• Here we characterized the effect of intraspinal grafting of clinical grade human fetal spinal cord-derived neural stem cells (HSSC) on the recovery of neurological function in a rat model of acute lumbar (L3) compression injury. (biomedcentral.com)
  • Three-month-old female Sprague-Dawley rats received L3 spinal compression injury. (biomedcentral.com)
  • Peri-acute intraspinal grafting of HSSC can represent an effective therapy which ameliorates motor and sensory deficits after traumatic spinal cord injury. (biomedcentral.com)
  • However, both strategies are associated with a substantial risk of spinal cord ischemia, which has been reported to occur-even in contemporary series by expert centers-in up to 12% of patients, depending on the extent of the disease. (bvsalud.org)
  • This concept of priming the collateral network in order to improve spinal cord blood supply showed promising experimental and early clinical outcomes, and consequently led to the initiation of the randomized controlled multicenter PAPAartis trial (Paraplegia Prevention in Aortic Aneurysm Repair by Thoracoabdominal Staging). (bvsalud.org)
  • Syrinx size, spinal cord dimensions, and extent of scarring were measured by magnetic resonance imaging. (biomedcentral.com)
  • however, differential diagnoses also included L4-S3 myelopathies, such as spinal column trauma, fibrocartilaginous embolic myelopathy, Hansen type I intervertebral disk disease, and myelitis. (hindawi.com)
  • Intraspinal grafting of human neural stem cells represents a promising approach to promote recovery of function after spinal trauma. (biomedcentral.com)
  • Extensive experimental and clinical data show that the mechanisms leading to a clinically-defined loss of neurological function after spinal trauma can in general be considered in two categories. (biomedcentral.com)
  • MIS2ACE can be performed under local anesthesia, enabling continuous monitoring of neurological function, and in case of clinical signs of imminent ischemia, preemptive interruption of the procedure. (bvsalud.org)
  • We hypothesize that younger patients suffer more extensive DeBakey type I dissection due to aortic wall integrity, allowing unhindered extension within the layers. (bvsalud.org)
  • Spinal Epidural Fistula is a rare (or, more correctly, rarely diagnosed) fistula between the epidural arterial arcade (also known as the retrocorporeal arcade, since it is located behind the vertebral body) and the epidural venous plexus, as seen in the diagram below. (neuroangio.org)
  • On the venous side, the ventral epidural venous plexus "D" is extensively connected up and down along the spinal canal, and communicates via multiple foraminal arteries (E) with the paraspinal veins (large vertical blue syllinders). (neuroangio.org)
  • The spinal bridging veins "F" connect the intradural spinal surface veins (G, H) with the extradural veins of the epidural venous plexus and foraminal veins. (neuroangio.org)
  • It is likely that many of these fistulas are asymptomatic, because of the many connections between components of the epidural plexus and with paraspinal veins outside the spinal canal via the foraminal veins (F). Thus, spine surface veins (G,H), remain unaffected despite their potential connection with the epidural plexus. (neuroangio.org)
  • Given this kind of venous redundancy, one would expect that an epidural fistula would be efficiently decompressed both via longitudinal connections of the epidural plexus and via foraminal veins, without causing any changes in the spinal veins. (neuroangio.org)
  • Sometimes, patients with extra-spinal AVMs ( Parkes-Weber Syndrome , for example) have their AVM venous drainage conducted into the epidural venous plexus - again, this does not congest spinal veins, as a rule. (neuroangio.org)
  • However, some epidural fistulas do become symptomatic by reflux of venous outflow into the spinal veins, as seen in the diagram below. (neuroangio.org)
  • Therefore, intraoperative neurophysiological monitoring (IONM) has been widely used for the purpose of minimizing the risk of postoperative neurological deterioration in spinal surgery by early detection of the electrophysiological signs of neural insult [ 5 ]. (e-arm.org)
  • The neurological dysfunctions were assessed by calculating the motor deficit index after ischemia surgery. (mirnainhibitors.com)
  • The incidence of iatrogenic neural injury during scoliosis surgery has been reported to be 1%-1.87%, which is relatively lower than that in other spinal surgeries [ 3 , 4 ]. (e-arm.org)
  • Motor evoked potentials (MEPs) and somatosensory evoked potentials (SEPs) have been used as the main modalities of IONM during spinal surgery. (e-arm.org)
  • Indeed, the number of people with cognitive decline will double in the next 25 years, due to the increase in life expectancy. (lilncog.eu)