These effects lead to enhanced proliferation, which is more dramatic in both IPAH and CTEPH PASMC. (ca.gov)
Enhanced proliferation is also shown to be attenuated by inhibition of Akt/mTOR in CTEPH PASMC. (ca.gov)
Thrombin has direct effects on PASMC increasing intracellular [Ca(2+)] and PASMC proliferation, an effect attributed to Akt phosphorylation. (ca.gov)
7. Inhibitory effect of NBL1 on PDGF-BB-induced human PASMC proliferation through blockade of PDGFβ-p38MAPK pathway. (nih.gov)
Two endothelin receptor antagonists (ERAs), bosentan and ambrisentan, are currently approved for the treatment of pulmonary arterial hypertension (PAH), a devastating disease involving an activated endothelin system and aberrant contraction and proliferation of pulmonary arterial smooth muscle cells (PASMC). (nih.gov)
Activation or disruption of EP3 did not influence PASMC proliferation. (elsevierpure.com)
Incubation of PASMCs with a high concentration of Mg2+ markedly inhibited PASMC proliferation and migration, and increased apoptosis, whereas a low level of Mg2+ produced the opposite effects. (johnshopkins.edu)
The goals of the existing study had been to determine whether differentially portrayed miR-214 is in charge of the abnormally improved proliferation of PASMCs also to recognize the molecular system root the aberrant improvement of PASMC proliferation. (research-in-field.com)
Pulmonary Hypertension2
These findings indicate that DHA activates PASMC KCa channels leading to vasorelaxation in pulmonary hypertension. (greenmedinfo.com)
This study is designed to determine the effects of thrombin on Akt signaling in pulmonary artery smooth muscle cells (PASMC) from normal humans and pulmonary hypertension patients. (ca.gov)
Inhibitory1
Since the association and dissociation rates of G protein-coupled receptor antagonists can influence their pharmacological activity in vivo, we used human PASMC to characterize inhibitory potency and receptor inhibition kinetics of macitentan, ambrisentan and bosentan using calcium release and inositol-1-phosphate (IP(1)) assays. (nih.gov)
Pathogenesis2
It is now well recognized that miRNAs, the small non-coding RNAs that promote degradation or suppress translation of target genes, such as miR-21, miR-1, miR-204, miR-130/301, are abnormally expressed in PASMCs isolated from PAH patients and animals and are correlated with dysregulation of PASMC functions and PAH pathogenesis [ 5 - 8 ]. (thno.org)
These data show that KCNK3 is definitely causally involved with hypoxia-induced signalling in PASMC and in PH pathogenesis. (biomedigs.org)
Inhibition1
1. Reversal of the Warburg effect with DCA in PDGF‑treated human PASMC is potentiated by pyruvate dehydrogenase kinase‑1 inhibition mediated through blocking Akt/GSK‑3β signalling. (nih.gov)
Pathway1
Thrombin treatment of PASMC resulted in a transient increase in Akt phosphorylation and had similar effects on the downstream targets of the Akt/mTOR pathway. (ca.gov)
Receptor1
Reverse transcriptase-polymerase chain reaction and immunoblotting of MCT28d rat PASMC extracts revealed scant expression of the IP receptor but stable expression of EP4 receptor, compared with controls. (nih.gov)
Concentration1
Forskolin (10 μM), an activator of adenylyl cyclase, which increases cAMP concentration, opened BKCa channels in single pulmonary arterial smooth muscle cells (PASMC) of the Sprague-Dawley rat. (pcom.edu)
Smooth1
Reduced reliance on mitochondrial respiration amplified glycolysis in pulmonary artery smooth muscle cell (PASMC) and activated GPD (glycerol-3-phosphate dehydrogenase), linking glycolysis to oxidative phosphorylation and lipid metabolism. (nih.gov)
Human1
In human beings, missense mutations have already been recognized in PH individuals [14C16], and pulmonary KCNK3 manifestation and KCNK3 currents in NB-598 Maleate IC50 PASMC will also be NB-598 Maleate IC50 reduced in PH individuals who usually do not bring this mutation [13]. (biomedigs.org)
Function2
KCNK3 manifestation and function are low in rat PASMC in monocrotaline-induced PH, as well as the KCNK3 activator ONO-RS-082 considerably ameliorates advancement of PH with this model [13]. (biomedigs.org)
This acquiring confirms a contribution from both mTORC1 and mTORC2 to mTOR-mediated adjustments in PASMC framework and function particularly, as similar outcomes were not seen in mice. (biongenex.com)