XDE-795 (97.4% pure) was fed in diet to Sprague-Dawley rats (30/sex/dose) at 0, 5, 20 and 100 mg/kg/day, 7 days/week for 2 generations. (fluoridealert.org)
Possible effects on offspring from parental ethanol (64175) exposure were studied in male and female Sprague-Dawley-rats exposed at levels of 16000 and 10000 parts per million (ppm). (cdc.gov)
Accordingly, male Sprague-Dawley (SD) and Brown Norway (BN) rats were maintained on either regular (Reg) or high fat (HF) diets for 24wk. (cdc.gov)
Behavior14
Scientists from Harvard University have discovered brain circuits in mice that control parental behavior. (bostonglobe.com)
Scientists from Harvard University have discovered brain circuits in mice that control parental behavior, and they were able to induce abrupt transformations - making abusive male mice act like doting fathers, for example - through simple manipulations that one outside researcher called stunning. (bostonglobe.com)
But she said that the new research gives insight into powerful neural circuits that govern parental behavior at a basic level. (bostonglobe.com)
But Dulac found that a key brain circuit that controls parental behavior looks identical in male and female mice - a finding that she suggests has implications for fathers' potential to be as nurturing as mothers. (bostonglobe.com)
In animals ranging from rats to lions to monkeys, parental behavior differs drastically between males and females. (bostonglobe.com)
She is working under the guidance of Assistant Professor Mariana Pereira to study the neurobiology underlying parental behavior across the postpartum period. (umass.edu)
3. Ironically, the behavior of Black Rats ( Rattus rattus ) in the wild, transmitting the Black Death Plague of the bacterium Yersinia pestis , has been used as God's instrumentality for teaching irreverent humans-and for testing them regarding theological truth! (icr.org)
Rats who were bred to exhibit "normal" rat behavior had no reaction to SSRI "treatment. (madinamerica.com)
Parental behavior, a set of interactions aimed at the care and protection of the young, serves as a prime example of social behavior. (harvard.edu)
started a dissection of the behavior circuit underlying parental behavior, from brain regions to genetically-defined cell populations. (harvard.edu)
Furthermore, this study has identified a genetically defined population in the medial preoptic area (MPOA) governing parental behavior. (harvard.edu)
The MPOA of the anterior hypothalamus has previously been implicated in the control of maternal behavior in rats, as well as in many other brain functions such as thermoregulation and reproduction. (harvard.edu)
What is the molecular identity of the neural population involved in control of parental behavior? (harvard.edu)
These findings represent the first genetic characterization of command-like neurons for parental responses in vertebrates and illustrate how the activation of a single cell population is able to switch on/off a social behavior. (harvard.edu)
Exposure14
1981. Production of discrete changes in dopamine and noradrenaline levels and turnover in various parts of the rat brain following exposure to xylene, ortho-, meta-, and para-xylene, and ethylbenzene. (cdc.gov)
Early exposure to parental smoking appears to influence the development of the airways and predispose to respiratory symptoms. (bmj.com)
Both intrauterine and environmental exposure to parental tobacco smoking was related to more respiratory symptoms and poorer lung function in adulthood in this multicultural study. (bmj.com)
An expert panel constructed a job exposure matrix of parental occupational exposure to 50 Hz magnetic fields. (bmj.com)
Results: The total risk of birth defects was not associated with parental exposure. (bmj.com)
Conclusion: The present study gives an indication of an association between selected disorders of the central nervous system and parental exposure to 50 Hz magnetic fields. (bmj.com)
These results demonstrate that early alterations to 5-HT signaling through SSRI exposure may disrupt nurturing parental behaviors and 5-HT receptor expression in affected female rat offspring," the researchers write. (madinamerica.com)
Neurochemical, but not behavioral, deviations in the offspring of rats following prenatal or paternal inhalation exposure to ethanol. (cdc.gov)
The authors conclude that inhalation exposure to ethanol does not produce behavioral teratogenic effects in rats, but does produce neurochemical alterations. (cdc.gov)
The critical effects of acute duration iodomethane exposure are: (1) fetal losses in rabbits, (2) lesions in rat nasal epithelium, and (3) transient neurotoxicity in rats. (cdc.gov)
Chronic exposure of rats resulted in increased thyroid follicular cell tumors from sustained perturbation of thyroid hormone homeostasis. (cdc.gov)
Rats were euthanized at 7, 12, and 24wk to evaluate local and systemic immune markers corresponding to the baseline, exposure, and recovery phases of the study, respectively. (cdc.gov)
In BN rats, resolution of immune alterations was further compromised by HF diet, as many exposure-induced alterations in local/systemic immune markers were still evident in HF/WF animals at 24wk. (cdc.gov)
Collectively, HF diet appeared to have a greater impact on global immune status and exposure-induced lung injury in SD rats, but a more pronounced effect on inflammation resolution in BN rats. (cdc.gov)
Toxicity1
