Particular gene. Medical search. Frequent questions

More than 100 mutations in the APOB gene are known to cause familial hypercholesterolemia. (medlineplus.gov)
The presence of two APOB gene mutations results in a more severe form of hypercholesterolemia that usually appears in childhood. (medlineplus.gov)
More than 120 mutations in the APOB gene have been found to cause familial hypobetalipoproteinemia (FHBL), a disorder that impairs the body's ability to absorb and transport fat. (medlineplus.gov)
Most APOB gene mutations that cause FHBL lead to the production of apolipoprotein B that is abnormally short. (medlineplus.gov)
The severity of the condition largely depends on the length of the abnormal apolipoprotein B. Some mutations in the APOB gene lead to the production of a protein that is shorter than apolipoprotein B-100, but longer than apolipoprotein B-48. (medlineplus.gov)
A gene can acquire mutations in their sequence, leading to different variants, known as alleles, in the population. (wikipedia.org)
Mutations in the gamma 2 chain gene (LAMC2) of kalinin/laminin 5 in the junctional forms of epidermolysis bullosa. (medscape.com)
At least three mutations in the MESP2 gene have been found to cause spondylothoracic dysostosis, a condition characterized by abnormal development of bones in the spine and ribs. (medlineplus.gov)
Mutations in the MESP2 gene prevent the production of any protein or lead to the production of an abnormally short, nonfunctional protein. (medlineplus.gov)
More than 700 mutations in the COL7A1 gene have been identified in people with dystrophic epidermolysis bullosa, a condition that causes the skin to be very fragile and to blister easily. (medlineplus.gov)
The recessive types of dystrophic epidermolysis bullosa (RDEB) result from mutations in both copies of the COL7A1 gene in each cell. (medlineplus.gov)
Most of the COL7A1 gene mutations responsible for RDEB-sev gen result in production of abnormally short pro-α1(VII) chains that cannot form type VII collagen. (medlineplus.gov)
A milder, dominant form of dystrophic epidermolysis bullosa (DDEB) results from mutations in one copy of the COL7A1 gene in each cell. (medlineplus.gov)
It is unclear how COL7A1 gene mutations are associated with an increased risk of a certain cancer called squamous cell carcinoma in people with dystrophic epidermolysis bullosa, particularly RDEB-sev gen. (medlineplus.gov)
Mutations in the COL7A1 gene can also cause a rare condition called epidermolysis bullosa with congenital localized absence of skin (also known as Bart syndrome or aplasia cutis congenita type VI). (medlineplus.gov)
Mutations in these genes affect proteins involved in the signaling pathway for pigment production and explain a large amount of the color variation in mammals. (creation.com)
Shull's studies suggested that harmful, vigor-killing gene mutations that accumulate naturally in every generation are exposed by inbreeding, but hidden by crossbreeding. (eurekalert.org)
Do Parents Pass Gene Mutations to Children? (kidshealth.org)
Do All Gene Mutations Cause Health Problems? (kidshealth.org)
Most gene mutations have no effect on health. (kidshealth.org)
This means that the mutant cells remain locked to further growth, making them vulnerable to mutations in other genes needed for their development and growth into a malignant cancer. (eurekalert.org)
The various forms of Waardenburg syndrome (WS), a neurocristopathy, arise from mutations in multiple genes. (medscape.com)
[ 6 ] Therefore, mutations in the PAX3 gene could affect regulation of the MITF gene, leading to abnormalities of melanocyte differentiation. (medscape.com)
Most, if not all, cases of WS1 are caused by mutations in the PAX3 gene located on chromosome band 2q35. (medscape.com)
Novel mutations of PAX3 , MITF , and SOX10 genes have been described in Chinese patients with WS1 or WS2. (medscape.com)
Mutations in the MITF gene, located on chromosome band 3p14.1-p12.3, cause some cases of WS2. (medscape.com)
Mutations in multiple genes cause the various forms of Waardenburg syndrome (WS). (medscape.com)

