Partial nephrectomy (open or minimally invasive) usually requires temporary renal arterial occlusion to limit intraoperative bleeding and improve access to intrarenal structures. (hindawi.com)
The quest for trifecta comprising warm ischemia time less than 25 minutes, negative surgical margins and no perioperative complications seems to be better accomplished by robotic partial nephrectomy, which is likely to become the new standard for minimally invasive partial nephrectomy. (asmepress.com)
Although open partial nephrectomy is an efficacious procedure, a minimally invasive approach might be more attractive to patients [3]. (asmepress.com)
Renal14
The robotic approach to renal surgery, particularly partial nephrectomy, has some inherent challenges, and some familiarity with the da Vinci robotic system is necessary. (medscape.com)
Targeting HIF-1α to Prevent Renal Ischemia-Reperfusion Injury: Does It Work? (hindawi.com)
This is a time-critical step due to the critical ischemia period of renal tissue. (hindawi.com)
Prolonged renal ischemia may lead to irreversible nephron damage in the remaining tissue and, ultimately, chronic kidney disease. (hindawi.com)
The aim of this review is to highlight the techniques and drugs that target HIF-1 α and ameliorate IRI associated with renal ischemia. (hindawi.com)
Partial nephrectomy uses a nephron-sparing approach and is increasingly becoming the gold standard for smaller tumors, tumors in solitary kidneys and patients with underlying poor renal function. (hindawi.com)
The two key factors that contribute to postoperative loss of renal function are ischemia time and degree of parenchymal loss [ 2 ]. (hindawi.com)
Beyond this period, critical ischemia ensues, where renal cells are irreversibly injured, eventually resulting in nephron loss and chronic kidney disease in 5-17% patients [ 4 ]. (hindawi.com)
A pharmacological agent that could reduce the risk of IRI and prolong the "safe" warm ischemia time would cause a global transformational change in the utilization of partial nephrectomy, with broader implications for renal transplantation, cardiac surgery, and the myriad other surgeries that involve IRI. (hindawi.com)
Is Robotic-assisted Partial Nephrectomy an Efficacious and Safe Procedure for Removal of Stage T1 Renal Tumors? (asmepress.com)
18 years with a renal tumour of clinical stage T1 coming for robotic partial nephrectomy. (asmepress.com)
A total of 40 patients were included in the study who underwent robotic-assisted partial nephrectomy for renal tumours less than 7 cm in size. (asmepress.com)
The European Organization for Research and Treatment of Cancer" provided the first Level I evidence that long-term oncologic outcomes between partial nephrectomy and radical nephrectomy were equivalent, allowing partial nephrectomy to become a standard of care for small renal masses [2]. (asmepress.com)
La exposición al ozono médico como protector y reparador del daño orgánico ha demostrado ser eficaz en investigaciones donde se ha visto su potencial para proteger los tejidos hepático, renal, cardíaco, pulmonar, pancreático, muscular, esquelético, intestinal y cerebral. (ozonoadelo.com.ar)
Oxidative2
However, during ischemia the activity of the antioxidant enzymes is diminished, leading to an increase in the formation of superoxide radicals and oxidative stress at reperfusion [ 9 ]. (hindawi.com)
The ischemic preconditioning (lscheP) is an inducible and potent endogenous mechanism by which repeated episodes of brief ischemia/reperfusion (l/R) confer a state of protection against subsequent sustained l/R. On the other hand, it has been demonstrated that ozone is able to promote an oxidative preconditioning through the increase and preservation of antioxidant endogenous systems. (lomr.org)
Robotic3
Since that time, at least one multi-institutional survey has demonstrated superiority of the robotic approach when compared to laparoscopic for outcomes of blood loss, hospital stay and a substantially shorter warm ischemia time, while maintaining equivalence in positive margin rate, operative time and complications. (medscape.com)
As the technique of RAPN (robotic-assisted partial nephrectomy) continues to develop and mature, intraoperative & perioperative outcomes continue to be reported [4]. (asmepress.com)
Recently there have been several reports indicating that robotic surgery facilitates the resection of the tumour and intracorporeal suturing thus decreasing the warm ischemia time [6-8]. (asmepress.com)
Surgical2
None of the cases was converted to open partial/radical nephrectomy and none had positive surgical margins in the histopathology reports. (asmepress.com)
Current clinical data support a "safe" warm ischemia time of 25 minutes, or a cold ischemia time (when the kidney is placed on ice slush) of 35 min while up to two hours can be tolerated [ 4 ]. (hindawi.com)
Time2
However, while the majority of cancers are suitable for partial nephrectomy, concern about the warm ischemia time has meant that only around 25% of small kidney cancers are treated with nephron-sparing surgery [ 3 ]. (hindawi.com)