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  • They have variously concluded that paroxetine is superior or equivalent to placebo and that it is equivalent to other antidepressants. (wikipedia.org)
  • Despite this, there was no clear evidence that paroxetine was better or worse compared with other antidepressants at increasing response to treatment at any point in time. (wikipedia.org)
  • A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants ('mood elevators') such as paroxetine during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). (medlineplus.gov)
  • You should know that your mental health may change in unexpected ways when you take paroxetine or other antidepressants to treat depression or other mental illness even if you are an adult over 24 years of age. (medlineplus.gov)
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  • Paroxetine is also effective for children with obsessive-compulsive disorder. (wikipedia.org)
  • The efficacy of paroxetine in the treatment of major depressive disorder, social anxiety disorder, obsessive compulsive disorder (OCD), panic disorder (PD), generalized anxiety disorder (GAD) is presumed to be linked to potentiation of serotonergic activity in the central nervous system resulting from inhibition of neuronal reuptake of serotonin (5-hydroxy-tryptamine, 5-HT). (nih.gov)
  • Paroxetine is a selective serotonin reuptake inhibitor (SSRI) used in the therapy of depression, anxiety disorders and obsessive-compulsive disorder. (nih.gov)
  • Paroxetine is used for treating depression or obsessive-compulsive disorder (OCD). (nordaur.com)
  • Selective serotonin reuptake inhibitors (SSRIs) - like paroxetine - are thought to work by increasing levels of serotonin in the brain. (youngminds.org.uk)
  • We do not know how paroxetine mixes with street drugs, but it is likely to be similar to other SSRIs. (youngminds.org.uk)
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  • Talk to your child's doctor about these risks and whether your child should take an antidepressant, Children younger than 18 years of age should not normally take paroxetine, but in some cases, a doctor may decide that paroxetine is the best medication to treat a child's condition. (medlineplus.gov)
  • You may have to take paroxetine for a month or longer before you begin to feel better. (mayoclinic.org)
  • Take Paroxetine by mouth with or without food. (nordaur.com)
  • Continue to take Paroxetine even if you feel well. (nordaur.com)
  • Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetine. (caliexoticpharm.com)
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  • Two medications, paroxetine hydrochloride and sertraline hydrochloride, are approved treatments for PTSD by the Food and Drug Administration (FDA). (frontiersin.org)
  • Comparing data used for the approval of paroxetine and sertraline and pooled data from Phase 2 studies, MAPS demonstrated that MDMA-assisted psychotherapy constitutes a substantial improvement over available pharmacotherapies in terms of safety and efficacy. (frontiersin.org)
  • Studies of MDMA-assisted psychotherapy had lower dropout rates compared to sertraline and paroxetine trials. (frontiersin.org)
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  • In vitro studies in animals also suggest that paroxetine is a potent and highly selective inhibitor of neuronal serotonin reuptake and has only very weak effects on norepinephrine and dopamine neuronal reuptake. (nih.gov)
  • which reported an uncontrolled, open study of the treatment of primary insomnia with the selective serotonin reuptake inhibitor antidepressant paroxetine in 14 patients. (psychiatrist.com)
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  • We investigated whether chronic treatment with paroxetine, a selective serotonin reuptake inhibitor, mitigates Aβ pathology in plaque-bearing double-transgenic amyloid precursor protein (APP)swe/presenilin 1 (PS1)DE9 mutants. (nih.gov)
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  • In 2013, low-dose paroxetine was approved in the US for the treatment of moderate-to-severe vasomotor symptoms such as hot flashes and night sweats associated with menopause. (wikipedia.org)
  • You may also experience changes in your mental health if you are a woman taking a low dose of paroxetine to treat hot flashes and you have never had depression or another mental illness. (medlineplus.gov)
  • You will be closely monitored when you start Paroxetine and whenever a change in dose is made. (nordaur.com)
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  • Moreover, if a patient's urge to drink alcohol is so strong that he or she will rather skip a dose, Paroxetine withdrawal signs and symptoms may occur. (addictionresource.com)
