Pathogenesis of vascular calcification. Medical search. Frequent questions

Vascular calcification is a common feature in atherosclerosis and associates with cardiovascular events. (cun.es)
In detail, this includes studies of what molecular mechanisms of vascular smooth cell phenotypic modulation and reprogramming are at work during the pathogenesis of vascular disease, vascular calcification in atherosclerosis (colloquially called hardening of the arteries), arterial stiffness, diabetic vasculopathy and vascular aging. (uab.edu)
The role of dietary potassium in regulating vascular calcification in atherosclerosis. (uab.edu)
The findings have important translational potential," said Paul Sanders, M.D., professor of nephrology in the UAB Department of Medicine and a co-author, "since they demonstrate the benefit of adequate potassium supplementation on prevention of vascular calcification in atherosclerosis-prone mice, and the adverse effect of low potassium intake. (zmescience.com)
Reduced dietary potassium intake has been linked to the pathogenesis of a variety of human diseases, including atherosclerosis, diabetes, and chronic kidney disease," the study said. (zmescience.com)
Atherosclerosis is the main pathophysiological foundation of cardiovascular disease, which was caused by inflammation and lipid metabolism disorder, along with vascular calcification. (thno.org)
It has multiple pharmacological effects, but no research on aortic calcification during atherosclerosis was performed. (thno.org)
This study investigated the effects of GLSP on atherosclerosis and aortic calcification and revealed the underlying mechanism. (thno.org)
In vivo , 8-week-aged male LDLR -/- mice were fed a high-fat diet to induce atherosclerosis along with aortic calcification. (thno.org)
Subsequently, the mice tissues were collected to evaluate the effects of GLSP on atherosclerosis, and aortic calcification, and to reveal the underlying mechanism. (thno.org)
We observed GLSP attenuated plaque area and aortic calcification in the mice with early and advanced atherosclerosis. (thno.org)
Long-term oxidative stress, autophagy and vascular inflammation could lead to atherosclerosis-related diseases. (frontiersin.org)
Importantly, the molecular mechanisms of arterial aging are also relevant to the pathogenesis of hypertension and atherosclerosis. (johnshopkins.edu)
Osteocalcin, Vascular Calcification, and Atherosclerosis: A Systematic Review and Meta-analysis. (nottingham.ac.uk)
It is the pathophysiologic aspects of obesity coupled with MetS that leads to changes in hemodynamics, atherosclerosis and calcification, myocardial metabolism, microvascular dysfunction that culminates in myocardial infarction and heart failure. (kauveryhospital.com)
Dr Bacha's laboratory at the Children's Nutrition research Center (CNRC) investigates the risk factors and mechanisms underlying the pathogenesis of the metabolic complications related to childhood obesity and insulin resistance with a focus on youth-onset type 2 diabetes, cardiovascular disease risk and subclinical atherosclerosis. (bcm.edu)
She utilized different methodologies to measure vascular function including pulse wave velocity and intima media thickness, and coronary artery calcifications (CAC), as early biomarkers of subclinical atherosclerosis. (bcm.edu)

Wang XR, Zhang JJ, Xu XX and Wu YG: Prevalence of coronary artery calcification and its association with mortality, cardiovascular events in patients with chronic kidney disease: A systematic review and meta-analysis. (spandidos-publications.com)
Scientists previously thought that coronary artery calcification was a benign, normal consequence of aging. (changingyourbusiness.com)

In vitro , we determined the major components of GLSP triterpenes by HPLC, and subsequently assessed the protective effects of these main active components on lipid metabolism, inflammation, and calcification in RAW264.7 and HASMC cells. (thno.org)
It should be interpreted as the clinical syndrome caused by critical ischaemia of calcified terminal skin (candelabra) arterioles, independently of whether the cause of chronic vascular calcification has been uraemia, chronic inflammation, ageing, pharmacological, genetic predisposition or all of them in combination. (renalandurologynews.com)
Oral dysbiosis, which potentially causes periodontitis to subsequently promote systemic inflammation and local vascular inflammation, increases the risks of cardiovascular diseases (CVDs). (degruyter.com)
Oral dysbiosis promotes periodontitis pathogenesis, enhancing chronic local inflammation in periodontal tissue, local production of pro-inflammatory cytokines and permeability of surrounding capillaries. (degruyter.com)