This definition includes genes that do not encode proteins (not all transcripts are messenger RNA). (wikipedia.org)
Therefore in this book I will consider genes as DNA sequences encoding information for functional products, be it proteins or RNA molecules. (wikipedia.org)
The gene makes a protein that controls the quantities of other proteins a cell produces, and studies in roundworms suggest that the gene is involved in growth and development throughout life. (newscientist.com)
Many proteins, and the genes that make them, aren't well understood, and there's still much to learn from the human genetic instruction book. (sciencenews.org)
Since genes use RNA molecules to make proteins, these snippets effectively "silence" genes that carry the same sequence. (newscientist.com)
For example, modifying a chemical reaction called methylation can change the function of a gene, causing it to increase or decrease production of certain proteins or to produce different kinds of proteins. (msdmanuals.com)

The AMP, joined by several other organizations and researchers, challenged Myriad's gene patents, arguing that human genes are naturally occurring and, therefore, should not be subject to patenting. (medscape.com)

The FDA approved the first topical gene therapy for treatment of wounds in patients with dystrophic epidermolysis bullosa (DEB). (medscape.com)
Gene Therapy covers both the research and clinical applications of novel therapeutic techniques based on a genetic component. (nature.com)
Gene Therapy covers a range of subject areas, to read content across the scope of the journal view the journal's subjects page here . (nature.com)
Gene Therapy now provides its latest table of contents as an RSS web feed. (nature.com)
This article is a great review of gene therapy as a therapy, and how it has evolved from an experiment that killed children to an accepted therapy that is saving and improving lives. (scienceblogs.com)
66.8% of gene therapy trials utilize genetically modified viruses. (scienceblogs.com)
There are 64 trials where the gene therapy occurred through an unknown vector. (scienceblogs.com)
I can only imagine a trial about something else finds 'There was gene therapy, we don't know how we did it! (scienceblogs.com)
I've heard of the HIV being used to cure a childhood cancer, but I don't know if that is gene therapy or not. (scienceblogs.com)
A few days later, the cells are broken open to release the full AAV gene therapy vectors, empty AAV vectors, and other components, like DNA and protein fragments. (novartis.com)
Novartis Gene Therapies efficiently produces a supply of gene therapy. (novartis.com)
Gene therapy - Overview covers definition, risk, results of this experimental procedure. (nbcchicago.com)
2012, December 1) Gene Therapy. (utah.edu)
One possible treatment may be a gene therapy strategy, if we could find a way to mimic the Marsili phenotype by overexpressing the mutated transcription factor," added co-author Professor John Wood (UCL Wolfson Institute for Biomedical Research). (sciencedaily.com)
Although gene therapy is defined as any treatment that changes gene function, it is often thought of as the insertion of normal genes into the cells of a person who lacks such normal genes because of a specific genetic disorder. (msdmanuals.com)
This technique is called gene insertion therapy or insertion gene therapy. (msdmanuals.com)
Currently, such gene insertion therapy is most likely to be effective in the prevention or cure of single-gene defects, such as cystic fibrosis. (msdmanuals.com)
A different method of gene therapy uses antisense technology. (msdmanuals.com)
It seems to have the potential to be more effective and safer than gene insertion therapy. (msdmanuals.com)
Another approach to gene therapy is to increase or decrease the activities of certain genes by using chemicals to modify chemical reactions in the cell that control gene expression. (msdmanuals.com)
In the gene therapy group our main interest is to develop systems for sufficient and sustained expression of transgenes in the CNS. (lu.se)
As of first of January 2022, StemTherapy and MultiPark have decided to merge the former iPSC, CRISPR and vector platforms into the new Cell and Gene Therapy Core . (lu.se)
The Cell and Gene Therapy core is an open-access infrastructure and our services include AAV and LV vector production, iPS reprogramming, iPS-edits and CRISPR experimental designs. (lu.se)

