Specific alkaline phosphatasePhosphorusCalciumAssayOsteopontinUrineCytokinesPrimary hyperparathyroidismOsteoblastUrinaryCollagenVitaminMarkersAnabolicProteinActivitySurvivalRegulatorLevelHumanTherapyActiveOsteoblastsHuman parathyroid hormoneOsteoblast differentiationMRNASerum osteocalcinMineralizationOsteoblasticBiomarkersPostmenopausal osteoporosisACTHGenesTestosteroneReplacement therapyEffectEffectsTotalCellsAdministrationWomen
Specific alkaline phosphatase3
- Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e', diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone- specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed. (fu-berlin.de)
- PEG-CS-PTH NP treated human primary osteoblast cells, upon PTH 1-34 receptor activation, produced second messenger-cAMP, which downstream stimulated intracellular calcium uptake, production of bone specific alkaline phosphatase, osteocalcin etc., which substantiates the anabolic effect of the peptide. (scilifelab.se)
- Measurement of serum alkaline phosphatase-in some cases, bone-specific alkaline phosphatase (BSAP)-along with several urinary markers, can be useful in the diagnosis of Paget disease. (medscape.com)
Phosphorus1
- High levels of serum parathyroid hormone (PTH) calcium (Ca) phosphorus (Phos) alkaline phosphatase (AP) and osteocalcin are common. (exposed-skin-care.net)
Calcium9
- An elevated concentration of serum calcium with elevated parathyroid hormone level is diagnostic of primary hyperparathyoidism. (wikidoc.org)
- Most consistent laboratory findings associated with the diagnosis of secondary hyperparathyroidism include elevated serum parathyroid hormone level and low to normal serum calcium . (wikidoc.org)
- An elevated concentration of serum calcium with elevated parathyroid hormone level in post renal transplant patients is diagnostic of tertiary hyperparathyoidism. (wikidoc.org)
- 20% of patients with proven primary hyperparathyroidism have normal total calcium and elevated parathyroid hormone . (wikidoc.org)
- Some patients with primary hyperparathyroidism may have elevated concentration of serum parathyroid hormone with normal serum calcium , which is usually suggestive of normocalcemic primary hyperparathyroidism. (wikidoc.org)
- Substantial clinical and laboratory data are presented (Table I). The subjects participating in the study had no endocrine disorder and no therapy involving steroids, oestrogens, vitamin D, parathyroid hormone or calcium supplements. (the-medical-dictionary.com)
- Parathyroid Hormone (PTH) Intact without Calcium Blo. (walkinlab.com)
- The Parathyroid Hormone (PTH) Intact without Calcium Blood Test measures the level of PTH in the blood to help screen for osteoporosis and other underlying health conditions. (walkinlab.com)
- Risk of osteoporosis is also directly linked to the use of many prescription and over-the-counter drugs: corticosteroids/steroids, thyroid hormones, anticonvulsants, aluminum containing antacids (ironically, often recommended as a calcium source by mainstream physicians), loop diuretics, gonadotropin-releasing hormones, and many others. (naturalmedicinejournal.com)
Assay2
- Method of choice for measuring intact parathyroid hormone include Immunoradiometric assay (IMRA) or Immunochemiluminescent assay (ICMA). (wikidoc.org)
- Furthermore, the degree of the proliferation and osteogenic differentiation of mesenchymal stem cells (MSCs) co-cultured with HGC-27 or SGC-7901 cells was analyzed by colony-formation assay, alizarin red staining, immunofluorescence, qPCR, immunoblotting, and alkaline phosphatase activity assay. (aging-us.com)
Osteopontin2
- The expression of the osteoblastic gene osteocalcin is reduced during embryonic life (days 18.5 and 19.5 post-coitum), whereas alkaline phosphatase and osteopontin levels are reduced early on but normalized or even increased by day 19.5 [ 18 ]. (biomedcentral.com)
- Alkaline phosphatase (ALP), osteocalcin (OCN), osteopontin (OPN), and runt-related transcription factor 2 (Runx2) are commonly used to evaluate differentiation and maturation of osteoblasts. (frontiersin.org)
Urine1
- Description: Quantitativesandwich ELISA kit for measuring Human Receptor-type tyrosine-protein phosphatase F (PTPRF) in samples from serum, plasma, urine, tissue homogenates, cell lysates. (scalegen.com)
Cytokines3
- Bone loss is associated with localized effects of metastatic deposits in the bone and/or systemic bone loss caused by bone resorption hormones or cytokines released into the systemic circulation by the gastric cancer [ 1 ]. (aging-us.com)
- The NPRC biomarker analyses laboratories analyze nonhuman primate (NHP) and human samples in all biomatrices for all reproductive hormones, metabolic hormones, neurotransmitters and peptides, cytokines and vitamins. (nprcresearch.org)