Furthermore, lithium chloride (Wnt activator) reversed the protective effect of STAT1 inhibition on VSMC calcification, while Dickkopf‑1 (Wnt inhibitor) exerted the opposite effect, suggesting that activation of the Wnt/β‑catenin signaling pathway was involved in STAT1‑mediated VSMC calcification. (spandidos-publications.com)

Calciphylaxis is a poorly understood and highly morbid syndrome of vascular calcification and skin necrosis. (medscape.com)
As we have seen in previous weeks, calciphylaxis is a severe and complex syndrome involving vascular calcification, thrombosis, and skin necrosis. (woundeducators.com)

Pathogenic vascular calcification, also known as hardening of the arteries , is something which affects millions of people worldwide - especially once you get past a certain age. (zmescience.com)

The impact of hepatitis virus infection on arterial calcification (AC) was not studied. (revistanefrologia.com)
Liver diseases are considered the risk factors for CVDs, where liver disease patients are more susceptible to endothelial dysfunction and arterial calcification, although the detailed mechanisms underlying the causality between liver diseases and CVDs require further study [ 5 ]. (degruyter.com)
Arterial calcification can be intimal or medial, each associated with different risk factors. (changingyourbusiness.com)

The mechanism of how the calcification signal from endothelial cells is transmitted to vascular smooth muscle cells (VSMCs) remains unknown. (spandidos-publications.com)
Alizarin Red S staining and calcium (Ca) content analysis were carried out to detect calcification in VSMCs. (spandidos-publications.com)
Exosomes derived from HP‑HUVECs promoted the calcification of VSMCs, as assessed by Alizarin Red S staining, alkaline phosphatase activity assays, Ca content measurements and the increased expression of runt‑related transcription factor 2 and osteopontin. (spandidos-publications.com)
Inhibition of STAT1 expression in VSMCs using fludarabine or knockdown of STAT1 expression using small interfering RNA alleviated the calcification of VSMCs. (spandidos-publications.com)
The present study investigated the effects of PQS on the calcification of vascular smooth muscle cell (VSMCs). (biomedcentral.com)
The present study used calcification medium containing 3 mM inorganic phosphate (Pi) to induce rat VSMCs calcification. (biomedcentral.com)
We investigated the effects of PQS on VSMCs calcification using alizarin red staining and alkaline phosphatase (ALP) activity assays. (biomedcentral.com)
During VSMCs calcification, PQS inhibited the mRNA and protein expression of Runx2 and BMP2. (biomedcentral.com)
Taken together, these findings suggest that PQS could effectively inhibit VSMCs calcification by ameliorating oxidative stress and regulating osteogenic genes via the promotion of Nrf2 expression. (biomedcentral.com)
The production of reactive oxygen species (ROS) and the oxidative modification of various biomolecules induce the transformation of VSMCs from the contractile type to the osteogenic type, which is accompanied by calcification [ 7 ]. (biomedcentral.com)
In vitro, IMD mitigated high glucose-induced calcification of vascular smooth muscle cells (VSMCs). (bvsalud.org)

Altogether, the altered immune and inflammatory responses, and endotoxemia contribute to the dysfunction and stress in cardiovascular cells (e.g . endothelial cells, vascular smooth muscle cells and cardiomyocytes), increasing cardiovascular risks. (degruyter.com)
In particular, it plays a vital role in the physiological and pathological activities of the three important cells, Endothelial cells, macrophages and vascular smooth muscle cells. (wjgnet.com)

The aged artery is characterized by endothelial disruption, enhanced vascular smooth muscle cell (VMSC) migration and proliferation, extracellular matrix (ECM) deposition, elastin fracture, and matrix calcification/amyloidosis/glycation. (johnshopkins.edu)

Aortic calcification - comparison between low, medium, and high Potassium (K) consumption. (zmescience.com)
Aortic calcification leads to reduced plaque stability and eventually causes plaque rupture which leads to cardiovascular events. (thno.org)
Presently, the drug to treat aortic calcification remains not to be available. (thno.org)
Moreover, GLSP inhibited aortic calcification by inactivating RUNX2-mediated osteogenesis in HASMCs. (thno.org)

