• The goals of the Center for Microbial Pathogenesis are to identify virulence mechanisms and define host response patterns with the overall objective of elucidating a detailed description of the structure, function and control of biological systems in health and disease, utilizing molecular and cellular, as well as genomic and proteomic approaches. (nationwidechildrens.org)
  • He is currently completing a PhD in Fabienne Mackay's laboratory on the role of BAFF and the innate immune system in the pathogenesis of SLE. (nature.com)
  • Innate immunity contributes to the pathogenesis of autoimmune diseases by activating lymphocytes and participating to the tissue damage. (els.net)
  • In this review I will present information on what is known about B-cell and T-cell immune memory and innate immunity and the pace of pathogenesis for the diseases we are currently preventing with vaccination, and I will examine the dynamic nature of the situation as changes in natural boosting occur. (aappublications.org)
  • However, it has become evident over the past two decades that epigenetic alterations of the chromatin, particularly the chromatin components in the promoter regions of tumor suppressors and oncogenes, play key roles in CRC pathogenesis. (mdpi.com)
  • The increased understanding of epigenetic regulation of gene expression in the context of CRC pathogenesis has led to development of epigenetic biomarkers for CRC diagnosis and epigenetic drugs for CRC therapy. (mdpi.com)
  • Recent genome‐wide association studies have reproducibly identified several loci involved in the pathogenesis of atherosclerosis, and most of the identified genes are newly implicated in the disease process. (els.net)
  • The identification of over 500 ASD risk genes, has enabled the molecular genetic dissection of the pathogenesis of the disease in model organisms such as mice. (frontiersin.org)
  • WASHINGTON (Feb. 4, 2014) - A new study by George Washington University (GW) researcher Michael Bukrinsky, M.D., Ph.D., shows similarities in the pathogenesis of prion disease -- misfolded proteins that can lead to neurological diseases -- and the HIV virus. (eurekalert.org)
  • This is a significant step forward in our understanding of the potential role of cell-to-cell transfer of alpha-synuclein in Parkinson's disease pathogenesis and we are very excited about the findings", says Professor Patrik Brundin at Lund University, Sweden, who led a team of investigators from research centres in Denmark, France and Portugal. (scienceblog.com)
  • In 2018, 100% of those students in the Molecular Mycology: Current Approaches to Fungal Pathogenesis course who requested financial aid received some support. (mbl.edu)
  • The roles of miRNAs in Enterovirus pathogenesis have recently begun to be noted. (mdpi.com)
  • Significance and future prospects: The current study indicates that B cells play reciprocal roles in the pathogenesis of SSc, exhibiting both pathogenic and protective functions. (news-medical.net)
  • are confident that quantitative interaction proteomics can aid clinical research in determining the role played by disease-specific variants in pathogenesis of NDD phenotypes. (thermofisher.com)
  • Piette EW, Rosenbach M. Granuloma annulare: Pathogenesis, disease associations and triggers, and therapeutic options. (medscape.com)
  • Blood, urine, and tissue samples will be evaluated both for standard diagnostic purposes and for research purposes using specialized molecular methods that may provide insights into specific disease pathogenesis. (clinicaltrials.gov)
  • Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. (elsevier.com)
  • Recent developments in genetic studies have been applied to atherosclerosis and are beginning to rapidly reveal the genetic factors that modulate the pathogenesis of this disease. (els.net)
  • The pathogenesis of a disease is the biological mechanism (or mechanisms) that leads to the diseased state. (wikipedia.org)
  • The pathogenesis of a disease is the mechanism by which the disease is caused. (medicalxpress.com)
  • Booster Vaccinations: Can Immunologic Memory Outpace Disease Pathogenesis? (aappublications.org)
  • 1 Creating PPI networks and comparing wild type with disease-specific protein isoforms, the researchers hoped to gain insight on functional changes important in pathogenesis. (thermofisher.com)
  • Recent discoveries, however, have led to important advances in understanding the pathogenesis of the condition. (nih.gov)
  • While the purpose of this volume is to serve as an update on recent advances in the etio-pathogenesis of glomerulopathies, the book offers the cu. (intechopen.com)
  • While the purpose of this volume is to serve as an update on recent advances in the etio-pathogenesis of glomerulopathies, the book offers the current and broad based knowledge in the field to readers of all levels in the nephrology community. (intechopen.com)
  • The long term objective of this research is to characterize the mechanisms responsible for the pathogenesis of idiosyncratic hypersensitivity reactions in children, particularly those involving carbamazepine and other aromatic anticonvulsants. (clinicaltrials.gov)
  • We also identify aspects of the BAFF system for which data in relation to SLE are still missing, and we suggest studies to investigate the pathogenesis of SLE and ways to refine anti-BAFF therapies. (nature.com)
  • This program announcement, Pathogenesis and Therapy of the Muscular Dystrophies, is related to the priority area chronic disabling conditions. (nih.gov)
  • This article is a two-part review of the pathogenesis of the Vertebral Subluxation Complex. (chiro.org)
  • This installment will begin an exploration of the references presented in that article concerning pathogenesis. (chiro.org)
  • This article provides an overview of malaria pathogenesis, synthesizing the recent field, laboratory, and epidemiological data that will lead to the development of strategies to reduce mortality and morbidity. (sciencemag.org)
  • Here, we evaluated the role of IL-6-producing Beffs and IL-10-producing Bregs in the pathogenesis of scleroderma using B cell-specific cytokine-deficient mice. (news-medical.net)