• The development of antibiotic resistance in periodontopathogens is a major issue given that these bacteria may migrate from the oral cavity to other organs where they may cause infections or transfer their antibiotic resistances to other bacterial species. (nature.com)
  • Bacteria survive in various environments by forming biofilms. (biomedcentral.com)
  • In this study, we evaluated the ability of two types of biosurfactants (rhamnolipids and surfactin) to inhibit growth and biofilm formation ability of oral pathogenic bacteria such as Aggregatibacter actinomycetemcomitans , Streptococcus mutans , and Streptococcus sanguinis . (biomedcentral.com)
  • Rhamnolipids inhibited the growth and biofilm formation ability of all examined oral bacteria. (biomedcentral.com)
  • Streptococcus mutans , a representative bacteria of tooth decay [ 10 ], forms plaques (biofilm) on tooth surfaces and produces lactate from sugars such as sucrose, which demineralizes teeth and causes dental caries. (biomedcentral.com)
  • Therefore, removal of biofilms formed by periodontopathogenic bacteria prevents a variety of diseases. (biomedcentral.com)
  • Anti-bacterial agents and disinfectants are effective against planktonic bacteria (bacteria suspended in liquid), however, they are not effective against biofilm-forming bacteria due to the difficulty of chemicals penetrating the biofilm. (biomedcentral.com)
  • [13] The biofilm bacteria can share nutrients and are sheltered from harmful factors in the environment, such as desiccation, antibiotics, and a host body's immune system. (wikipedia.org)
  • They can be found very early in Earth's fossil records (about 3.25 billion years ago) as both Archaea and Bacteria, and commonly protect prokaryotic cells by providing them with homeostasis, encouraging the development of complex interactions between the cells in the biofilm. (wikipedia.org)
  • [8] [5] The first colonist bacteria of a biofilm may adhere to the surface initially by the weak van der Waals forces and hydrophobic effects. (wikipedia.org)
  • To confirm which media and which bacterial colony densities can enrich certain kinds of bacteria, we selected eight common media and used them to enrich the gut microorganisms on agar plates. (springeropen.com)
  • We investigated how the nutritional components and densities influence the composition and diversity of the bacterial community, which bacteria could be enriched and the conditions of nutritional composition or density that allowed enrichment, and what the interaction was among bacteria at various densities. (springeropen.com)
  • A safe bio-preservative agent, lactic acid bacteria (LAB) can inhibit the growth of pathogenic bacteria and spoilage organisms. (frontiersin.org)
  • This study focused on the changes in biofilm activity and related metabolic pathways of S. aureus treated with lactic acid bacteria planktonic CFS (LAB-pk-CFS) and biofilm state (LAB-bf-CFS). (frontiersin.org)
  • However, there have not been many investigations on how pathogenic bacteria are affected by the metabolic properties of planktonic and biofilm probiotics. (frontiersin.org)
  • Here, we used untargeted metabolomics to investigate the potential impacts of planktonic bacteria (LAB-pk-CFS) and biofilm colonies (LAB-bf-CFS) on the metabolism of S. aureus biofilms. (frontiersin.org)
  • Cationic amphiphiles greatly inhibits the biofilm formation of the pathogenic bacteria in BV. (technologypublisher.com)
  • Antimicrobial peptides (AMPs) hold great potential in treating BV as they can effectively disrupt the bacterial membrane causing cell death, a mechansim that is difficult for bacteria to develop drug resistance to. (technologypublisher.com)
  • In an in vitro study, the CAms were shown to effectively inhibit BV-associated pathogens but not the healthy vaginal bacteria lactobacilli. (technologypublisher.com)
  • For biofilm development, bacteria had been inoculated to your final OD600 of 0.05 in to the supplemented TSB liquid medium in uncoated polystyrene tissue-culture plates (Greiner) and incubated anaerobically at 37 C for 5 times. (acancerjourney.info)
  • All of these pathogenic bacteria are planktonic or free floating, when single, and upon aggregation , they build biofilms. (yeastinfectionadvisor.com)
  • Activated lactoferrin (ALF) is a new form of a naturally occurring protein from milk that acts as a powerful deterrent to pathogenic bacteria that may be present on a meat surface. (ift.org)
  • The antibacterial activity against various pathogenic and drug-resistant bacteria was tested using crude garlic extracts, garlic powder (GP), garlic extracts using various solvents, GO, and phytochemicals isolated from garlic. (frontiersin.org)