Did results from a genetic test tell you that you have a methylenetetrahydrofolate reductase ( MTHFR ) gene variant? (cdc.gov)
Talk to your doctor or a genetic counselor if you have concerns about what having one of these extremely rare MTHFR gene variants means for your health care. (cdc.gov)
Genes evolve due to natural selection / survival of the fittest and genetic drift of the alleles. (wikipedia.org)
gene cloning ( DNA cloning ) The production of exact copies ( clones ) of a particular gene or DNA sequence using genetic engineering techniques. (encyclopedia.com)
Across hundreds of thousands of single letter differences peppered across the human genome, all four research teams found genetic variations near the gene LIN28B associated with earlier or later first periods. (newscientist.com)
To find other genes associated with these traits, researchers will need to scan the genomes of even more women and look for less common genetic variations, says Kári Stefánsson , CEO of deCODE Genetics in Reykjavik, Iceland. (newscientist.com)
Several genes affecting the development of symptomatic epilepsies have already been identified, but the genetic background of multifactorial idiopathic epilepsies often remain unknown. (sciencedaily.com)
A peek at tardigrades' genetic diaries may dispel a rumor about an amazing feat the tiny creatures were supposed to perform: borrowing large numbers of genes from other organisms. (sciencenews.org)
This genetic program is disrupted when DNA damage activates a cancer gene or inactivates a gene that restricts cell growth. (eurekalert.org)
Polymerase chain reaction (PCR) Genetic diagnostic technologies are scientific methods that are used to understand and evaluate an organism's genes. (msdmanuals.com)
The cells of the body contain our genetic make-up (DNA), which contains genes. (lu.se)

These genes make up different DNA sequences called genotypes. (wikipedia.org)
and (3) regulatory sequences control gene expression but are not part of the gene itself. (wikipedia.org)
Improved access to bioinformatics tools enables scientists to process, manage, and store raw data, annotate sequences to define genes, and quantitate RNA sequence data to get insight into gene expression patterns. (genengnews.com)

See also Genes and Chromosomes. (msdmanuals.com)
Genes and Chromosomes Genes are segments of deoxyribonucleic acid (DNA) that contain the code for a specific protein that functions in one or more types of cells in the body or the code for functional ribonucleic. (msdmanuals.com)

It is indicated for the treatment of wounds in patients aged 6 months and older with dystrophic epidermolysis bullosa with mutation(s) in the collagen type VII alpha 1 chain (COL7A1) gene. (medscape.com)

During gene expression, the DNA is first copied into RNA. (wikipedia.org)
This study involves a comprehensive, multi-modal, and integrative assessment of biomarkers implicated in the pathophysiology of PTSD, including measuring differences in whole-blood gene expression and other blood biomarkers of key neurobiological systems, an approach critical to informing risk and resilience prediction algorithms for PTSD, and to develop novel psychopharmacologic approaches for the treatment of this disabling condition in disaster responders and other trauma survivors. (cdc.gov)
In her current position as a biologist, her focus on human DNA polymerases continues and expands towards studying genome-wide gene expression changes in yeast strains. (nih.gov)
Scientists armed with whole genome sequence data can now ask questions about genome structure and organization that impact gene expression. (genengnews.com)
Amy Radunz, a nutritionist from the department of animal sciences at the University of Wisconsin in River Falls, has partnered with molecular biologist Hasan Khatib, an associate professor at University of Wisconsin-Madison, to ask how differences in maternal diet during pregnancy induce gene expression and DNA methylation changes in fetal tissues in sheep. (genengnews.com)
Our optimized, custom lentiviral vectors are fully compatible with Chromium Single Cell Gene Expression v3 and v3.1 (Next GEM) solution utilizing Feature Barcode technology. (sigmaaldrich.com)
We used the paradigmatic GATA-PU.1 axis to explore, at the systems level, dynamic relationships between transcription factor (TF) binding and global gene expression programs as multipotent cells differentiate. (lu.se)
and (4) how dynamic modeling of DNA-binding and gene expression data can be used to infer regulatory logic of TF circuitry. (lu.se)
To address the problem of sustained expression in vivo (a major limitation of many gene transfer methods as of now) we are investigating the use of different promoters, post-transcriptional regulating elements and vectors. (lu.se)
The researchers were able to confirm the findings in vitro in the laboratory by turning off certain genes and thereby reducing their expression. (lu.se)

Few traits are caused by a single gene. (amnh.org)
Mapping of the oil palm tree genome has revealed a single gene responsible regulating its yield, offering the possibility to breed new variants for increased production, say scientists behind the project. (foodnavigator.com)
Another theory for heterosis, supported by our discovery, postulates that improved vigor stems from only a single gene - an effect called "superdominance" or "overdominance. (eurekalert.org)
To find overdominant genes, the team developed a novel approach by turning to a vast tomato "mutant library" - a collection of 5,000 plants, each of which has a single mutation in a single gene that causes defects in various aspects of tomato growth, such as fruit size, leaf shape, etc. (eurekalert.org)
This hybrid, the team found, produced greater yields because there was one normal copy and one mutated copy of a single gene that produces a protein called florigen. (eurekalert.org)
The concept that a mutation in only one copy of a single gene can improve yield has broad implications for plant breeding. (eurekalert.org)
Target a single gene using Zinc Finger Nucleases or screen a whole genome with fully customizable CRISPR products. (sigmaaldrich.com)