- The orderly progress of bone reconstruction is a complex process that involves many factors, including enzymes, hormones, and cytokines ( 2 ). (researchpad.co)
Primary hyperparathyroidism1
- A 10-year prospective study of primary hyperparathyroidism with or without parathyroid surgery. (thieme-connect.de)
Osteoblast1
- As the osteoblast transitions to an osteocyte, alkaline phosphatase is reduced, and casein kinase II is elevated, as is osteocalcin. (wikipedia.org)
Urinary1
- There is a mild elevation in bone turnover indices including serum alkaline phosphatase activity, osteocalcin , and urinary hydroxypiridinium collagen crosslinks. (wikidoc.org)
Collagen1
- 188 PTH and 1,25-&hydroxyvitamin D3 11,25-(OH)2D,), synthesize and secrete matrix proteins, such as collagen type 1 and osteocalcin, and are osteogenic when implanted in v~vo. (docksci.com)
Vitamin1
- Mann-Whitney U test and Univariate Logistic regression analysis showed that the cemented vertebra recompression was correlated with BMD, contact between bone cement and endplates, parathyroid hormone (PTH), and 25-hydroxy vitamin D3 (25-OH-D3). (biomedcentral.com)
Markers1
- New methods of measuring bone density and bone markers such as osteocalcin [serum bone-Gla-protein (BGP)] have made it possible to detect failure in bone mineral turnover and remodelling. (the-medical-dictionary.com)
Anabolic1
- Parathyroid hormone is the only anabolic medication. (ommegaonline.org)
Protein1
- Frequently, mesenchymal and hematopoietic progenitors are associated with the action of parathyroid hormone-related protein (PTHrP), a well-known regulator of tumour-associated bone destruction [ 1 ], as well as with the hypercalcemia seen in many types of cancer [ 2 ]. (aging-us.com)
Activity1
- Properties associated with the OB plasma membrane include alkaline phosphatase (AP) activity and the presence of parathyroid hormone (PTH) receptors,") although neither of these is unique to the OB. (docksci.com)
Survival1
- A number of other special tests can now be carried out on the blood taken, such as serological tests to show the course and survival of infections, and various hormone tests. (wmc.hu)
Regulator1
- The principal regulator of thyroid function is the pituitary hormone thyroid-stimulating hormone (TSH), which in turn is controlled by positive input from the hypothalamic hormone thyrotropin-releasing hormone (TRH) and by negative input from T4 and T3. (nationalacademies.org)
Level1
- Parathyroid hormone (PTH) level of the O 3 group was significantly higher than the AAP group (p=0.006). (eaht.org)
Human1
- Oral formulation of human parathyroid hormone 1-34 (PTH 1-34) is an alternative patient compliant route in treating osteoporosis. (scilifelab.se)
Therapy1
- Hormone replacement therapy does not have a role in pediatric management unless the low bone mass is attributable to hypogonadism. (medscape.com)
Active1
- 2001). Some T3, the active form of thyroid hormone, is secreted directly by the thyroid along with T4, but most T3 is produced from T4 by one of two deiodinases (Types I and II 1 ) in the peripheral tissue (Schneider et al. (nationalacademies.org)
Osteoblasts3
- 9. Involvement of alkaline phosphatase in the modulation of receptor signaling in osteoblasts: evidence for a difference between human parathyroid hormone-related protein and human parathyroid hormone. (nih.gov)
- Apart from Calcium, another nutrient that plays an important role in the mineralization of skeleton in Vitamin D. Osteocalcin, which is produced primarily by osteoblasts during bone formation, is considered to be one of the markers for osteoporosis. (ijrcog.org)
- Moreover, the effects of 0.25 μmol/L simvastatin on alkaline phosphatase activities of osteoblasts were most significant. (cjter.com)
Human parathyroid hormone2
- 2. [Effects of different human parathyroid hormone 1-34 administration on SaoS-2 cells]. (nih.gov)
- Nafarelin alone (200 microg intranasally twice daily) or nafarelin plus human parathyroid hormone-(1-34) (hPTH-[1-34]) (40 microg subcutaneously daily). (nih.gov)
Osteoblast differentiation2
- 12. Parathyroid hormone exerts disparate effects on osteoblast differentiation depending on exposure time in rat osteoblastic cells. (nih.gov)
- The effect of simvastatin on osteoblast differentiation was measured with alkaline phosphatase activities. (cjter.com)
MRNA2
- 4. Carboxyl-terminal parathyroid hormone peptide (53-84) elevates alkaline phosphatase and osteocalcin mRNA levels in SaOS-2 cells. (nih.gov)
