Paraffin embedded human nodal protein. Medical search. Frequent questions

Both CD4+ and CD8+ NPM-ALK-edited T lymphocytes showed rapid and reproducible competitive advantage in culture and led to in vivo disease development with nodal and extra-nodal features. (biomedcentral.com)
By 8-12 months of age approximately 15% of the mice with cutaneous papillomas (15/100) developed splenomegaly, lymphadenopathy and extra-nodal involvement of liver, gastrointestinal tract and central nervous system (Figure 1 C, D). H&E staining of lymphoid organs liver (Figure 1 E), lymph node (Figure 1 F) and spleen (Figure 1 H) showed all with atypical lymphomatous infiltration. (biomedcentral.com)

Antibody is used with formalin-fixed and paraffin-embedded sections. (thermofisher.com)
The specimens were formalin-fixed and paraffin embedded. (iiarjournals.org)

Larger size, nodal spread, and metastasis have a larger stage number and a worse prognosis. (wikipedia.org)
Additionally, a high HDAC2 expression was significantly associated with an overexpression of HER2 (n=203, p=0.005) and the presence of nodal metastasis (n=200, p=0.04). (biomedcentral.com)
Our data showed that TRIP13 overexpression was correlated with aggressive characteristics, such as advanced tumor stage, nodal metastasis, distant metastasis, and poor survival. (antiviralbiologic.com)
Elevated expression of TRIP13 in BCa is associated with stage progression, metastasis, and poor survival To investigate the potential relationship between increased TRIP13 expression and the clinical features of BCa, we evaluated the expression of TRIP13 in 342 paraffin-embedded BCa tissue samples using immunohistochemical staining. (antiviralbiologic.com)
Although not significant grade II and III tumours, lymph vascular invasion, ductal carcinoma in situ, and nodal metastasis (≥3) were seen in a higher percentage in methylated tumours. (bvsalud.org)
Human epididymis protein 4 in association with Annexin II promotes invasion and metastasis of ovarian cancer cells. (gzsys.org.cn)

The primary antibody is intended for laboratory professional use in the detection of the corresponding protein in formalin-fixed, paraffin-embedded tissue stained in manual qualitative immunohistochemistry (IHC) testing. (thermofisher.com)
This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
Understanding immune phenotypes and human gastric disease in situ requires an approach that leverages multiplexed immunohistochemistry (mIHC) with multispectral imaging to facilitate precise image analyses. (biomedcentral.com)
Characterizing immune phenotypes in human gastric disease tissues via multiplexed immunohistochemistry may help guide PD-L1 clinical therapy. (biomedcentral.com)
Our study aimed to evaluate the expression of human epidermal growth factor (HER2Neu) in periampullary cancers using immunohistochemistry and fluorescent in situ hybridization. (bvsalud.org)
Tumor Her2/ neu is generally assessed as protein overexpression by using immunohistochemistry (IHC), and patients with tumors that either have 2+ or 3+ results with this method become good candidates for treatment with trastuzumab. (biomedcentral.com)
Immunohistochemistry was performed to validate the expression of two upregulated (EpCAM, FADD) and two downregulated (NDRG1, αB-crystallin) proteins in 190 paraffin-embedded tissue samples. (biomedcentral.com)
We performed a cost-minimization analysis to compare the cost of biomarker analysis for estrogen receptor, progesterone receptor and human epidermal growth factor receptor-2 status with immunohistochemistry versus STRAT4. (bvsalud.org)
METHODS: Fifty-three paraffin-embedded tissue blocks of colorectal resections and corresponding patient information were retrieved from the archives of the Anatomic and Molecular Pathology Department of Lagos University Teaching Hospital.A 4-micron slide section was obtained from each specimen and immunohistochemistry for COX-2 and HER-2 expression was performed. (bvsalud.org)

Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). (zeta-corp.com)
Open in a separate window Figure 1 Increased expression of TRIP13 in human BCa tissues. (antiviralbiologic.com)
a) TRIP13 protein expression in the TMA consisting of BCa tissues and matched adjacent normal bladder tissues (n=46 cases). (antiviralbiologic.com)
b) Representative immunohistochemical staining of CDK2-IN-4 TRIP13 expression in human BCa tissues (T) and adjacent normal tissues (N). (c) gene expression in human BCa samples based on two independent studies (Lee et al. (antiviralbiologic.com)
ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1), cytotoxic T cells (CD8 + T) and regulatory T cells (Foxp3), in formalin-fixed, paraffin-embedded tissues of various human gastric diseases. (biomedcentral.com)
The Hedgehog (Hh) family of secreted proteins plays an important role during embryonic development in regulating growth, patterning and morphogenesis of many tissues ( Ingham and McMahon, 2001 ). (silverchair.com)
Identification and Comparison of Differentiation-Related Proteins in Hepatocellular Carcinoma Tissues by Proteomics. (gzsys.org.cn)
This analysis supports the GGI as a good predictor of relapse for ER-positive patients, even among patients who receive L. Validation of these results, in a larger series from BIG 1-98, is planned using the simplified GGI represented by a smaller set of genes and tested by qRT-PCR on paraffin-embedded tissues. (biomedcentral.com)
Quantitative iTRAQ proteomics analysis was used to detect differentially expressed proteins between lymph node metastases and their paired primary tumor tissues from 23 patients with metastatic breast cancer. (biomedcentral.com)
We identified 637 differentially regulated proteins (397 upregulated and 240 downregulated) in lymph node metastases compared with their paired primary tumor tissues. (biomedcentral.com)

It is a main inductor of genes of antioxidant proteins and phase II detoxifying enzymes [ 1 ]. (hindawi.com)
The major categories are the histopathological type, the grade of the tumor, the stage of the tumor, and the expression of proteins and genes. (wikipedia.org)
HPV-infected cells express some viral proteins encoded by genes called E6 and E7, and can inactivate p53 protein and the retinoblastoma-type pro-tein RBP involved in the regulation of proliferation and cell death. (cuci.ro)
This multiplex mRNA expression test is designed to measure the expression of six genes (3 biomarkers and 3 controls) in formalin-fixed, paraffin-embedded breast cancer tissue from patients with early stage invasive breast cancer. (cepheid.com)
The weighted expression of these genes is combined with two clinical factors (tumor size and nodal status) using a proprietary algorithm to produce a binary risk score (high risk vs low risk) that is designed to predict the likelihood of distant disease recurrence in the next 10 years. (cepheid.com)
Together, these findings suggest that Rps27 and Rps27l are evolutionarily retained because their subfunctionalized expression patterns render both genes necessary to achieve the requisite total expression of two equivalent proteins across cell types. (stanford.edu)

Using systematic random sampling method, 64 formalin fixed paraffin embedded (FFPE) IDC tissue blocks were selected for this study. (bvsalud.org)

In sentinel node, SOX-10 is positive in metastatic melanomas and nodal capsular nevus but not in dendritic cells, which usually express S100 protein. (thermofisher.com)

Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas. (zeta-corp.com)
Human Immunodeficiency Virus Type I (HIV-1) infection is associated with a high incidence of B-cell lymphomas. (biomedcentral.com)
Similar to human HAL, Tg lymphomas are preceded by diffuse lymphadenopathy and increased pro-inflammatory serum cytokines. (biomedcentral.com)
Murine models for human AIDS-related B cell lymphomas have been lacking. (biomedcentral.com)
Most lymphomas are nodal with variable involvement of the bone marrow and peripheral blood. (msdmanuals.com)

Unlike cancer arising in the human population, tumors in genetically engineered mouse models arise in mice with well defined genetic backgrounds where genetic variability can be minimized. (molvis.org)
We assessed Her-2/ neu alteration using CISH on formalin-fixed paraffin-embedded primary invasive ductal carcinoma tumors in which IHC (CB11 antibody) had previously been performed, and we compared the results with IHC. (biomedcentral.com)

External Positive control materials should be fresh autopsy/biopsy/surgical specimens fixed, processed and embedded as soon as possible in the same manner as the patient sample (s). (thermofisher.com)

High SRC expression in pretherapeutic tumor samples significantly correlated with a negative postoperative nodal status (p=0.005). (jcancer.org)

These viral proteins also interact with other several cellular factors and lead to revoke normal cell cycle checkpoint stand cell death mechanisms 13 . (bvsalud.org)

The aim of this study was to determine the evolution of E-cadherin expression in no special type (NST) primary breast carcinoma and to correlate this with that in distant, paired nodal metastases (LNM) and molecular classification. (iiarjournals.org)
Furthermore an increased protein expression in residual tumor tissue was associated with fewer distant metastases (p=0.04). (jcancer.org)

Measurement of PD-L1 protein is limited by the lack of standardized immunohistochemical methods and variable performance of antibodies. (aacrjournals.org)
Dr. Rao and his collaborators, Dr. Robert Damoiseaux and Dr. Neil Garg, are working on new and innovative methods to target a novel protein that is important in acute leukemia and a range of other cancer types. (uclahealth.org)

In this study, we aimed to determine the pattern of immunohistochemical profiles of IDC using oestrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor 2 receptor (HER2) and proliferative index (Ki-67) biomarkers in our tertiary healthcare facility in Uyo, Akwa Ibom State, Nigeria given the dearth of its data in our environment. (bvsalud.org)