Simple organisms like these allow scientists to dissect the functions of individual genes, a task which can be impossible amid the complexity of the human system. (bbc.co.uk)

The MTHFR gene provides instructions for your body to make the MTHFR protein , which helps your body process folate. (cdc.gov)
The APOB gene provides instructions for making two versions of the apolipoprotein B protein, a short version called apolipoprotein B-48 and a longer version known as apolipoprotein B-100. (medlineplus.gov)
There are two types of molecular genes: protein-coding genes and non-coding genes. (wikipedia.org)
However, genes that produce repressor RNAs were proposed in the 1950s and by the 1960s, textbooks were using molecular gene definitions that included those that specified functional RNA molecules such as ribosomal RNA and tRNA (noncoding genes) as well as protein-coding genes. (wikipedia.org)
This product may be protein (as is the case in the majority of genes) or may be RNA (as is the case of genes that code for tRNA and rRNA). (wikipedia.org)
The MESP2 gene provides instructions for making a transcription factor, which is a protein that attaches (binds) to specific regions of DNA and helps control the activity of particular genes. (medlineplus.gov)
The MESP2 protein controls the activity of genes in the Notch pathway, an important pathway in embryonic development. (medlineplus.gov)
The MESP2 protein regulates Notch activity by turning on (activating) genes in the Notch pathway, which ultimately block (repress) the activity of the NOTCH1 protein. (medlineplus.gov)
The COL7A1 gene provides instructions for making a protein called pro-α1(VII) chain that is used to assemble a larger protein called type VII collagen. (medlineplus.gov)
This complex gene codes for a complex protein important in a number of pathways. (creation.com)
This complex organization of the gene reflects the complex nature of the protein receptor it produces. (creation.com)
The identified genomic region is likely to be the strongest single risk factor for epilepsy in Belgian Shepherds, and we are studying an interesting gene variant causing an amino acid change in the protein level. (sciencedaily.com)
A group of scientists at Northwestern University developed a way to transform the Cas9 protein into a spherical nucleic acid (SNA) and load it with vital components for accessing an extensive range of tissue and cell types, as well as the intracellular compartments essential for gene editing . (isaaa.org)
Using DNA from blood samples, the researchers conducted a whole exome sequencing -- mapping out the protein-coding genes in the genome of each family member. (sciencedaily.com)

The Mendelian gene is the classical gene of genetics and it refers to any heritable trait. (wikipedia.org)
More thorough discussions of this version of a gene can be found in the articles on Genetics and Gene-centered view of evolution. (wikipedia.org)
The molecular gene definition is more commonly used across biochemistry, molecular biology, and most of genetics - the gene that's described in terms of DNA sequence. (wikipedia.org)

A gene variant is a change in a DNA sequence that is different from the expected DNA sequence. (cdc.gov)
The Mendelian gene is a basic unit of heredity and the molecular gene is a sequence of nucleotides in DNA that is transcribed to produce a functional RNA. (wikipedia.org)
We define a gene as a DNA sequence that is transcribed. (wikipedia.org)
A gene is a DNA sequence that codes for a diffusible product. (wikipedia.org)
Dr Hamer, who in 1993 claimed to have identified a DNA sequence linked to male homosexuality, said the existence of the "god gene" explained why some people had more aptitude for spirituality than others. (telegraph.co.uk)

The transmission of genes to an organism's offspring is the basis of the inheritance of phenotypic traits. (wikipedia.org)

