AnatomyOrganismsDiseasesChemicals and Drugs
MumpsMumps virusMumps VaccineMeasles-Mumps-Rubella VaccineParotitisRubellaMeaslesRubella VaccineOrchitisRubulavirusVaccines, CombinedAntibodies, ViralMeasles VaccineMeningitis, AsepticRubella virusLabyrinthitisLabyrinth DiseasesVertigoCochleaEar, Inner
VaccineRubellaParotitisOrchitisVaccinationReported mumps casesVaricellaEpidemiologyCases of mumpsCause of mumpsAcuteViral infectionsNeuraminidaseInfectionParamyxovirusVirusesRespiratory secretionsGenusComplicationsEncephalitisAntibodyCytomegalovirusParotid glandsDiagnosisAdultsTransmissionHistoricallyTypicallyCongenitalProteinImmuneHumans1971ImmunizationDiseaseMolecularSubclinicalNucleocapsidClinical presentation
Vaccine24
  • The live virus vaccine is usually given in combination with the MMR vaccine (measles, mumps, and rubella). (antiinfectivemeds.com)
  • In 1971, a combined measles, mumps, and rubella (MMR) vaccine was licensed for use in the United States. (cdc.gov)
  • He only received the first dose of the measles, mumps, and rubella vaccine. (medbullets.com)
  • This revised Immunization Practices Advisory Committee (ACIP) recommendation on mumps vaccine updates the 1982 recommendation (1). (cdc.gov)
  • Following the introduction of the live mumps virus vaccine in 1967 and recommendation of its routine use in 1977, the incidence rate of reported mumps cases decreased steadily in the United States. (cdc.gov)
  • Best known is the live attenuated virus vaccine of chick embryo origin, used for routine immunization of children and for immunization of adolescents and adults who have not had mumps or been immunized with live mumps vaccine. (lookformedical.com)
  • Children are usually immunized with measles-mumps-rubella combination vaccine. (lookformedical.com)
  • Mumps and mumps vaccine: a global review. (lookformedical.com)
  • Based on data reported to WHO up to April 1998, mumps vaccine is routinely used by national immunization programmes in 82 countries/areas: 23 (92%) of 25 developed countries, 19 (86%) of 22 countries with economies in transition (mainly the Newly Independent States of the former Soviet Union), and 40 (24%) of 168 developing countries. (lookformedical.com)
  • Countries already using mumps vaccine should monitor immunization coverage and establish routine mumps surveillance with investigation of outbreaks. (lookformedical.com)
  • Where mumps is targeted for elimination, countries need to add a second dose of mumps vaccine for children, keeping in mind that the disease may still occur in susceptible adults. (lookformedical.com)
  • Infection can be prevented with vaccination, either via an individual mumps vaccine or through combination vaccines such as the MMR vaccine, which also protects against measles and rubella. (covid19liveupdates.org)
  • Here, we have developed one such approach, a highly efficacious, intranasally delivered, trivalent measles-mumps-SARS-CoV-2 spike (S) protein (MMS) vaccine candidate that induces robust systemic and mucosal immunity with broad protection. (bvsalud.org)
  • This vaccine candidate is based on three components of the MMR vaccine, a measles virus Edmonston and the two mumps virus strains [Jeryl Lynn 1 (JL1) and JL2] that are known to provide safe, effective, and long-lasting protective immunity. (bvsalud.org)
  • This MMS vaccine is an efficacious, broadly protective next-generation COVID-19 vaccine candidate, which is readily adaptable to new variants, built on a platform with a 50-y safety record that also protects against measles and mumps. (bvsalud.org)
  • To expand upon our previous work, we performed a genome-wide association study (GWAS) to discover host genetic variants associated with mumps vaccine-induced cellular immune responses. (bvsalud.org)
  • These findings motivate further research into the functional roles of SIGLEC genes in the regulation of mumps vaccine-induced immunity. (bvsalud.org)
  • In that description of vaccinations, the authors included the use of the measles-mumps-rubella (MMR) vaccine and mercury / thimerosal (thiomersal) exposure from other vaccines. (blogspot.com)
  • The authors found elevated antibody levels to MMR (Measles Mumps Rubells Vaccine) in 60% of autistic children, none in controls. (jeffreydachmd.com)
  • Here authors reported complete cure of periungual and genital warts that were treated by multiple approach consisting of mumps-measles-rubella vaccine, radiofrequency ablation and oral acitretin. (ijord.com)