  • The constant presence of pathogenic bacteria in the oral cavity, through a number of factors such as pro-inflammatory cytokines or proteolytic enzymes, supports mechanisms of chronic destruction of connective and bone tissue, which causes disease progression and hinders its treatment. (sciendo.com)
  • Initially, subgingival biofilm with a range of anaerobic bacteria was considered pathogenic, then species such as Aggregatibacter (previously Actinobacillus ) actinomycetemcomitans or Porphyromonas gingivalis were identified as particularly pathogenic. (sciendo.com)
  • Biofilms form when groups of bacteria cover themselves in a sticky mixture of sugars, protein, and DNA. (the-scientist.com)
  • Within the biofilm, bacteria take on different responsibilities. (the-scientist.com)
  • Biofilms are considered a virulence factor because they make the bacteria found throughout the body more virulent. (mercercluster.com)
  • Abdul Kaimari, a junior neuroscience major, has been part of Hensel's research team where they have been focusing on inhibiting biofilm pathways of pathogenic bacteria through efflux pump research. (mercercluster.com)
  • Biofilm is a complex matrix consisting of extracellular polysaccharides, DNA, and proteins that protect bacteria from a variety of physical, chemical, and biological stresses allowing them to survive in hostile environments. (intechopen.com)
  • Bacteria can be found in planktonic form or in specific conditions, as sessile aggregates on both biotic and abiotic surfaces originating complex structures known as biofilm. (intechopen.com)
  • The biofilm matrix consists of polysaccharides, proteins, and DNA and constitutes a stubborn source that protects bacteria from a variety of physical, chemical, and biological stresses. (intechopen.com)
  • Unlike antibacterials that aim to inhibit cell growth, antivirulence therapies are based on the inhibition of bacterial virulence. (nature.com)
  • The study, " Antibacterial Activity and Biofilm Inhibition by Surface Modified Titanium Alloy Medical Implants Following Application of Silver, Titanium Dioxide, and Hydroxyapatite Coatings ," was published by Nanotoxicology . (dentistrytoday.com)
  • Finally, another study demonstrated that an active constituent in oregano, carvacrol, exhibited inhibition of biofilms against microbes. (naturalpath.net)
  • AuNPs also showed biofilm inhibition, with the highest of 98% in S. aureus . (dovepress.com)
  • This is the first report on rapid and efficient synthesis of AgNPs, AuNPs and AgAuNPs from P. zeylanica and their effect on quantitative inhibition and disruption of bacterial biofilms. (dovepress.com)
  • Any drug impairing crucial processes for bacterial life will inevitably lead to the development of drug-resistant strains, whereas the inhibition of biofilm formation might prevent the onset of bacterial resistance. (intechopen.com)
  • Moreover, genetically diverse commensal and pathogenic E. coli strains and Salmonella typhimurium responded with cell filamentation and modulation in colony morphotype formation to CapV Q329R expression. (nih.gov)
  • QuoNova has optimized its proprietary QSB technology to obtain small molecules with a broad activity profile that are effective against multiple pathogenic Gram-positive and Gram-negative bacterial strains as well as fungi. (blogspot.com)
  • She accepted the project and aided me in obtaining the proper bacterial strains, navigating through research problems, and developing proper testing protocols. (mercercluster.com)
  • In this section, we will focus on proteins involved in biofilm formation as useful targets for the development of new drugs that can effectively and specifically impair biofilm formation with slight effects on cell survival, thus avoiding the generation of drug-resistant strains. (intechopen.com)
  • Given its central role in biofilm formation, F. nucleatum may represent a key target for controlling biofilm formation. (nature.com)
  • Therefore, inhibiting the growth of oral pathogens, as well as effectively preventing biofilm formation contribute to reducing these risks. (biomedcentral.com)
  • The main bacterial pathogens connected with periodontitis include can utilize sialoglycoproteins for biofilm growth, we showed that growth and initial adhesion with sialylated mucin and fetuin were inhibited two- to threefold with the sialidase inhibitor oseltamivir. (acancerjourney.info)
  • In this study, we examined the efficacy of silver zeolite for preventing biofilm formation by common foodborne pathogens such as Listeria innocua Seeliger and Escherichia coli O157:H7. (wur.nl)
  • The study was performed against three biofilm building pathogens, mainly Escherichia coli, Proteus mirabilis , and Serratia marcescens . (yeastinfectionadvisor.com)