The CRISPR/Cas9 toolbox has already allowed the manipulation of gene function in basal land plants, butterflies, crickets and Atlantic salmon, and many more are sure to follow. (mdpi.com)
This topical collection on " Gene Editing " aims to provide a forum for discussions on the latest technical developments in the fields of general genome engineering technologies, including (i) the establishment of cell culture systems, and (ii) the development of established and emerging organismal models by CRISPR/Cas9 or similar genome engineering tools. (mdpi.com)
Sigma-Aldrich ® Advanced Genomics delivers complete support for every step of CRISPR-based gene editing research at any scale. (sigmaaldrich.com)
Whether you are looking to knockout, knock-in, knockdown, or overexpress your targets, our comprehensive suite of CRISPR gene-editing tools and services will take your research Beyond the Bench. (sigmaaldrich.com)
Gain even greater insights into complex biological networks using Sigma-Aldrich ® Advanced Genomics CRISPR activation and CRISPR inhibition libraries for gene knockdown and overexpression experiments. (sigmaaldrich.com)
Whether you need help designing your CRISPR experiment, require assistance troubleshooting, or simply want to better understand how you can apply gene editing methods in your research, Sigma-Aldrich ® Advanced Genomics is here to guide you. (sigmaaldrich.com)
In this article, we present an application of our novel E. coli CRISPR/Cas-mediated Lambda-Red (λ-Red) homologous recombination (HR) vector system, which facilitates gene editing through the homology-directed repair (HDR) of double-stranded DNA breaks (DSBs) created by Cas9 endonuclease, using either ssDNA or dsDNA as an editing template. (sigmaaldrich.com)
A team of researchers at Tamil Nadu Agricultural University, India , used the CRISPR tool for target editing of OsSWEET13 , a bacterial leaf blight (BLB) susceptible gene in rice . (isaaa.org)

In 2023, Americans do own their own genes and can feel secure in them not being used against us. (medscape.com)

Most biological traits are under the influence of polygenes (many different genes) as well as gene-environment interactions. (wikipedia.org)
These alleles encode slightly different versions of a gene, which may cause different phenotypical traits. (wikipedia.org)
Most traits are caused by the combination of your genes and the environment you grow up in. (amnh.org)

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. (nih.gov)
Clustering of gene ontology terms in genomes. (lu.se)

This made it far easier for the researchers to reveal what role the family of p53 genes plays in all animals. (bbc.co.uk)
However, the researchers also found that the gene extends the life span of worms that are starving, and helps to keep worms alive when they are struggling in conditions where oxygen is in short supply. (bbc.co.uk)
And eventually, the genes identified could lead to treatments for these conditions, as well as for diseases linked to prolonged or shortened fertility, such as breast cancer and osteoporosis, researchers say. (newscientist.com)
The researchers are already planning to explore if genes related to florigen in other crops can cause heterosis and improve yield. (eurekalert.org)
Researchers also found that the human Lef1 gene is not active in so-called serrated cancers of the large intestine, referring to the serrated pattern on the surface of the tumor formed by proliferating stem cell crypts. (eurekalert.org)
The researchers then conducted two animal studies to understand how the gene affects pain sensations in mice. (sciencedaily.com)
Bacteria with similar genes also had been reported in isolates from Malaysia, a development the researchers called "deeply concerning. (medscape.com)

Studies on twins showed that those with this gene, a vesicular monoamine transporter that regulates the flow of mood-altering chemicals in the brain, were more likely to develop a spiritual belief. (telegraph.co.uk)
Further analysis of the mice bearing the mutation clarified that the gene regulates a number of other genes that have previously-established connections to pain signalling. (sciencedaily.com)

DNA (deoxyribonucleic acid is the carrier of all our genes. (kidshealth.org)

Each person has two copies of the MTHFR gene: one from his or her mother and one from his or her father. (cdc.gov)
Rarely, a person with familial hypercholesterolemia is born with two mutated copies of the APOB gene. (medlineplus.gov)
Humans have about 30,000 genes and carry two copies of every gene, one copy from each parent. (amnh.org)
Most affected individuals have the Glu103Ter mutation in both copies of the MESP2 gene. (medlineplus.gov)

Spider webs look like the perfect trap for ensnaring insects, but a spider 'tree of life' based on hundreds of genes suggests many spiders jettisoned the web in favour of other ways of capturing prey. (nature.com)
Evidence suggests that the MITF gene transactivates the tyrosinase gene, which is involved in melanocyte differentiation. (medscape.com)
The finding of multiple-drug resistance in MCRPEC isolates suggests these organisms were able to recruit other resistance genes, "which could raise difficulties in the treatment of patients with clinical infection due to MCRPEC," the authors write. (medscape.com)
We found changes in those genes, which suggests that changes to DNA methylation as a result of physical activity could be one of the mechanisms through which these genes affect the risk of disease", says Tina Rönn, adding that this has never been studied in fat cells before and that they have now mapped the DNA methylome in fat. (lu.se)