Chen's ongoing VA-funded research seeks to uncover the molecular mechanisms underlying vascular complications in diabetes, an important health problem for veterans and non-veterans alike. (uab.edu)
All of these disease share common vascular complications, such as vascular calcification. (zmescience.com)
Inorganic phosphate in the pathogenesis of pregnancy-related complications. (navbo.org)
Her work on the pathophysiological mechanisms of prediabetes and type 2 diabetes contributed to the current understanding of the pathophysiology of the disease in children, and the importance of the defect in beta cell function to the pathogenesis and the rapid progression of type 2 diabetes and its complications in childhood. (bcm.edu)

However, the underlying mechanisms of vascular calcification have not been established. (biomedcentral.com)

[ 9 , 10 ] Chronic inflammatory conditions may predispose to calciphylaxis by reducing serum levels of fetuin-A, an important inhibitor of calcification produced in the liver. (medscape.com)
IMD receptor antagonist IMD17-47 and cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) inhibitor H89 abolished the inhibitory effects of IMD on GLUT1 and VSMC calcification. (bvsalud.org)

Oxidative stress may be involved in the pathogenesis of vascular calcification. (cun.es)

However, the significance of this relationship became uncertain when vascular calcification was subsequently shown to be prevalent in uremia, yet the syndrome of vascular calcification with cutaneous necrosis was less common. (medscape.com)
The pathogenesis of the port-wine stain (PWS) is still not completely understood, but it is linked to progressive ectasia of the superficial cutaneous vascular network [ 13 , 14 ]. (hindawi.com)

[ 2 ] constructed an experimental model and was able to precipitate systemic calcification, somewhat analogous to this syndrome, in nephrectomized rats. (medscape.com)
Systemic corticosteroids should be avoided in calciphylaxis as they may exacerbate arteriolar calcification. (woundeducators.com)
Systemic sclerosis is a multisystem disorder with vascular instability as a clinical hallmark. (skintherapyletter.com)

As high intake of vitamin D is a cause of raised calcium levels (hypercalcemia), the addition of vitamin K may be beneficial in helping to prevent vascular calcification, particularly in people with chronic kidney disease. (wikipedia.org)
Chapter One addresses the pulmonary vascular resistance (PVR) and total pulmonary vascular capacitance (Cp) product of the pulmonary circulation as a global estimate of right ventricular (RV) afterload, the assessment of the local arterial stiffness indices and its relationship with PVR and Cp, and finally, reviews the cause-effect relationships between large/conduit stiffening and distal/resistive vascular disease. (novapublishers.com)
Vascular calcification is commonly observed in chronic kidney disease. (spandidos-publications.com)
Ren SC, Mao N, Yi S, Ma X, Zou JQ, Tang X and Fan JM: Vascular calcification in chronic kidney disease: An update and perspective. (spandidos-publications.com)
Nelson AJ, Raggi P, Wolf M, Gold AM, Chertow GM and Roe MT: Targeting vascular calcification in chronic kidney disease. (spandidos-publications.com)
Düsing P, Zietzer A, Goody PR, Hosen MR, Kurts C, Nickenig G and Jansen F: Vascular pathologies in chronic kidney disease: Pathophysiological mechanisms and novel therapeutic approaches. (spandidos-publications.com)
Raggi P: Cardiovascular calcification in end stage renal disease. (spandidos-publications.com)
In this review article, we are summarizing the pathogenesis, risk factors, and possible management strategies of cardiovascular disease in CKD. (antpublisher.com)
Given the high mortality and the rarity of the disease, it would be desirable in the future to share patients' data in international registries and to refine management by studying the pathogenesis more thoroughly and introducing new drugs," the investigators noted. (renalandurologynews.com)
A new study aims to characterize the pathogenesis of youth-onset prediabetes and type 2 diabetes to better identify youth at risk for the disease. (bcm.edu)

Vasoocclusion also is in part due to the interaction between sickled cells and the vascular endothelium. (medscape.com)