  • Rezai MS, Ghasempouri H, Asqary Marzidareh O, Yazdani Cherati J, Rahmatpour Rokni G. Intralesional Injection of the Measles-Mumps-Rubella Vaccine into Resistant Palmoplantar Warts: A Randomized Controlled Trial. (ijord.com)
  • A strong correlation between autism and the MMR (Measles, Mumps, Rubella) vaccine is also observed, which may be partially explained via an increased sensitivity to acetaminophen administered to control fever. (blogspot.com)
  • In April 2020, the measles-mumps-rubella (MMR) vaccine was touted as a "major breakthrough" against COVID-19. (tapnewswire.com)
  • Jeffrey D. Cirillo, a professor of microbial pathogenesis and immunology at Texas A&M Health Science Center, went so far as to state, "This is the only vaccine in the world that can be given to combat COVID-19 right now. (tapnewswire.com)
Rubella6
  • These revised recommendations of the Advisory Committee on Immunization Practices (ACIP) on measles, mumps, and rubella prevention supersede recommendations published in 1989 and 1990. (cdc.gov)
  • This statement summarizes the goals and current strategies for measles, rubella, and congenital rubella syndrome (CRS) elimination and for mumps reduction in the United States. (cdc.gov)
  • U.S. Public Health Service year 2000 objectives include eliminating measles, rubella, and congenital rubella syndrome, and reducing mumps incidence to less than 500 reported cases per year. (cdc.gov)
  • Since 1995, fewer cases of measles, rubella, and mumps have been reported than at any time since nationwide disease reporting began, and elimination of indigenous transmission appears feasible. (cdc.gov)
  • Two examples: "Abnormal measles-mumps-rubella antibodies and CNS autoimmunity in children with autism", J Biomed Sci. (uncommondescent.com)
  • She had shown she was very high with Mumps and Rubella and CMV. (energywave.com)
Parotitis9
  • Mumps is an acute viral illness caused by a paramyxovirus that typically presents as swelling of the parotid (parotitis) or other salivary gland[s]. (cdc.gov)
  • The incubation period ranges from 12-25 days, but parotitis typically develops 16 to 18 days after exposure to mumps virus. (cdc.gov)
  • A person with mumps is considered infectious from 2 days before through 5 days after parotitis onset. (cdc.gov)
  • 22] Although mumps virus has been isolated from 7 days before through 11-14 days after parotitis onset,[22-24] the highest percentage of RT-PCR positive results and the highest virus loads occur closest to parotitis onset and decrease rapidly thereafter. (cdc.gov)
  • 27] No studies have assessed peak infectiousness in mumps patients who do not have parotitis (e.g., patients who only have nonspecific respiratory symptoms or only have complications like orchitis). (cdc.gov)
  • Mumps, historically known as epidemic parotitis, was one of the most common early childhood infections before the routine use of mumps vaccination starting in 1968. (antiinfectivemeds.com)
  • Mumps parotitis rarely has prodromal symptoms. (antiinfectivemeds.com)
  • The differential diagnosis of mumps parotitis includes suppurative parotitis and salivary calculus. (antiinfectivemeds.com)
  • Mumps and bacterial parotitis were differentiated by 1800, but neither was effectively treated. (medscape.com)
Orchitis10
  • 11-14] Among vaccinated patients, complications of mumps are uncommon but occur more frequently among adults than children, mainly due to higher rates of orchitis among post-pubertal males. (cdc.gov)
  • 8] About half of patients with mumps orchitis develop testicular atrophy of the affected testicles. (cdc.gov)
  • 15,16] While there is a theoretical risk for temporary sterility or subfertility from oligospermia, azoospermia, or asthenospermia among men with mumps orchitis,[15] no studies have assessed risk for permanent infertility. (cdc.gov)
  • Mumps is typically characterized by inflammation of the parotid glands but also can be accompanied by orchitis, aseptic meningitis, pancreatitis, and deafness ( 3 ). (cdc.gov)
  • Orchitis is an uncommon complication of mumps in adults and adolescents, with the highest rate found in the 15- to 29-year age group. (antiinfectivemeds.com)
  • Roughly 75% of mumps orchitis is unilateral. (antiinfectivemeds.com)
  • Among the reported mumps-associated complications, strong epidemiologic and laboratory evidence for an association with meningoencephalitis, deafness, and orchitis has been reported (2). (cdc.gov)
  • Orchitis (usually unilateral) has been reported as a complication in 20%-30% of clinical mumps cases in postpubertal males (3). (cdc.gov)