The gene appears to protect tissues not only against cancer but also other potential threats, such as oxygen starvation. (bbc.co.uk)
The study also looked at the impact of paternally expressed genes: IGF2, PEG1, PEG3, DLK1, and DIO3 for transcriptomic and epigenomic alterations of the imprinted genes in fetal tissues. (genengnews.com)

However, a few people with spondylothoracic dysostosis have the Glu103Ter mutation in one copy of the MESP2 gene and either the Leu125Val or the Glu230Ter mutation in the other copy. (medlineplus.gov)
A mutation in one copy of the gene results in the exact dose of florigen required to cause heterosis. (eurekalert.org)

human insulin, for example, is now produced by bacteria containing the cloned insulin gene. (encyclopedia.com)
Scientists have uncovered evidence that one specific gene may play a crucial role in preserving human life under conditions of stress. (bbc.co.uk)
Tim Lightfoot, director of the Sydney and J.L. Huffines Institute for Sports Medicine and Human Performance at Texas A&M has authored papers on voluntary physical activity in rodents and humans, and he sees a connection between ADHD, exercise, and dopamine genes. (thedailybeast.com)
Human allantoicase gene: cDNA cloning, genomic organization and chromosome localization. (nih.gov)
Genomic organization and chromosome localization of the murine and human allantoicase gene. (nih.gov)
Lisa Schlager of Chevy Chase, Maryland, demonstrates outside of the Supreme Court as arguments were made in a case seeking to determine whether human genes can be patented. (howstuffworks.com)
On June 13, 2013, though, the U.S. Supreme Court ruled that human genes could not be patented -- but that brand new inventions that used or replicated DNA could. (howstuffworks.com)
Even before the 2013 ruling that human genes could not be patented, the judicial road that has led to today's laws regarding patent rights to substances made inside the human body has not always been bump-free. (howstuffworks.com)
Using a technique that analyses 480 000 positions throughout the DNA, they could see that epigenetic changes had occurred in 7 000 genes (a human has 20 000-25 000 genes). (lu.se)

Novartis Gene Therapies has developed a reproducible manufacturing process. (novartis.com)
Novartis Gene Therapies is committed to manufacturing excellence. (novartis.com)
Many safeguards are in place to develop safe and high-quality gene therapies. (novartis.com)

A new epilepsy gene for idiopathic epilepsy in Belgian Shepherds has been found in the canine chromosome 37. (sciencedaily.com)
By comparing the genome of dogs with epilepsy and healthy control dogs a gene region in chromosome 37 was discovered, which if homozygous, increases the risk of epilepsy seven-fold. (sciencedaily.com)
Epilepsy genes have not previously been identified in this chromosome region, so the discovery will reveal an entirely new epilepsy gene in dogs and possibly also in humans. (sciencedaily.com)
The Research group of Hannes Lohi has begun an extensive gene-sequencing project in which the entire identified chromosome region will be 'read through' with a next-generation sequencing method. (sciencedaily.com)

Humans and chimpanzees share about 98 percent of the same genes. (amnh.org)
However, humans have three forms of the p53 gene with overlapping functions which has made it difficult to pin down its exact role. (bbc.co.uk)
He pointed out: "Religious believers can point to the existence of god genes as one more sign of the creator's ingenuity - a clever way to help humans acknowledge and embrace a divine presence. (telegraph.co.uk)

The Lef1 gene is induced in tumors known as adenomas in the gut. (eurekalert.org)

DEB is caused by mutation(s) in the COL7A1 gene, which results in reduced or absent levels of biologically active COL7. (medscape.com)

CompoZr Zinc Finger Nucleases (ZFNs) are used to create modified cell lines with targeted gene deletions, gene insertions, or gene corrections. (sigmaaldrich.com)