Sections were immunostained for estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (Her2), basal cytokeratin CK5, nuclear protein Ki67 and E-cadherin with a Leica Bond-Max autostainer. (iiarjournals.org)
Seven of the 10 cases had been assigned to receive L. Cases and controls were comparable with respect to menopausal and nodal status, local and chemotherapy, and HER2 positivity. (biomedcentral.com)

5-year survival rates are approximately 50% and decrease to 20-40% when there is nodal involvement [ 3 ].In recent years, studies have examined concomitant and multimodality treatments to improve survival outcomes. (oncoscience.us)

The aim of this study was to analyze the expression of HNF4A, estrogen receptor (ER), progesterone receptor (PR) and gross cystic disease fluid protein 15 (GCDFP-15) in a Brazilian cohort. (biomedcentral.com)

Selective loss of E-cadherin can cause de-differentiation and invasiveness in human carcinomas, leading this marker to be classified as a tumor suppressor ( 5 ). (iiarjournals.org)
Anxa2 plays a critical role in enhanced invasiveness of the multidrug resistant human breast cancer cells. (gzsys.org.cn)
Association of a characteristic membrane pattern of annexin A2 with high invasiveness and nodal status in colon adenocarcinoma. (gzsys.org.cn)

Our experiments verify earlier reviews of colocalization between in situ finish labeled DNA and eNOS protein. (hifsignaling.com)

however, such operational efficiencies are unlikely, and more laboratories are pursuing human epidermal growth factor receptor-2 analysis as targeted therapies become increasingly available. (bvsalud.org)

Here we have synthesized and investigated new variants of sp2-IGLs for their ability to suppress the activation of human monocyte-derived dendritic cells (DCs) by lipopolysaccharide (LPS) signaling through Toll-like receptor 4. (cnrs.fr)

In 20-30% of breast carcinomas, Her-2/ neu status is altered, and this is manifested either as amplification of the gene or overexpression of the protein product [ 3 ]. (biomedcentral.com)
Each case was randomly matched with four controls based upon nodal status and treatment (T or L). The prognostic value of GGI was assessed as a continuous predictor and divided at the median. (biomedcentral.com)

In addition, NRF1 and NRF2 mRNA and miR-23B, miR-93, miR-144, miR-212, miR-340, miR-383, and miR-510 levels were analysed with real-time qPCR from 54 paraffin-embedded naevi and melanoma samples. (hindawi.com)
A basic risk score was constructed from a subset of the MTRs shown to be prognostic for breast cancer survival (mRNA and protein level). (cepheid.com)

Tumor PD-L1 protein expression may predict response to drugs targeting this pathway. (aacrjournals.org)
Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
The primary objective was to look for the association between BRCA1 protein expression and DNA promoter methylation. (bvsalud.org)
Expression of B cell-stimulatory cytokines IL-1β, IL-6, IL-10, IL-12 p40 , IL-13 and TNFα and HIV proteins p17, gp120 and nef were elevated in the Tg mice with lymphoma. (biomedcentral.com)
Increased expression of HIV proteins and the B-cell stimulatory factors is consistent with the interpretation that one or more of these factors play a role in lymphoma development. (biomedcentral.com)
Scope includes mutations and abnormal protein expression. (cancerindex.org)
To determine the expression of tissue inhibitors of metalloproteinases (TIMP-2) in oral squamous cell carcinoma (OSCC) and the difference in its expression level between positive and negative HPV-16 (human papilloma virus- 16) OSCC patients. (bvsalud.org)
Clinical significance of annexin II expression in human non-small cell lung cancer. (gzsys.org.cn)
Subfunctionalized expression drives evolutionary retention of ribosomal protein paralogs Rps27 and Rps27l in vertebrates. (stanford.edu)
For paralogs that encode components of protein complexes such as the ribosome, a central question is whether they encode functionally distinct proteins, or whether they exist to maintain appropriate total expression of equivalent proteins. (stanford.edu)
Our work represents the most in-depth characterization of a mammalian ribosomal protein paralog to date and highlights the importance of considering both protein function and expression when investigating paralogs. (stanford.edu)
Expression of High-Mobility Group Box 1 (HMGB1), a multifunctional protein involved in DNA function as well as cell proliferation, inflammation, and the immune response, has been reported to be prognostic in several types of malignancies. (biomedcentral.com)

Identification of aldolase A as a potential diagnostic biomarker for colorectal cancer based on proteomic analysis using formalin-fixed paraffin-embedded tissue. (gzsys.org.cn)

