• Myeloma cells produce an abnormal type of immunoglobulin called paraprotein (also known as monoclonal immunoglobulin, myeloma protein, or simply M protein). (leukaemia.org.au)
  • Monoclonal gammopathy of undetermined significance (MGUS) is a premalignant hematological condition arising from B‑cells, characterized by the presence of monoclonal immunoglobulin production, also known as paraprotein. (springermedizin.at)
  • MGUS is defined as bone marrow clonal plasma cells less than 10% in the setting of a paraprotein in the serum or urine or both (serum M-protein less than 3 g/dL [30 g/L]) and the absence of plasma cell-related end-organ damage. (mhmedical.com)
  • Multiple myeloma (MM) is a plasma cell malignancy in which monoclonal plasma cells proliferate in bone marrow, resulting in an overabundance of monoclonal paraprotein (M protein), destruction of bone, and displacement of other hematopoietic cell lines. (medscape.com)
  • The cancerous myeloma cells typically produce immunoglobulins (monoclonal antibodies), which are often referred to as a paraprotein or M-protein. (vin.com)
  • Her multiple myeloma then stabilised with a paraprotein level falling to 13 g/L. Over the following 5 years she only took curcumin and her myeloma has continued to remain stable, her blood counts are in the normal range, and there has been minimal fluctuation in her paraprotein levels. (canceractive.com)
  • In myeloma, abnormal plasma cells release only one type of antibody known as paraprotein, which has no useful function. (myeloma.org.au)
  • It is often through the measurement of this paraprotein that myeloma is diagnosed and monitored. (myeloma.org.au)
  • Particular interests are transplant rejection, electron microscopy and paraprotein-related renal injury. (kcl.ac.uk)
  • Filtration of the paraprotein by the kidneys leads to abnormal kidney function and even kidney failure. (vin.com)
  • This model from the same Minnesota population proposes a risk-stratification model based on serum M-protein concentration, type of paraprotein, and presence of an abnormal serum free kappa:lambda light chain ratio (Rajkumar 2005). (qxmd.com)
  • Type 1 cryoglobulinemia is from a paraprotein produced by a plasma cell dyscrasia or a lymphoproliferative disorder. (asn-online.org)
  • Subsequent immunofixation with electrophoresis identified the monoclonal protein as an IgG antibody (paraprotein) with a lambda light chain (arrow). (medscape.com)
  • The clinical manifestations of Waldenström macroglobulinemia result from the presence of the IgM paraprotein and malignant lymphoplasmacytic cell infiltration of the bone marrow and other tissue sites. (medscape.com)
  • A study by Pasricha et al found that bone marrow features, particularly the degree of plasma cell infiltration, correlates with IgM paraprotein concentration at diagnosis. (medscape.com)
  • By the third month of follow up, serum and CSF paraprotein disappeared and lytic skull lesions regressed. (bmj.com)
  • Serum immunofixation showed a monoclonal IgG kappa paraprotein. (asn-online.org)
  • MM is matological malignancies, which can be up characterized by monoclonal paraprotein to 75% in acute leukaemia. (who.int)
  • No symptoms and no organ damage from the paraprotein. (mhmedical.com)
  • This case highlights how IgM paraprotein can interfere with creatinine estimation by enzymatic assay and the utility of alternative methods of estimating serum creatinine. (elsevierpure.com)
  • Results of immunofixation with antibodies against G, M, and A heavy chains and κ and λ light chains were negative, indicating that this additional electrophoretic fraction did not indicate the presence of a paraprotein. (aacc.org)
  • Serum protein electrophoresis revealed the presence of an IgM paraprotein. (elsevierpure.com)
  • Excessive levels of paraprotein increase the "thickness" of the blood and result in hyperviscosity syndromes that may damage the eye (causing blindness), the nervous system (causing nerve or brain signs), the heart (cardiomyopathy), or in blood clotting (bleeding tendencies). (vin.com)
  • It would seem that platelet clumping in this case was due to the abnormally raised paraprotein level. (blogspot.com)
  • An atypical case of SSc should always include skin biopsy (including fascia), paraprotein and focused system review to exclude mimics of SSc including paraneoplastic conditions. (medscape.com)
  • As the paraprotein level was reduced, so the platelet clumping subsided. (blogspot.com)
  • during which time patients are at risk for paraprotein flare and HVS. (medscape.com)
  • Only 4 of the 31 patients did not demonstrate at least a 25% reduction in paraprotein, and the majority of patients achieved at least a 50% reduction. (ascopost.com)
  • First, secretion of the IgM paraprotein leads to hyperviscosity and vascular complications because of physical, chemical, and immunologic properties of the paraprotein. (medscape.com)
  • Thus, the anti-MAG IgM antibodies which are present in IgM paraprotein associated neuropathies outline a comparatively uniform medical and prognostic phenotype. (aetox.com)
  • This abnormal protein is known by several different names, including monoclonal immunoglobulin , monoclonal protein (M protein ) , M spike , or paraprotein . (cancer.org)
  • The aim of this study was to analyze prothrombotic coagulation disorders in patients with paraprotein-producing B-cell disorders, such as MGUS, systemic amyloidosis, Waldenström's macroglobulinemia, and MM. (medscape.com)
  • Weird disturbances of fibrinogen cleavage will elevate both thrombin and reptilase time, and these include excessive fibrin degradation byproducts, paraprotein, amyloidosis, and so forth. (derangedphysiology.com)
  • Because paraproteins have different physical and chemical properties, there isn't a direct link between the amount of paraprotein in the blood and how thick the blood is. (medical-definitions.net)
  • A persistent polyclonal elevation in IgG, A and M was noted, with the IgM kappa paraprotein increased to 3.3 g/L. Serum ferritin was mildly elevated (361 μg/L, normal range 18-325). (biomedcentral.com)
  • and CBR, or clinical benefit rate, is MR [minor response] or greater, so a 25% reduction in paraprotein or greater. (cancernetwork.com)
  • 100% of pts achieved a reduction of paraprotein, 18/19 a 100% reduction. (ehaweb.org)
  • 18. Paraprotein deposits in the skin. (nih.gov)
  • Regular blood tests are performed to measure your paraprotein and/or light chain level. (myeloma.org.uk)
  • In that case, the test should be done again, but this time special care should be taken to keep the blood at 37°C because the paraprotein may form clumps at room temperature. (medical-definitions.net)
  • The IgM paraprotein is usually made by these cells, and many of the symptoms of the disease are linked to this macroglobulin. (medical-definitions.net)
  • It is of particular interest that in this paraprotein the major component is a biantennary complex-type oligosaccharide that lacks a fucose residue and an oligosaccharide with the structure (Formula: see text) exists as one of the most abundant components. (nih.gov)