The most common variant in the MTHFR gene is MTHFR C677T. (cdc.gov)
T or MTHFR 677 C→T. This means at the 677 position in the MTHFR gene, "C" is the expected DNA base and "T" is the gene variant. (cdc.gov)
Another common gene variant is the MTHFR A1298C variant. (cdc.gov)
This gene variant occurs at the 1298 position in the MTHFR gene. (cdc.gov)
This means at the 1298 position in the MTHFR gene, the expected DNA base "A", is replaced by "C", the gene variant. (cdc.gov)
Interestingly, the 7R variant of the DRD4 gene is more common in populations that have migrated long distances, as well as those that are nomadic, compared with settled populations. (thedailybeast.com)
His team found a variant near the gene associated with earlier breast development in girls and, in boys, earlier voice-breaking. (newscientist.com)

They then went on to look specifically at methylation in genes linked to type 2 diabetes and obesity. (lu.se)

The product is filtered to remove impurities and meticulously separate the full AAV vectors containing therapeutic genes from the empty ones. (novartis.com)
These vectors can be used both for direct injection (in vivo gene transfer) or transduction of cells in culture for subsequent transplantation (ex vivo gene transfer). (lu.se)

Particular versions of dopamine receptor genes have been associated with higher physical activity and lower body mass index. (thedailybeast.com)
[ 4 ] The 6 genes involved in WS are PAX3 (encoding the paired box 3 transcription factor), MITF (microphthalmia-associated transcription factor), EDN3 (endothelin 3), EDNRB (endothelin receptor type B), SOX10 (encoding the Sry bOX10 transcription factor), and SNAI2 (snail homolog 2), with different frequencies. (medscape.com)

Apr 14, 2019 · Gene Wolfe was an American science fiction and fantasy writer. (yahoo.com)
Apr 16, 2019 · Gene Wolfe , a towering figure in science fiction whose magnum opus The Book of the New Sun was hailed as a masterpiece by Ursula K Le Guin, has died at the age of 87. (yahoo.com)
Apr 29, 2019 · Between 1970 or so and the turn of the century, through a seemingly unending flow of novels and stories, the American science fiction writer Gene Wolfe , who has died aged 87, enjoyed a creative. (yahoo.com)
Apr 16, 2019 · Gene Wolfe , the author of such acclaimed books as The Fifth Head of Cerberus and The Book of the New Sun, died Sunday at age 87, "after his long battle with heart disease," according to his. (yahoo.com)

The FBI is offering a reward of up to $5,000 for information leading to the arrest of Vincent Eugene Tomera. (fbi.gov)

It is important to know that there are other extremely rare MTHFR gene variants not discussed here. (cdc.gov)
These gene variants may have significant effects on your health. (cdc.gov)
Multiple studies-including a meta-analysis of all published studies-have also replicated the finding that one of those variants, the 7R version of the DRD4 gene, increases an individual's risk for attention deficit hyperactivity disorder, or ADHD. (thedailybeast.com)
Genes also play a role in menopause, and two research teams have identified several gene variants associated with advancing or delaying menopause by as much as two years. (newscientist.com)
All four teams focused their hunts on gene variations found in at least 10 per cent of the population, while Stefánsson thinks that rarer variants may play a more significant role in menarche. (newscientist.com)

Instead, the abnormal genes are simply switched off. (msdmanuals.com)

But blood samples showed that the risk of RSV infection did not depend on levels of immune molecules, suggesting that RNAi's protective effect was due to the silencing of genes. (newscientist.com)
Using antisense technology, modified RNA molecules can combine with specific parts of the DNA, preventing the affected genes from functioning. (msdmanuals.com)

By identifying the specific gene mutation an individual's epilepsy risk could be assessed, although the gene mutation may also be common in dogs that never become symptomatic of epilepsy. (sciencedaily.com)

Most people with familial hypercholesterolemia inherit one altered copy of the APOB gene from an affected parent and one normal copy of the gene from the other parent. (medlineplus.gov)
This situation occurs when the person has two affected parents, each of whom passes on one altered copy of the gene. (medlineplus.gov)

These are known as transgenes and are specifically designed to replace the function of a gene that patients need. (novartis.com)

Genes carry the codes that make all living things. (amnh.org)
David Epstein on the genes that make us move-and their evolutionary purpose. (thedailybeast.com)
The yield-boosting power of this gene, which controls when plants make flowers, works in different varieties of tomato, and crucially, across a range of environmental conditions. (eurekalert.org)