- Moreover, serum from the FOP patient enhanced the levels of ALP, osteocalcin and bone morphogenetic protein-2 mRNA in these cells. (scirp.org)
Serum osteocalcin2
- There was an inverse correlation between T-scores and serum osteocalcin and alkaline phosphatase (AP) levels, on one hand, and Dpd, on the other. (medscape.com)
- Beg M, Akhtar N, Alam MF, Rizvi I, Ahmad J, Gupta A. Vitamin D status and serum osteocalcin levels in post-menopausal osteoporosis: Effect of bisphosphonate therapy. (ijrcog.org)
Mineralization2
- Osteogenic differentiation of caspase-8 deficient cells was inhibited as these cells displayed a decreased level of mineralization and lower activity of alkaline phosphatase. (frontiersin.org)
- Also, 1α,25(OH) 2 D 3 enhanced the alkaline phosphatase (ALP) activity and mineralization in HDPCs. (molcells.org)
Osteoblastic3
- 7. Second messenger signaling of c-fos gene induction by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: its role in osteoblast proliferation and osteoclast-like cell formation. (nih.gov)
- 11. Second messenger signaling in the regulation of cytosolic pH and DNA synthesis by parathyroid hormone (PTH) and PTH-related peptide in osteoblastic osteosarcoma cells: role of Na+/H+ exchange. (nih.gov)
- 17. Cross talk of dual-signal transduction systems in the regulation of DNA synthesis by parathyroid hormone in osteoblastic osteosarcoma cells. (nih.gov)
Biomarkers1
- Of the known biomarkers, tartrate-resistant acid phosphatase 5b (TRACP-5b), undercarboxylated osteocalcin (Uc-OC), and bone-specific alkaline phosphatase (BAP) have been shown to be useful for bone density, while homocysteine and pentosidine are reported to be excellent specific biomarkers for bone quality [ 11 ] and have been demonstrated to be useful for predicting bone mineral density (BMD) and fractures. (biomedcentral.com)
Postmenopausal osteoporosis1
- Due to the decline in estrogen levels in postmenopausal osteoporosis, hormone replacement therapy (HRT), such as estradiol, has been used to ameliorate the condition. (drugbank.com)
ACTH1
- Increased levels of plasma adrenocorticotropic hormone (ACTH), reduction of cortisol and aldosterone, hyponatremia and hyperkalemia are the most common laboratory abnormalities[1,3]. (researchsquare.com)
Genes1
- Other significantly down-regulated genes included those coding osteocalcin, bone morphogenetic proteins (-3, -4 and -7), collagens (-1a1, -14a1) or Phex . (frontiersin.org)
Testosterone1
- Testosterone is the hormone responsible for bone strength and breakdown in men. (innovareacademics.in)
Replacement therapy3
- Hormone replacement therapy does not have a role in pediatric management unless the low bone mass is attributable to hypogonadism. (medscape.com)
- 6 Thus, hormone replacement therapy is of limited value in the long term strategy to prevent or delay postmenopausal bone loss. (bmj.com)
- Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links. (ijrcog.org)
Effect1
- 19. [Effect of signal-selective parathyroid hormone analogue peptide on expressions of Wnt signaling factors]. (nih.gov)
Effects3
- 1. [The effects of continuous stimulation with different doses of parathyroid hormone 1-34 fragment on human SaoS-2 cells]. (nih.gov)
- The Agency for Toxic Substances and Disease Registry (ATSDR 2003) discussed four papers on thyroid effects and two papers on parathyroid effects and concluded that "there are some data to suggest that fluoride does adversely affect some endocrine glands. (nationalacademies.org)
- The following section reviews material on the effects of fluoride on the endocrine system-in particular, the thyroid (both follicular cells and parafollicular cells), parathyroid, and pineal glands. (nationalacademies.org)
Total2
- Total blood count along with blood hormones values counseled me inside the regular restrict.To evaluate the impact of irrigation canals in malaria tranny, a survey was performed within Dhenkanal region of Orissa, India. (8-bromo-camp.com)
- 19) As total pancreatectomy markedly reduces the pancreatic hormone level, leading to a mortal hypoglycaemia, we attempted to maintain plasma glucose within the normal range by constant I.V. (comparewords.com)
Cells1
- 18. Dibutyryl cyclic adenosine monophosphate differentially regulates cell proliferation in low and high alkaline phosphatase SaOS-2 human osteosarcoma cells: evidence for mediation by the insulin-like growth factor-II system. (nih.gov)
Administration1
- Short-term intermittent administration of parathyroid hormone (PTH) prevents bone loss from the spine in women treated with a gonadotropin-releasing hormone (GnRH) analog. (nih.gov)
Women1
- BMD and serum intact osteocalcin in post-menopausal osteoporosis women. (ijrcog.org)