The reduced ability of the hosts immune response to control bacterial infection apparently results in a bacteremia of longer duration, and in some patients the presence of angiogenic lesions that are unique among bacterial infections to Bartonella. (nih.gov)
Here, the current status of the role of the immune response in both controlling infection and in B. henselae-triggered immunopathogenesis is presented. (nih.gov)
In experiments with mice, B. henselae was eliminated within a few days to 1 week after systemic (intraperitoneal or intravenous) infection ( 4 ). (cdc.gov)
Both Coombs positivity and cold agglutinating antibody have been reported in association with infection and although pathogenesis of the anaemia is thought to have an immune-mediated component, this has not been characterised. (vin.com)
Asymptomatic infection with B. henselae or B. clarridgeiae is common in cats, which are therefore considered to be a major reservoir for human infection. (vin.com)
Cat-scratch disease is due to an infection by B. henselae and manifests as gradual regional lymph nodes enlargement ( armpit , groin , neck ) which may last 2-3 months or longer and a distal scratch and/or red-brown skin papule (not always seen at the time of the disease). (mdwiki.org)
IMMUNOBIOLOGY AND PATHOGENESIS - HIV infection produces both quantitative and qualitative time-dependent deleterious effects on the immune system. (medilib.ir)
Bacterial3
Bartonella henselae: subversion of vascular endothelial cell functions by translocated bacterial effector proteins. (nih.gov)
Bartonella henselae will infect endothelial cells and white blood cells leading to complications in the eyes, spleen nervous system, kidney, and bones if left untreated. (ticklab.org)
Inoculation1
During the past 2 years, we identified live Bartonella henselae in the primary inoculation sites of 3 patients after a cat scratch. (cdc.gov)
Bartonellosis1
Bartonellosis is an infectious disease produced by bacteria of the genus Bartonella . (mdwiki.org)
Infect1
Bartonella henselae can infect humans resulting in a wide range of disease syndromes including cat-scratch disease, fever with bacteremia, endocarditis, bacillary angiomatosis, and bacillary peliosis hepatis, among others. (nih.gov)
The causative agent of this neglected disease is Bartonella bacilliformis , which is a motile, aerobic, facultative intracellular alpha-2-proteobacterium. (biomedcentral.com)
High-stringency Southern blots indicate that all five pathogenic Bartonella spp. (umt.edu)
Mycobacterium1
Some Brucella species inhibit host cell apoptosis, similar to Chlamydia, Bartonella henselae , and Mycobacterium bovis . (ophrp.org)
Immunopathogenesis1
Little is known about the organism's pathogenesis in long-lasting lymphadenopathy, but an immunopathogenesis is assumed ( 1 ). (cdc.gov)
Facultative intracellular1
Members of the genus Bartonella are facultative intracellular bacteria, alpha 2 subgroup Pseudomonadota . (mdwiki.org)
Lymph nodes1
B. henselae is infrequently grown from the lymph nodes of humans, and only in a few cases was B. henselae isolated from patients with CSD ( 2 , 3 ). (cdc.gov)
Endemic1
Bartonella bacilliformis is endemic to South American Andean valleys and is transmitted via sand flies ( Lutzomyia spp. (biomedcentral.com)
Humans4
In humans, B. henselae and B. clarridgeiae have been shown to be the agents of the common, but usually self-limiting cat scratch disease (CSD). (vin.com)
Bartonella quintana, the agent of trench fever and a cause of endocarditis and bacillary angiomatosis in humans, has the highest reported in vitro hemin requirement for any bacterium. (umt.edu)
Bartonella bacilliformis is transmitted to humans by female phlebotomine sand flies ( Lutzomyia spp. (biomedcentral.com)
Quintana3
Hemin-Binding Surface Protein from Bartonella Quintana" by James A. Carroll, Sherry A. Coleman et al. (umt.edu)
and Minnick, Michael F., "Hemin-Binding Surface Protein from Bartonella Quintana" (2000). (umt.edu)
B. henselae and B. quintana can cause bacillary angiomatosis, a vascular proliferative disease involving mainly the skin, and other organs. (mdwiki.org)
