ReversibleAnti-cholinesteraseCarbamateRivastigmineAcetylcholinesterase InhibitorsDonepezilPyridostigmineAChEMemantineBenzodiazepinesInhibitsAcetylcholineBChEPilocarpinePotentAlzheimer'sDrugsAgentsDrugReversible cholinesterase inhibitorIndirect-acting parasympathoCholinergicAnticholinesteraseMioticsPharmacologySelectiveAcetylcholinesteraseParasympatheticAgentDementiaSymptomsMechanismEffectsAction
Reversible5
- Pyridostigmine, a reversible cholinesterase inhibitor, is a parasympathomimetic. (ewha.ac.kr)
- Donepezil Hydrochloride (E2020) is a reversible, selective AChE inhibitor with an IC 50 of 6.7 nM for AChE activity. (medchemexpress.com)
- Physostigmine salicylate (Eserine salicylate) is a reversible acetylcholinesterase ( AChE ) inhibitor. (medchemexpress.com)
- Galantamine is a parasympathomimetic, specifically, a reversible cholinesterase inhibitor. (pharmacycode.com)
- Eserine is a parasympathomimetic alkaloid, specifically, a reversible cholinesterase inhibitor. (galchimia.com)
Anti-cholinesterase2
- Cholinesterase inhibitors (ChEIs), also known as anti-cholinesterase, are chemicals that prevent the breakdown of the neurotransmitter acetylcholine or butyrylcholine. (wikipedia.org)
- Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica , exerts anti-cholinesterase properties towards acetyl cholinesterase ( AChE ) and butyrylcholinesterase ( BChE ) with IC 50 s of 0.66 µM and 7.39 µM, respectively. (medchemexpress.com)
Carbamate1
- PubChem] Indication: For the treatment of poisoning by susceptible organophosphorous nerve agents having cholinesterase activity as well as organophosphorous or carbamate insecticides. (sdrugs.com)
Rivastigmine1
- Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. (wikipedia.org)
Acetylcholinesterase Inhibitors2
- This group of inhibitors is divided into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase inhibitors (BChEIs). (wikipedia.org)
- Galantamine is in a class of medications called acetylcholinesterase inhibitors. (pharmacycode.com)
Donepezil1
- Donepezil is a specific and potent AChE inhibitor. (medchemexpress.com)
Pyridostigmine1
- Pyridostigmine - A cholinesterase inhibitor with a slightly longer duration of action than neostigmine. (sdrugs.com)
AChE3
- There are two types: acetylcholinesterase (AChE, acetylcholine hydrolase) and butyrylcholinesterase (BChE, acylcholine acylhydrolase), also known as nonspecific cholinesterase or pseudocholinesterase. (medchemexpress.com)
- The difference between the two types of cholinesterase is their relative preferences for substrates: AChE hydrolyzes acetylcholine faster while BChE hydrolyzes butyrylcholine faster. (medchemexpress.com)
- Galanthamine is a potent acetylcholinesterase ( AChE ) inhibitor with an IC 50 of 500 nM. (medchemexpress.com)
Memantine1
- Cholinesterase inhibitors and memantine for dementia. (wikipedia.org)
Benzodiazepines1
- John Baker summarises a review of commonly prescribed medication that covers seven psychiatric drugs, including antidepressants, antipsychotics, benzodiazepines, amphetamines, methylphenidate and cholinesterase inhibitors. (nationalelfservice.net)
Inhibits1
- TMPyP4 tosylate is a telomerase inhibitor and inhibits cancer cells proliferation. (medchemexpress.com)
Acetylcholine1
- Cholinesterase (ChE) is a family of enzymes present in the central nervous system, particularly in nervous tissue, muscle and red cells, which catalyze the hydrolysis of the neurotransmitter acetylcholine into choline and acetic acid, a reaction necessary to allow a cholinergic neuron to return to its resting state after activation. (medchemexpress.com)
BChE1
- Tetra (monoisopropyl) pyrophosphoramide (Iso-OMPA) and ethopropazine are selective BChE inhibitors. (wikipedia.org)
Pilocarpine1
- The most commonly used parasympathomimetic to treat primary glaucoma is 2% pilocarpine. (wedgewoodpharmacy.com)
Potent2
- Demecarium bromide is a potent, long acting cholinesterase- inhibitor used topically to treat acute glaucoma. (wedgewoodpharmacy.com)
- α-NETA is a potent and noncompetitive choline acetyltransferase (ChA) inhibitor with an IC 50 of 9 μM. (medchemexpress.com)
Alzheimer's1
- Physostigmine is a covalent inhibitors, it is used to treat glaucoma, Alzheimer's disease , and delayed gastric emptying. (galchimia.com)
Drugs6
- ChEIs are indirect-acting parasympathomimetic drugs. (wikipedia.org)
- Parasympathomimetic drugs cause contraction of the muscles associated with the ciliary body and of the iris sphincter. (wedgewoodpharmacy.com)
