OxidativeHydrogenReactiveSuperoxide dismutaseProteinsSebaceous glandsInhibitMediatorsAlzheimer'sReactsCompoundsLevelsNeurodegenerativeVitroSystemicFerroptosisSignificantlyMalondialdehydeMetabolismProteinDamageExperimentalLevelCompositionSevereInflammatoryPlasmaAcidTreatmentFactorFoundCellBloodEvidenceDrugs
Oxidative15
- In addition, oxygen-derived reactive oxygen species including hydrogen peroxide and nitrogen free radicals, such as superoxide, hydroxyl radical and nitric oxide radical, undergo a complicated sequence of electron transfer reactions with other biomolecules, which lead to their modified physiological functions and diverse biological and pathophysiological consequences (e.g. oxidative stress). (nih.gov)
- Ferroptosis-inducing factors can directly or indirectly affect glutathione peroxidase through different pathways, resulting in a decrease in antioxidant capacity and accumulation of lipid reactive oxygen species (ROS) in cells, ultimately leading to oxidative cell death. (nature.com)
- INTRODUCTION: Increasing evidence suggests that oxidative stress may be involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). (drlauda.at)
- The excessive production of reactive oxygen species (ROS) has been suggested as a common outcome from all these pathways leading to increased oxidative damage at the level of lipid peroxidation [ 9 ] and culminating in DN in association with DM [ 10 ]. (biomedcentral.com)
- Oxidative stress has been implicated in the pathogenesis of age-related macular degeneration (AMD), the leading cause of blindness in the elderly, with retinal pigment epithelial (RPE) cells playing a key role. (princeton.edu)
- In this study our aim was to evaluate the differences in the burden of oxidative stress in patients with COPD, smokers, and non-smokers by measuring hydrogen peroxide (H 2 O 2 ), malondialdehyde (MDA), and 8-isoprostane levels in the exhaled breath condensate (EBC) samples. (rcjournal.com)
- Oxidative stress has been implicated in the pathogenesis and progression of chronic obstructive pulmonary disease. (ersjournals.com)
- Preclinical numerous studies have featured retinal oxidative anxiety within the pathogenesis involving diabetic person retinopathy. (hsp90-inhibitors.com)
- In addition, in the peroxisome-rich lean meats of dealt with rodents catalase molecule exercise improved as well as oxidative destruction (because tested by lipid peroxidation) rejected. (hsp90-inhibitors.com)
- The study hypothesized that oxidative by-product like hydrogen peroxide (H 2 O 2 ), would reacts with hemoglobin (Hb) and help to initiate autoimmunity in patients with type 1 diabetes. (scialert.net)
- In view of these, the present study was hypothesized that oxidative by-products like hydrogen peroxide, would react with Hb and help to initiate autoimmunity in patients with type 1 diabetes mellitus. (scialert.net)
- Our study demonstrates that pre-treatment of hesperidin for five days reduced the iron induced oxidative stress indicated by the reduction in lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase activities and a rise in the glutathione-s-transferase, catalase, and superoxide dismutase and glutathione contents in the mice liver. (biomedres.us)
- Free" iron produces hydroxyl radicals from superoxide and hydrogen peroxide via Fenton chemistry inducing oxidative stress in the cells [4]. (biomedres.us)
- Reactive oxygen species (ROS) is a general term for active oxygen-containing compounds including hydroxyl radical (·OH), hydrogen peroxide (H2O2) and superoxide radical (O2−), which was generated in the process of oxidative metabolism5,6,7. (solamonrenewableenergy.com)
- Squalene is problematic because it suffers massive oxidative damage when exposed to UV rays (and probably also to other inflammatory insults) and turns into squalene peroxide . (healthtoempower.com)
Hydrogen8
- 8 The tar phase of smoke contains the hydroxyl radical (OH) and hydrogen peroxide (H 2 O 2 ). (rcjournal.com)
- This can be measured as hydrogen peroxide and 8-isoprostane in exhaled breath condensate. (rcjournal.com)
- Objective- The study was designed to evaluate and compare the in-vitro anti-cataract activity of aqueous extracts of Abiespindrowleaves (APE) and Luffacylindrica fruits (LCE) against hydrogen peroxide induced cataractogenesis, using isolated goat lenses. (ukessays.com)
