AllogeneicPeripheral blood stemGVHDAllelesDonor and recipientGenotypeChemotherapyGermlineRecipientTransplantGenesStemTumorHumanPatientsImmuneOccursHighCompatibilityDonorsTransplantationUmbilicalTransplantsStem cellHaploidenticalPatientsTissueCord bloodDestroyUnitsClinicalMortalityMatchCellsIndividuals
Allogeneic2
- Microtransplantation (MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
- Due to their HLA-independent mode of action, allogeneic Vγ9Vδ2 T cells can be considered for clinical application. (nature.com)
Peripheral blood stem1
- This is a single arm pilot study using TCR alpha/beta+ T cell-depleted peripheral blood stem cells (PBSC) from closely matched unrelated donors or partially matched/haploidentical related donors for hematopoietic stem cell transplant (HSCT) in patients with acquired and inherited bone marrow failure (BMF) syndromes. (sparkcures.com)
GVHD5
- Upper GI enteric GVHD occurs in approximately 13% of patients who receive HLA-identical transplants and manifests as anorexia and dyspepsia without diarrhea. (medscape.com)
- In contrast to organ/tissue transplant associated GvHD, the incidence of TA-GvHD is increased with HLA matching (first-degree or close relatives). (wikipedia.org)
- The degree of HLA disparity between donor and recipient is a well-known and widely accepted independent risk factor for GVHD development [ 2 ]. (hindawi.com)
- With the growing understanding of GVHD pathogenesis, there is increasing attraction to non-HLA genotype as a tool to GVHD prediction in the last ten years [ 3 ]. (hindawi.com)
- Recently published data suggest that enteral nutrition (EN), given as systematic artificial nutrition support, could decrease grade III-IV graft-versus-host disease (GVHD) and infectious events, which are associated with early toxicity after allo-HSCT and then have an impact on early transplant-related mortality (D100 mortality). (biomedcentral.com)
Alleles4
- These studies present evidence that an HLA-I genotype with two alleles with higher sequence divergence, known as the HLA-I evolutionary divergence (HED), may enable the presentation of more diverse immunopeptidomes and hence facilitate subsequent T cell recognition and the adaptive immune response. (biomedcentral.com)
- We developed a framework for inference of germline variants from tumor panel sequencing, including imputation, quality control, inference of genetic ancestry, germline polygenic risk scores, and HLA alleles. (biomedcentral.com)
- was found in 45% of patients and 35% of them had one or two HLA- em DRB1*04 /em alleles. (exposed-skin-care.net)
- Genetic studies have exhibited multiple HLA- em DRB1 /em alleles encoding a conserved sequence at amino acid positions 70C74 are associated with susceptibility and severity of RA. (exposed-skin-care.net)
Donor and recipient1
- Matched HLA between donor and recipient is not necessary. (wikipedia.org)
Genotype1
- The human leukocyte antigen class I (HLA-I) genotype has been linked with differential immune responses to infectious disease and cancer. (biomedcentral.com)
Chemotherapy1
- Chemotherapy is used by lower doses only to destroy cancer and partially suppress patient's immune system, which will be reinitiated by donor's stem cells soon after transplantation, and will play a role as recipient-versus-tumor (RVT) effect combining donor cells' graft-versus-tumor (GVT) effect. (wikipedia.org)
Germline2
- However, the clinical relevance of germline HLA-mediated immunity in gastrointestinal (GI) cancer remains elusive. (biomedcentral.com)
- We studied the associations of two parameters of germline HLA as heterozygosity and evolutionary divergence (HED, a quantifiable measure of HLA-I evolution) with the clinical outcomes of patients in both cohorts. (biomedcentral.com)
Recipient2
- citation needed] Donor's Requirements: Mismatched HLA with recipient Age between 18 and 60 years old Good overall state of health No major heart or lung surgical history No infectious diseases such as HIV, hepatitis or syphilis, etc. (wikipedia.org)
- If the cells are too mismatched the recipient can develop graft-versus-host disease. (cells4life.com)
Transplant1
- The impacts of nutritional support should exceed the limits of nutritional status improvement: EN may directly reduce immunological and infectious events, as well as decrease early transplant-related morbidity and mortality. (biomedcentral.com)
Genes3
- As the most polymorphic genes in the human genome, the HLA genes have a genetically predetermined background and play an essential role in host immune response. (biomedcentral.com)
- Variants of the HLA genes can possibly shape the sequence repertoire of neopeptides presented and influence the T cell receptor (TCR) repertoire during their continuous interaction [ 11 ]. (biomedcentral.com)
