Francisella tularensis is a highly infectious, facultative Among these, pulsed-fi eld gel electrophoresis (PFGE) is intracellular pathogen and the causative agent of the more widely adopted and was recently proposed for diag- zoonotic disease tularemia. (cdc.gov)
Tularemia is caused by the bacteria Francisella tularensis which is typically spread by ticks, deer flies, and contact with infected animals. (wikipedia.org)
Research is focused on studying the molecular mechanisms involved in the pathogenesis of Vibrio cholerae , the bacterium that causes cholera, and Francisella tularensis , the bacterium that causes tularemia. (utsa.edu)
The Working centers, civilian and military govern- one can but feel that the status of tularemia, Group on Civilian Biodefense consid- mental agencies, and other public health both as a disease in nature and of man, is one ers F tularensis to be a dangerous poten- and emergency management institu- of potentiality . (cdc.gov)
Tularemia, a bacterial zoonosis, is caused by Francisella tularensis, one of the most infectious pathogenic bacteria known. (cdc.gov)
His current research focuses on understanding the role of bacterial virulence factors in pathogenesis and host response, and the development of subunit and live vaccines to prevent tularemia and glanders due to the select agents Francisella tularensis and Burkholderia mallei , respectively. (vt.edu)
Since the first meeting in 1995 in Sweden, the International Conferences on Tularemia have been a major driver of substantial advances in understanding of tularemia pathogenesis, bacteriology, diagnosis, and treatment. (tularemia.org)
At the Annual Biophysical Society Meeting in San Francisco, Geoffrey K. Feld, a Postdoctoral researcher in the Physical&Life Sciences Directorate at Lawrence Livermore National Laboratory (LLNL), described the team's work to uncover the secrets of the bacterium Francisella tularensis , which causes tularemia. (science20.com)
Once these questions are elucidated, a broader understanding of environmental persistence and pathogenesis might lead to better diagnostics and/or novel countermeasures to combat tularemia," he added. (science20.com)
Francisella tularensis can live both within and outside the cells of the animal it infects, meaning it is a facultative intracellular bacterium. (wikipedia.org)
Another area of interest is the study of pathogenic mechanisms of Francisella tularensis , a potential bioweapon, with particular interest in determining how this bacterium evades killing within host macrophages. (utsa.edu)
Background: Francisella is a genus of gram-negative bacterium highly virulent in fishes and human where F. tularensis is causing the serious disease tularaemia in human. (uib.no)
Subsp11
Human disease caused by F. tularensis subsp. (cdc.gov)
High-resolution typing of F. tularensis is currently lecular and epidemiologic analyses of natural isolates of F. attainable only by the use of multilocus variable-number tularensis subsp. (cdc.gov)
Cilj ovog istraživanja bio je ispitati ulogu ATG5-ovisne autofagije u unutarstaničnom životu F. tularensis subsp. (nsk.hr)
Materijal i metode: Ulogu ATG5-ovisne autofagije in vitro ispitali smo praćenjem unutarstaničnog razmnožavanja i citotoksičnog učinka F. tularensis subsp. (nsk.hr)
Rezultati: Farmakološki inhibitori autofagije i nedostatak ATG5 statistički su smanjili unutarstanično razmnožavanje i citotoksični učinak F. tularensis subsp. (nsk.hr)
Bergen Open Research Archive: Whole genome sequencing of the fish pathogen Francisella noatunensis subsp. (uib.no)
We have completed the sequencing and draft assembly of the Francisella noatunensis subsp. (uib.no)
Compared to other available Francisella genomes, it is most similar to the genome of Francisella philomiragia subsp. (uib.no)
Comparing the novel genome with other available Francisella genomes, we found around 2.5% of unique genes present in Francisella noatunensis subsp. (uib.no)
Pathogen2
Francisella tularensis, a potent human pathogen and a pu- needed, not only because of their use in clinical and public tative bioterrorist agent, we combined analysis of insertion- health work but also because of a rising concern associated deletion (indel) markers with multiple-locus variable-number with risks for bioterrorism ( 4 , 8 ). (cdc.gov)
Advanced development of medical countermeasures to the rapidly progressive and potentially fatal zoonosis of humans caused by the intracellular bacterial pathogen, Francisella tularensis is an explicit goal of this meeting. (tularemia.org)
Mycobacterium1
The BioHealthBase Bioinformatics Resource Center (BRC) (www.biohealthbase.org) is a public bioinformatics database and analysis resource for the study of specific biodefense and public health pathogens - Influenza virus, Francisella tularensis, Mycobacterium tuberculosis, Microsporidia species and ricin toxin. (mssm.edu)
Bacteria3
This encystment phenotype was rapidly induced by F. tularensis in the laboratory and was required for the long-term survival of the bacteria. (science20.com)
Our preliminary data indicate that F. tularensis bacteria lacking these proteins are diminished in their ability to infect or survive in human immune cells, which indicates that these proteins may also contribute to F. tularensis virulence," Feld said. (science20.com)
A study is performed to evaluate the pathogenesis of Gram-negative bacteria that can cause meningitis . (osmosis.org)
Secretion system1
