• Regulation Drug Development (Evaluative Studies 21) American Enterprise Institute (1975) ISBN 0844731676 Council on Drugs New Drugs and Developments in Therapeutics: Pargyline Hydrochloride (Eutonyl) JAMA. (wikipedia.org)
  • Pargyline hydrochloride has antihypertensive and anticancer activities. (medchemexpress.com)
  • Pargyline (hydrochloride) is a click chemistry reagent, itcontains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. (medchemexpress.com)
  • Dangerous potentiation of meperidine hydrochloride by pargyline hydrochloride. (webmd.com)
  • in neural stem cells was further backed with the observation that intracranial viral transduction from the LSD1 little interfering RNA (siRNA) or intraperitoneal shot from the LSD1 inhibitors pargyline and tranylcypromine resulted in dramatically decreased neural progenitor proliferation in the hippocampal dentate gyri of wild-type adult mouse brains. (sciencepop.org)
  • Nevertheless knockout of TLX appearance abolished the inhibitory aftereffect of pargyline and tranylcypromine on neural progenitor proliferation recommending that TLX is crucial for the LSD1 inhibitor impact. (sciencepop.org)
  • pargyline (Abbott), iproniazid and nialamide (both from Sigma-Chem) (all at 1 x 10 3 M), alpha - propyldopacetamide (Aldrich) and 6-fluorotryptophan (Regis) (both 1 x 10 4 M) did not alter 5HT level. (erowid.org)
  • The effect of this peptide was demonstrated not only when the HA turnover was determined by the pargyline-induced t-MH accumulation but when it was estimated by the HA depletion induced by α-fluoromethylhistidine, a specific inhibitor of histidine decarboxylase. (elsevierpure.com)
  • They silenced KDM1 expression with siRNA or inhibited it with pargyline or NCL-1 and found that reducing its expression or inhibiting it pharmacologically reduced glioma cell line growth in vitro. (medindia.net)
  • Pargyline is promoted only for the treatment of hypertension, and not for depression. (wikipedia.org)
  • In experiments with both human and animal beta cells, the researchers found that pargyline protects beta cells and increases their rate of survival. (jdrf.org.au)
  • In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme). (wikipedia.org)
  • They also found that renalase is similar to the protein targeted by a high blood pressure drug, pargyline, first made available more than 60 years ago. (jdrf.org.au)
  • When the histamine (HA) turnover in the brain of mice was estimated on the basis of the pargyline-induced accumulation of tele-methylhistamine (t-MH), a predominant metabolite of brain HA, the enhancing effect of phencyclidine (PCP) on the HA turnover was antagonized by a large dose of naloxone. (elsevierpure.com)
  • and are specifically inhibited by clorgyline and deprenyl, respectively while neither MAO -A nor MAO -B inhibitors (pargyline and clorgyline, respectively) could block renalase. (diff.org)
  • In addition to its actions as an MAOI, pargyline has been found to bind with high affinity to the I2 imidazoline receptor (an allosteric site on the MAO enzyme). (wikipedia.org)
  • After 1 month, an MAOI (pargyline, 10 mg/kg) and psychodynamic psychotherapy were added. (optio3.com)
  • Pargyline is promoted only for the treatment of hypertension, and not for depression. (wikipedia.org)
  • It also increased the l levels of 5-HIAA in whole brain and decreased the depletion of 5-HIAA caused by p-chlorophenylalanine (p-c.p.a.) or pargyline. (nottingham.ac.uk)
  • Single doses of carbamazepine increased the levels of NA in the midbrain and decreased the depletion of 5-HIAA after p-c.p.a. and pargyline. (nottingham.ac.uk)