Species2
Polymerase Chain Reaction may also assist in diagnosis by detecting the presence of Bartonella species DNA in serum. (ticklab.org)
DNA was extracted by using a QIAamp Tissue Kit (QIAGEN, Valencia, CA, USA) and was used as a template in a previously described real-time reverse transcription-PCR (RT-PCR) specific for a portion of the Bartonella 16S-23S intergenic spacer region and the PAP31 gene for detection of B. henselae ( 6 ). (cdc.gov)
BLAST searches indicate that the closest homologs to HbpA include the Bartonella henselae phage associated membrane protein, Pap31 (58.4% identity), and the OMP31 porin from Brucella melitensis (31.7% identity). (umt.edu)
Infections2
Boulouis H.J., Chang C.-C., Henn J.B., Kasten R.W., Chomel B.B., Factors associated with the rapid emergence of zoonotic Bartonella infections, Vet. (vetres.org)
Although the names are similar, these feline infections are associated with different epidemiology, pathogenesis and disease patterns. (vin.com)
Diseases1
Haemobartonella and Bartonella : Two Very Different Diseases! (vin.com)
Diagnosis2
Dr. Yao's research interests are molecular pathogenesis and diagnosis, and host-parasite interaction of parasites of medical/veterinary importance and One Health. (rossu.edu)
Although this definition encompasses many aspects of the pathogenesis and clinical aspects of the condition, it is important to remember that this disease has no pathognomonic clinical signs that permit a definitive diagnosis to be made upon initial owner interview and clinical examination [ 2 ]. (biomedcentral.com)
Vascular1
B. henselae is the cause of peliosis hepatis, which is defined as a vascular proliferation of sinusoid hepatic capillaries resulting in blood-filled spaces in the liver in HIV patients and organ transplant recipients. (mdwiki.org)
Angiogenic1
Recently, the role of immune effector cells that produce angiogenic cytokines upon stimulation with B. henselae has been proposed. (nih.gov)
Bacteria1
Currently, little is known about the pathogenesis of this bacteria, but we do know that it possesses a number of virulence factors, which are like assault weaponry that help it attack and destroy the host cells. (osmosis.org)
Molecular2
Moreover, on the basis of molecular methods, we recently identified that the scalp eschars from 2 patients who were bitten by a tick contained B. henselae ( 5 ). (cdc.gov)
Here, we review the current knowledge on autoaggregation, the role of autoaggregation in biofilm formation and pathogenesis, and molecular mechanisms leading to aggregation using specific examples. (aimspress.com)
Clinical1
This topic focuses on the immunobiology, pathogenesis, and clinical features of IRIS. (medilib.ir)
Scratch disease2
Patients with intact immune function who become infected with B. henselae usually get cat-scratch disease, a disease that usually involves lymphadenopathy resulting from a strong cellular immune response to the bacterium. (nih.gov)
Gimenez stain of Bartonella henselae obtained by the culture in human embryonic lung of the skin biopsy of a patient with cat scratch disease, France, 2010. (cdc.gov)
Disease1
Minimal change disease (MCD) is a common cause of the nephrotic syndrome in children and adults, but the underlying pathogenesis is unclear. (clinlabnavigator.com)
Agent1
Bartonella henselae, a gram-negative rod, is considered the principal etiologic agent. (medscape.com)
Patients2
We report isolation of B. henselae from a swab specimen and the skin biopsy specimens sampled from the skin papule of 3 patients with CSD. (cdc.gov)
B. henselae can be associated with bacteremia, bacillary angiomatosis, and peliosis hepatis in HIV patients, and bacteremia and endocarditis in immunocompetent and immunocompromised patients. (mdwiki.org)
Skin1
Those studies propose that Bartonella is present in the midgut of arthropod vectors and is released onto the mammalian skin in feces in order to pass to the dermal niche after erosion of the skin. (biomedcentral.com)
Study1
In this study, our objective was to determine if B. henselae was present in the papule, which is developed in the scratch line. (cdc.gov)