- In a speed-dating context, women, but not men, showed preferences for partners based on Major Histocompatibility Complex (MHC) complementarity through SNP analysis, with different SNPs influencing attraction directionally based on proximity to major HLA genes, and MHC-based indices held comparable influence to self-reported personality attributes in predicting second date offers for both genders. (dnaromance.com)
Stem1
- The further away in the family tree, the less likely that you can use that baby's stem cells as the chances of even partially matching get smaller. (cells4life.com)
Tumor1
- Of note, a combinatorial biomarker of HLA-B HED and tumor mutational burden (TMB) may better stratify potential responders. (biomedcentral.com)
Human2
- [10] It is less common in younger patients and in those with closer human leukocyte antigens (HLA) matches between donor and the patient. (wikipedia.org)
- γδ T cells, specifically the Vγ9Vδ2 subset, which is the dominate subset among γδ T cells in human peripheral blood, recognize target cells in a human leukocyte antigen (HLA)-independent manner. (nature.com)
Patients5
- For the PUCH cohort, we performed HLA genotyping by whole exome sequencing (WES) analysis on the peripheral blood samples from all patients. (biomedcentral.com)
- Interestingly, in both the PUCH and MSK GI cohorts, patients with high HLA-B HED showed a better OS compared with low HLA-B HED subgroup. (biomedcentral.com)
- Furthermore, patients with high HLA-B HED were characterized with a decreased prevalence of multiple driver gene mutations and an immune-inflamed phenotype. (biomedcentral.com)
- Our results unveil how HLA-B evolutionary divergence influences the ICB response in patients with GI cancers, supporting its potential utility as a combinatorial biomarker together with TMB for patient stratification in the future. (biomedcentral.com)
- Two hundred forty patients treated with allo-HSCT for a haematological malignancy will be randomly assigned to two groups to receive either EN or PN. (biomedcentral.com)
Immune1
- HLA typing looks at certain factors related to the immune system. (cells4life.com)
Occurs1
- Wheezing Wheezing is a high-pitched, whistling sound that occurs during breathing when the airways are partially blocked. (msdmanuals.com)
High1
- HLA- em DRB1 /em genotypes, high disease activity, high disability scores, and high levels of acute phase proteins [2]. (exposed-skin-care.net)
Compatibility1
- HLA testing needs to take place to determine compatibility. (cells4life.com)
Donors7
- 9. CD6+ T cell depleted allogeneic bone marrow transplantation from genotypically HLA nonidentical related donors. (nih.gov)
- These regions were classified as fully matched, partially matched, or mismatched between donors recipients. (nih.gov)
- These pentavalent VSTs were generated from healthy seropositive donors and were cryopreserved in aliquots that were available for immediate use in patients with refractory viral infections who were partially human leukocyte antigen (HLA)-matched with the VST donors. (medscape.com)
- This trial expands the use of transplantation by allowing the use of less closely matched donors, but the trial reduces the risks of the severe complications often associated with mismatched donor transplants by using a novel conditioning (chemotherapy and radiation) regimen. (nih.gov)
- Patients 18 to 70 years old - Patients must have available both: a)One or more potential related mismatched donors (biologic parent(s) or siblings (full or half) or children). (stanfordhealthcare.org)
- At least low resolution DNA based human leukocyte antigen (HLA) typing at HLA-A, -B, and -DRB1 for potential haploidentical sibling donors is required. (stanfordhealthcare.org)
- Recent use of unrelated and HLA non-identical donors has unfortunately increased the incidence of GvHD. (justia.com)
Transplantation10
- Reduced intensity conditioning (RIC) was used with either unrelated double umbilical cord blood (dUCB) or HLA-haploidentical related donor bone marrow (Haplo-marrow) transplantation. (nih.gov)
- 1. Intentional induction of mixed chimerism and achievement of antitumor responses after nonmyeloablative conditioning therapy and HLA-matched donor bone marrow transplantation for refractory hematologic malignancies. (nih.gov)
- 8. T-cell depletion plus salvage immunotherapy with donor leukocyte infusions as a strategy to treat chronic-phase chronic myelogenous leukemia patients undergoing HLA-identical sibling marrow transplantation. (nih.gov)
- 11. Unmanipulated HLA 2-3 antigen-mismatched (haploidentical) stem cell transplantation using nonmyeloablative conditioning. (nih.gov)
