Heterocyclic compounds are cyclic compounds in which one or more ring atoms are not carbon (that is, hetero atoms). (medmuv.com)
Antibody-drug conjugate1
The invention also relates to methods of using antibodies and antibody-drug conjugate compounds for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions. (justia.com)
Ethylene2
The parent compound is aziridine (or ethylene imine), with molecular formula C 2H 4NH. (wikipedia.org)
The bond angles in aziridine are approximately 60°, considerably less than the normal hydrocarbon bond angle of 109.5°, which results in angle strain as in the comparable cyclopropane and ethylene oxide molecules. (wikipedia.org)
Amines1
Aziridine is less basic than acyclic aliphatic amines, with a pKa of 7.9 for the conjugate acid, due to increased s character of the nitrogen free electron pair. (wikipedia.org)
Reactive2
Aziridines are reactive substrates in ring-opening reactions with many nucleophiles due to their ring strain. (wikipedia.org)
Cysteine engineered anti-MUC16 antibodies are engineered by replacing one or more amino acids of a parent anti-MUC16 antibody with non cross-linked, reactive cysteine amino acids. (justia.com)
Nitrogen4
Angle strain in aziridine also increases the barrier to nitrogen inversion. (wikipedia.org)
Thermolysis or photolysis of triazolines expels nitrogen, producing an aziridine. (wikipedia.org)
The aromatic heterocycles include such compounds as pyridine, where nitrogen replaces one of the СН groups in benzene, and pyrrole , in which the aromatic sextet is supplied by the four electrons of the two double bonds and the lone pair on nitrogen. (medmuv.com)
Morpholine is a six-membered ring containing oxygen and nitrogen, and its alkalinity is much lower than that of its parent piperidine. (chemenu.com)
Molecules1
Our ready-to-use ChemScene compound libraries consist of over 4000 small molecules with validated biological and pharmacological activities. (chemscene.com)
Cyclization2
According to DFT calculations (B3LYP/6-31+G(d,p)), the cycloaddition can involve two modes of nucleophilic attack of the dihydroazireno[2,1-b]oxazole intermediate on acetyl(methyl)ketene followed by aziridine ring opening into atropoisomeric oxazolium betaines and cyclization. (spbu.ru)
Aziridines are most commonly prepared by related cyclization reactions. (medmuv.com)
Organic1
Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)
Humans1
The International Agency for Research on Cancer (IARC) classifies aziridine compounds as possibly carcinogenic to humans (IARC Group 2B). (wikipedia.org)
Biological2
Bioactive compounds are a general term for a class of substances that can cause certain biological effects in the body, which are the main source of small molecule drugs. (chemscene.com)
MCE owns a unique collection of 17212 compounds with confirmed biological activities and clear targets. (chemscene.com)
Functional2
An amine functional group displaces the adjacent halide in an intramolecular nucleophilic substitution reaction to generate an aziridine. (wikipedia.org)
1,2-diamine substructures are prevalent functional motifs found in natural products, pharmaceutical compounds, and ligands. (uky.edu)
Drugs1
The analytical properties of these compounds are compared with the structurally similar 3,4-methylenedioxyamphetamine (MDA) derivatives, a popular series of drugs of abuse. (erowid.org)
Form1
Traditionally, it has been believed that a 1,2,3-triazoline is an unstable species in the presence of heat or light and will readily extrude N2 to form an imine or an aziridine. (uky.edu)
Chemical1
The nonaromatic compounds have physical and chemical properties that are typical of the particular hetero atom. (medmuv.com)
Specific2
The mass spectra for these compounds provide specific structural information for the identification of these compounds. (erowid.org)
These compounds generally penetrate cell membranes, act on specific target proteins in cells, regulate intracellular signaling pathways, and cause some changes in cell phenotype. (chemscene.com)
Similar2
similar products were obtained with some other carbonyl compounds. (go.jp)
Compounds of the HMDA series have UV absorption properties similar to the MDAs because both series contain the same 3,4-methylenedioxyphenyl chromophore. (erowid.org)
Organic compounds1
Common among these 10 interactions of organic compounds, their power to detect excess cancer agents is the electrophilic nature of or their metabolites, with DNA and R 1 risk at particular sites. (who.int)
Synthesis3
Nitrene addition to alkenes is a well-established method for the synthesis of aziridines. (wikipedia.org)
The Hoch-Campbell ethylenimine synthesis involves the reaction of certain oximes with Grignard reagents, which affords aziridines. (wikipedia.org)
The De Kimpe aziridine synthesis allows for the generation of aziridines by reacting an α-chloroimine with a nucleophile, such as hydride, cyanide, or a Grignard reagent. (wikipedia.org)
Mutagenic1
In making the overall evaluation, the IARC Working Group took into consideration that aziridine is a direct-acting alkylating agent, which is mutagenic in a wide range of test systems and forms DNA adducts that are promutagenic. (wikipedia.org)
Feature1
Comparing the Electronic Structure of Iron, Cobalt, and Nickel Compounds That Feature a Phosphine-Substituted Bis(imino)pyridine Chelate. (academictree.org)