  • The antimicrobial, anti-adhesive and anti-biofilm activities of both BS against the above mentioned MDR pathogens were determined. (biomedcentral.com)
  • Anti-adhesive and anti-biofilm activities were also observed for the aforementioned pathogens between 25 and 50 mg/ml. (biomedcentral.com)
  • The primary cause of failure, though, is peri-implantitis as pathogenic microbes in the oral cavity develop into biofilms on implants. (dentistrytoday.com)
  • Microbes form a biofilm in response to a number of different factors, [9] which may include cellular recognition of specific or non-specific attachment sites on a surface, nutritional cues, or in some cases, by exposure of planktonic cells to sub-inhibitory concentrations of antibiotics . (wikipedia.org)
  • by inhibiting the production of virulence factors such as exopolysaccharides and metabolic activity such as surface hydrophobicity playing an important role in bacterium-host cell interactions and biofilm architecture in microbes, respectively [ 7 ] . (encyclopedia.pub)
  • Biofilms are home to millions of microbes, but disrupting their interactions could produce more effective antibiotics. (the-scientist.com)
  • These biofilms of aggregating microbes are everywhere: on rocks, bathtubs, and medical devices. (the-scientist.com)
  • The slimy coating on unbrushed teeth is biofilm, and the beneficial microbes on your skin and gut often grow collectively. (the-scientist.com)
  • We report here that myricetin, but not its glycosylated form, can remarkably decrease the production of several S. aureus virulence factors, including adhesion, biofilm formation, hemolysis and staphyloxanthin production, without interfering with growth. (nature.com)
  • They also prevented biofilm formation by F. nucleatum at concentrations that did not interfere with bacterial growth. (nature.com)
  • It plays a key role in subgingival biofilm formation by bridging the early colonizers (streptococci and actinomyces) and the late colonizers ( Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola ) 3 that make up the red complex initially described by Socransky et al . (nature.com)
  • Techniques to inhibit biofilm formation are essential and have wide applications. (biomedcentral.com)
  • We also attempted to determine the step in the biofilm formation process that was inhibited by biosurfactants. (biomedcentral.com)
  • The results clearly demonstrated that rhamnolipids inhibit biofilm formation after the initiation process, however, they do not affect attachment or maturation. (biomedcentral.com)
  • Rhamnolipids inhibit oral bacterial growth and biofilm formation by A. actinomycetemcomitans Y4, and may serve as novel oral drug against localized invasive periodontitis. (biomedcentral.com)
  • Thus, there is a requirement for the development of a simpler and more effective oral care capable of inhibiting oral bacterial growth and biofilm formation. (biomedcentral.com)
  • Furthermore, CapV Q329R production substantially alters the lipidome and colony morphotype including rdar biofilm formation with modulation of the production of the biofilm activator CsgD, and affects additional bacterial traits such as the efficiency of phage infection and antimicrobial susceptibility. (nih.gov)
  • The formation of a biofilm begins with the attachment of free-floating microorganisms to a surface. (wikipedia.org)
  • Therapeutic failures of antibiotics used to treat macrolide-susceptible Streptococcus pyogenes infections may be due to biofilm formation. (microbiologyresearch.org)
  • Fibrinogen induces biofilm formation by Streptococcus suis and enhances its antibiotic resistance. (microbiologyresearch.org)
  • Biofilm formation protecting pathogenic candida. (livermedic.com)
  • Biofilm formation was assessed by cresyl violet assay, quantification of colony-forming units and scanning electron microscopy, and atomic force microscopy. (wur.nl)
  • The results of this study demonstrate that the silver zeolite could inhibit foodborne pathogenic biofilm formation and could potentially serve as an effective antimicrobial coating for food contact surfaces. (wur.nl)
  • The AuNPs weaken the biofilm formation of Proteus sp. (encyclopedia.pub)
  • Regarding to the biofilm formation ability, all treatments reduced the total biomass. (preprints.org)
  • Once they reach a certain density, then there's a lot of those molecules which turn on this genetic probe program, and the ones that we are studying are the genetic program for biofilm formation. (mercercluster.com)
  • Biofilm formation requires three different stages: cell attachment to a solid substrate, adhesion, and growth. (intechopen.com)