- Chemotherapy is used by lower doses only to destroy cancer and partially suppress patient's immune system, which will be reinitiated by donor's stem cells soon after transplantation, and will play a role as recipient-versus-tumor (RVT) effect combining donor cells' graft-versus-tumor (GVT) effect. (wikipedia.org)
- The preferred treatment is bone marrow/stem cell transplantation (BMT/SCT) from an HLA-identical healthy sib or close relative. (nih.gov)
- the other of which was BMT CTN 0603 , which used partially HLA-mismatched related bone marrow (Haplo-marrow) transplantation. (nih.gov)
- A Multi-Center, Phase III, Randomized Trial of RIC and Transplantation of (dUCB) Versus HLA-Haplo Related Bone Marrow for Patients With Hematologic Malignancies. (stanfordhealthcare.org)
- Transplantation of 2 partially HLA-matched umbilical cord blood units to enhance engraftment in adults with hematologic malignancy. (mja.com.au)
- With BMT, the patient may have either a related or unrelated donor who has the same or closely matched Human Leukocyte Antigen (HLA) typing necessary for successful transplantation. (health.mil)
Umbilical1
- Transplants included both matched and mismatched bone marrow cells, as well as umbilical cord cells. (medscape.com)
Transplants1
- Upper GI enteric GVHD occurs in approximately 13% of patients who receive HLA-identical transplants and manifests as anorexia and dyspepsia without diarrhea. (medscape.com)
Stem cell1
- Today the siblings are both being treated at LPCH, where they are receiving a ground-breaking treatment combining stem cell and kidney transplant from their HLA-partially matched parents. (omnia-health.com)
Haploidentical1
- Additional Patient Inclusion Criteria for Patients Assigned to Haploidentical BM Arm: Patients must be HLA typed at high resolution using DNA based typing at the following HLA-loci: HLA-A, -B, -C and DRB1 and have available a related haploidentical BM donor with 2, 3, or 4 HLA-mismatches. (stanfordhealthcare.org)
Patients8
- Eighty-four patients receiving an SCT from an HLA-identical sibling (n=68) or an unrelated donor (n=16) were analyzed. (nih.gov)
- For patients lacking a HLA-matched related donor, it is routine to initiate an unrelated donor search. (nih.gov)
- However some patients, particularly ethnic minorities, experience disease progression while awaiting identification of a suitably HLA-matched donor. (nih.gov)
- Patients less than 71 years of age with acute leukemia or lymphoma and lacking a suitable HLA-matched related donor were eligible to participate. (nih.gov)
- In a subset of patients, the partially HLA-matched (third-party) VSTs persisted for several weeks and were not associated with alloreactivity. (medscape.com)
- We performed a SNP array on chromosome 6 in CD34 + purified blasts from 19 patients diagnosed with advanced MDS and 8 patients with other myeloid malignancies to evaluate the presence of loss of heterozygosity (LOH) in HLA and its impact on disease progression. (oncotarget.com)
- LOH HLA was not detected in the remaining 24 patients, who all had adverse risk factors. (oncotarget.com)
- In summary, the clinical outcome of patients with advanced MDS might be influenced by HLA allelic loss, wich allows subclonal expansions to evade cytotoxic-T and NK cell attack. (oncotarget.com)
Tissue1
- This clinical trial is designed to allow transplant from a parent or other close relative who may be only a half match with respect to tissue typing (HLA pattern). (nih.gov)
Cord blood2
- and, one that uses two partially matched cord blood units. (stanfordhealthcare.org)
- Graft-versus-host disease in children who have received a cord-blood or bone marrow transplant from an HLA-identical sibling. (mja.com.au)
Destroy1
- However, in 2016 she acquired a fungal pneumonia that progressed to infect and partially destroy her chest bones leaving her doctors scrambling to find a treatment before it turned deadly. (nih.gov)
Units1
- Next, Remove the signal within 10 units around the precursor ions in the MS2 to avoid signal interference or mismatch caused by unfragmented precursor ions. (liangxiao.pro)
Clinical1
- Serotype-specific clinical manifestations may be partially determined by differences in cell tropism. (medscape.com)
Mortality1
- The fully matched D1S80 pairs showed a better overall survival (72% vs 38%) and lower non-relapse mortality (17% vs 50%) compared to the partially matched or mismatched pairs. (nih.gov)
Match1
- These siblings are benefiting from a method of graft engineering pioneered by the author that makes it safer to receive stem cells from a donor who does not have an exact HLA match. (omnia-health.com)
Cells1
- Moreover, as HLA-mismatched stem cells are employed, donor availability is extremely extended. (wikipedia.org)
Individuals1
- However, most individuals with ADA-deficient SCID lack an HLA-identical related donor. (nih.gov)