αB-crystallin, a stress-related protein that has recently been shown to be important for cell invasion and survival, was identified as a potential prognostic biomarker to predict the outcome of breast cancer patients. (biomedcentral.com)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. (novusbio.com)

PARPs are proteins that help repair DNA mutations. (bcan.org)

Annexin II promotes invasion and migration of human hepatocellular carcinoma cells in vitro via its interaction with HAb18G/CD147. (gzsys.org.cn)

INHIBITORS While in the latest study we observed that IN inhibits TGF signaling as well as activin and nodal signaling. (hifsignaling.com)

Long-term efficacy and downstream mechanism of anti-annexinA2 monoclonal antibody (anti-ANX A2 mAb) in a pre-clinical model of aggressive human breast cancer. (gzsys.org.cn)
Conclusion Breast cancer biomarker analysis with STRAT4 has the potential to reduce the required human and capital resources in subSaharan African laboratories, leading to improved treatment selection and better clinical outcomes. (bvsalud.org)

The forkhead box (Fox) gene family is a group of highly conserved transcription factors that are expressed in diverse species, including yeast and humans. (oncotarget.com)
We report a human case of ocular filariasis, caused by a species of Breinlia nematode, from Queensland, Australia. (cdc.gov)

The Furry (Fry) gene encodes a large protein (~ 330 kDa) that is evolutionarily conserved from yeast to humans. (nature.com)

Human malignant melanoma stained with anti-SOX-10 antibody using peroxidase-conjugate and DAB chromogen. (thermofisher.com)
Human neuroendocrine carcinoma stained with anti-CD56 antibody using peroxidase-conjugate and DAB chromogen. (zeta-corp.com)

Human papillomavirus (HPV) and Epstein-Barr virus (EBV) are important aetiological risk factors for tumours of the head and neck. (biomedcentral.com)

The paretic phase of avian inflammatory demyelinating polyradiculoneuritis immunobiologically resembles the late-acute disease stages of human acute inflammatory demyelinating polyneuropathy, and is characterised by a Th1-to-Th2 shift. (biomedcentral.com)

These animals are immunized with peripheral myelin or with the purified myelin proteins P0, P2 and/or PMP22. (biomedcentral.com)

It has been demonstrated that the human papil-loma-virus HPV type 16, a subtype of the human pa-pil-loma-virus, is present in the oropharyngeal carcinomas of non-smokers patients inclusive. (cuci.ro)

Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. (cancerindex.org)

Choroidal melanoma is the most common primary malignant ocular tumor in human adults. (molvis.org)

We report a human case of an ocular infection by a Breinlia sp. (cdc.gov)
Human Immunodeficiency Virus Type I (HIV-1) infection is associated with an elevated incidence of B-cell non-Hodgkin's lymphoma (NHL) and in recent years also with Hodgkin's lymphoma [ 1 ]. (biomedcentral.com)
Epidemiological and molecular studies have determined that the persistence of infection with high-risk human papillomaviruses (HR-HPVs) types is the most common risk factor for the development of head and neck malignancies 10-12 . (bvsalud.org)

The furry ( fry ) gene encodes an evolutionarily conserved protein with a wide variety of cellular functions, including cell polarization and morphogenesis in invertebrates. (nature.com)
One such immune checkpoint is programmed cell death protein 1 (PD-1). (biomedcentral.com)

We performed CRISPR/Cas9-mediated genome editing of the NPM-ALK chromosomal translocation in primary human activated T lymphocytes. (biomedcentral.com)

These proteins play a master role in diverse physiological processes and diseases such as the homeostatic tissue remodeling and cancer 17 . (bvsalud.org)

We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
However, strikingly, expressing Rps27 protein from the endogenous Rps27l locus or vice versa completely rescues loss-of-function lethality and yields mice with no detectable deficits. (stanford.edu)

Anatomy1

Diseases2

Chemicals and Drugs3

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes1

Information Science2

Extra-nodal2

Formalin-fixed and paraffin-embedded2

Metastasis6

Immunohistochemistry9

Tissues11

Genes6

FFPE1

Metastatic1

Lymphomas5

Tumors2

Specimens1

0.0051

Viral proteins1

Distant2

Methods2

Immunohistochemical1

Her22

Involvement1

Progesterone receptor1

Invasiveness3

Situ1

Epidermal1

Dendritic cells1

Status2

MRNA2

Expression12

Colorectal1

Prognostic1

Diagnosis1

Mutations1

Vitro1

Inhibitors1

Clinical2

Species2

Yeast1

Antibody2

Papillomavirus1

Acute1

Peripheral1

Carcinomas1

Interact1

Malignant1

Infection3

Cell2

Primary1

Role1

Mice2