  • The microbial community is also a natural source of metabolites and has the potential to be used to create antimicrobial and anti-biofilm agents. (frontiersin.org)
  • Streptococcus sanguinis is another plaque-forming strain that has been reported to cause infective endocarditis by forming biofilms on the endocardium and heart valves [ 11 ]. (biomedcentral.com)
  • We demonstrate here that overexpression of the patatin-like phospholipase variant CapV Q329R , but not CapV, causes pronounced sulA-independent pyridoxine-inhibited cell filamentation in the Escherichia coli K-12-derivative MG1655 associated with restriction of flagella production and swimming motility. (nih.gov)
  • The tea extracts and components displayed various degrees of antibacterial activity that may involve damage to the bacterial cell membrane and the chelation of iron. (nature.com)
  • Although physical methods are fundamental for removing oral biofilms, there is a wide variation in its efficiency due to individual differences. (biomedcentral.com)
  • The antimicrobial properties of Melaleuca essential oil alternifolia to oral biofilms have been reported in several studies [9-12]. (bvsalud.org)
  • The control of the dental biofilm allows the maintenance of oral health and prevents the development of diseases such as caries and periodontal disease, which are strongly related to tooth loss [1]. (bvsalud.org)
  • The role of bacterial biofilms in chronic infections. (livermedic.com)
  • In alternative medicine, the roots have been used to cleanse the blood and liver, reduce inflammation and control bacterial infections. (yeastinfectionadvisor.com)
  • They also concluded that by removing these biofilms burdock would help the host immune system fight these infections . (yeastinfectionadvisor.com)
  • Several BS exhibit anti-bacterial, anti-fungal and anti-viral activities, making them appropriate candidates to combat infections [ 3 ]. (biomedcentral.com)
  • The presence of biofilms causes numerous problems in the field of medicine, interfering with clinical therapy of chronic and wound-related infections as well as persistent infections of various indwelling medical devices [ 15 ]. (biomedcentral.com)
  • Garlic ( Allium sativum ), a popular food spice and flavoring agent, has also been used traditionally to treat various ailments especially bacterial infections for centuries in various cultures around the world. (frontiersin.org)
  • Bacterial biofilms play an important role in UTIs, responsible for persistent infections leading to recurrences and relapses. (mdpi.com)
  • The high resistance of pathogenic microorganisms to different, and even the most modern antibiotics is becoming an increasingly serious problem for clinical medicine that could be decided using nanoparticles of various metals, including AuNPs. (encyclopedia.pub)
  • AuNPs are a valuable element against bacterial biofilms. (encyclopedia.pub)
  • Additionally, it inhibits the physiological traits of the S. aureus biofilm, including hydrophobicity, motility, eDNA, and PIA associated to the biofilm. (frontiersin.org)
  • The metabolites of S. aureus biofilm treated with LAB-CFS were greater in the LAB-bf-CFS than they were in the LAB-pk-CFS, according to metabolomics studies. (frontiersin.org)
  • S. aureus produces large biofilm formations that support its pathogenicity and confer protection and subsequently drug resistance ( 5 ). (frontiersin.org)
  • The differentially expressed genes and proteins linked to S. aureus biofilms have been identified using transcriptomic and proteomic investigations ( 14 - 17 ). (frontiersin.org)
  • Because of this, it is crucial to understand how LAB-CFS affects the makeup and function of metabolites in S. aureus biofilms. (frontiersin.org)
  • Both BS also displayed anti-adhesive and anti-biofilm abilities against A. baumannii , E. coli and S. aureus . (biomedcentral.com)
  • Fusobacterium nucleatum plays a key role in creating the pathogenic subgingival biofilm that initiates destructive periodontitis. (nature.com)
  • Periodontitis treatments are aimed at eliminating the periodontal bacterial load by supragingival and subgingival mechanical debridement. (nature.com)
  • Aggregatibacter actinomycetemcomitans has been strongly associated with localized aggressive periodontitis via its ability to form biofilms in the subgingival cavity [ 12 ]. (biomedcentral.com)
  • When coated stainless steel coupons were incubated with Listeria and E. coli, significant reductions in bacterial growth were achieved. (wur.nl)
  • Burdock was found to reduce the biofilms by 50.79% for E. coli , 69.49% for P. mirabilis , and 75.84% for S. marcescens . (yeastinfectionadvisor.com)