Metabolism and Toxicity of Thioacetamide and Thioacetamide S-Oxide in Rat Hepatocytes. (ku.edu)
Maternal4
Sarah's current research focuses on investigating neurobiological mechanisms of the dynamic maternal brain circuitry underlying cognitive, motivational, and affective processes at the chemical and genetic level in healthy rat mothers as well as in a rat model that exhibits heritable postpartum depression-like symptomatology. (umass.edu)
Specifically, rats exposed to SSRIs exhibited less licking and grooming of their pups during the nighttime, less arched-back nursing during the daytime, and went about their maternal care activities in an unpredictable and inconsistent manner compared with rats who were not exposed to SSRIs. (madinamerica.com)
The researchers also examined the brains of the rats, finding that those exposed to SSRIs had abnormal serotonin receptor expression in two areas of the brain thought to be involved in maternal care, the medial preoptic area and the prefrontal cortex. (madinamerica.com)
STERN, J. Somatosensation and maternal care in Norway rats. (bvsalud.org)
Wistar1
1963). Oleic, linoleic, and linolenic acids, and their triglycerides, were chlorinated with 36 Cl-chlorine and administered orally to male Wistar rats. (inchem.org)
Fischer1
97.4% pure) was fed in diet to Fischer 344 rats at 0, 5, 20 or 80 mg/kg/day for 1 2 years. (fluoridealert.org)
Norway1
Methods: The Medical Birth Registry of Norway was linked with census data on parental occupation. (bmj.com)
Hepatocytes1
Journal Article] Hepatocytic parental progenitor cells of rat small hepatocytes maintain a self-renewal capability after long-term culture. (nii.ac.jp)
Females3
Male rats were given 0, 750, 1500 or 3000 mg/kg neat JP-8 daily by gavage for 70 days prior to mating with naive females to assess fertility and sperm parameters. (europa.eu)
Males: The dose formulation was administered orally by gavage to specific group of rats at approximately the same time (± 2 hours from the time of test item administration on day 1 except on day 17, wherein it exceeded ±2 hours) each day for 2 weeks prior to mating and the treatment was continued during the mating period and until approximately 80% of the females delivered. (europa.eu)
Cell-type specific ablation of the MPOA Gal cells leads to parental defects in virgin females, mothers and fathers, whereas optogenetic activation of these neurons in virgin males suppressed pup-directed aggression and induces pup grooming. (harvard.edu)
Neural circuits1
Furthermore, these results provide a precious entry point for further dissection of neural circuits underlying parental care and pup-directed aggression. (harvard.edu)
Dose2
Here, an hTERT-BMSCs/Tet-on/GAL cell line was constructed using a single Tet-on-inducible lentivirus system, and subsequent experiments demonstrated that the secretion of rat GAL from hTERT-BMSCs/Tet-on/GAL was switched on and off under the control of an inducer in a dose-dependent manner. (hindawi.com)
Mammary transfer of chlorinated oleic acid to a 2-week-old suckling rat occurred to the extent of 15.9% of the parental dose in 24 hours, compared with 34.0% for unchlorinated oleic acid. (inchem.org)
Doses3
The test item was administered in graduated doses to three groups of male and female rats. (europa.eu)
Single oral doses of tritiated oleic acid of 36 Cl-chlorinated oleic acid were administered to groups of male rats which were then killed at periods of 1-28 days after administration. (inchem.org)
In rats, single doses cause centrilobular necrosis accompanied by increases in plasma transaminases and bilirubin. (ku.edu)
Alterations1
At 7wk, HF-fed animals exhibited several immune alterations (blood leukocyte/neutrophil number, lymph node B-cell proportionality)-effects which were more pronounced in SD rats. (cdc.gov)
Absorption2
2005. Effect of methyl substitution of benzene in the percutaneous absorption and skin irritation in hairless rats. (cdc.gov)
Absorption, distribution, and excretion Rats fed diets containing 4.1% lipids extracted from chlorine- treated flour showed a decrease in polyunsaturated fatty acids and a corresponding increase in palmitic, oleic, and palmitoleic acids in fat depots when compared with controls receiving 4.1% lipid from untreated flour. (inchem.org)
Pups1
Utilizing the same line, this study found that Trpc2 knockout virgin males do not attack pups and are parental, suggesting a key role of the vomeronasal system in controlling pup-directed aggression. (harvard.edu)
HOUSING1
Housing: The rats were housed individually in Makrolon type M III cages supplied by Becker & Co., Castrop-Rauxel, Germany (floor area of about 800 cm²). (europa.eu)
Study7
A study was undertaken to determine whether the consequences of parental smoking could be traced in adulthood. (bmj.com)
A new study in rats found that those who had been exposed to antidepressants in utero had an impaired ability to nurture their own children in later life. (madinamerica.com)
The rats in this study were exposed to citalopram (Celexa), a popular antidepressant. (madinamerica.com)
One criticism of the study is that it involved only healthy rats. (madinamerica.com)
However, in a previous study , researchers found that rats bred to exhibit "depressive-like" symptoms (anhedonia, passive stress coping, and psychomotor retardation) reacted to SSRIs with worsening symptoms over time. (madinamerica.com)