- Hydrogen peroxide (0.05M) was used to induce cataract in goat eye lenses. (ukessays.com)
- Cigarette smoke is a major source of oxidants, e.g. free radicals, including semiquinone and hydroxyl radicals, nitric oxide and hydrogen peroxide, in the lungs 3 . (ersjournals.com)
- Right after catalase transduction, higher glucose-induced hydrogen peroxide production had been considerably diminished in the human being retinal cellular traces. (hsp90-inhibitors.com)
- Metal interactions with hydrogen peroxide have been frequently implicated in catalyzing free radical-mediated damage. (scialert.net)
- To test this hypothesis, Hb was modified by reactive oxygen species, generated by in vitro reaction of hemoglobin with hydrogen peroxide. (scialert.net)
Reactive2
- In 2012, Dixon 1 first proposed the concept of ferroptosis, an iron-dependent, non-apoptotic mode of cell death characterized by the accumulation of lipid reactive oxygen species (ROS). (nature.com)
- These free radicals produced by iron are highly reactive and they interact with proteins, DNA and lipid inflicting severe damage to these biomolecules and subsequently tissue injury [5]. (biomedres.us)
Superoxide dismutase3
- At the end of the study period (6 weeks), blood pressure, blood glycosylated hemoglobin (HbA 1c ), serum creatinine, blood urea nitrogen (BUN), kidney tissue levels of superoxide dismutase (SOD), catalase (CAT), glutathione peroxide (GPx), aldose reductase (AR) activities and malondialdehyde (MDA) concentration were measured. (biomedcentral.com)
- The glutathione, glutathione-s-transferase, catalase, superoxide dismutase, lipid peroxidation, lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase levels were estimated in the liver of iron treated mice after 30 days post-iron treatment. (biomedres.us)
- Treatment of hesperidin for 5 days before iron overload elevated the activities of glutathione-s-transferase, catalase, and superoxide dismutase and glutathione concentration, whereas the activities of lactate dehydrogenase, aspartic acid transaminase, and alanine aminotransaminase and lipid peroxidation declined significantly. (biomedres.us)
Proteins2
- Pathogenesis-related proteins (PRs) are a kind of potential disease-existent substances in plants. (biomedcentral.com)
- When there is an overproduction of ROS/RNS or a deficiency of enzymatic or non-enzymatic antioxidants, a biological damage to cellular lipids (lipoperoxidation), proteins, glucides and DNA may occur. (biomedcentral.com)
Sebaceous glands3
- Sebaceous glands' output is on a holocrine platform, built upon disintegration of sebocytes where their lipids synthesis into the droplets occurs. (hippocratesusa.com)
- Sebaceous products ought to be differentiated from skin surface lipids, and the two nomenclatures may not interchangeably be used since skin surface lipids are derived from two major sources, sebaceous glands which produces sebum, an oily substance, and makes up to 90% of skin surface lipids, and epidermal keratinocytes which give rise to epidermal, stratum corneum, lipids with equal amounts of ceramides, cholesterol and fatty acids. (hippocratesusa.com)
- In addition, the treatment of ear skin with squalene peroxidation by-products caused marked hyperplasia and hyperkeratosis of the epithelium in follicular infundibulum, and increased the proliferation of the sebaceous glands. (healthtoempower.com)
Inhibit3
- Oxyacanthine and bertamine were also among the most active compounds to inhibit lipid peroxidation. (google.com)
- Collectively, these results demonstrate that iron overload induces lysosomal accumulation and impairs lysosomal function, likely due to iron-induced lipid peroxides that can inhibit lysosomal enzymes. (princeton.edu)
- The CG8005 gene in Drosophila S2 embryonic cells could regulate the proliferation and apoptosis of S2 embryonic cells by disrupting the redox homeostasis, and antioxidant NAC could inhibit cell apoptosis and promotes cell proliferation by scavenging ROS in Drosophila S2 embryonic cells, which is expected to provide novel insights for the pathogenesis of male infertility and spermatogenesis. (solamonrenewableenergy.com)
Mediators2
