• NXG in our patient presents with exclusively dermal granulomatous inflammation mimicking interstitial granuloma annulare. (thrombin-inhibitor.com)
  • Many cutaneous side effects have been reported with their use in rheumatoid arthritis including psoriasis , dermatitis , leukocytoclastic vasculitis, lichenoid drug eruptions , and non-infectious cutaneous granulomatous reactions, such as disseminated granuloma annulare , sarcoidosis-like lesions, and interstitial granulomatous dermatitis. (arthritisdaily.net)
  • Subcutaneous granuloma annulare is characterized by firm or hard asymptomatic nodules in the deep dermis or subcutaneous tissues, with individual lesions measuring from 5 mm to 4 cm in diameter. (medscape.com)
  • Proposed pathogenic mechanisms for granuloma annulare include cell-mediated immunity (type IV), immune complex vasculitis, and an abnormality of tissue monocytes. (medscape.com)
  • 1976), proposed an alternative pathogenesis: cell-mediated immunity. (wikipedia.org)
  • She suffered from Raynaud's phenomenon for 35 years, and, at the age of 29, a biopsy of nodular lesions affecting the elbows, ankles and hands revealed rheumatoid nodules/granuloma annulare. (springeropen.com)
  • Here we review JAK inhibitors currently under investigation for the treatment of alopecia areata, vitiligo, sarcoidosis, necrobiosis lipoidica, granuloma annulare, and systemic lupus erythematosus with a special emphasis on safety and the implications of JAK inhibitors during the novel coronavirus 2019 pandemic. (nih.gov)
  • The etiology and pathogenesis of lichen sclerosus (LS) is unknown but may include genetic, infectious, environmental, and hormonal factors. (medscape.com)
  • Localized granuloma annulare is characterized by skin-colored to violaceous lesions up to 5 cm in diameter. (medscape.com)
  • Most lesions of granuloma annulare disappear in pre-pubertal patients with no treatment within two years while older patients (50+) have rings for upwards of 20 years. (wikipedia.org)
  • Arcuate dermal erythema: This is an uncommon form of granuloma annulare that manifests as infiltrated erythematous patches that may form large, hyperpigmented rings with central clearing. (medscape.com)
  • Theories of pathogenesis are diverse and include a T-cell mediated hypersensitivity reaction, an immune-mediated vasculopathy, or a primary degenerative disorder of dermal collagen. (dermatologyadvisor.com)
  • The differential diagnosis of NL includes principally granuloma annulare and necrobiotic xanthogranuloma, both of which share clinical and histopathologic similarities with NL. (dermatologyadvisor.com)
  • Perforating granuloma annulare is usually localized to the dorsal hands and fingers or may be generalized on the trunk and extremities. (medscape.com)
  • En: McKee P, Calonje E, Granter S, Pathology of the skin with clinical correlations. (asocolderma.org.co)
  • Granuloma annulare (GA) is a benign inflammatory dermatosis. (medscape.com)
  • Granuloma annulare (GA) is a benign, inflammatory disorder of the skin that has no proven aetiology or widely accepted theory of pathogenesis. (annals.edu.sg)
  • The Janus kinase-signal transducer and activator of transcription (JAK-STAT) intracellular signaling pathway is implicated in the pathogenesis of a number of inflammatory dermatoses. (nih.gov)
  • Las enfermedades perforantes más importantes incluyen formas primarias (colagenosis perforante reactiva, foliculitis perforante, enfermedad de Kyrle, dermatosis perforante serpiginosa) y secundarias (granuloma anular, seudoxantoma elástico, etc. (asocolderma.org.co)
  • Although the pathogenesis of Leser-Thrélat sign is not fully understood, there are data suggesting an association with tumor-secreting growth factors including epidermal growth factor and transforming growth factor-alpha, both of which can stimulate the epidermal growth factor receptor (8). (bvsalud.org)
  • Although there are many theories about the origin of pompholyx, the pathogenesis of the disease is still unknown. (ilovedermatology.com)
  • Some reports associate chronic stress with granuloma annulare as a trigger of the disease. (medscape.com)
  • Granuloma annulare (GA) is a common, sometimes chronic skin condition which presents as reddish bumps on the skin arranged in a circle or ring. (wikipedia.org)
  • Granuloma annulare is relatively common disease that occurs in all age groups, but it is rare in infancy. (medscape.com)
  • Piette EW, Rosenbach M. Granuloma annulare: pathogenesis, disease associations and triggers, and therapeutic options. (legehandboka.no)
  • Then, upon lysosomal enzyme release by these sequestered cells, connective tissue damage ensues, which results in GA. Later, these authors found data suggesting that activation of macrophages and fibroblasts are involved in the pathogenesis of GA and that fibrin and the rare IgM and C3 deposition around vessels were more likely a delayed-type hypersensitivity with resulting tissue and vessel changes rather than an immune-complex mediated disease. (wikipedia.org)
  • Aberrant mesenchymal tissue differentiation may contribute to the pathogenesis of ES. (logicalimages.com)
  • Familial cases of granuloma annulare observed in identical twins and siblings in several generations, along with an association of granuloma annulare with HLA phenotypes, suggest the possibility of a hereditary component in some cases. (medscape.com)
  • Rallis E, Stavropoulou E, Korfitis C. Granuloma annulare of childhood successfully treated with potent topical corticosteroids previously unresponsive to tacrolimus ointment 0.1%: report of three cases. (legehandboka.no)
  • Tacrolimus 0.1% and granuloma annulare: description of three cases. (legehandboka.no)
  • The range of predisposing events and associated diseases is diverse, and granuloma annulare is thought to represent a reaction pattern with many different initiating factors. (medscape.com)
  • By Mierlo at English Wikipedia - Transferred from en.wikipedia to Commons by Stevenfruitsmaak using CommonsHelper. (medscape.com)
  • The specificity of autoimmune injury to cartilaginous tissues has led investigators to test the hypothesis that a cartilage-specific autoantibody is central to the pathogenesis of relapsing polychondritis. (medscape.com)
  • Granuloma annulare is an idiopathic condition, though many catalysts have been proposed. (wikipedia.org)
  • Granuloma annulare also has some predilection for the sun-exposed areas and photodamaged skin. (medscape.com)