  • Some testicular atrophy occurs in about 35% of cases of mumps orchitis, but sterility rarely occurs. (cdc.gov)
  • Permanent deafness, orchitis, and pancreatitis are other untoward effects of mumps. (lookformedical.com)
Vaccination5
  • Before the vaccination era, mumps epidemics occurred in 3- to 4-year cycles. (antiinfectivemeds.com)
  • Changes include: a discussion of the evolving epidemiologic characteristics of mumps, introduction of a cutoff of 1957 as the oldest birth cohort for which mumps vaccination is routinely recommended, and more aggressive outbreak-control measures. (cdc.gov)
  • By the 1970s, vaccines had been created to protect against infection, and countries that have adopted mumps vaccination have seen a near-elimination of the disease. (covid19liveupdates.org)
  • BACKGROUND: We have previously described genetic polymorphisms in candidate genes that are associated with inter-individual variations in antibody responses to mumps vaccination. (bvsalud.org)
  • CONCLUSIONS: Our results suggest that SNPs in the SIGLEC5/SIGLEC14 genes play a role in cellular and inflammatory immune responses to mumps vaccination. (bvsalud.org)
Reported mumps cases3
  • Subsequently, the goals of the initiative were extended to include reducing the number of reported mumps cases to less than or equal to 1600 by 1996. (cdc.gov)
  • Reported rates of mumps encephalitis range as high as five cases per 1000 reported mumps cases. (cdc.gov)
  • It occurs with an estimated frequency of 0.5-5.0 per 100,000 reported mumps cases. (cdc.gov)
Varicella2
  • Mumps is not as easily transmitted as measles or varicella (i.e., airborne transmission). (cdc.gov)
  • Viral infections (especially infections with coxsackieviruses and echoviruses but also influenza, Epstein-Barr, varicella, hepatitis, mumps, and HIV viruses) are the commonest cause of acute pericarditis and probably are responsible for many cases classified as idiopathic. (health.am)
Epidemiology1
  • TWiP 223: Voluminous diarrhea November 28, 2023 TWiP solves the case of the Haitian female with AIDS and voluminous diarrhea, and review the pathogenesis, epidemiology, prevention and treatment of malaria Chagas disease. (microbe.tv)
Cases of mumps1
Cause of mumps2
Acute2
Viral infections2
  • This increase suggests that besides genetical factors environmental perturbations (including viral infections) are also involved in the pathogenesis of T1D. (nih.gov)
  • Data obtained in rodents and in vitro systems have improved our insight in the possible role of viral infections in the pathogenesis of human T1D. (nih.gov)
Neuraminidase2
  • Mumps virus encodes seven genes in the following order: nucleocapsid (N) protein, V/P/I (V/phospho-(P)/I) proteins, matrix (M) protein, the most abundant protein in virions, fusion (F) protein, small hydrophobic (SH) transmembrane protein, hemagglutinin-neuraminidase (HN), and the large (L) protein, which combines with the P protein to form the RNA-dependent RNA polymerase (RdRp). (wikipedia.org)
  • Closely related to mumps virus, haemagglutinin and neuraminidase present, unlike RSV. (virology-online.com)
Infection7
  • Mumps reinfection in patients who previously had natural infection or recurrent mumps (parotid swelling resolves and then weeks to months later occurs on the same or other side) can also occur. (cdc.gov)
  • Mumps infection may present only with nonspecific or primarily respiratory symptoms or may be asymptomatic. (cdc.gov)
  • Mumps infection during the first trimester of pregnancy confers an increased risk of spontaneous abortion but no increased risk of fetal malformation. (antiinfectivemeds.com)
  • Naturally acquired mumps infection, including the estimated 30% of infections that are subclinical, confers long-lasting immunity. (cdc.gov)
  • Further research is needed to determine whether mumps infection contributes to the pathogenesis of diabetes mellitus. (cdc.gov)
  • Vaccines used to prevent infection by MUMPS VIRUS. (lookformedical.com)
  • Mumps infection is usually self-limiting, coming to an end as the immune system clears the infection. (covid19liveupdates.org)
Paramyxovirus2
Viruses2
  • Mumps is often inappropriately thought to be "less communicable" than other pediatric viruses. (antiinfectivemeds.com)
  • Wild type mumps viruses are highly neurotropic and a frequent cause of aseptic meningitis in unvaccinated humans. (lookformedical.com)
Respiratory secretions2
  • having direct contact with a mumps patient's infectious respiratory secretions by droplet transmission (e.g., kissing, sharing saliva-contaminated objects like water bottles, or being coughed or sneezed on). (cdc.gov)