Genes are sections of DNA, which is found in every cell in your body. (amnh.org)
They found that the gene plays a crucial role in killing off cells damaged by exposure to harmful substances such as radiation. (bbc.co.uk)
Indeed, two teams found that several other genes linked to height also predict age at menarche. (newscientist.com)
It could be down to a gene that controls cells' ability to process caffeine, scientists have found. (foodnavigator.com)
The higher their score, the greater a person's ability to believe in a greater spiritual force and, Dr Hamer found, the more likely they were to share the gene, VMAT2. (telegraph.co.uk)
They initially used mice that had been bred with the ZFHX2 gene entirely absent, and found them to have altered pain thresholds. (sciencedaily.com)

There are many different ways to use the term "gene" based on different aspects of their inheritance, selection, biological function, or molecular structure but most of these definitions fall into two categories, the Mendelian gene or the molecular gene. (wikipedia.org)

But scientists from the University of California have discovered that a rudimentary worm called a nematode carries only one version of the gene. (bbc.co.uk)
A set of scientists have proposed the controversial idea that hyperactivity and impulsivity may have had advantages in the ancestral state of man in nature, leading to the preservation of genes that increase ADHD risk. (thedailybeast.com)

Genes also play a role in a person's risk for some diseases and health conditions. (kidshealth.org)
Sometimes this method does not work because the liposomes are not absorbed into the person's cells, the new gene does not work as intended, or the new gene is eventually lost. (msdmanuals.com)

Each region of the DNA helix that produces a functional RNA molecule constitutes a gene. (wikipedia.org)

A genotype is the combination of the set of genes responsible for a particular trait. (cdc.gov)

The DNA containing the target gene(s) is split into fragments using restriction enzymes . (encyclopedia.com)
thus, a bacterial host will give rise to a colony of cells containing the cloned target gene. (encyclopedia.com)

The identified region has excellent neurological candidate genes for epilepsy and ongoing follow-up research is aimed to identify the specific gene causing epilepsy. (sciencedaily.com)

She said that although p53 was possibly the most studied gene in the world, the Californian research team had managed to shed new light on its function through studying the nematode worm. (bbc.co.uk)
There are only few genes in the identified region and I believe that the ongoing analyses will help us to discover the specific epilepsy gene," says Professor Hannes Lohi who led the research. (sciencedaily.com)
It is amongst these genes that future research may find new treatment targets for blocking of cancer stem cell niches. (eurekalert.org)
His findings were criticised last night by leading clerics, who challenge the existence of a "god gene" and say that the research undermines a fundamental tenet of faith - that spiritual enlightenment is achieved through divine transformation rather than the brain's electrical impulses. (telegraph.co.uk)
Our study shows that exercise has a positive effect, because the epigenetic pattern of genes that affect fat storage in the body is altered", says Charlotte Ling, research group leader for Epigenetics and Diabetes. (lu.se)

Using a lentiviral vector containing either H-Ras oncogene and a hairpin targeting p53 or both tumor suppressor genes, NF-1 and p53, Dr. Friedmann-Morvinski can induce the formation of a glioma tumor in mice injected in the brain. (genengnews.com)

The function of the Lef1 gene in the body is to regulate the activity of hierarchically downstream genes. (eurekalert.org)

Anatomy13

Organisms18

Diseases6

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment62

Psychiatry and Psychology8

Phenomena and Processes87

Disciplines and Occupations11

Anthropology, Education, Sociology and Social Phenomena1

Humanities3

Information Science19

Named Groups1

Health Care32

Geographicals5

Mutations27

Proteins6

Arguing that human genes1

Therapy23

Genetic11

Sequences3

Chromosomes2

Collagen type VII alpha 1 chain1

Expression10

Single gene7

Individual genes1

Protein14

Genetics3

Sequence5

Organism's1

CRISPR8

20231

Traits3

Ontology2

Researchers7

Regulates2

Deoxyribonucleic acid1

Copies4

Suggests4

Tissues2

Mutation in one copy2

Human9

Therapies3

Chromosome4

Humans3

Tumors1

COL7A11

Deletions1

Variant7

Methylation1

Vectors2

Receptor2

20194

5,0001

Variants5

Abnormal1

Molecules2

Individual's1

Copy of the gene2

Function of a gene1

Make3

Found6

Aspects1

Scientists2

Person's2

Produces1

Trait1

Target gene2

Specific gene1

Research5

Mice1

Regulate1