- This barrier also imparts distinctive function in immunology and microbiology of the skin by regulating inflammatory markers and modulation of the skin microbiome and indeed sebocytes recognition as immunomodulatory and immunocompetent cells is burgeoning through their contribution to production or regulation of cytokines, chemokines, adipokines such as leptin and lipid mediators. (hippocratesusa.com)
- Lipid Mediators in Acne. (healthtoempower.com)
Alzheimer's2
- The Journal of Alzheimer's Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer's disease. (iospress.com)
- Lyubartseva G, Lovell MA (2012) A potential role for zinc alterations in the pathogenesis of Alzheimer's disease. (springer.com)
Reacts1
- In this methon malodialdehidt end product of the lipid peroxidation, reacts with thiobarbut, ric acid and produces pink reaction end product. (sislietfaltip.org)
Compounds1
- An analysis of current developments in the field of new medicinal products for NDD suggests that most of the activity is focused on a search for multi-target compounds that affect the key aspects of pathogenesis [ 4 ]. (actanaturae.ru)
Levels4
- Reasons of the endothelial damage in preei lampsia are low blood protacycline levels, low plathelet ci unts, increased lipid peroxidation. (sislietfaltip.org)
- Oi study groupconsisted of 40 preeclamptic preganacies and 2 healty pregnant women, whom we have primarily measure plasma lipid peroxide level and secondarily measured serui cholestrol, triglyceride, uric acid, total protein, albumin, bit od plathelet count, hematocrit, and fibrinogen levels. (sislietfaltip.org)
- Moreover, manipulation of supersulfide levels was beneficial for pathogenesis of various diseases. (nih.gov)
- There is a report that the use of NAC has also been associated with a significant reduction in lipid peroxidation and a significant increase in GSH levels in the liver and erythrocytes of mice15. (solamonrenewableenergy.com)
Neurodegenerative2
- Abnormalities in the metabolism of the transition metals iron and copper have been demonstrated to play a crucial role in the pathogenesis of various neurodegenerative diseases. (drlauda.at)
- Drug development for the treatment of neurodegenerative diseases has to confront numerous problems occurring, in particular, because of attempts to address only one of the causes of the pathogenesis of neurological disorders. (actanaturae.ru)
Vitro1
- To investigate whether H. pylori can cause lipid peroxidation in lymphocytes in vitro and to look for experimental evidence of lipid peroxidation induced by H. pylori , the lipid peroxide (LPO) level in peripheral blood lymphocytes was measured using the thiobarbituric acid fluorescence method. (aku.edu)
Systemic2
- The above results suggest that SA can enhance tomato plant resistance by modulating the expression of genes encoding for ROS-scavenging players, altering the activity of resistance-related enzymes, and inducing the expression of pathogenesis-related genes to produce systemic acquired resistance. (biomedcentral.com)
- In a murine model of systemic iron overload, RPE cells accumulated lipid peroxidation adducts and lysosomes, developed progressive hypertrophy, and underwent cell death. (princeton.edu)
Ferroptosis4
- This paper systematically summarizes the latest progress in ferroptosis research, with a focus on providing references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases. (nature.com)
- Is iron necessary to promote the production of lipid peroxides, or can other substances take the place of iron in ferroptosis? (nature.com)
- In view of this, we reviewed the latest research progress on ferroptosis to provide some references for further understanding of its pathogenesis and for proposing new targets for the treatment of related diseases. (nature.com)
- Death of GSCs was apparently due to the iron dependent form of programmed cell death characterized by the accumulation of lipid peroxides called ferroptosis. (nature.com)
Significantly1
- Aβ was found to associate significantly with these lipid emulsions during their preparation. (iospress.com)
Malondialdehyde1
- 10 Malondialdehyde (MDA) is a toxic product associated with lipid peroxidation. (rcjournal.com)
Metabolism2
- Products of lipoxygenase metabolism are known to play a role in the pathogenesis of psoriasis. (google.com)
- Chylomicron-like lipid emulsions, resembling chylomicrons in composition, size and metabolism were prepared in the presence of [125 I]Aβ1-40. (iospress.com)
