Filamentous fungi, commonly known as molds, refer to those that grow as multicellular colonies. (lookformedical.com)
Parasitic1
is a diphasic fungus characterized by a parasitic cycle (Fig.1) which is unique amongst medically important fungal pathogens. (rtrn.net)
Metabolism1
Cell wall: Like most pathogenic fungi, the cell wall of Coccidioides immitis is rich in chitin and chitin metabolism is a reasonable target for the design of antifungal agents. (kenyon.edu)
Geographic2
Incidence of disease has risen consistently in recent years, and the geographic distribution of Coccidioides spp. (cdc.gov)
Epidemiologic trends display dramatic shifts with expanding geographic ranges, identification of new at-risk groups, increasing prevalence of resistant infections, and emergence of novel multidrug-resistant pathogenic fungi. (cdc.gov)
Cells3
Cells of Coccidioides immitis in the hyphal stage have thin, structure-less walls and a cytoplasmic membrane. (kenyon.edu)
Dimorphic fungi grow as mold in the environment and as yeast cells or spherules (sac-like cells that are the reproductive form of the fungus) in vivo. (msdmanuals.com)
It is generally referred to as a dimorphic fungus since it grows both as yeast and filamentous cells. (ensembl.org)
Specimens1
Find and identify disease-causing fungi in patient and environmental specimens (laboratories: see specimen submission information for details). (cdc.gov)
Arid1
The dimorphic fungi live in the soils of arid and semiarid regions of the western United States, as well as parts of Mexico, Central America, and South America. (cdc.gov)
California2
Formal description of Coccidioides immitis was performed by Rixford and Gilchrist from a case observed in California in 1986 (3) . (kenyon.edu)
and C. immitis is primarily found in central and southern California. (cdc.gov)
Infections2
The breadth of fungi causing human disease and the spectrum of clinical presentations associated with these infections has widened. (cdc.gov)
Superficial infections of the skin or its appendages by any of various fungi. (lookformedical.com)
Human1
They differ from FUNGICIDES, INDUSTRIAL because they defend against fungi present in human or animal tissues. (lookformedical.com)
Growth2
Sputum culture of Coccidioides immitis on Sabouraud's medium, showing white, cottony fungus growth. (kenyon.edu)
Scaly papule or warty growth, caused by five fungi, that spreads as a result of satellite lesions affecting the foot or leg. (lookformedical.com)
Primary1
While most Ascomycetes tend to associate principally with plants, the dimorphic fungiCoccidioides immitis and Coccidioides posadasii are primary pathogens of immunocompetent mammals, including humans. (nau.edu)
Grow1
Substances that destroy fungi by suppressing their ability to grow or reproduce. (lookformedical.com)
Identification1
My research interest is in the identification and characterization of dominant antigens of Coccidioides spp. (rtrn.net)
Structure1
We used whole-genome sequencing to differentiate locally acquired cases in Washington on the basis of the previously identified phylogeographic population structure of Coccidioides spp. (cdc.gov)
Important1
Beware: it is not all good, it can suppress important fungi from growing. (slideshare.net)