• Multilocus variation-pathogenic variants in two or more disease genes-can potentially explain the underlying genetic basis for apparent phenotypic expansion in cases for which the observed clinical features extend beyond those reported in association with a "known" disease gene. (nih.gov)
  • The virus, which is highly pathogenic for poultry, appears already to have travelled westward as far as Poland and Hungary, and southwards to Kerala Province in India, according to recent official notifications to the World Organization for Animal Health, or OIE. (fao.org)
  • With this week's announcement of the USDA confirming Highly Pathogenic subtype H5N2 in several different types of poultry flocks in Minnesota, South Dakota, North Dakota, Wisconsin and Iowa, the state is increasing its surveillance. (medicalnewstoday.com)
  • Recent evidence that Ig can traverse cell membranes, interact with intracellular proteins, and induce apoptosis has provided new evidence for a pathogenic role for such autoantibodies. (mdpi.com)
  • Outer membrane proteins of pathogenic spirochetes. (prohealth.com)
  • The misclassification of benign genetic variants as pathogenic is common across all medical specialties, including neurology. (lww.com)
  • They found multiple patients, all of whom were of African or unspecified ancestry, who had received positive reports, with variants misclassified as pathogenic on the basis of the understanding at the time of testing. (lww.com)
  • The increased use of genomic sequencing in patients with rare neurogenetic diseases has led to more frequent observation of variants previously reported as pathogenic in the pre-genomic era," said Brent L. Fogel, MD, PhD, FAAN, director of the Neurogenetics Clinic at the University of California, Los Angeles (UCLA). (lww.com)
  • An important concern is always whether such variants are simply benign alleles common to specific populations and, in the absence of genetic data from these diverse populations, we cannot know if such variants are truly pathogenic and risk misdiagnosing our patients," he said. (lww.com)
  • Thus, this particular nonpathogenic member of the Vibrionaceae is an ideal candidate for comparative genome analyses with pathogenic vibrios. (pnas.org)
  • This immune response down regulates or deletes the pathogenic T cells, thus ablating the disease pathogenesis. (google.com)
  • Two pathogenic pathways have been described, which include a nonimmune-mediated mechanism and an immune-mediated mechanism. (springer.com)
  • Collectively, our data thus unveil a clinically relevant pathogenic mechanism for HSCR that involves cell-autonomous changes in ECM composition surrounding eNCCs. (jci.org)
  • A DNA defect in a particular gene may not be pathogenic if there is a compensatory mechanism accounting for dysfunctional product and if the dysfunctional product is not toxic for the cell. (els.net)
  • 35,36 The results 34 indicate that oxLDL aggravates the clinical manifestations of APS and suggest that autoantibodies cross-reactive with oxLDL may provide a pathogenic mechanism for accelerated atherosclerosis in APS. (ahajournals.org)
  • Pathogenic mechanism of second hand smoke induced inflammation and COPD. (biomedsearch.com)
  • In order to provide novel targets for antivirulence therapy, and to reveal the phylogeny of the mART toxin family, R. Fieldhouse, Ph.D. student, developed an in silico strategy for identifying new mARTs from the sequenced genomes of pathogenic bacteria (7). (uoguelph.ca)
  • Most are harmless, some are beneficial, and some are pathogenic. (reference.com)
  • It is only when the body becomes out of balance due to a chronic condition, such as malnutrition, that pathogenic bacteria are able to gain a foothold and overrun harmless or beneficial bacteria in these areas of the body. (reference.com)
  • Although some small deviations from the wildÔÇÉtype properties of a particular biomolecule or a network may be harmless and result in natural differences between individuals, the deviations of the same magnitude occurring in different molecule or network can be pathogenic. (els.net)
  • Although the vast majority of bacteria are harmless or beneficial, quite a few bacteria are pathogenic . (primidi.com)
  • By using an antiserum to the purified lectin, the corresponding cDNA was isolated from an expression library of the pathogenic E. histolytica isolate HM-1:IMSS. (pnas.org)
  • To better understand these symbiotic activities in V. fischeri , and to begin to identify features common to beneficial and pathogenic bacteria, we sequenced the genome of strain ES114, the model light-organ symbiont of the squid Euprymna scolopes ( 9 ). (pnas.org)
  • Our data emphasize the critical role of the clinician in diagnostic genomic analyses and demonstrate that apparent phenotypic expansion may represent blended phenotypes resulting from pathogenic variation at more than one locus. (nih.gov)
  • Pathogenic spirochetes are the causative agents of several important diseases including syphilis, Lyme disease , leptospirosis, swine dysentery, periodontal disease and some forms of relapsing fever. (prohealth.com)
  • Although Koch's postulates have not been completely fulfilled, our findings are consistent with the identification of a new pathogenic virus in the United States," the authors write. (doctorslounge.com)
  • Most, if not all, pathogenic bacteria have developed strategies to counteract complement attack, allowing them to establish infection', says Anna Blom, professor at Lund University who participated in the study. (news-medical.net)
  • The main obstacles to predicting pathogenic DNA variations are the complexity of biological reactions and the difficulty of assessing the threshold of the change that will make it pathogenic. (els.net)