  • This review summarizes new de-velopments in our understanding of diverse virulence factors associated encoding genes used by different pathotypes of enteric pathogenic E. coli to cause intestinal and extraintestinal diseases in humans. (preprints.org)
  • Bacterial biofilm reduction is still the basis of treating gingivitis and periodontitis. (sciendo.com)
  • generando en la comunidad odontológica estudios con enfoque en: reducción de la incidencia de caries, mejorar el pronóstico de periodontitis y disminución de halitosis y candidiasis. (scielo.edu.uy)
  • The observations were largely in concordance with the biofilm assay results. (biomedcentral.com)
  • Biofilms are three-dimensional structures consisting of various microbial populations attached to a surface by extracellular polymeric substances (EPS) produced by these microorganisms [ 1 ]. (biomedcentral.com)
  • A biofilm comprises any syntrophic consortium of microorganisms in which cells stick to each other and often also to a surface. (wikipedia.org)
  • Biofilms can attach to a surface such as a tooth or rock, and may include a single species or a diverse group of microorganisms. (wikipedia.org)
  • which the sialidase enzymes of some pathogenic bacterias donate to virulence, specifically of these that reside on and/or invade mucosal areas. (acancerjourney.info)
  • The reactive organosulfur compounds form disulfide bonds with free sulfhydryl groups of enzymes and compromise the integrity of the bacterial membrane. (frontiersin.org)
  • Bacterial vaginosis (BV) is a common polymicrobial infection in women of reproductive age, affecting 10-30% of women in developed nations. (technologypublisher.com)
  • These results suggest CAms are a promising new generation of antimicrobials for treating bacterial vaginosis. (technologypublisher.com)
  • The recent demonstration of a vaginal biofilm in bacterial vaginosis and its postulated importance in the pathogenesis of recurrent bacterial vaginosis, including relative resistance to therapy, has led to the hypothesis that biofilms are crucial for the development of vulvovaginal candidiasis. (interlabservice.ru)
  • In a cross-sectional study, vaginal tissue biopsies were obtained from 35 women with clinically, microscopically, and culture-proven vulvovaginal candidiasis and compared with specimens obtained from 25 healthy women and 30 women with active bacterial vaginosis. (interlabservice.ru)
  • We investigated vaginal biopsies from 35 women with VVC using fluorescent in situ hybridization and compared with specimens from healthy women and women with bacterial vaginosis. (interlabservice.ru)
  • Different from bacterial vaginosis, we found no biofilm elements in vaginal biopsies obtained from women with VVC. (interlabservice.ru)
  • In recent years, microbial culturomics has been a culturing approach that uses multiple techniques, such as MALDi-TOF mass spectrometry and 16S rRNA sequencing, for the identification of bacterial species. (springeropen.com)
  • Simultaneously, concepts of so-called health-promoting biofilm appear, which are based on the theory of symbiosis between bacterial species and the specific response of the host to a given type of biofilm. (sciendo.com)
  • The ability of the surface to resist the attachment of biofilms provides a complementary approach to chemical sanitation. (wur.nl)
  • In [ 8 ] , bacterial surface attachment, flagella loss, biofilm assemblage, and clumping inside biofilm are demonstrated as the antibacterial processes. (encyclopedia.pub)
  • [2] [3] The cells within the biofilm produce the EPS components, which are typically a polymeric conglomeration of extracellular polysaccharides , proteins , lipids and DNA . (wikipedia.org)
  • Biofilms are conglomerations of bacterial cells protected by self-synthesized extracellular polysaccharide matrices (EPS). (biomedcentral.com)
  • The microbial cells growing in a biofilm are physiologically distinct from planktonic cells of the same organism, which, by contrast, are single cells that may float or swim in a liquid medium. (wikipedia.org)
  • Biofilms are an ensemble of microbial cells irreversibly associated with a surface and enclosed in an essentially self-produced matrix. (intechopen.com)
  • GAS) is always of clinical significance in wounds where it can initiate infection, destroy skin grafts and persist as a biofilm. (microbiologyresearch.org)
  • Pathogenic fungi ( C. albicans , Aspergillus spp. (encyclopedia.pub)
  • We, therefore, summarize the impacts of the T6SS effectors with a special focus on bacterial interactions with animals, plants, and fungi. (preprints.org)
  • To corroborate these results, biofilms were observed by scanning electron microscopy (SEM) and confocal microscopy. (biomedcentral.com)