- Parasympathomimetic drugs also increase aqueous humor protein and may cause vasodilation of the conjunctiva. (wedgewoodpharmacy.com)
- Parasympathomimetic drugs may cause a flare up of iritis. (wedgewoodpharmacy.com)
- Sympathomimetic drugs such as dipivefrin also increase the outflow of aqueous humor but by a different mechanism than the parasympathomimetic drugs such as demecarium bromide. (wedgewoodpharmacy.com)
- The update of a 2007 Cochrane review of parasympathomimetic drugs for dry mouth after radiotherapy did not identify an new studies. (nationalelfservice.net)
Agents1
- Cholinesterase inhibitors came to a public attention in 2020 when Russian opposition and dissent figure Alexei Navalny was treated in Berlin Charité hospital for alleged poisoning by a Russian-made nerve agent which is known since 2019 as belonging to the Novichok agents subgroup of ChEI. (wikipedia.org)
Drug1
- Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (bvsalud.org)
Reversible cholinesterase inhibitor2
- Tacrine is a parasympathomimetic- a reversible cholinesterase inhibitor that is indicated for the treatment of mild to moderate dementia of the Alzheimer's type. (illumina.com)
- Pyridostigmine trade name Mestinin is a parasympathomimetic and a reversible cholinesterase inhibitor. (allaboutheaven.org)
Indirect-acting parasympatho2
- ChEIs are indirect-acting parasympathomimetic drugs. (wikipedia.org)
- Demecarium is an indirect-acting parasympathomimetic agent, also known as a cholinesterase inhibitor and anticholinesterase. (aksci.com)
Cholinergic1
- These new therapies involve the development of novel and more selective cholinergic agonists and allosteric modulators as well as selective cholinesterase inhibitors, which may improve cognitive and behavioral symptoms, and also provide neuroprotection in several brain diseases. (okstate.edu)
Anticholinesterase1
- The mechanism of tacrine is not fully known, but it is suggested that the drug is an anticholinesterase agent which reversibly binds with and inactivates cholinesterases. (illumina.com)
Miotics1
- Some sources use the term miotics only for the parasympathomimetics but any drug used to induce miosis is included here. (bvsalud.org)
Pharmacology1
- Parasympathomimetics and parasympatholytics Pharmacology. (slideshare.net)
Selective1
- Tetra (monoisopropyl) pyrophosphoramide (Iso-OMPA) and ethopropazine are selective BChE inhibitors. (wikipedia.org)
Acetylcholinesterase2
- This group of inhibitors is divided into two subgroups, acetylcholinesterase inhibitors (AChEIs) and butyrylcholinesterase inhibitors (BChEIs). (wikipedia.org)
- Paraoxon and rivastigmine are both acetylcholinesterase inhibitors and butyrylcholinesterase inhibitors. (wikipedia.org)
Parasympathetic1
- Parasympathomimetic is used specifically to describe an ACh-like effect on effector cells innervated by postganglionic neurons of the parasympathetic nervous system (PSNS). (veteriankey.com)
Agent2
- Cholinesterase inhibitors came to a public attention in 2020 when Russian opposition and dissent figure Alexei Navalny was treated in Berlin Charité hospital for alleged poisoning by a Russian-made nerve agent which is known since 2019 as belonging to the Novichok agents subgroup of ChEI. (wikipedia.org)
- It is used as a parasympathomimetic bronchoconstrictor agent and as a diagnostic aid for bronchial asthma. (lookformedical.com)
Dementia1
- Cholinesterase inhibitors and memantine for dementia. (wikipedia.org)
Symptoms1
- Routine administration of atropine with MYTELASE is contraindicated since belladonna derivatives may suppress the parasympathomimetic (muscarinic) symptoms of excessive gastrointestinal stimulation, leaving only the more serious symptoms of fasciculation and paralysis of voluntary muscles as signs of overdosage. (nih.gov)
Mechanism1
- PB is structurally related to neostigmine bromide and neostigmine methylsulfate which have demonstrated significant inhibition of chemically-induced liver, stomach, or colon tumors in rats, presumably through a parasympathomimetic mediated mechanism. (nih.gov)
Effects1
- Like neostigmine, MYTELASE suppresses cholinesterase but has the advantage of longer duration of action and fewer side effects on the gastrointestinal tract. (nih.gov)
Action1
- and cholinesterase inhibitors, which allow endogenous ACh to accumulate and thereby intensify and prolong its action (Brown and Taylor, 2006). (veteriankey.com)