However, rats have long been considered a good proxy for studying biological effects that would be considered unethical to study in humans. (madinamerica.com)
The switch between the two opposing behaviors raises an important and fascinating question in the study of parental interactions. (harvard.edu)
Receptor2
To investigate the role of the cAMP-dependent protein kinase (PKA) in the desensitization and down-regulation of the D 1 dopamine receptor, we stably expressed the rat cDNA for this receptor in mutant Chinese hamster ovary (CHO) cell lines deficient in PKA activity. (aspetjournals.org)
The transfected parental and mutant cell lines were found to express ∼1 pmol/mg D 1 receptor binding activity ( B max ) as determined using [ 3 H]SCH-23390 binding assays. (aspetjournals.org)
Whenever rats are used for scientific experiments, in laboratories (or elsewhere) they are nicknamed "lab rats"-with some serving as the "control" group, to be compared with the "experimental" group, the latter being subjected so some kind of experimental event or condition, similar to the controlled experiment devised by the prophet Daniel in Babylon. (icr.org)
Neuromuscular abilities were similar to those in control rats. (cdc.gov)
Buy hot toys and hobbies like Ride On Cars for kids with parental remote control, RC Helicopters , Nitro Rc Cars , RC Cars , RC Planes , RC Submarines , RC Toys , and RC boats . (trendtimes.com)
Male4
In order to stagger delivery dates, male rats were paired with more than one female rat between 70 and 90 days of dosing with JP-8. (europa.eu)
Male rats were gavaged during cohabitation and returned to individual cages after successful mating. (europa.eu)
Male rats were cohabitated with one female at a time. (europa.eu)
Mating: During mating, two rats (one male and one female) were housed in standard polysulfone cages with stainless steel top grill having facilities for pelletted food and drinking water in polycarbonate bottles. (europa.eu)
Clone1
Targeted clone R-Olig2 (like the other clones) retained pluripotency, typical hESC morphology, and a normal parental karyotype 46,XY. (ca.gov)
Experimental1
Experimental and simulation studies in the rat. (wikipedia.org)
Cages1
Pre mating: Two rats of same sex were housed per cage in sterilized standard polysulfone cages (Size: L 425 x B 266 x H 175 mm), with stainless steel top grill having facilities to pelletted food and drinking water in polycarbonate bottles. (europa.eu)
Time2
The only time that the story slips is at the points where the friends, sitting at Anni's apartment speak jargons about the education system, parental pressure, and rat race. (wionews.com)
however, diet appeared to preferentially impact SD rats at this time point, as several inflammatory markers (lymph node cellularity, lung neutrophils) were further elevated in HF over Reg animals. (cdc.gov)
Race3
The three idiots, Rancchoddas Shyamaldas Chanchad (Aamir Khan), Raju Rastogi (Sharman Joshi) and Farhan Qureshi (R Madhavan), are perfect archetypes of the new age Indian who is essentially a non-conformist, questioning outmoded givens, choosing to live life on his own terms and chartering new roads that consciously skirt the rat race. (indiatimes.com)
Sometimes I feel bad being out of the parental rat race to get my kids up to speed on swimming and gymnastics and martial arts and violin and all that … but … meh. (hobomama.com)
Winning the Rat Race: Why is parental self-care important? (wisc.edu)
Decrease2
1 Even if some studies of children indicate that the harmful effects of parental smoking decrease when the children grow older, 4 there is some evidence of permanent damage to the airways with reduced lung function 10, 11 and an increased risk for asthma 12, 13 or wheezing illness 14 in adults exposed to parental smoking in childhood. (bmj.com)
90% down-regulation of D 1 receptors in the parental cell line but only a 50 and 30% decrease in the 10260 and 10248 cells, respectively. (aspetjournals.org)
Groups2
The researchers began with two groups of female rats: one group was exposed to SSRIs in utero, while the other group was not. (madinamerica.com)
The researchers then observed how the two groups of rats reacted to their own babies later on. (madinamerica.com)
Of course, they begin on the beaten track -- due to societal/parental pressure -- but refuse to become cogs in the wheel. (indiatimes.com)
Care1
This week, we talk about parental self-care and why it matters. (wisc.edu)
Relative1
The 10260 mutant CHO cell line has been characterized as expressing less than 10% of type I and type II PKA activities relative to the parental 10001 CHO cell line. (aspetjournals.org)
Important1
En conclusion, le TDAH représente un problème de santé important parmi les élèves du primaire à Mansoura, en Égypte. (who.int)
Method1
COPPA, or the Child Online Privacy and Protection Act of 1998, is a law in the United States requiring websites which can potentially collect information from minors under the age of 13 to have written parental consent or some other method of legal guardian acknowledgment, allowing the collection of personally identifiable information from a minor under the age of 13. (estima.com)
Children1
Parental choices about health, safety, and whatever else is best for children are part of what parenting is all about. (icr.org)
Expression1
This was corroborated by myoblast coculture, transplantation into the rat spinal cords, and whole genome expression profiling. (ca.gov)