Disorders that are most often implicated in the pathogenesis of calciphylaxis include chronic renal failure, obesity, diabetes mellitus, hypercalcemia, hyperphosphatemia, an elevated calcium-phosphate product, secondary hyperparathyroidism, and a variety of hypercoagulable states. (medscape.com)

There are several different classes of calcifications that are considered "probably benign" or "suspicious. (marytingaud.com)
Recent statistics show that 98% of "probably benign" calcifications are not cancer. (marytingaud.com)
Benign cysts are observed in older patients and may be due to cystic degeneration or vascular accidents. (msdmanuals.com)

In addition, members of the laboratory investigate the structure and function of human autoantigens, with the intention of determining the role of these antigens in the pathogenesis of autoimmune diseases. (massgeneral.org)
The discovery and characterization of new antigens implicated in the pathogenesis of T1D is a high priority as it can lead to new diagnostic tools and anticipate that studies proposed by Dr. Baker will provide critical information to target autoreactive T cells though antigen-specific therapies. (cuanschutz.edu)

Thisdiscovery has uncovered a potential dietary intervention for vascular calcification, and it has been highlighted by the NIH and featured in multiple news outlets, including Newsweek, Science Daily and USA Today. (uab.edu)

Chapter Four reviews links between bone turnover, vascular calcifications and arterial stiffness. (novapublishers.com)
evaluated the role of abnormal bone in the pathogenesis of vascular calcification in animal models and humans, examined treatments to reduce fractures, and most recently examined the role of nutrition on CKD-Mineral Bone Disorder. (asn-online.org)
Chapter 13 in Aikawa E and Hutchinson J, Cardiovascular Calcification and Bone Mineralization, Springer Nature Publishers. (navbo.org)
I am currently working on the mechanisms controlling bone growth and their involvement in the pathogenesis of Adolescent Idiopathic Scoliosis (AIS), with a specific interest in leptin and the endocannabinoid system. (nottingham.ac.uk)

Her notable Circulation Research report that gave the first genetic proof for the key role of an osteogenic transcriptional factor, Runx2, in regulating calcification of smooth muscle cells. (uab.edu)
For example, hydrogen peroxide (H 2 O 2 ) is a classic oxidant stressor that promotes vascular cell calcification by increasing the expression of the osteogenic transcription factor runt-related transcription factor 2 (Runx2) [ 11 ]. (biomedcentral.com)

BACKGROUND AND AIMS: Vascular calcification (VC) is regarded as an independent risk factor for cardiovascular events in type 2 diabetic patients. (bvsalud.org)

Chen has published more than 70 papers in high-impact, peer-reviewed journals, and she received a Vascular Biology Special Recognition Award in 2018 from the American Heart Association for her outstanding contribution to vascular biology research. (uab.edu)

Cerebral cavernous malformation (CCM), either sporadic or familial, is a devastating vascular malformation affecting the central nervous system that can present with intracerebral hemorrhage, seizure, and new focal neurologic deficits resulting in substantial morbidity and mortality. (bvsalud.org)
Genetic abnormalities have been implicated in the pathogenesis, but familial inheritance. (msdmanuals.com)

They found that especially in the case of mice who were eating high-fat foods, potassium levels significantly impacted vascular stiffness. (zmescience.com)
They found that low-potassium mice had a significant increase in vascular calcification. (zmescience.com)
In contrast, the mice fed a high-potassium diet had markedly inhibited vascular calcification. (zmescience.com)

Her Circulation Research finding of a novel mechanism in diabetes underlying the role of protein-O-GlcNAC modification in promoting vascular calcification. (uab.edu)
Impact of diabetes on site and pattern of calcification. (revistanefrologia.com)
MetS is consistently associated with high Cardio-Vascular event risk and high incidence of Type 2 Diabetes mellitus. (kauveryhospital.com)

However, the role and mechanism of PQS in vascular calcification are not unclear. (biomedcentral.com)
Despite the well-known risk factors, the pathogenesis of ICH is unclear, and the site of bleeding has rarely been demonstrated histologically due to the difficulty in examining tissue destroyed by hemorrhage as well as secondary bleeding caused by the disruption of surrounding arteries [ 12 , 13 ]. (nature.com)