The availability of hundreds of bacterial genomes allowed a comparative genomic study of the Type VI Secretion System (T6SS), recently discovered as being involved in pathogenesis. (biomedcentral.com)
Virulence2
Based on virulence tests and nostic and epidemiologic work on F. tularensis by PulseNet biochemical assays, F. tularensis is divided into 4 subspe- laboratories throughout the United States ( 7 ). (cdc.gov)
The functions of novel proteins putatively involved in F. tularensis virulence are revealed by X-ray crystallography. (science20.com)
Burkholderia1
He and his co-investigators, James "Randy" Heflin, a professor in the Department of Physics in the university's College of Science, and Abey Bandera, a research assistant professor in the veterinary college, are working to develop nanoscale optical fiber biosensor tests, or assays, for detection of Francisella tularensis, Burkholderia mallei , and B. pseudomallei . (vt.edu)
Pathogenic2
orientalis Toba04 and a list of genes uniquely present in the human-pathogenic Francisella subspecies. (uib.no)
Evolutionary analysis of the Francisella genomes, strongly suggests that human and fish pathogenic Francisella species have evolved independently from free-living metabolically competent Francisella species. (uib.no)
Novicida1
To filter errors resulting from these intrinsic biases in the "negative" TM approach, a statistical framework has recently been developed and tested in P. aeuginosa PAO1 and Francisella tularensis novicida [ 7 ] TM datasets. (biomedcentral.com)
Further, because of its low infectious dose and lethality when inhaled, Francisella tularensis was developed as a bioweapon by three countries, and remains on of the five potential bio-terrorist agents of most concern. (tularemia.org)
Species3
Recently Francisella species have been reported to cause mortality in aquaculture species like Atlantic cod and tilapia. (uib.no)
These findings will contribute to understanding the evolution of Francisella species and pathogenesis. (uib.no)
Recent reports demonstrated the importance of T6SS in pathogenesis of several bacterial species. (biomedcentral.com)
Characterization1
Rasley and colleagues believe that careful characterization of these two novel F. tularensis proteins may shed light on how this organism persists in the environment and causes disease. (science20.com)
Infect1
F. tularensis can infect humans through the skin, mucous membranes, gastrointestinal tract, and lungs. (cdc.gov)
Metabolically1
Specifically, we demonstrated that amoebae exposed to fully virulent F. tularensis rapidly form cysts -- dormant, metabolically inactive cells -- that allow the amoebae to survive unfavorable conditions," said Amy Rasley, the research team leader. (science20.com)
Subspecies3
In standard medical practice, subspecies determination subspecies division, delineation of clades A.I and A.II of of F. tularensis typically involves biochemical fermenta- subspecies tularensis , differentiation of Japanese strains tions. (cdc.gov)
Several DNA-based methods have been found useful for typing of F. tularensis at the subspecies level ( 1 , 10 - 13 ). (cdc.gov)
time-consuming, produces complex banding pattern data, tularensis may be fulminate or even lethal, whereas disease and has a restrictive discriminatory capacity when applied caused by other subspecies is less severe, although often to F. tularensis ( 7 , 14 - 17 ). (cdc.gov)
Genome2
From 5 representative F. F. tularensis is included among the top 6 "category A" po- tularensis genome sequences, 38 indel markers with ca- tential bioterrorism agents believed to have the greatest po- nonical properties, i.e., capable of sorting strains into ma- jor genetic groups, were selected. (cdc.gov)
Results: The genome is rearranged compared to the available Francisella genomes even though we found no IS-elements in the genome. (uib.no)
Genomics1
Faculty in this area use state-of-the-art approaches such as genetics of model organisms, bioinformatics, computational biology and functional genomics to study cellular development, signal transduction, regulation of gene expression, microbial pathogenesis, and the evolutionary origin of higher organisms. (umd.edu)
Disease1
Currently, we don't know the protein targets in the host -- amoeba, human, etc. -- that the REP proteins act on, nor do we know the mechanism by which the proteins could help F. tularensis survive in the environment or cause disease," Feld said. (science20.com)
F. tularensis is found in widely diverse animal hosts and habitats and can be recovered from contaminated water, soil, and vegetation. (cdc.gov)
Agar2
For discrimination of strains Martin agar ( 25 ), suspended in phosphate-buffered saline, of F. tularensis , MLVA is the obvious choice. (cdc.gov)
The laboratorial isolation of F. tularensis requires special media such as buffered charcoal yeast extract agar. (wikipedia.org)
Biological1
F. tularensis could be used as a biological weapon in a number of ways, but an aerosol release would likely have the greatest adverse medical and public health consequences. (cdc.gov)
Model1
View of Analyzing the contribution to pathogenesis by three putative transcriptional regulators of Francisella tularensis using the chicken embryo infection model. (pwvas.org)
Role1
Understanding the interaction patterns between a particular virus and human proteins plays a crucial role in unveiling the underlying mechanism of viral infection and pathogenesis. (biomedcentral.com)
Analysis1
tularensis suggest a population split of the tandem repeat analysis (MLVA). (cdc.gov)