  • Furthermore, scanning electron microscopy (SEM) revealed considerable morphological and ultrastructural changes in treated biofilms, confirming the membrane-targeting effects of CAms. (technologypublisher.com)
  • [10] [11] A cell that switches to the biofilm mode of growth undergoes a phenotypic shift in behavior in which large suites of genes are differentially regulated . (wikipedia.org)
  • For silver zeolite suspended in growth media, concentrations of 0.3% w/v were effective at reducing bacterial growth of L. innocua after 8 h. (wur.nl)
  • The active compounds in the leaf extracts can inhibit the growth of micro-organisms in the oral cavity. (yeastinfectionadvisor.com)
  • Considered generally recognized as safe (GRAS) by the Food and Drug Administration and recently approved by the U.S. Dept. of Agriculture for use on fresh beef, ALF can be sprayed onto carcasses to help prevent bacterial contamination during processing or can be applied to a subprimal or finished beef surface prior to final packaging to inhibit bacterial growth and extend shelf life. (ift.org)
  • After 24 h of incubation, MIC was determined as the lowest concentration capable of inhibiting microbial growth, identified by the resazurin reaction (100 µg/mL). (bvsalud.org)
  • Then, we calculated the numbers of bacterial colonies and collected the bacterial culture mixtures from each kind of medium. (springeropen.com)
  • biofilms were grown up essentially as defined previously (Roy colonies had been harvested and cleaned twice in clean TSB. (acancerjourney.info)
  • Sublethal concentrations of manuka honey effectively prevented the binding of S. pyogenes to the human tissue protein fibronectin, but did not inhibit binding to fibrinogen. (microbiologyresearch.org)
  • The cellular number in older biofilms was evaluated as defined previously (Roy adhesion, fundamentally the same circumstances as for older biofilm development were utilized, except which the assays had been incubated for just 3 h at 37 C anaerobically. (acancerjourney.info)
  • Potentially, vaginal biofilm could explain acute sporadic VVC or be more relevant in recurrent VVC (RVVC) as a vaginal reservoir for yeast organisms following antifungal therapy and explain vaginal recolonization. (interlabservice.ru)
  • The present study aimed at clarifying the histopathology of vulvovaginal candidiasis including the presence or absence of vaginal biofilm. (interlabservice.ru)
  • Current antibiotic treatment regimens often fail to fully eradicate the pathogenic biofilm and may lead to recurrance due to antibiotic resistence. (technologypublisher.com)
  • Subpopulations of cells within the biofilm differentiate to perform various activities for motility, matrix production, and sporulation, supporting the overall success of the biofilm. (wikipedia.org)
  • These promising results, which are the subject of continuing research, further underscore the potential of QuoNova's QSB in combating the detrimental effects of biofilms, especially in clinical environments, where mixed microbial communities predominate. (blogspot.com)
  • In this study, the effect of manuka honey on S. pyogenes (M28) was investigated in vitro with planktonic and biofilm cultures using MIC, MBC, microscopy and aggregation efficiency. (microbiologyresearch.org)
  • A biofilm usually begins to form when a free-swimming bacterium attaches to a surface. (wikipedia.org)
  • As the biofilm matures and the community needs change, an individual bacterium may take on new responsibilities. (the-scientist.com)
  • Biofilms may form on living (biotic) or non-living (abiotic) surfaces and can be prevalent in natural, industrial, and hospital settings. (wikipedia.org)
  • Biofilms are hypothesized as crucial for the development of vulvovaginal candidiasis (VVC). (interlabservice.ru)
  • While much has been reported on T6SS-mediated prokaryotic competition, very little is understood about the mechanisms of bacterial interactions with eukaryotic hosts. (preprints.org)
  • As a postdoctoral researcher in Dianne Newman 's lab at the California Institute of Technology, Dar developed a way to track gene activity across the entire biofilm with submicrometer resolution. (the-scientist.com)
  • Biofilms are thought to have arisen during primitive Earth as a defense mechanism for prokaryotes, as the conditions at that time were too harsh for their survival. (wikipedia.org)
  • Histopathological lesions of vulvovaginal candidiasis are primarily invasive in nature and polymicrobial and do not resemble biofilms. (interlabservice.ru)
  • Histopathological lesions in 26 of 35 biopsies from VVC were exclusively invasive and accompanied by bacterial co-invasion. (interlabservice.ru)