In conclusion, the present results indicated that exosomal STAT1 derived from HP‑treated HUVECs could promote VSMC calcification, and activation of the Wnt/β‑catenin pathway may be a potential mechanism of the VSMC calcification promoted by exosomes. (spandidos-publications.com)

Vascular calcification prior to transplant surgery could predispose patients to later calciphylaxis, along with trauma, hypotension, and a hypercoagulable state, they explained. (renalandurologynews.com)

To describe the general principles of the transmission, pathogenesis, and diagnosis of tuberculosis. (cdc.gov)
The approach to diagnosis of tuberculosis follows from the concepts of its pathogenesis. (cdc.gov)
To provide a classification scheme for tuberculosis that is based on pathogenesis, is consistent with current chemotherapeutic and chemopreventive recommendations, and is applicable to all in whom the diagnosis is or should be considered. (cdc.gov)

Yamada S and Giachelli CM: Vascular calcification in CKD-MBD: Roles for phosphate, FGF23, and Klotho. (spandidos-publications.com)

In 1879, Sturge reported on a case with bilateral facial nevus, vascular deformity, and congenital glaucoma in the right eye and spasms affecting the patient's left side of the body [ 9 ]. (hindawi.com)

It is now known that Central/Visceral Obesity with its Insulin Resistance and or Hyperinsulinemia is central in the pathogenesis of MetS. (kauveryhospital.com)
She also demonstrated that peripheral endothelial function is a biomarker of vascular health modulated by insulin sensitivity in youth. (bcm.edu)

[ 3 ] Since then, a multitude of case reports of calciphylaxis have documented data outlining its morbidity and therapeutic dilemmas, as well as a quest to better understand its etiology and pathogenesis. (medscape.com)
The pathogenesis of calciphylaxis remains obscure and is likely the result of a multiplicity of comorbid factors or events. (medscape.com)

Methods Circulating (n = 179) and hepatic expression (n = 95) of ghrelin and LEAP-2 were measured in patients with severe obesity and available liver pathology analysis undergoing Roux-en-Y gastric bypass (RYGB). (unav.edu)
The non-invasive assessment of MAFLD combined with PreDM and MetS features might provide further accuracy in predicting hyperglucaemic status with the description of singular clinical phenotypes.Methods: A retrospective cohort study was performed on 2799 patients recruited in the Vascular-Metabolic CUN cohort. (unav.edu)
Site of calcification and calcification score in seronegative versus hepatitis B & C positive patients according to severity of viremia. (revistanefrologia.com)
Patients have acral sclerosis associated with vascular instability in addition to internal organ involvement. (skintherapyletter.com)

CONCLUSIONS: These findings revealed that IMD exerted its anti-calcification effect by inhibiting GLUT1, providing a novel therapeutic target for diabetic VC. (bvsalud.org)

Many risk factors contribute to the aetiology and pathogenesis of CKD or are shared risk factors for CKD progression. (medscape.com)

Other authors are more restrictive in their definition, as a means of preventing the term Möbius syndrome from being assigned to conditions of a different pathogenesis. (medscape.com)
Numerous theories exist concerning the primary underlying pathogenesis of Möbius syndrome. (medscape.com)

Anatomy24

Organisms7

Diseases46

Chemicals and Drugs75

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes27

Disciplines and Occupations1

Technology, Industry, Agriculture3

Information Science1

Health Care17

Atherosclerosis17

Coronary artery2

Inflammation4

Mediated VSMC calcification1

Skin necrosis2

Hardening of the a1

Arterial calcification3

VSMCs11

Endothelial cells2

Extracellular1

Aortic4

Complications4

Mechanisms of vascular1

Inhibitor2

Oxidative1

Cutaneous2

Systemic3

Disease10

Endothelium1

Calcium-phosphate1

Benign3

Antigens2

Dietary1

Bone4

Runx22

Cardiovascular events1

Biology1

Familial2

Mice3

Diabetes3

Unclear2

Mechanism1

Predispose1

Diagnosis3

Roles1

Bilateral1

Insulin2

Calciphylaxis2

Patients4

Diabetic1

Risk factors1

Syndrome2