  • Mumps virus is spread via respiratory secretions, with humans being the only natural reservoir. (antiinfectivemeds.com)
Genus2
Complications1
  • Mumps can occur in a person who is fully vaccinated, but vaccinated persons are at much lower risk for mumps and mumps complications. (cdc.gov)
Encephalitis1
  • Furthermore, in many of these countries, mumps-associated encephalitis and deafness have nearly vanished. (lookformedical.com)
Antibody2
  • snip- "Stemming from this evidence, we suggest that an inappropriate antibody response to MMR, specifically the measles component thereof, might be related to pathogenesis of autism. (uncommondescent.com)
  • In places where mumps is less common, however, laboratory diagnosis using antibody testing, viral cultures, or real-time reverse transcription polymerase chain reaction may be needed. (covid19liveupdates.org)
Cytomegalovirus1
  • Experimental evidence suggests that inflammatory proteins play a critical role in the pathogenesis of cytomegalovirus-induced hearing loss. (medscape.com)
Parotid glands1
  • Mumps virus typically infects the parotid glands but has the ability to infect other glandular tissue (Box 1). (antiinfectivemeds.com)
Diagnosis1
  • Our article summarizes these new advances in the diagnosis of HLH and includes a review of clinical findings, updated understanding of the pathogenesis, and promising new testing methods. (medscape.com)
Adults1
  • The increased occurrence of mumps in susceptible adolescents and young adults has been demonstrated in several recent outbreaks in high schools and on college campuses (5,6) and in occupational settings (7). (cdc.gov)
Transmission1
  • Mumps virus is transmitted person to person through direct contact with saliva or respiratory droplets of a person infected with mumps (i.e., droplet transmission). (cdc.gov)
Historically1
  • Mumps historically has been a highly prevalent disease, commonly occurring in outbreaks in densely crowded spaces. (covid19liveupdates.org)
Typically1
  • Mumps typically requires close contact to spread, especially among vaccinated populations. (cdc.gov)
Congenital1
  • There is no evidence that mumps during pregnancy causes congenital malformations. (cdc.gov)
Protein2
  • We are interested in understanding how cellular metabolism and protein condensation are interlinked to the pathogenesis of brain tumour. (qmul.ac.uk)
  • To investigate whether immune-mediated mechanisms are involved in the pathogenesis of autism, we used immunocytochemistry, cytokine protein arrays, and enzyme-linked immunosorbent assays to study brain tissues and cerebrospinal fluid (CSF) from autistic patients and determined the magnitude of neuroglial and inflammatory reactions and their cytokine expression profiles. (blogspot.com)
Immune2
  • Mumps immune globulin has little clinical value. (antiinfectivemeds.com)
  • METHODS: We performed a GWAS of mumps-specific immune response outcomes (11 secreted cytokines/chemokines) in a cohort of 1,406 subjects. (bvsalud.org)
Humans1
19711
  • MuV was first recognized as a species in 1971, and it has been given the scientific name Mumps orthorubulavirus. (wikipedia.org)
Immunization1
Disease6
  • Mumps disease is generally self-limited, but it may be moderately debilitating. (cdc.gov)
  • However, for the first time since mumps became a reportable disease, the reported peak incidence rate shifted from 5-9-year-olds to older age groups for two consecutive years (1986 and 1987). (cdc.gov)
  • Nonetheless, despite this age shift in reported mumps, the overall reported risk of disease in persons 10-14 and greater than or equal to 15 years of age is still lower than that in the prevaccine and early postvaccine era. (cdc.gov)
  • Mumps is a viral disease caused by the mumps virus. (covid19liveupdates.org)
  • describe differentiating features of the disease: pathogenesis of the disease including any common vectors, any common means of contraction, any individuals that are more likely to contract the disease, etc. (nursingdons.com)
  • Although the ocular pathogenesis of Cogan syndrome is not fully understood, it has been postulated to be an autoimmune disease in which autoantibodies target corneal, inner ear, and endothelial antigens. (aao.org)
Molecular1
Subclinical1
Nucleocapsid1
  • The genome of the mumps virus is encased by N proteins to form a flexible, loosely coiled helical ribonucleoprotein (RNP) complex consisting of the genome surrounded by a nucleocapsid that RdRp is bound to. (wikipedia.org)
Clinical presentation1