Protein3
- endotel hasar , d k prostasiklin kan d zeyleri, trombositlerin agregasyonu, d k trombosit say s ve vazospazm, hipertansiyon, protein ri ve dem gibi fizyolojik ve metabolik de i ikliklerde artm lipid peroksidasyonunun ve kandaki antioksidanlar n koruyucu kapasitelerinin a lmas n n, rol oynad g sterilmi tir. (sislietfaltip.org)
- These can then react with the peroxides formed during the autoxidation process itself or elsewhere in the protein`s vicinity. (scialert.net)
- Fatty acid-binding protein 3 (FABP3) located in renal mesangial and distal tubular cells, and had been shown to be a sensitive marker of renal injury, potentially be a mediator in pathogenesis of chronic kidney disease (CKD). (medsci.org)
Damage2
- Sperm cell membranes are high in polyunsaturated fatty acids and are sensitive to oxygen free radical induced damage mediated by lipid peroxidation. (scialert.net)
- Applying squalene peroxide to rabbit ears caused comedoes (pimples) to form, and the severity of acne was related to the degree of damage squalene suffered. (healthtoempower.com)
Experimental2
- Rutin prevents experimental selenite-induced cataractogenesis in rat pups, possibly by preventing depletion of antioxidant enzymes and of GSH, and by inhibiting lipid peroxidation. (molvis.org)
- Dvorshchenko C., Vakal S., Beregovyi S. Lipid peroxidation in rat gastric mucosa subcellular fraction under experimental ulcer. (ukrbiochemjournal.org)
Level1
- The aim i the study was investigate the reletionship between plazma I pid peroxide level and pathogenesis of preeclampsia. (sislietfaltip.org)
Composition1
- For years, moderate-intensity continuous training (MICT) has been the most popular exercise modality for improving body composition, cardiorespiratory fitness, insulin resistance, and lipid profile [ 2 , 5 ]. (hindawi.com)
Severe1
- However, spermatozoa's lipids are the main substrates for peroxidation, which may provoke severe functional disorder of sperm. (scialert.net)
Inflammatory1
- Start of the acne formation process seems to be triggered by inflammatory signals from keratin-producing cells (the result of exposure to squalene peroxide) and has nothing to do with bacteria. (healthtoempower.com)
Plasma1
- Our results indicate that circulating FABP3 in patients with T2DM is associated with eGFR, which suggests that increased plasma FABP3 may be involved in the pathogenesis of CKD. (medsci.org)
Acid2
- The addition of peroxide with the glutamyl-375 and aspartyl-225 of lactoperoxidase forms ester bonds between these amino acid residues and the heme 1- and 5-methyl groups, respectively. (wikipedia.org)
- 5 Isoprostanes are produced by ROS mediated peroxidation of arachidonic acid. (rcjournal.com)
Treatment1
- Nowadays, therapeutic regimes for diabetes and DCM include several clinical managements, involving lifestyle modifications (diet and exercise), glucose and lipid control (antidiabetic and lipid-lowering drugs), hypertension treatment, and coronary artery diseases intervention. (frontiersin.org)
Factor2
- Decreased concentrations of antioxidant support the hypothesis that alcoholic hepatitis is an important causative factor in pathogenesis of lipid peroxidation. (sumathipublications.com)
- Smoking is the most important factor in the pathogenesis of COPD. (rcjournal.com)
Found2
- Between the results of lipoxgenase inhibition and the lipid peroxidation a linear correlation was found. (google.com)
- The degree of squalene peroxidation was found to correlate positively with the size of the comedones elicited. (healthtoempower.com)
Cell1
- Egr-1 and Sp-1 may regulate the transcription of genes that are associated with the pathogenesis of gastric ulcer (growth factors, cell cycle regulators, etc. (ukrbiochemjournal.org)
Blood1
- Helicobacter pylori-induced lipid peroxidation in peripheral blood lym" by Xue-Gong Fan, Javed Yakoob et al. (aku.edu)
Evidence2
- Several lines of evidence implicate Helicobacter pylori infection in the pathogenesis of gastritis and peptic ulceration. (aku.edu)
- Although the pathogenesis of CKD remains unclear, evidence indicates that early recognition and interventions may delay the progression to ESRD and cardiovascular disease [ 3 ]. (medsci.org)
Drugs1
- The central issue is the absence of drugs that affect the disease pathogenesis. (actanaturae.ru)