  • The doctor or pharmacist will give you the manufacturer's patient information sheet (Medication Guide) when you begin treatment with paroxetine. (medlineplus.gov)
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  • In 2012, the United States Department of Justice fined GlaxoSmithKline $3 billion for withholding data, unlawfully promoting use in those under 18, and preparing an article that misleadingly reported the effects of paroxetine in adolescents with depression following its clinical trial study 329. (wikipedia.org)
  • A variety of meta-analyses have been conducted to evaluate the efficacy of paroxetine in depression. (wikipedia.org)
  • Paroxetine tablets, suspension (liquid), and extended-release (long-acting) tablets are used to treat depression, panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks), and social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life). (medlineplus.gov)
  • Reversible hepatotoxicity of paroxetine in a patient with major depression. (nih.gov)
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  • page needed] Several studies have concluded that paroxetine is superior to placebo in the treatment of panic disorder. (wikipedia.org)
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  • A pilot study done at their center, however, showed that paroxetine - which is approved by the US Food and Drug Administration for social anxiety disorder - was more effective than placebo in reducing social anxiety severity in individuals with co-occurring social anxiety disorder and alcoholism (Randall CL et al. (medscape.com)
  • A total of 22 individuals were randomized to placebo, and 20 individuals were randomized to paroxetine (starting at 10 mg daily and increasing to a target of 60 mg daily by week 4) for 16 weeks. (medscape.com)
  • Only 1 person in the paroxetine group and no one in the placebo group dropped out of the study. (medscape.com)
  • At week 16, the paroxetine group had a more than 50% reduction in baseline LSAS score vs a 32% reduction in baseline LSAS score for the placebo group. (medscape.com)
  • Paroxetine for Primary Insomnia: Possible Placebo Effect? (psychiatrist.com)
  • The documentation for drug registration contained 16 studies in which paroxetine had been randomised against placebo. (biomedcentral.com)
  • We included only double blind, parallel design studies with patients (all adults) randomised to either paroxetine or placebo. (biomedcentral.com)
  • Altogether 16 studies met these criteria (references 79 to 93 and 95 in the Expert Report), containing respectively 916 and 550 paroxetine and placebo treated patients. (biomedcentral.com)
  • One important exception was a study (reference 91) with a preponderance of paroxetine use over placebo and lasting for 17 weeks. (biomedcentral.com)
  • Taking this censoring into account, paroxetine treatment made up 190.7 patient years altogether and placebo 73.3 patient years. (biomedcentral.com)
  • Paroxetine is also FDA-approved for generalized anxiety disorder. (wikipedia.org)
  • Paroxetine capsules (Brisdelle) are used to treat hot flashes (sudden feelings of warmth, especially in the face, neck, and chest) in women who are experiencing menopause (stage of life when menstrual periods become less frequent and stop and women may experience other symptoms and body changes). (medlineplus.gov)
  • Do not stop using paroxetine suddenly, or you could have unpleasant withdrawal symptoms. (caliexoticpharm.com)
  • Moreover, Paroxetine interactions may range from mild symptoms to severe, life-threatening conditions such as arrhythmias, convulsions, and even coma. (addictionresource.com)
  • According to a study published in the journal of Alcohol Research and Health , in Paroxetine and alcohol interaction, alcohol can worsen the depressive symptoms of the patient. (addictionresource.com)
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  • We found that the probability of increased intensity of suicide attempts per year in adults taking paroxetine was 0.90 with a "pessimistic" prior, and somewhat less with two more neutral priors. (biomedcentral.com)
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  • Paroxetine associated hepatotoxicity: a report of 3 cases and a review of the literature. (nih.gov)
  • Do not use paroxetine within 14 days before or 14 days after you have used an MAO inhibitor , such as isocarboxazid , linezolid , methylene blue injection, phenelzine , rasagiline , selegiline , or tranylcypromine . (caliexoticpharm.com)
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